Preventing severe hypoxia during emergent intubation: is nasopharyngeal oxygenation the answer?

Critically ill patients requiring emergent endotracheal intubation are at risk for life-threatening hypoxemia during the intubation procedure, particularly when the patient is apneic and not receiving any supplemental oxygen. In a current study, Engström and colleagues investigated the effect of nasopharyngeal oxygenation in eight anesthetized pigs with induced acute lung injury. The investigators confirmed, even in this model, that pharyngeal oxygenation significantly prolonged the time to desaturation during periods of apnea. Recognizing the limitations of directly extrapolating these experimental results to critically ill human subjects, the findings do support the contention that, until proven otherwise, nasopharyngeal oxygenation should at least be considered as one technique to diminish hypoxemic complications in very sick patients, particularly those with underlying pulmonary impairment.

Th e prospective investigation by Engström and colleagues in a previous issue of Critical Care sets out to deter mine if apneic oxygenation via a pharyngeal catheter during endotracheal intubation would prevent or increase the time to life-threatening hypoxemia in an animal model with acute lung injury [1]. In this investigation, eight anesthetized piglets with induced lung collapse were randomized to receive either 10 L of oxygen per minute via a pharyngeal catheter or no oxygen. Th e investi gators found that pharyngeal oxygenation markedly prolonged the time to severe systemic arterial oxygen desaturation, defi ned as oxygen saturation (SpO2) of less than 60%.
Emergency endotracheal intubation in the critical care unit and in the emergency department can be fraught with complications. Diffi culty with oxygenation can be challenging in the critically ill as they have much less reserve and are more prone to desaturate during the brief apneic period that occurs while the patient is being intubated [2]. Traditionally, patients typically do not receive supplemental oxygen as attempts are made to pass the endotracheal tube through the vocal cords. In one prehospital study, for example, it was found that among 54 trauma patients who had been intubated following a rapid sequence induction technique, 57% experienced signifi cant desaturation with a median duration of 160 seconds [3].
Th e specifi c premise of the current investigation by Engström and colleagues was to use an animal model involving induced acute lung injury in order to demonstrate that even in underlying conditions at greater risk for life-threatening hypoxemia, the oxygen desaturation can be minimized by using the pharyngeal catheter supplemental oxygen technique. One limitation of the study was that the authors chose a threshold saturation level that was markedly low (60%). In other studies of critically ill adults, 'severe hypoxemia' was defi ned as a SpO2 of less than 80% and 'hypoxemia' was defi ned as a SpO2 of less than 90% [4,5]. It would be helpful to know when the piglets' SpO2 fell below 90%, a point at which traditional concerns for hypoxia during intubation typically begin for most clinicians. Th ough less contentious, the investigators chose a continuous 10-minute period of apnea as their cutoff point for desaturation. One prospective cohort study of endotracheal intubation attempts in critically ill adults demonstrated that 10.3% of intubations did require 10 or more minutes to achieve [4]. However, these patients had multiple intubation attempts in which they were ventilated with a bag-valvemask (BVM) between intu ba tion attempts. Accordingly,

Abstract
Critically ill patients requiring emergent endotracheal intubation are at risk for life-threatening hypoxemia during the intubation procedure, particularly when the patient is apneic and not receiving any supplemental oxygen. In a current study, Engström and colleagues investigated the eff ect of nasopharyngeal oxygenation in eight anesthetized pigs with induced acute lung injury. The investigators confi rmed, even in this model, that pharyngeal oxygenation signifi cantly prolonged the time to desaturation during periods of apnea. Recognizing the limitations of directly extrapolating these experimental results to critically ill human subjects, the fi ndings do support the contention that, until proven otherwise, nasopharyngeal oxygenation should at least be considered as one technique to diminish hypoxemic complications in very sick patients, particularly those with underlying pulmonary impairment.

© 2010 BioMed Central Ltd
Preventing severe hypoxia during emergent intubation: is nasopharyngeal oxygenation the answer? it is likely that none of these patients had a continuous 10-minute period of prolonged apnea.
Several reports in the anesthesia literature support the use of nasopharyngeal oxygenation following preoxygen ation in human subjects, but all in relatively healthy, cooperative persons. For example, Teller and colleagues [6] conducted a randomized placebo controlled trial in 12 uncomplicated patients undergoing endotracheal intubation during scheduled surgery. An 8 Fr catheter was inserted through a nasal airway and insuffl ated with oxygen (3 L/minute). Th ey found that the arterial oxygen saturation (SaO2) never fell below 97% during the entire 10 minutes of apnea. How the results of these studies would then translate to critically ill human subjects undergoing emergent intubation remains to be seen, particularly among those with underlying pulmonary impairment. It makes intuitive sense that if one provides supplemental oxygenation using a method that allows simultaneous intubation procedures to take place, the time to desaturation would be prolonged, and the experimental evidence certainly supports that contention. Although the presence of a pharyngeal catheter may provide a barrier to obtaining a good seal when using modern BVM devices, it appears (as observed with previous studies) that such a device could be rapidly replaced whenever the BVM is removed.
Overall, the authors succeeded in demonstrating the benefi ts of pharyngeal oxygen administration in reducing the risk of desaturation during intubation in the presence of acute lung injury using an animal model. Although the study design implemented in the current investigation would be diffi cult to repeat in human subjects, this study supports the intuitive contention that pharyngeal oxygen ation should be considered during emergent intubation of critically ill patients, particularly during periods of apnea. Severe life-threatening hypoxemia is a wellknown adverse consequence of emergent intu bations and any reasonable measure used to minimize this risk is a reasonable conclusion. Th e authors should be congratulated for taking this fi rst step in the methodical process of proper evidence-based approaches in clinical care of the critically ill.