Correction: Nitrogen washout/washin, helium dilution and computed tomography in the assessment of end expiratory lung volume

Following publication of our recent article [1], we noticed several errors relating to the figures. The complete set of correct figures follows below (Figure 1, 2, 3, 4 and 5). The legend for Figure 5, 'Comparison of end expiratory lung volume (EELV) measured by the helium dilution technique and the nitrogen washout/washin method', was incorrect and should read as follows: Comparison of end expiratory lung volume (EELV) measured by the helium dilution technique and the nitrogen washout/ washin method. (a) The EELV measured by the helium dilution as a function of the EELV measured by nitrogen washout/washin method (EELV helium dilution =-111.85 + 0.89 × EELV GE, r 2 = 0.82, p < 0.00001). (b) The Bland-Altman plot of the EELV measured with the nitrogen washout/washin technique and the EELV measured with the helium dilution method. The x-axis shows the mean of the two measurements and the y-axis shows the difference between the EELV measured by then helium dilution method and the nitrogen washout/washin method (average difference-229 ± 164 ml, limits of agreement-558 – 100 ml). The values in graph (a) of Figures 1, 4 and 5 had been plotted onto the incorrect axis. The panels in Figure 3 had been switched. Graph (a) should be the linear regression plot and graph (b) should be the Bland-Altman plot.


(page number not for citation purposes)
Following publication of our recent article [1], we noticed several errors relating to the figures. The complete set of correct figures follows below (Figure 1, 2, 3, 4 and 5).
The legend for Figure 5, 'Comparison of end expiratory lung volume (EELV) measured by the helium dilution technique and the nitrogen washout/washin method', was incorrect and should read as follows: Comparison of end expiratory lung volume (EELV) measured by the helium dilution technique and the nitrogen washout/ washin method. (a) The EELV measured by the helium dilution as a function of the EELV measured by nitrogen washout/washin method (EELV helium dilution = -111.85 + 0.89 × EELV GE, r 2 = 0.82, p < 0.00001). (b) The Bland-Altman plot of the EELV measured with the nitrogen washout/washin technique and the EELV measured with the helium dilution method. The x-axis shows the mean of the two measurements and the y-axis shows the difference between the EELV measured by then helium dilution method and the nitrogen washout/washin method (average difference -229 ± 164 ml, limits of agreement -558 -100 ml).

Figure 2
The relative error of the procedire performed by the Engstrom Carestation. This is expressed as (EELV GE -EELV CT SCAN )/EELV CT SCAN as a function of the ratio between tidal volume and the end expiratory lung volume (EELV) measured by computed tomography (CT) scan ((EELV GE -EELV CT SCAN )/EELV CT SCAN = 0.05 + 0.43 × (Tidal Volume/EELV CT SCAN , r 2 = 0.58, p < 0.0001).
(page number not for citation purposes)

Figure 3
Accuracy of the nitrogen washin-washout technique. (a) The relation between the EELV measured by increasing the FiO 2 as a function of the EELV obtained decreasing FiO 2 . The EELV obtained increasing the FiO 2 was -56 + 1.0078 multiplied by the EELV obtained decreasing the FiO 2 (r 2 = 0.84, p < 0.0001). (b) The Bland-Altman plot of the EELV measurement obtained increasing the FiO 2 and the EELV obtained decreasing the FiO 2 . The x axis shows the mean of the two measurements and the difference between the EELV measured by increasing FiO 2 and the y axis shows the EELV obtained decreasing FiO 2 (average difference 48 ± 165 ml, limits of agreement -117-213 ml).

Figure 4
Comparison of end expiratory lung volume (EELV) measured by the helium dilution technique and the computed tomography (CT) scan.
(a) The EELV measured by the helium dilution technique as a function of the EELV measured by the CT scan (EELV helium dilution = 20 + 0.84 × EELV CT scan, r 2 = 0.91, p < 0.00001). (b) The Bland-Altman plot of the EELV measured with the CT scan and the EELV measured with the helium dilution method. The x axis shows the mean of the two measurements and the y axis shows the difference between the EELV measured by the helium dilution method and the EELV measured by the CT scan (average difference -136 ± 133 ml, limits of agreement -3 -269 ml). The difference between the EELV measured with the helium dilution method and the EELV measured with CT scan was significantly correlated with the EELV, expressed as the average between the two measurements (Helium EELV -CT scan EELV = -15.52764 + -0.17034 × (helium EELV + CT scan EELV)/2, r 2 = 0.21, p = 0.005838).

Figure 5
Comparison of end expiratory lung volume (EELV) measured by the helium dilution technique and the nitrogen washout/washin method.
(a) The EELV measured by the helium dilution as a function of the EELV measured by nitrogen washout/washin method (EELV helium dilution = -111.85 + 0.89 × EELV GE, r 2 = 0.82, p < 0.00001). (b) The Bland-Altman plot of the EELV measured with the nitrogen washout/washin technique and the EELV measured with the helium dilution method. The x-axis shows the mean of the two measurements and the y-axis shows the difference between the EELV measured by then helium dilution method and the nitrogen washout/washin method (average difference -229 ± 164 ml, limits of agreement -558 -100 ml).