Continuous glucose sensors for glycaemic control in the ICU: have we arrived?

Dr Blixt and colleagues show in an elegant pilot study that the continuous measurement of glucose in venous blood by microdialysis in a central venous catheter is feasible in critically ill patients. The performance of this type of continuous glucose monitoring device equals the performance of the commonly used handheld blood glucose meters. But are we, as ICU physicians and nurses, now ready to implement such continuous blood glucose sensors into the daily practice of the ICU? The only yardstick to this is "are these devices truly helping us ...in our critically ill patients".


Introduction
Tight blood glucose control, within the range of fasting blood glucose levels, reduced morbidity in critically ill patients in the setting of well-controlled single-centre studies. Tight blood glucose control also lowered mortality in adult and paediatric patients after cardiac surgery [1,2]. In contrast, the large, international multicentre clinical NICE-SUGAR study showed increased mortality in the patients undergoing tight blood glucose control [3]. Due to NICE-SUGAR's pragmatic nature, variations in the essential parts of gl ycaemic control were allowed [4]. Particularly, all sorts of glucose measurement method ologies were used: handheld blood glucose meters, blood gas analysers and central laboratory measurements. Blood for the measurement could be of arterial, venous or capillary origin.
Two major conclusions were drawn from this NICE-SUGAR trial [4]. First, glycaemic control must be important in critically ill patients because its manipulation may decrease or increase mortality. Second, more attention is needed for the technological aspects of blood glucose control, notably the blood glucose measurements and the glycaemia control systems, that give advice on the insulin dosage [5].
Hence, continuous blood glucose monitoring (CGM) devices could become an integral part of safe and eff ective glycaemic control in order to provide patient benefi t, while minimising the workload for the nurses.

Pilot studies... and hopefully more
Th e small (n = 10) implementation study by Dr Blixt and colleagues showed that, in patients who underwent upper abdominal surgery, the point accuracy of microdialysis CGM is in line with that of the handheld blood glucose meters, with a 95% confi dence interval of ±2 mmol/l (36 mg/dl) [6,7]. A similar study with the same CGM device in cardiac surgery patients yielded comparable results [8]. Th ese results were obtained in a time period of 20 hours and a context of tolerating hyperglycaemia up to 11 mmol/l (198 mg/dl).
Clearly, this device is meeting the criteria for safety and performance, suffi cient to obtain a CE mark ( Figure 1): the device is safely measuring blood glucose levels with an acceptable accuracy in the normoglycaemic and hyperglycaemic range. Are we now ready for wide CGM implementation? Probably not, for two reasons.
First, for handheld blood glucose meters, such a level of accuracy is deemed insuffi cient to manage tight glycaemic control [9,10]. For handheld blood glucose meters and the current CGM devices the 95% confi dence interval range (36 mg/dl) is larger than the range (30 mg/dl) for tight glycaemic control (80 to 110 mg/dl). Th ese sensors may also overestimate blood glucose levels in the hypoglycaemic zone. Th e presence of continuous data and the embedded trend information may compensate this moderate point accuracy in CGM sensors. If this was true, CGM should easily help us in realising tight glycaemic control while avoiding hypo glycaemia and increased blood glucose variability.
Second, the clinical evidence is still too weak. Randomised controlled trials will be required to show that these devices can deliver this ambition in ideal circum stances Abstract Dr Blixt and colleagues show in an elegant pilot study that the continuous measurement of glucose in venous blood by microdialysis in a central venous catheter is feasible in critically ill patients. The performance of this type of continuous glucose monitoring device equals the performance of the commonly used handheld blood glucose meters. But are we, as ICU physicians and nurses, now ready to implement such continuous blood glucose sensors into the daily practice of the ICU? The only yardstick to this is "are these devices truly helping us ...in our critically ill patients".
(effi cacy) and in the usual clinical setting of any ICU across the globe (eff ectiveness). A (subcutaneous) CGM device reached similar point accuracies (46 mg/dl), but in a single-centre effi cacy randomised controlled trial the device only decreased the incidence of hypoglycaemia without improving blood glucose control or variability [11,12]. Th e clinical community is now eagerly awaiting these randomised controlled trials with the newer CGM devices to decide on their applicability. Th e comparator in these trials should be the current gold standard of glucose measurements in arterial blood by a blood gas analyser. Additionally, change in patient-centred outcome measures of the glucose dynamics should be the focus of these trials [13].
Such a roadmap may seem tedious and expensive for CGM validation. Never theless, this will be essential to convince the evidence-based medicine trained physician. Moreover, healthcare payers and society will pass the fi nal judge ment: is it worth it? Otherwise, expert nurses [1,14] or computerised protocols [15,16] using intermittent blood glucose measurements may remain the cost-eff ective gold standard.

Conclusion
Th e point accuracy of a near-continuous blood glucose sensor with microdialysis through a central venous line is acceptable for monitoring in the normoglycaemic and hyperglycaemic range. However, the device is currently not good enough for blood glucose management within a narrow range. Th e clinical benefi t and cost-eff ectiveness of these CGM devices still have to be demonstrated against the current gold standard of intermittent arterial glucose measurements in a blood gas analyser.

CGM, continuous blood glucose monitoring.
Competing interests DM has received, through KU Leuven, speaker's honoraria and travel reimbursements from Maquet and Medtronic.