Sustained low-efficiency dialysis in surgical acute kidney injury - really useful?

In a recent issue of Critical Care, we read with interest the article by Schwenger and colleagues [1] on sustained low-effi ciency dialysis (SLED) versus continuous venovenous hemofi ltration (CVVH) in surgical patients with acute kidney injury. Th e authors have to be congratulated for their eff orts to shed some light on the clinical usefulness of the SLED technology as an alternative to conventional renal replacement therapy (RRT) modalities. However, in our opinion, the study has some important limitations: According to the protocol (NCT00322530), the authors aimed to enroll 100 patients per group, a sample size that may be justifi ed only for an anticipated (but unlikely) mortality diff erence of roughly 20%. Th us, the present study is clearly underpowered to detect diff erences in the primary outcome (90-day mortality). Unfortunately, neither baseline pulmonary function nor indications for respiratory support are presented. Th is leaves ample room for speculation that – in such a small population with a high percentage of patients for whom severe pulmonary complications are common – the shorter duration of ventilator support in the SLED group may be related to factors other than the RRT modality.

In a recent issue of Critical Care, we read with interest the article by Schwenger and colleagues [1] on sustained low-effi ciency dialysis (SLED) versus continuous venovenous hemofi ltration (CVVH) in surgical patients with acute kidney injury. Th e authors have to be congratulated for their eff orts to shed some light on the clinical usefulness of the SLED technology as an alternative to conventional renal replacement therapy (RRT) modalities. However, in our opinion, the study has some important limitations: According to the protocol (NCT00322530), the authors aimed to enroll 100 patients per group, a sample size that may be justifi ed only for an anticipated (but unlikely) mortality diff erence of roughly 20%. Th us, the present study is clearly underpowered to detect diff erences in the primary outcome (90-day mortality).
Unfortunately, neither baseline pulmonary function nor indications for respiratory support are presented. Th is leaves ample room for speculation that -in such a small population with a high percentage of patients for whom severe pulmonary complications are commonthe shorter duration of ventilator support in the SLED group may be related to factors other than the RRT modality.
Despite the protocol (NCT00322530), the authors do not present renal recovery at 90 days. 'Time after RRT initiation' is a questionable renal outcome taking into account the lack of clearly defi ned RRT stop criteria and the unusual use of high-dose diuretics during (!) RRT.
With respect to these and other [2] limitations of the present study and the continuous RRT benefi ts shown in a recent meta-analysis [3], adequately powered studies comparing SLED and continuous venovenous hemo diafi ltration are still urgently needed.

Veda t Schwenger, Markus Weigand and Christian Morath
We thank Heringlake and colleagues for their comments. Indeed, our study has several limitations that had been addressed thoroughly in the Limitations section of our article: 'the power of the study may be probably insuffi cient to fi nally judge whether one or the other treatment modality is superior in terms of survival' [1]. However, with comparable effi cacy and safety of SLED and CVVH, the question comes down to economics, and the power of our study was clearly suffi cient to discriminate diff erences in economics in favor of SLED therapy. Th erefore, according to the best available evidence we have, dialysis techniques such as SLED are not inferior to continuous RRTs but do cost signifi cantly less [1,[4][5][6].
As discussed in the article, we feel (as Heringlake and colleagues do) that the shorter duration of ventilator support in the SLED group may be related to factors other than the RRT modality per se [1]. As discussed in the Limitations section, there are no generally accepted stop criteria for RRTs in intensive care units (ICUs). Since we had a surgical collective with often nonoliguric acute renal failure, we defi ned recovery of renal function as cessation of RRT but continuation of medical therapy.
In summary, to the best of our knowledge, we presented what is so far the largest prospective randomized trial for the comparison of SLED using a single-pass batch dialysis system (SLED-BD) and CVVH for the treatment of acute kidney injury in patients in the surgical ICU. Most outcome parameters were not diff erent while SLED therapy was associated with signifi cantly lower costs.