Down but not out: myocardial depression in sepsis

Myocardial depression in septic patients is well recognized yet still poorly understood. The prognostic significance in terms of overall mortality when it is identified, remains in dispute. Parameters of left ventricular function measured by tissue Doppler imaging may assist in resolving whether dysfunction identified early in the course of sepsis is a good prognostic sign.

Myocardial impairment resulting from systemic sepsis has been recognized for more than a quarter of a century, yet much about the phenomenon remains a mystery. Th e incidence of myocardial depression in the critically ill patient with sepsis is uncertain because of the imprecision with which myocardial depression is described, the defi nition of sepsis, and the fact that published studies display marked heterogeneity in patient selection and methods of evaluation. For example, earlier studies included variable populations of patients and relied on radionuclide or pulmonary artery catheter methods, whereas techniques such as tissue Doppler imaging have been around for only the last decade. Depression of myocardial function in septic patients is likely to be more common than previous thought because echocardiography is now more readily available and used by critical care physicians experienced in using it. Weng and colleagues [1], in measuring echocardiographic, clinical, and laboratory variables in 61 patients with septic shock, found that left ventricular tissue Doppler parameters demonstrated potentially useful prognostic information. In particular, the peak systolic velocity measured at the mitral annulus (Sa), a measure of the long-axis systolic motion of the left ventricle, was signifi cantly lower in survivors than non-survivors. Using a cutoff value of 9 cm/second predicted 90-day mortality with a sensitivity and a specifi city of 75% and 86%, respectively. Left ventricular ejection fraction measurements between survivors and non-survivors were not signifi cantly diff erent. Th is work is the latest in a series of studies examining the pathophysiology of sepsis-induced cardiomyopathy and, more specifi cally, its prognostic signifi cance.
Earlier work using radionuclide and pulmonary artery catheter studies indicated that dilatation of the left ventricle was associated with a lower mortality in patients with sepsis [2]. Later studies using echo Doppler techniques did not confi rm the relationship between left ventricular dilatation and improved outcome from sepsis but did confi rm the relationship between left ventricular dysfunction and outcome. Vieillard-Baron and colleagues [3] found that 60% of their patients with sepsis experienced underlying left ventricular dysfunction as a result of sepsis when evaluated by transesophageal echocardiographic examination. Th e assumption that septic cardiomyopathy is somehow benefi cial and indicates a better patient outcome should be treated with caution. Th is is an attractive hypothesis, but the focus may be incorrect. Th e contrary emphasis could be that the hyperkinetic state present in many patients with sepsis indicates profound vasoplegia and this is responsible for the increased mortality in this group [4]. Also, the clinician needs to consider more than left ventricular systolic function as left ventricular diastolic function and right heart function can also be aff ected in sepsis, either independently or collectively [5]. Even when the more recent sophisticated echo Doppler techniques are applied, there is disagree ment regarding the prognostic or potentially protective value of cardiac depression. In a study of only 21 patients, E/Ea (early diastolic transmitral velocity/early mitral annular diastolic velocity ratio), but not Sa, was an independent predictor of mortality in septic shock [6]. In a larger and more recent study involving 262 patients with severe sepsis, the presence of systolic dysfunction, diastolic dysfunction, or both was associated with a higher mortality [7].
Th e actual cause of the cardiac dysfunction found in many patients with severe sepsis is still uncertain and multiple etiologies are proposed. Cytokines have been favorite candidates over the years; a circulating myocardial depressant factor was fi rst postulated by Wiggers [8] in 1947 and was advanced further by Parillo and colleagues [9] in 1985. Complement molecules, nitric oxide, cellular adhesion molecules, disordered intra cellular energetics, and abnormalities in intracellular calcium fl uxes are some of the more recently postulated causes [10].
Considerable uncertainty still surrounds the incidence, etiology, assessment, and prognostic signifi cance of septic cardiomyopathy, and the fi ndings by Weng and colleagues should be observed in this light. It is unlikely that a single measurement such as Sa will prove to be a robust prognostic marker, particularly since the range for this parameter in the healthy population is so broad [11]. It may be that recently developed echo Doppler tech niques will provide a more accurate set of methods of evaluating cardiac dysfunction in severe sepsis. Recent developments, including velocity vector tracking and fourdimensional echocardiography, open a window on ventricular rotation during systole, a signifi cant contri butor to cardiac output. In the past, echo Doppler techniques -which, apart from magnetic resonance imaging, are the best tools available for assessing ventricular function -have not taken into account the contribution of twisting and torsion of the ventricle, estimated to account for 40% of cardiac output. Tissue Doppler imaging has enhanced our understanding of left ventricular function, and the fi nding that Sa may be an important prognostic marker in septic cardiomyopathy is a stimulus to more closely examine myocardial reaction to the insult. Th e cardiac sequelae of severe sepsis can be severe, and bedside echocardiographic assessment is essential to the further understanding of this most intriguing condition.

Abbreviation
Sa, systolic velocity measured at the mitral annulus.