On the imperfect synchrony between patient and ventilator

Because patient-ventilator asynchrony (PVA) is recognized as a major clinical problem for patients undergoing ventilatory assistance, automatic methods of PVA detection have been proposed in recent years. A novel approach is airflow spectral analysis, which, when related to visual inspection of airway pressure and flow waveforms, has been shown to reach a sensitivity and specificity of greater than 80% in detecting an asynchrony index of greater than 10%. The availability of automatic non-invasive methods of PVA detection at the bedside would likely be of benefit in intensive care unit practice, but they may be limited by shortcomings, so clear proof of their effectiveness is needed.

Non-invasive automatic methods to detect patient-ventilator asynchrony (PVA) have been proposed repeatedly in recent years [1][2][3][4][5]. Th e reason for this increasing interest is the notion that, unlike patients with an asynchrony index (AI) of less than 10%, those with high rates of PVA (as defi ned by an AI of greater than 10%) are characterized by poorer outcome (that is, longer durations of mechanical ventilation [6][7][8] and ICU stay [7,8], a reduced number of ventilator-free days [8], a higher rate of tracheotomy [7], and lower probabilities of survival [6] and home discharge [8]).
We do not know whether PVA itself causes this increased morbidity by prolonging the time spent on mechanical ventilation or instead is a marker of poor respiratory function in sicker patients at increased risk of high morbidity. In the fi rst case, decreasing PVA would improve a patient's outcome, whereas in the second case, PVA would just represent a prognostic factor. Never theless, in both cases, recognizing PVA would be a valuable clinical piece of information.
In this issue of Critical Care, Gutierrez and colleagues [1] present a new method that is based on airfl ow spectral analysis for the detection of PVA and that is characterized not by synchronous breaths but by a less organized spectral pattern. When this novel approach is correlated to visual inspection of airway pressure and fl ow waveforms in detecting an AI of greater than 10%, sensitivity and specifi city both exceeded 80%, and this led the authors to conclude that this method could be adapted to ventilators for PVA monitoring. Such a continuous non-invasive monitoring device would facilitate the recognition of PVA and help to evaluate the eff ectiveness of measures adopted to face it, such as reducing sedation, changing ventilator mode, or varying ventilator settings, chiefl y by decreasing the amount of assistance or by improving the match between neural and mechanical inspiration or by both means.
Th e studies in which PVA is assessed by visual inspection of the ventilator waveforms are commonly performed by trained observers or researchers who have a high level of knowledge in this specifi c fi eld and who might not refl ect the average skill of the ICU professionals. New data on the ability of ICU physicians to recognize PVA at the bedside show that the chance to detect PVA by ventilator waveform observation in the 'real world' is less than anticipated [9], making automatic methods of PVA detection, such as the one proposed by Gutierrez and colleagues [1], even more helpful than expected. However, it is worthwhile to consider the potential limitations of (a) the automatic methods of PVA detection in general and (b) this approach acting in the frequency domain in particular.
It is unclear whether inspection of airway pressure and fl ow waveform represents a valid gold standard. Some studies proposing automatic methods of PVA detection use indices of inspiratory eff ort, such as esophageal [2,5] and trans-diaphragmatic [4] pressure. Th e latter approach is not susceptible to potential biases arising from neuroventilatory uncoup ling in those situations in which, although the excitation of the respiratory muscles (neural

Abstract
Because patient-ventilator asynchrony (PVA) is recognized as a major clinical problem for patients undergoing ventilatory assistance, automatic methods of PVA detection have been proposed in recent years. A novel approach is airfl ow spectral analysis, which, when related to visual inspection of airway pressure and fl ow waveforms, has been shown to reach a sensitivity and specifi city of greater than 80% in detecting an asynchrony index of greater than 10%. The availability of automatic non-invasive methods of PVA detection at the bedside would likely be of benefi t in intensive care unit practice, but they may be limited by shortcomings, so clear proof of their eff ectiveness is needed. eff ort or drive) generates pressure (mechanical eff ort), this pressure is not translated into fl ow and volume [9][10][11]. Indeed, in extreme cases of poor neuro-mechanical coupling (that is, impaired transformation of the muscle electrical activation into pressure), even the esophageal and trans-diaphragmatic pressures might not be completely eff ective in ascertaining a patient's neural drive [9,11,12]. Our chances of determining the occurrence of neuro-ventilatory and neuro-mechanical uncoupling by visual inspection of the airway pressure and fl ow waveforms are limited, but it is uncertain to what extent this may actually hamper our ability to detect PVA at the bedside.
More specifi cally, to consider a method based on an analysis of the frequency spectrum [1], further evaluation is necessary to clarify whether such an approach may fi t (a) modes of ventilation that allow the patient to retain full control of the breathing pattern and that are characterized by high breath-by-breath variability [12] and (b) non-invasive ventilation in which asynchronies frequently occur [13,14] and, given that the patient is usually alert, non-chemical behavioral inputs infl uence the neural drive and breathing pattern [15].
In the last decade, we have greatly increased our knowledge about PVA. We are now aware that it occurs more frequently than previously perceived and, given its correlation with poorer outcome, is clinically relevant. Further research is necessary to address several unresolved issues, and recognition of PVA in the clinical setting is surely one of these. Th e imperfect synchrony between patient and ventilator has become a stand-alone topic within the fi eld of mechanical ventilation.