Assessment of fluid responsiveness during increased intra-abdominal pressure: keep the indices, but change the thresholds

Dynamic variables of fluid responsiveness are useful guides for fluid management in patients under controlled positive pressure ventilation. In the previous issue of Critical Care, Jacques and colleagues show that these variables remain reliable predictors of fluid responsiveness in a porcine model of intra-abdominal hypertension, but threshold values are higher than during normal intra-abdominal pressure. Their threshold values, however, cannot be applied to clinical practice. This study suggests that intra-abdominal pressure must be measured in critically ill patients, and 'supranormal' values of dynamic variables should be analyzed with caution. The 'fluid responsive part' of an increased dynamic variable in such patients may be estimated by measuring its change during a fluid challenge.

In the previous issue of Critical Care, Jacques and colleagues [1] report that respiratory variations in stroke volume (SVV) and in arterial pulse pressure (PPV) remain reliable indices of fl uid responsiveness in a porcine model of intra-abdominal hypertension (IAH). Th reshold values, however, are higher than during normal intra-abdominal pressure (IAP), so that a 'supranormal' SVV or PPV does not necessarily mean fl uid respon siveness during IAH.
Why is this study important? Dynamic indices such as PPV and SVV are accurate predictors of volume responsive ness in critically ill patients under controlled positive pressure ventilation, with an accuracy greater than that of traditional static indices of cardiac preload. Th e mean threshold values allowing optimal discrimination between fl uid responders and non-responders were 12.5 ± 1.6% for PPV and 11.6 ± 1.9% for SVV in a recent systematic review of the literature [2]. Th ese results, however, did not include patients where conditions prevented correct measurement of these indices (such as cardiac arrhythmias or spontaneous ventilation) or may have been associated with reduced accuracy (especially small tidal volumes or acute cor pulmonale). A third category of circumstances, where dynamic indices remain robust indicators of fl uid responsiveness if (and only if ) used with diff erent thresholds, may also be identifi ed and constitute an additional refi nement in PPV/SVV inter pre tation. It was suspected early on that the magnitude of tidal volume would infl uence the threshold value of functional hemodynamics [3]. More recently, Biais and coworkers [4] showed that prone position (for scoliosis surgery) does not alter the ability of both PPV and SVV to predict fl uid responsiveness, but induces a signifi cant increase in PPV and SVV, probably related to a decrease in static compliance of the respiratory system. Accord ingly, the 'optimal' threshold value for PPV in this study was 11% in the supine position, and 15% in the prone position [4]. In recent years, elevated IAP has been increasingly recognized in medical and surgical critically ill patients [5]. Cardiovascular dysfunction and failure are commonly encountered in the patient with IAH, and one of the bases of management is optimization of systemic perfusion and organ function, which includes accurate assessment of preload and preload responsiveness [5]. However, static indices of preload are diffi cult to interpret in patients with IAH [6]. Assessing fl uid responsiveness with the passive leg raising maneuver in these patients results in false negative cases [7]. Experimental studies have shown that IAH increases dynamic variables [6] and, accordingly, 25% of patients with IAH may be non-responsive to volume infusion despite a PPV >12% [7]. Recently,

Abstract
Dynamic variables of fl uid responsiveness are useful guides for fl uid management in patients under controlled positive pressure ventilation. In the previous issue of Critical Care, Jacques and colleagues show that these variables remain reliable predictors of fl uid responsiveness in a porcine model of intra-abdominal hypertension, but threshold values are higher than during normal intra-abdominal pressure. Their threshold values, however, cannot be applied to clinical practice. This study suggests that intra-abdominal pressure must be measured in critically ill patients, and 'supranormal' values of dynamic variables should be analyzed with caution. The 'fl uid responsive part' of an increased dynamic variable in such patients may be estimated by measuring its change during a fl uid challenge. Renner and colleagues [8] found in a porcine model that PPV, but not SVV (derived from pulse contour analysis), remained a sensitive and specifi c predic tor of fl uid responsiveness, although the threshold value for PPV increased from 11.5% (mean IAP = 7 mmHg) up to ≥20.5% (mean IAP = 26 mmHg).
Th us, what does the study by Jacques and colleagues [1] add to previous knowledge? First, they confi rm former results with a protocol that elegantly combines, for the fi rst time, changes in IAP, blood withdrawal, and fl uid loading. Second, they show that SVV, when directly measured using an ultrasound transit-time fl ow probe placed around the aortic root, is also predictive of fl uid responsiveness in IAH. Th is contrasts with the results reported by Renner and colleagues [8], who acquired SVV via pulse contour monitoring, suggesting that the accuracy of the latter may be altered during IAH. Th ird, their data strongly suggest that, at least in their experimental conditions, the 'non-responsive' part of the increase in dynamic indices during IAH is due to an increase in right ventricular afterload.
Th ese new data should, however, be extrapolated to critically ill patients with caution. In this study, baseline PPV and SVV were much higher than in humans or in other experimental studies. High tidal volume as used in the study (13 ± 1 ml/kg in the presence of severe reduction in chest wall compliance) may explain, in part, these fi ndings as well as the signifi cant increase in right ventricular afterload, a result not found by Renner and colleagues [8]. In addition, the high IAP level used in the study (30 mmHg) corresponds to the more severe level (grade IV, IAH >25 mmHg [5]) of IAH in patients. Finally, a high but discriminative threshold could be identifi ed by the authors because a precise and controlled value of IAP was induced in all animals, which would not be the case in clinical practice. Th us, what is demonstrated in this study is qualitative (there is an increase in dynamic indices in the presence of IAP, with one part responsive to fl uid infusion) rather than quantitative. Th e threshold values reported by Jacques and colleagues have no direct clinical relevance. Th e consequences for clinical practice are thus that IAP must be measured in critically ill patients, and dynamic indices such as PPV should be used, but, in order to avoid excess of fl uids, higher than classical (10 to 13%) thresholds should be considered when IAP is increased. As a gradual increase of threshold values with IAP is very likely, no precise value can be recommended so far. In a given patient with increased PPV, a fl uid challenge may be performed and the resulting change in PPV/SVV quantifi ed since only the 'preload-dependent part' of PPV is likely to be reduced with volume infusion. Whether the PPV value obtained at completion of such fl uid load in such a patient may be used as the 'operational' threshold for the following hours of management, provided that other major determinants of PPV (IAP and tidal volume) are kept constant, can be reasonably hypothesized but deserves further validation.