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Citation: Critical Care 2024 28:103
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Quality of life-related and non-quality of life-related issues in ICU survivors and non-ICU-treated controls: a multi-group exploratory factor analysis
Quality of life (QoL) is a key outcome measure in healthcare. However, the heterogeneity in its definitions presents challenges in the objective evaluation of improvement. Universal questionnaires, tailored fo...
Citation: Critical Care 2024 28:102 -
Hydrocortisone rapidly and significantly reduces the IL-6 level in blood and lungs of patients with COVID-19-related ARDS
Citation: Critical Care 2024 28:101 -
Unraveling the role of HIF-1α in sepsis: from pathophysiology to potential therapeutics—a narrative review
Sepsis is characterized by organ dysfunction resulting from a dysregulated inflammatory response triggered by infection, involving multifactorial and intricate molecular mechanisms. Hypoxia-inducible factor-1α...
Citation: Critical Care 2024 28:100 -
Association between intensive care unit nursing grade and mortality in patients with cardiogenic shock and its cost-effectiveness
Despite the high workload of cardiac intensive care unit (ICU), there is a paucity of evidence on the association between nurse workforce and mortality in patients with cardiogenic shock (CS). This study aimed...
Citation: Critical Care 2024 28:99 -
Physical activity is associated with a lower risk of contracting and dying in infection and sepsis: a Swedish population-based cohort study
Sepsis is a condition where the immune response to infection becomes dysregulated and life-threatening. It is not known whether lifestyle factors influence the risk of sepsis. The aim of the present study is t...
Citation: Critical Care 2024 28:98 -
Vascular leak in sepsis: physiological basis and potential therapeutic advances
Sepsis is a life-threatening condition characterised by endothelial barrier dysfunction and impairment of normal microcirculatory function, resulting in a state of hypoperfusion and tissue oedema. No specific ...
Citation: Critical Care 2024 28:97 -
Breath metabolomics for diagnosis of acute respiratory distress syndrome
Acute respiratory distress syndrome (ARDS) poses challenges in early identification. Exhaled breath contains metabolites reflective of pulmonary inflammation.
Citation: Critical Care 2024 28:96 -
The long-term intercorrelation between post-burn pain, anxiety, and depression: a post hoc analysis of the “RE-ENERGIZE” double-blind, randomized, multicenter placebo-controlled trial
Despite the growing prevalence of burn survivors, a gap persists in our understanding of the correlation between acute burn trauma and the long-term impact on psychosocial health. This study set out to investi...
Citation: Critical Care 2024 28:95 -
Correction : Selected articles from the annual update in intensive care and emergency medicine 2020
Citation: Critical Care 2024 28:94 -
Intra-aortic balloon pump in patients undergoing VA-ECMO: an analysis of the Chinese Extracorporeal Life Support Registry
Citation: Critical Care 2024 28:93 -
Sepsis-associated acute kidney injury: recent advances in enrichment strategies, sub-phenotyping and clinical trials
Acute kidney injury (AKI) often complicates sepsis and is associated with high morbidity and mortality. In recent years, several important clinical trials have improved our understanding of sepsis-associated A...
Citation: Critical Care 2024 28:92 -
Clustering COVID-19 ARDS patients through the first days of ICU admission. An analysis of the CIBERESUCICOVID Cohort
Acute respiratory distress syndrome (ARDS) can be classified into sub-phenotypes according to different inflammatory/clinical status. Prognostic enrichment was achieved by grouping patients into hypoinflammato...
Citation: Critical Care 2024 28:91 -
Feasibility of 3D-EIT in identifying lung perfusion defect and V/Q mismatch in a patient with VA-ECMO
Citation: Critical Care 2024 28:90 -
Association between tranexamic acid administration and mortality based on the trauma phenotype: a retrospective analysis of a nationwide trauma registry in Japan
In trauma systems, criteria for individualised and optimised administration of tranexamic acid (TXA), an antifibrinolytic, are yet to be established. This study used nationwide cohort data from Japan to evalua...
Citation: Critical Care 2024 28:89 -
Monocyte state 1 (MS1) cells in critically ill patients with sepsis or non-infectious conditions: association with disease course and host response
Sepsis is a life-threatening condition arising from an aberrant host response to infection. Recent single-cell RNA sequencing investigations identified an immature bone-marrow-derived CD14+ monocyte phenotype wit...
Citation: Critical Care 2024 28:88 -
Effect of a self-developed fixation device on preventing endotracheal intubation-related pressure injury: a randomised controlled trial
To evaluate the effects of our self-developed endotracheal tube fixation device in mechanically ventilated patients.
Citation: Critical Care 2024 28:87 -
43rd International Symposium on Intensive Care & Emergency Medicine
Citation: Critical Care 2024 28(Suppl 1):68 -
A comparison of extracorporeal and conventional cardiopulmonary resuscitation for cardiac arrest
Citation: Critical Care 2024 28:86 -
The incidences of acute mesenteric ischaemia vary greatly depending on the population and diagnostic activity
Citation: Critical Care 2024 28:85 -
Trauma systems in high socioeconomic index countries in 2050
Considerable political, structural, environmental and epidemiological change will affect high socioeconomic index (SDI) countries over the next 25 years. These changes will impact healthcare provision and cons...
Citation: Critical Care 2024 28:84 -
The elusive relationship between cardiac filling and fluid responsiveness
Citation: Critical Care 2024 28:83 -
Effects of prone positioning on lung mechanical power components in patients with acute respiratory distress syndrome: a physiologic study
Prone positioning (PP) homogenizes ventilation distribution and may limit ventilator-induced lung injury (VILI) in patients with moderate to severe acute respiratory distress syndrome (ARDS). The static and dy...
Citation: Critical Care 2024 28:82 -
Trends in pre-hospital volume resuscitation of blunt trauma patients: a 15-year analysis of the British (TARN) and German (TraumaRegister DGU®) National Registries
Fluid resuscitation has long been a cornerstone of pre-hospital trauma care, yet its optimal approach remains undetermined. Although a liberal approach to fluid resuscitation has been linked with increased com...
Citation: Critical Care 2024 28:81 -
Scrutinizing mechanical circulatory support in cardiogenic shock: Have we jumped the gun?
Despite increasing therapeutic options and disposable resources, cardiogenic shock (CS) remains a formidable condition with high mortality. Today, veno-arterial extracorporeal membrane oxygenation and microaxi...
Citation: Critical Care 2024 28:80 -
Albumin for sepsis-related peripheral tissue hypoperfusion
Citation: Critical Care 2024 28:79 -
Prognostic value of near-infrared spectroscopy regional oxygen saturation and cerebrovascular reactivity index in acute traumatic neural injury: a CAnadian High-Resolution Traumatic Brain Injury (CAHR-TBI) Cohort Study
Near-infrared spectroscopy regional cerebral oxygen saturation (rSO2) has gained interest as a raw parameter and as a basis for measuring cerebrovascular reactivity (CVR) due to its noninvasive nature and high sp...
Citation: Critical Care 2024 28:78 -
Impact of COVID-19 on posttraumatic stress disorder in ICU survivors: a prospective observational comparative cohort study
Posttraumatic stress disorder (PTSD) after a stay in the intensive care unit (ICU) can affect one in five ICU survivors. At the beginning of the coronavirus disease 2019 (COVID-19) pandemic, admission to the I...
Citation: Critical Care 2024 28:77 -
Real-time machine learning model to predict short-term mortality in critically ill patients: development and international validation
A real-time model for predicting short-term mortality in critically ill patients is needed to identify patients at imminent risk. However, the performance of the model needs to be validated in various clinical...
Citation: Critical Care 2024 28:76 -
Flow starvation during square-flow assisted ventilation detected by supervised deep learning techniques
Flow starvation is a type of patient-ventilator asynchrony that occurs when gas delivery does not fully meet the patients’ ventilatory demand due to an insufficient airflow and/or a high inspiratory effort, an...
Citation: Critical Care 2024 28:75 -
Mean arterial pressure during cardiopulmonary bypass: A modifiable risk factor for acute kidney injury in cardiac surgery patients?
Citation: Critical Care 2024 28:74 -
Transitions of blood immune endotypes and improved outcome by anakinra in COVID-19 pneumonia: an analysis of the SAVE-MORE randomized controlled trial
Endotype classification may guide immunomodulatory management of patients with bacterial and viral sepsis. We aimed to identify immune endotypes and transitions associated with response to anakinra (human inte...
Citation: Critical Care 2024 28:73 -
Long-term outcome in new onset refractory status epilepticus: a retrospective study
New onset refractory status epilepticus (NORSE) is a neurologic emergency without an immediately identifiable cause. The complicated and long ICU stay of the patients can lead to perceiving a prolongation of t...
Citation: Critical Care 2024 28:72 -
Pathophysiology of acute lung injury in patients with acute brain injury: the triple-hit hypothesis
It has been convincingly demonstrated in recent years that isolated acute brain injury (ABI) may cause severe dysfunction of peripheral extracranial organs and systems. Of all potential target organs and syste...
Citation: Critical Care 2024 28:71 -
Accuracy of respiratory muscle assessments to predict weaning outcomes: a systematic review and comparative meta-analysis
Several bedside assessments are used to evaluate respiratory muscle function and to predict weaning from mechanical ventilation in patients on the intensive care unit. It remains unclear which assessments perf...
Citation: Critical Care 2024 28:70 -
Toxicities, intensive care management, and outcome of chimeric antigen receptor T cells in adults: an update
Chimeric antigen receptor T cells are a promising new immunotherapy for haematological malignancies. Six CAR-T cells products are currently available for adult patients with refractory or relapsed high-grade B...
Citation: Critical Care 2024 28:69 -
The acute mesenteric ischaemia (AMESI) study: a matter of incidence
Citation: Critical Care 2024 28:67 -
Impact of hyperoxia on the gut during critical illnesses
Molecular oxygen is typically delivered to patients via oxygen inhalation or extracorporeal membrane oxygenation (ECMO), potentially resulting in systemic hyperoxia from liberal oxygen inhalation or localized ...
Citation: Critical Care 2024 28:66 -
Imatinib treatment improves hyperglycaemic dysregulation in severe COVID-19: a secondary analysis of blood biomarkers in a randomised controlled trial
SARS-CoV-2 can induce insulin resistance, which is, among others, mediated by adipose tissue dysfunction and reduced angiotensin-converting enzyme 2 (ACE2) enzymatic activity. In SARS-CoV-2-infected mice, the ...
Citation: Critical Care 2024 28:65 -
Prevention of post-operative delirium using an overnight infusion of dexmedetomidine in patients undergoing cardiac surgery: a pragmatic, randomized, double-blind, placebo-controlled trial
After cardiac surgery, post-operative delirium (PoD) is acknowledged to have a significant negative impact on patient outcome. To date, there is no valuable and specific treatment for PoD. Critically ill patie...
Citation: Critical Care 2024 28:64 -
Using a targeted metabolomics approach to explore differences in ARDS associated with COVID-19 compared to ARDS caused by H1N1 influenza and bacterial pneumonia
Acute respiratory distress syndrome (ARDS) is a life-threatening critical care syndrome commonly associated with infections such as COVID-19, influenza, and bacterial pneumonia. Ongoing research aims to improv...
Citation: Critical Care 2024 28:63 -
The use of mechanical CPR for IHCA during the COVID-19 pandemic as compared to the pre-pandemic period
Citation: Critical Care 2024 28:62 -
Violence against healthcare professionals in intensive care units: a systematic review and meta-analysis of frequency, risk factors, interventions, and preventive measures
To assess the frequency, risk factors, consequences, and prevention of violence against healthcare workers in intensive care units.
Citation: Critical Care 2024 28:61 -
How often do we need to update PEEP setting during prone positioning in ARDS?
Citation: Critical Care 2024 28:60 -
Reflections on epidemiological investigations of sepsis in the Asian Region
Citation: Critical Care 2024 28:59 -
Improving management of ARDS: uniting acute management and long-term recovery
Acute Respiratory Distress Syndrome (ARDS) is an important global health issue with high in-hospital mortality. Importantly, the impact of ARDS extends beyond the acute phase, with increased mortality and disa...
Citation: Critical Care 2024 28:58 -
Extracorporeal cardiopulmonary resuscitation versus conventional CPR in cardiac arrest: an updated meta-analysis and trial sequential analysis
Extracorporeal cardiopulmonary resuscitation (ECPR) may reduce mortality and improve neurological outcomes in patients with cardiac arrest. We updated our existing meta-analysis and trial sequential analysis t...
Citation: Critical Care 2024 28:57 -
Novel subtypes of severe COVID-19 respiratory failure based on biological heterogeneity: a secondary analysis of a randomized controlled trial
Despite evidence associating inflammatory biomarkers with worse outcomes in hospitalized adults with COVID-19, trials of immunomodulatory therapies have met with mixed results, likely due in part to biological...
Citation: Critical Care 2024 28:56 -
Evidence supports the use of hydrocortisone for patients with community-acquired pneumonia
Citation: Critical Care 2024 28:55 -
Healthcare-associated infections in patients with severe COVID-19 supported with extracorporeal membrane oxygenation: a nationwide cohort study
Both critically ill patients with coronavirus disease 2019 (COVID-19) and patients receiving extracorporeal membrane oxygenation (ECMO) support exhibit a high incidence of healthcare-associated infections (HAI...
Citation: Critical Care 2024 28:54
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- ISSN: 1364-8535 (electronic)