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  1. Ceftolozane/tazobactam, a combination antibacterial agent comprising an anti-pseudomonal cephalosporin and β-lactamase inhibitor, is approved for the treatment of hospital-acquired/ventilator-associated bacter...

    Authors: Marin H. Kollef, Jean-François Timsit, Ignacio Martin-Loeches, Richard G. Wunderink, Jennifer A. Huntington, Erin H. Jensen, Brian Yu and Christopher J. Bruno
    Citation: Critical Care 2022 26:373
  2. Although guidelines provide excellent expert guidance for managing patients with septic shock, they leave room for personalization according to patients’ condition. Hemodynamic monitoring depends on the evolut...

    Authors: Daniel De Backer, Maurizio Cecconi, Michelle S. Chew, Ludhmila Hajjar, Xavier Monnet, Gustavo A. Ospina-Tascón, Marlies Ostermann, Michael R. Pinsky and Jean-Louis Vincent
    Citation: Critical Care 2022 26:372
  3. Sepsis is a complex health condition, leading to long-term morbidity and mortality. Understanding the risk factors for recurrent sepsis, as well as its impact on mid- and long-term mortality among other risk f...

    Authors: Fanny Pandolfi, Christian Brun-Buisson, Didier Guillemot and Laurence Watier
    Citation: Critical Care 2022 26:371
  4. Magnetic resonance imaging (MRI) carries prognostic importance after traumatic brain injury (TBI), especially when computed tomography (CT) fails to fully explain the level of unconsciousness. However, in crit...

    Authors: Sophie Richter, Stefan Winzeck, Endre Czeiter, Krisztina Amrein, Evgenios N. Kornaropoulos, Jan Verheyden, Gabriela Sugar, Zhihui Yang, Kevin Wang, Andrew I. R. Maas, Ewout Steyerberg, András Büki, Virginia F. J. Newcombe and David K. Menon
    Citation: Critical Care 2022 26:369
  5. Acute kidney injury (AKI) requiring renal replacement therapy (RRT) is a serious complication in the ICU that results in increased mortality and risk of chronic kidney disease (CKD). Some studies suggest RRT m...

    Authors: Edouard Soum, Jean-François Timsit, Stephane Ruckly, Didier Gruson, Emmanuel Canet, Kada Klouche, Laurent Argaud, Maïté Garrouste-Orgeas, Christophe Mariat, François Vincent, Sophie Cayot, Michael Darmon, Julien Bohé, Carole Schwebel, Lila Bouadma, Claire Dupuis…
    Citation: Critical Care 2022 26:367
  6. Since the advent of critical care in the twentieth century, the core elements that are the foundation for critical care systems, namely to care for critically ill and injured patients and to save lives, have e...

    Authors: Annette M. Esper, Yaseen M. Arabi, Maurizio Cecconi, Bin Du, Evangelos J. Giamarellos-Bourboulis, Nicole Juffermans, Flavia Machado, Sandra Peake, Jason Phua, Kathryn Rowan, Gee Young Suh and Greg S. Martin
    Citation: Critical Care 2022 26:366
  7. Defining the optimal moment to start renal replacement therapy (RRT) in acute kidney injury (AKI) remains challenging. Multiple randomized controlled trials (RCTs) addressed this question whilst using absolute...

    Authors: Paweł Morzywołek, Johan Steen, Stijn Vansteelandt, Johan Decruyenaere, Sigrid Sterckx and Wim Van Biesen
    Citation: Critical Care 2022 26:365
  8. Renal hypoperfusion is one of the most common causes of acute kidney injury (AKI), especially in shock and perioperative patients. An optimal blood pressure (BP) target to prevent AKI remains undetermined. We ...

    Authors: Phu Nguyen Trong Tran, Prit Kusirisin, Piyanut Kaewdoungtien, Jeerath Phannajit and Nattachai Srisawat
    Citation: Critical Care 2022 26:364
  9. Patients with COVID-19-related acute respiratory distress syndrome (ARDS) require respiratory support with invasive mechanical ventilation and show varying responses to recruitment manoeuvres. In patients with...

    Authors: Daan F. L. Filippini, Elisa Di Gennaro, Rombout B. E. van Amstel, Ludo F. M. Beenen, Salvatore Grasso, Luigi Pisani, Lieuwe D. J. Bos and Marry R. Smit
    Citation: Critical Care 2022 26:363
  10. Mobilisation and exercise intervention in general are safe and feasible in critically ill patients. For patients requiring catecholamines, however, doses of norepinephrine safe for mobilisation in the intensiv...

    Authors: Maximilian Lindholz, Clara M. Schellenberg, Julius J. Grunow, Simone Kagerbauer, Annette Milnik, Daniel Zickler, Stefan Angermair, Anett Reißhauer, Martin Witzenrath, Mario Menk, Sebastian Boie, Felix Balzer and Stefan J. Schaller
    Citation: Critical Care 2022 26:362
  11. Most of the patients who die after cardiac arrest do so because of hypoxic-ischemic brain injury (HIBI). Experimental evidence shows that temperature control targeted at hypothermia mitigates HIBI. In 2002, on...

    Authors: Claudio Sandroni, Daniele Natalini and Jerry P. Nolan
    Citation: Critical Care 2022 26:361
  12. Among critically ill patients with acute kidney injury (AKI), earlier initiation of renal replacement therapy (RRT) may mitigate fluid accumulation and confer better outcomes among individuals with greater flu...

    Authors: Ron Wald, Brian Kirkham, Bruno R. daCosta, Ehsan Ghamarian, Neill K. J. Adhikari, William Beaubien-Souligny, Rinaldo Bellomo, Martin P. Gallagher, Stuart Goldstein, Eric A. J. Hoste, Kathleen D. Liu, Javier A. Neyra, Marlies Ostermann, Paul M. Palevsky, Antoine Schneider, Suvi T. Vaara…
    Citation: Critical Care 2022 26:360
  13. Sedative agents may variably impact the stress response. Dexmedetomidine is a sympatholytic alpha2-adrenergic agonist mainly used as a second-line sedative agent in mechanically ventilated patients. We hypothesis...

    Authors: John P. R. Moore, Yahya Shehabi, Michael C. Reade, Michael Bailey, John F. Fraser, Lauren Murray, Christopher Anstey and Mervyn Singer
    Citation: Critical Care 2022 26:359
  14. A defining feature of prolonged critical illness is muscle wasting, leading to impaired recovery. Supplementation with a tailored blend of amino acids may bolster the innate gut defence, promote intestinal muc...

    Authors: Nicholas Heming, Robert Carlier, Helene Prigent, Ahmed Mekki, Camille Jousset, Frederic Lofaso, Xavier Ambrosi, Rania Bounab, Virginie Maxime, Arnaud Mansart, Pascal Crenn, Pierre Moine, Fabien Foltzer, Bernard Cuenoud, Tobias Konz, John Corthesy…
    Citation: Critical Care 2022 26:358
  15. Targeted temperature management (TTM) is recommended following cardiac arrest; however, time to target temperature varies in clinical practice. We hypothesised the effects of a target temperature of 33 °C when...

    Authors: Rupert F. G. Simpson, Josef Dankiewicz, Grigoris V. Karamasis, Paolo Pelosi, Matthias Haenggi, Paul J. Young, Janus Christian Jakobsen, Jonathan Bannard-Smith, Pedro D. Wendel-Garcia, Fabio Silvio Taccone, Per Nordberg, Matt P. Wise, Anders M. Grejs, Gisela Lilja, Roy Bjørkholt Olsen, Alain Cariou…
    Citation: Critical Care 2022 26:356
  16. Ventilator-associated pneumonia caused by Pseudomonas aeruginosa (PA) in hospitalised patients is associated with high mortality. The effectiveness of the bivalent, bispecific mAb MEDI3902 (gremubamab) in prevent...

    Authors: Jean Chastre, Bruno François, Marc Bourgeois, Apostolos Komnos, Ricard Ferrer, Galia Rahav, Nicolas De Schryver, Alain Lepape, Iftihar Koksal, Charles-Edouard Luyt, Miguel Sánchez-García, Antoni Torres, Philippe Eggimann, Despoina Koulenti, Thomas L. Holland, Omar Ali…
    Citation: Critical Care 2022 26:355
  17. The survival rate of patients with critical coronavirus disease-19 (COVID-19) over time is inconsistent in different settings. In Japan, a national database was organized to monitor and share the patient gener...

    Authors: Shinichiro Ohshimo, Keibun Liu, Takayuki Ogura, Yoshiaki Iwashita, Shigeki Kushimoto, Nobuaki Shime, Satoru Hashimoto, Yuji Fujino and Shinhiro Takeda
    Citation: Critical Care 2022 26:354
  18. Spontaneous pneumomediastinum (SP) has been described early during the COVID-19 pandemic in large series of patients with severe pneumonia, but most patients were receiving invasive mechanical ventilation (IMV...

    Authors: Alexandre Elabbadi, Tomas Urbina, Enora Berti, Damien Contou, Gaëtan Plantefève, Quintana Soulier, Audrey Milon, Guillaume Carteaux, Guillaume Voiriot, Muriel Fartoukh and Aude Gibelin
    Citation: Critical Care 2022 26:350
  19. Several biomarkers have been proposed to predict the occurrence of acute kidney injury (AKI); however, their efficacy varies between different trials. The aim of this study was to compare the predictive perfor...

    Authors: Heng-Chih Pan, Shao-Yu Yang, Terry Ting-Yu Chiou, Chih-Chung Shiao, Che-Hsiung Wu, Chun-Te Huang, Tsai-Jung Wang, Jui-Yi Chen, Hung-Wei Liao, Sheng-Yin Chen, Tao-Min Huang, Ya-Fei Yang, Hugo You-Hsien Lin, Ming-Jen Chan, Chiao-Yin Sun, Yih-Ting Chen…
    Citation: Critical Care 2022 26:349
  20. Non-invasive ventilation (NIV) with bi-level positive pressure ventilation is a first-line intervention for selected patients with acute hypercapnic respiratory failure. Compared to conventional oxygen therapy...

    Authors: N. Ovtcharenko, E. Ho, W. Alhazzani, A. Cortegiani, B. Ergan, R. Scala, G. Sotgiu, D. Chaudhuri, S. Oczkowski and K. Lewis
    Citation: Critical Care 2022 26:348
  21. The intensive care unit (ICU) is an emotionally taxing environment. Patients and family members are at an increased risk of long-term physical and psychological consequences of critical illness, known collecti...

    Authors: Sarah Petrecca, Adrian Goin, David Hornstein, Milanka Stevanovic and Adamo Anthony Donovan
    Citation: Critical Care 2022 26:346
  22. The delayed diagnosis of acute kidney injury (AKI) episodes and the lack of specificity of current single AKI biomarkers hamper its management. Urinary peptidome analysis may help to identify early molecular c...

    Authors: Alexis Piedrafita, Justyna Siwy, Julie Klein, Amal Akkari, Ana Amaya-garrido, Alexandre Mebazaa, Anna Belen Sanz, Benjamin Breuil, Laura Montero Herrero, Bertrand Marcheix, François Depret, Lucie Fernandez, Elsa Tardif, Vincent Minville, Melinda Alves, Jochen Metzger…
    Citation: Critical Care 2022 26:344
  23. Steroid profiles in combination with a corticotropin stimulation test provide information about steroidogenesis and its functional reserves in critically ill patients.

    Authors: Josef Briegel, Patrick Möhnle, Didier Keh, Johanna M. Lindner, Anna C. Vetter, Holger Bogatsch, Dorothea Lange, Sandra Frank, Ludwig C. Hinske, Djillali Annane and Michael Vogeser
    Citation: Critical Care 2022 26:343
  24. Authors: Patrick M. Honore, Sebastien Redant, Pharan Djimafo, Sydney Blackman, Ibrahim Bousbiat, Emily Perriens, Thierry Preseau, Bogdan Vasile Cismas, Keitiane Kaefer, Leonel Barreto Gutierrez, Sami Anane, Andrea Gallerani and Rachid Attou
    Citation: Critical Care 2022 26:342

    The original article was published in Critical Care 2022 26:100

  25. Sepsis is a severe systemic inflammatory response to infections that is accompanied by organ dysfunction and has a high mortality rate in adult intensive care units. Most genetic studies have identified gene v...

    Authors: Tamara Hernandez-Beeftink, Beatriz Guillen-Guio, Jose M. Lorenzo-Salazar, Almudena Corrales, Eva Suarez-Pajes, Rui Feng, Luis A. Rubio-Rodríguez, Megan L. Paynton, Raquel Cruz, M. Isabel García-Laorden, Miryam Prieto-González, Aurelio Rodríguez-Pérez, Demetrio Carriedo, Jesús Blanco, Alfonso Ambrós, Elena González-Higueras…
    Citation: Critical Care 2022 26:341
  26. Previously identified phenotypes of acute respiratory distress syndrome (ARDS) have been limited by a disregard for temporal dynamics. We aimed to identify longitudinal phenotypes in ARDS to test the prognosti...

    Authors: Hui Chen, Qian Yu, Jianfeng Xie, Songqiao Liu, Chun Pan, Ling Liu, Yingzi Huang, Fengmei Guo, Haibo Qiu and Yi Yang
    Citation: Critical Care 2022 26:340
  27. Chronic obstructive pulmonary disease (COPD) is one of most common comorbidities in acute respiratory distress syndrome (ARDS). There are few specific studies on the appropriate ventilation strategy for patien...

    Authors: Xuesong Liu, Xiao Liu, Jue Meng, Dongdong Liu, Yongbo Huang, Ling Sang, Yonghao Xu, Zhiheng Xu, Weiqun He, Sibei Chen, Rong Zhang, Xiaoqing Liu and Yimin Li
    Citation: Critical Care 2022 26:339
  28. We conducted a proof of concept study where Anapnoguard endotracheal tubes and its control unit were used in 15 patients with COVID-19 acute respiratory distress syndrome. Anapnoguard system provides suction, ...

    Authors: Eloisa Sofia Tanzarella, Gianmarco Lombardi, Silvia Baroni, Francesca Sarlo, Salvatore Lucio Cutuli, Simone Carelli, Melania Cesarano, Veronica Gennenzi, Gabriele Pintaudi, Joel Vargas, Antonio Maria Dell’Anna, Domenico Luca Grieco, Andrea Urbani, Massimo Antonelli and Gennaro De Pascale
    Citation: Critical Care 2022 26:338
  29. Sepsis is a life-threatening complication of the body’s response to infection. The financial, medical, and psychological costs of sepsis to individuals and to the healthcare system are high. Most sepsis cases ...

    Authors: Jeanna Parsons Leigh, Rebecca Brundin-Mather, Stephana Julia Moss, Angie Nickel, Ariana Parolini, Deirdre Walsh, Blair L. Bigham, Alix J. E. Carter, Alison Fox-Robichaud and Kirsten M. Fiest
    Citation: Critical Care 2022 26:337
  30. Bereaved ICU family surrogates are at risk of comorbid prolonged grief disorder (PGD), posttraumatic stress disorder (PTSD), and depression. Knowledge about temporal relationships between PGD, PTSD, and depres...

    Authors: Fur-Hsing Wen, Holly G. Prigerson, Wen-Chi Chou, Chung-Chi Huang, Tsung-Hui Hu, Ming Chu Chiang, Li-Pang Chuang and Siew Tzuh Tang
    Citation: Critical Care 2022 26:336
  31. Early public-access defibrillation (PAD) effectively improves the outcomes of out-of-hospital cardiac arrests (OHCA), but several strategies implemented to prevent the spread of coronavirus disease 2019 (COVID...

    Authors: Tasuku Matsuyama, Kosuke Kiyohara, Tetsuhisa Kitamura, Chika Nishiyama, Takeyuki Kiguchi and Taku Iwami
    Citation: Critical Care 2022 26:335
  32. Renal replacement therapy (RRT) remains the key rescue therapy for critically ill patients with severe acute kidney injury (AKI). However, there are currently no tools available to predict successful liberatio...

    Authors: Thilo von Groote, Felix Albert, Melanie Meersch, Raphael Koch, Christian Porschen, Oliver Hartmann, Deborah Bergmann, Peter Pickkers and Alexander Zarbock
    Citation: Critical Care 2022 26:333
  33. Survival rates in refractory out-of-hospital cardiac arrest (OHCA) remain low with conventional advanced cardiac life support (ACLS). Extracorporeal life support (ECLS) implantation during ongoing resuscitatio...

    Authors: Daniel Rob, Jana Smalcova, Ondrej Smid, Ales Kral, Tomas Kovarnik, David Zemanek, Petra Kavalkova, Michal Huptych, Arnost Komarek, Ondrej Franek, Stepan Havranek, Ales Linhart and Jan Belohlavek
    Citation: Critical Care 2022 26:330
  34. Steroids have been shown to reduce inflammation, hypoxic pulmonary vasoconstriction (HPV) and lung edema. Based on evidence from clinical trials, steroids are widely used in severe COVID-19. However, the effec...

    Authors: Gaetano Perchiazzi, Aleksandra Larina, Tomas Hansen, Robert Frithiof, Michael Hultström, Miklos Lipcsey and Mariangela Pellegrini
    Citation: Critical Care 2022 26:328
  35. Virtual reality (VR) and augmented reality (AR) are aspiring, new technologies with increasing use in critical care medicine. While VR fully immerses the user into a virtual three-dimensional space, AR adds ov...

    Authors: Raphael Romano Bruno, Georg Wolff, Bernhard Wernly, Maryna Masyuk, Kerstin Piayda, Susannah Leaver, Ralf Erkens, Daniel Oehler, Shazia Afzal, Houtan Heidari, Malte Kelm and Christian Jung
    Citation: Critical Care 2022 26:326
  36. The enteral route is commonly utilised to support the nutritional requirements of critically ill patients. However, there is paucity of data guiding clinicians regarding the appropriate method of delivering th...

    Authors: Aaron J. Heffernan, C. Talekar, M. Henain, L. Purcell, M. Palmer and H. White
    Citation: Critical Care 2022 26:325