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  1. Regardless of the available antifungals, intraabdominal candidiasis (IAC) mortality continues to be high and represents a challenge for clinicians.

    Authors: Emilio Maseda, Ignacio Martín-Loeches, Rafael Zaragoza, Javier Pemán, Jesús Fortún, Santiago Grau, Gerardo Aguilar, Marina Varela, Marcio Borges, María-José Giménez and Alejandro Rodríguez
    Citation: Critical Care 2023 27:382
  2. Out-of-plane (OOP) approach is frequently used for ultrasound-guided insertion of central venous catheter (CVC) owing to its simplicity but does not avoid mechanical complication. In-plane (IP) approach might ...

    Authors: Antoine Villa, Vladimir Hermand, Vincent Bonny, Gabriel Preda, Tomas Urbina, Maxime Gasperment, Paul Gabarre, Louai Missri, Jean-Luc Baudel, Daniel Zafimahazo, Jérémie Joffre, Hafid Ait-Oufella and Eric Maury
    Citation: Critical Care 2023 27:379
  3. Reintubation is a common complication in critically ill patients requiring mechanical ventilation. Although reintubation has been demonstrated to be associated with patient outcomes, its time definition varies...

    Authors: Aiko Tanaka, Yoshimitsu Shimomura, Akinori Uchiyama, Natsuko Tokuhira, Tetsuhisa Kitamura, Hirofumi Iwata, Haruka Hashimoto, Suguru Ishigaki, Yusuke Enokidani, Tomonori Yamashita, Yukiko Koyama, Naoya Iguchi, Takeshi Yoshida and Yuji Fujino
    Citation: Critical Care 2023 27:378

    The Matters Arising to this article has been published in Critical Care 2024 28:37

    The Matters Arising to this article has been published in Critical Care 2023 27:395

  4. Cancer and sepsis share risk factors, and sepsis patients may have impaired immune response and increased morbidity long after intensive care. This study aimed to assess whether sepsis survivors are at increas...

    Authors: Johanna Hästbacka, Anna But, Gunnar Strandberg and Miklós Lipcsey
    Citation: Critical Care 2023 27:376
  5. The triggering factors of sepsis-induced myocardial dysfunction (SIMD) are poorly understood and are not addressed by current treatments. S100A8/A9 is a pro-inflammatory alarmin abundantly secreted by activate...

    Authors: Gabriel Jakobsson, Praveen Papareddy, Henrik Andersson, Megan Mulholland, Ravi Bhongir, Irena Ljungcrantz, Daniel Engelbertsen, Harry Björkbacka, Jan Nilsson, Adrian Manea, Heiko Herwald, Marisol Ruiz-Meana, Antonio Rodríguez-Sinovas, Michelle Chew and Alexandru Schiopu
    Citation: Critical Care 2023 27:374

    The Matters Arising to this article has been published in Critical Care 2024 28:9

    The Matters Arising to this article has been published in Critical Care 2023 27:480

  6. Response to prophylactic platelet transfusion is suspected to be inconsistent in critically ill patients questioning how to optimize transfusion practices. This study aimed to describe prophylactic platelet tr...

    Authors: Florian Reizine, Sarah Le Marec, Anthony Le Meur, Maëlys Consigny, Florian Berteau, Laetitia Bodenes, Marie Geslain, Zoe McQuilten, Catherine Le Niger, Julien Huntzinger, Philippe Seguin, Jean-Baptiste Thibert, David Simon, Jean Reignier, Pierre-Yves Egreteau, Jean-Marc Tadié…
    Citation: Critical Care 2023 27:373
  7. Sepsis-induced immunosuppression is a frequent cause of opportunistic infections and death in critically ill patients. A better understanding of the underlying mechanisms is needed to develop targeted therapie...

    Authors: Julia Leonhardt, Mirrin J. Dorresteijn, Sophie Neugebauer, Diana Mihaylov, Julia Kunze, Ignacio Rubio, Frank-Stephan Hohberger, Silke Leonhardt, Michael Kiehntopf, Klaus Stahl, Christian Bode, Sascha David, Frank A. D. T. G. Wagener, Peter Pickkers and Michael Bauer
    Citation: Critical Care 2023 27:372
  8. The primary aim was to explore the concept of isolated and combined threshold-insults for brain tissue oxygenation (pbtO2) in relation to outcome in traumatic brain injury (TBI).

    Authors: Teodor Svedung Wettervik, Erta Beqiri, Anders Hånell, Stefan Yu Bögli, Michal Placek, Mathew R. Guilfoyle, Adel Helmy, Andrea Lavinio, Ronan O’Leary, Peter J. Hutchinson and Peter Smielewski
    Citation: Critical Care 2023 27:370

    The Matters Arising to this article has been published in Critical Care 2023 27:396

  9. No univocal recommendation exists for microbiological diagnosis of ventilator-associated pneumonia (VAP). Sampling of either proximal or distal respiratory tract likely impacts on the broad range of VAP incide...

    Authors: Davide Mangioni, Mauro Panigada, Emanuele Palomba, Chiara Bobbio, Liliane Chatenoud, Laura Alagna, Jacopo Fumagalli, Andrea Gori, Anna Grancini, Amedeo Guzzardella, Andrea Lombardi, Caterina Matinato, Andrea Meli, Antonio Muscatello, Laura Porretti, Mara Tomasello…
    Citation: Critical Care 2023 27:369
  10. Extubation failure is associated with increased mortality. Cough ineffectiveness may be associated with extubation failure, but its quantification for patients undergoing weaning from invasive mechanical venti...

    Authors: Vincent Bonny, Jeremie Joffre, Paul Gabarre, Tomas Urbina, Louai Missri, Mathilde Ladoire, Maxime Gasperment, Jean-Luc Baudel, Bertrand Guidet, Guillaume Dumas, Eric Maury, Laurent Brochard and Hafid Ait-Oufella
    Citation: Critical Care 2023 27:368
  11. Critical care patients often require central venous cannulation (CVC). We hypothesized that real-time biplane ultrasound-guided CVC would improve first-puncture success rate and reduce mechanical complications...

    Authors: Ying-Ying Li, Yi-Hao Liu, Lin Yan, Jing Xiao, Xin-Yang Li, Jun Ma, Li-Gang Jia, Rui Chen, Chao Zhang, Zhen Yang, Ming-Bo Zhang and Yu-Kun Luo
    Citation: Critical Care 2023 27:366
  12. While numerous randomized controlled trials (RCTs) have been conducted in the field of trauma, a substantial portion of them are yielding negative results. One potential contributing factor to this trend could...

    Authors: Thomas Jeanmougin, Elaine Cole, Baptiste Duceau, Mathieu Raux and Arthur James
    Citation: Critical Care 2023 27:363
  13. This study aims to determine the relationship between spinal cord perfusion pressure (SCPP) and breathing function in patients with acute cervical traumatic spinal cord injuries.

    Authors: Ravindran Visagan, Ellaine Boseta, Argyro Zoumprouli, Marios C. Papadopoulos and Samira Saadoun
    Citation: Critical Care 2023 27:362
  14. Prediction of fluid responsiveness in acutely ill patients might be influenced by a number of clinical and technical factors. We aim to identify variables potentially modifying the operative performance of flu...

    Authors: Jorge Iván Alvarado Sánchez, Juan Daniel Caicedo Ruiz, Juan José Diaztagle Fernández, Luís Eduardo Cruz Martínez, Fredy Leonardo Carreño Hernández, Carlos Andrés Santacruz Herrera and Gustavo Adolfo Ospina-Tascón
    Citation: Critical Care 2023 27:361
  15. Non-ventilator-associated ICU-acquired pneumonia (NV-ICU-AP), a nosocomial pneumonia that is not related to invasive mechanical ventilation (IMV), has been less studied than ventilator-associated pneumonia, an...

    Authors: Louis-Marie Galerneau, Sébastien Bailly, Nicolas Terzi, Stéphane Ruckly, Maité Garrouste-Orgeas, Johanna Oziel, Vivien Hong Tuan Ha, Marc Gainnier, Shidasp Siami, Claire Dupuis, Jean-Marie Forel, Anaïs Dartevel, Julien Dessajan, Christophe Adrie, Dany Goldgran-Toledano, Virginie Laurent…
    Citation: Critical Care 2023 27:359

    The Correction to this article has been published in Critical Care 2024 28:117

  16. Cardiac surgery-associated acute kidney injury (CSA-AKI) is frequent. While two network meta-analyses assessed the impact of pharmacological interventions to prevent CSA-AKI, none focused on non-pharmacologica...

    Authors: Geoffroy Hariri, Lucie Collet, Lucie Duarte, Guillaume L. Martin, Matthieu Resche-Rigon, Guillaume Lebreton, Adrien Bouglé and Agnès Dechartres
    Citation: Critical Care 2023 27:354
  17. Singapore and Osaka in Japan have comparable population sizes and prehospital management; however, the frequency of ECPR differs greatly for out-of-hospital cardiac arrest (OHCA) patients with initial shockabl...

    Authors: Yohei Okada, Nur Shahidah, Yih Yng Ng, Michael Y. C. Chia, Han Nee Gan, Benjamin S. H. Leong, Desmond R. Mao, Wei Ming Ng, Taro Irisawa, Tomoki Yamada, Tetsuro Nishimura, Takeyuki Kiguchi, Masafumi Kishimoto, Tasuku Matsuyama, Norihiro Nishioka, Kosuke Kiyohara…
    Citation: Critical Care 2023 27:351
  18. This work provides an epidemiological overview of out-of-hospital cardiac arrest (OHCA) in children in Germany between 2007 and 2021. We wanted to identify modifiable factors associated with survival.

    Authors: Stephan Katzenschlager, Inga K. Kelpanides, Patrick Ristau, Matthias Huck, Stephan Seewald, Sebastian Brenner, Florian Hoffmann, Jan Wnent, Jo Kramer-Johansen, Ingvild B. M. Tjelmeland, Markus A. Weigand, Jan-Thorsten Gräsner and Erik Popp
    Citation: Critical Care 2023 27:349
  19. One of five global deaths are attributable to sepsis. Hyperferritinemic sepsis (> 500 ng/mL) is associated with increased mortality in single-center studies. Our pediatric research network’s objective was to o...

    Authors: Zhenziang Fan, Kate F. Kernan, Yidi Qin, Scott Canna, Robert A. Berg, David Wessel, Murray M. Pollack, Kathleen Meert, Mark Hall, Christopher Newth, John C. Lin, Allan Doctor, Tom Shanley, Tim Cornell, Rick E. Harrison, Athena F. Zuppa…
    Citation: Critical Care 2023 27:347
  20. Retrospective studies have demonstrated that the deep learning-based cardiac arrest risk management system (DeepCARS™) is superior to the conventional methods in predicting in-hospital cardiac arrest (IHCA). T...

    Authors: Kyung-Jae Cho, Jung Soo Kim, Dong Hyun Lee, Sang‑Min Lee, Myung Jin Song, Sung Yoon Lim, Young-Jae Cho, You Hwan Jo, Yunseob Shin and Yeon Joo Lee
    Citation: Critical Care 2023 27:346
  21. Respiratory mechanics is a key element to monitor mechanically ventilated patients and guide ventilator settings. Besides the usual basic assessments, some more complex explorations may allow to better charact...

    Authors: François M. Beloncle, Jean-Christophe Richard, Hamid Merdji, Christophe Desprez, Bertrand Pavlovsky, Elise Yvin, Lise Piquilloud, Pierre-Yves Olivier, Dara Chean, Antoine Studer, Antonin Courtais, Maëva Campfort, Hassene Rahmani, Arnaud Lesimple, Ferhat Meziani and Alain Mercat
    Citation: Critical Care 2023 27:343
  22. Approximately 20% of patients with acute brain injury (ABI) also experience acute kidney injury (AKI), which worsens their outcomes. The metabolic and inflammatory changes associated with AKI likely contribute...

    Authors: Faeq Husain-Syed, Tomonori Takeuchi, Javier A. Neyra, Gonzalo Ramírez-Guerrero, Mitchell H. Rosner, Claudio Ronco and Ashita J. Tolwani
    Citation: Critical Care 2023 27:341
  23. Except in a few retrospective studies mainly including patients under chemotherapy, information regarding the impact of immunosuppressive therapy on the prognosis of patients admitted to the intensive care uni...

    Authors: Julien Vaidie, Edwige Peju, Louise-Marie Jandeaux, Mathieu Lesouhaitier, Jean-Claude Lacherade, Antoine Guillon, Xavier Wittebole, Pierre Asfar, Bruno Evrard, Thomas Daix, Philippe Vignon and Bruno François
    Citation: Critical Care 2023 27:340
  24. The primary aim was to explore the association of global cerebral physiological variables including intracranial pressure (ICP), cerebrovascular reactivity (PRx), cerebral perfusion pressure (CPP), and deviati...

    Authors: Teodor Svedung Wettervik, Erta Beqiri, Stefan Yu Bögli, Michal Placek, Mathew R. Guilfoyle, Adel Helmy, Andrea Lavinio, Ronan O’Leary, Peter J. Hutchinson and Peter Smielewski
    Citation: Critical Care 2023 27:339

    The Matters Arising to this article has been published in Critical Care 2023 27:452

  25. Few specific methods are available to reduce the risk of diaphragmatic dysfunction for patients under mechanical ventilation. The number of studies involving transcutaneous electrical stimulation of the diaphr...

    Authors: Clément Medrinal, Margaux Machefert, Bouchra Lamia, Tristan Bonnevie, Francis-Edouard Gravier, Roger Hilfiker, Guillaume Prieur and Yann Combret
    Citation: Critical Care 2023 27:338
  26. Vascular leakage is a major feature of acute respiratory distress syndrome (ARDS). We aimed to evaluate the efficacy of FX06, a drug under development that stabilizes interendothelial cell junctions, at reduci...

    Authors: Emmanuelle Guérin, Lisa Belin, Guillaume Franchineau, Loïc Le Guennec, David Hajage, Mamadou Hassimiou Diallo, Thomas Frapard, Lucie Le Fèvre, Charles-Edouard Luyt, Alain Combes, Stéphane Germain, Jan Hayon, Pierre Asfar and Nicolas Bréchot
    Citation: Critical Care 2023 27:331