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  1. The importance of assessing venous congestion in ICU patients is widely acknowledged, but its study is hampered by the lack of a practical evaluation tool. The Venous Excess Ultrasound Grading System (VExUS), ...

    Authors: Stefan Andrei, Pierre-Alain Bahr, Maxime Nguyen, Belaid Bouhemad and Pierre-Grégoire Guinot
    Citation: Critical Care 2023 27:224
  2. Continuous renal replacement therapy (CRRT) is a widely used standard therapy for critically ill patients with acute kidney injury (AKI). Despite its effectiveness, treatment is often interrupted due to clot f...

    Authors: Zhifeng Zhou, Chen Liu, Yingying Yang, Fang Wang, Ling Zhang and Ping Fu
    Citation: Critical Care 2023 27:222
  3. Bleeding and thrombosis induce major morbidity and mortality in patients under extracorporeal membrane oxygenator (ECMO). Circuit changes can be performed for oxygenation membrane thrombosis but are not recomm...

    Authors: Thibaut Genty, Stanislas Burguburu, Audrey Imbert, Calypso Roman, Wirth Camille, Jacques Thès and François Stéphan
    Citation: Critical Care 2023 27:219
  4. Early mobilisation in critical care is recommended within clinical guidance; however, mobilisation prevalence across the UK is unknown. The study aimed to determine the proportion of patients mobilised out of ...

    Authors: Claire Black, Helen Sanger, Ceri Battle, Allaina Eden and Evelyn Corner
    Citation: Critical Care 2023 27:217
  5. Cytokine adsorption using the CytoSorb® adsorber has been proposed in various clinical settings including sepsis, ARDS, hyperinflammatory syndromes, cardiac surgery or recovery after cardiac arrest. The aim of...

    Authors: Sören Becker, Hannah Lang, Clara Vollmer Barbosa, Zhejia Tian, Anette Melk and Bernhard M. W. Schmidt
    Citation: Critical Care 2023 27:215

    The Matters Arising to this article has been published in Critical Care 2023 27:444

    The Matters Arising to this article has been published in Critical Care 2023 27:357

  6. Sepsis is the most common cause of admission to intensive care units worldwide. Sepsis patients frequently suffer from sepsis-associated encephalopathy (SAE) reflecting acute brain dysfunction. SAE may result ...

    Authors: Barbora Bircak-Kuchtova, Ha-Yeun Chung, Jonathan Wickel, Johannes Ehler and Christian Geis
    Citation: Critical Care 2023 27:214
  7. Findings from preclinical studies and one pilot clinical trial suggest potential benefits of epidural analgesia in acute pancreatitis. We aimed to assess the efficacy of thoracic epidural analgesia, in additio...

    Authors: Matthieu Jabaudon, Alexandra Genevrier, Samir Jaber, Olivier Windisch, Stéphanie Bulyez, Pierre-François Laterre, Etienne Escudier, Achille Sossou, Philippe Guerci, Pierre-Marie Bertrand, Pierre-Eric Danin, Martin Bonnassieux, Leo Bühler, Claudia Paula Heidegger, Russell Chabanne, Thomas Godet…
    Citation: Critical Care 2023 27:213
  8. Patients with community-acquired pneumonia (CAP) admitted to the intensive care unit (ICU) have high mortality rates during the acute infection and up to ten years thereafter. Recommendations from internationa...

    Authors: Luis Felipe Reyes, Esteban Garcia, Elsa D. Ibáñez-Prada, Cristian C. Serrano-Mayorga, Yuli V. Fuentes, Alejandro Rodríguez, Gerard Moreno, Alirio Bastidas, Josep Gómez, Angélica Gonzalez, Christopher R. Frei, Leo Anthony Celi, Ignacio Martin-Loeches and Grant Waterer
    Citation: Critical Care 2023 27:212
  9. The optimal treatment duration and the nature of regimen of antibiotics (monotherapy or combination therapy) for Pseudomonas aeruginosa ventilator‑associated pneumonia (PA-VAP) remain debated. The aim of this stu...

    Authors: Arnaud Foucrier, Thomas Dessalle, Sophie Tuffet, Laura Federici, Claire Dahyot‑Fizelier, François Barbier, Julien Pottecher, Antoine Monsel, Tarik Hissem, Jean‑Yves Lefrant, Alexandre Demoule, Jean‑Michel Constantin, Alexandra Rousseau, Tabassome Simon, Marc Leone and Adrien Bouglé
    Citation: Critical Care 2023 27:211

    The Matters Arising to this article has been published in Critical Care 2023 27:364

  10. The relevance of current consensus threshold to define oliguria has been challenged by small observational studies. We aimed to determine the optimal threshold to define oliguria in critically-ill patients.

    Authors: Nathan Axel Bianchi, Marco Altarelli, Céline Monard, Tatiana Kelevina, Aziz Chaouch and Antoine Guillaume Schneider
    Citation: Critical Care 2023 27:207
  11. Fluid normally exchanges freely between the plasma and interstitial space and is returned primarily via the lymphatic system. This balance can be disturbed by diseases and medications. In inflammatory disease ...

    Authors: Randal O. Dull and Robert G. Hahn
    Citation: Critical Care 2023 27:206
  12. Venous congestion is an under-recognized contributor to mortality in critically ill patients. Unfortunately, venous congestion is difficult to measure, and right heart catheterization (RHC) has been considered...

    Authors: August Longino, Katharine Martin, Katarina Leyba, Gabriel Siegel, Edward Gill, Ivor S. Douglas and Joseph Burke
    Citation: Critical Care 2023 27:205
  13. Since oxygen content and oxygen consumption typically remain unchanged within a short period, variation in central venous oxygen saturation (ΔScvO2) during fluid challenge can theoretically track the changes in c...

    Authors: Jianneng Pan, Yuxiang Sun, Zhaojun Xu, Pingping Dong and Xiaoyang Zhou
    Citation: Critical Care 2023 27:203
  14. Authors: Bairbre A. McNicholas, Emanuele Rezoagli, Andrew J. Simpkin, Sankalp Khanna, Jacky Y. Suen, Pauline Yeung, Daniel Brodie, Gianluigi Li Bassi, Tai Pham, Giacomo Bellani, John F. Fraser and John Laffey
    Citation: Critical Care 2023 27:202

    The original article was published in Critical Care 2023 27:3

  15. A quantitative assessment of pulmonary edema is important because the clinical severity can range from mild impairment to life threatening. A quantitative surrogate measure, although invasive, for pulmonary ed...

    Authors: Dominik Schulz, Sebastian Rasch, Markus Heilmaier, Rami Abbassi, Alexander Poszler, Jörg Ulrich, Manuel Steinhardt, Georgios A. Kaissis, Roland M. Schmid, Rickmer Braren and Tobias Lahmer
    Citation: Critical Care 2023 27:201
  16.  Circulatory failure is classified into four types of shock (obstructive, cardiogenic, distributive, and hypovolemic) that must be distinguished as each requires a different treatment. Point-of-care ultrasound...

    Authors: Takuo Yoshida, Takuya Yoshida, Hisashi Noma, Takeshi Nomura, Akihiro Suzuki and Takahiro Mihara
    Citation: Critical Care 2023 27:200
  17. Prevalence, risk factors and medical management of persistent pain symptoms after critical care illness have not been thoroughly investigated.

    Authors: Alexandre Bourdiol, Vincent Legros, Fanny Vardon-Bounes, Thomas Rimmele, Paul Abraham, Clément Hoffmann, Claire Dahyot-Fizelier, Maud Jonas, Pierre Bouju, Cédric Cirenei, Yoann Launey, Gregoire Le Gac, Samia Boubeche, Edouard Lamarche, Olivier Huet, Lucillia Bezu…
    Citation: Critical Care 2023 27:199
  18. Ventilator-induced lung injury (VILI) is caused by overdistension of the alveoli by the repetitive recruitment and derecruitment of alveolar units. This study aims to investigate the potential role and mechani...

    Authors: Peng Ding, Rui Yang, Cheng Li, Hai-Long Fu, Guang-Li Ren, Pei Wang, Dong-Yu Zheng, Wei Chen, Li-Ye Yang, Yan-Fei Mao, Hong-Bin Yuan and Yong-Hua Li
    Citation: Critical Care 2023 27:196
  19. A previous retrospective single-centre study suggested that the percentage of time spent with cerebral perfusion pressure (CPP) below the individual lower limit of reactivity (LLR) is associated with mortality...

    Authors: Erta Beqiri, Frederick A. Zeiler, Ari Ercole, Michal M. Placek, Jeanette Tas, Joseph Donnelly, Marcel J. H. Aries, Peter J. Hutchinson, David Menon, Nino Stocchetti, Marek Czosnyka and Peter Smielewski
    Citation: Critical Care 2023 27:194

    The Matters Arising to this article has been published in Critical Care 2023 27:311

  20. Multiple organ dysfunction syndrome (MODS) is an important cause of post-operative morbidity and mortality for children undergoing cardiac surgery requiring cardiopulmonary bypass (CPB). Dysregulated inflammat...

    Authors: Alexis L. Benscoter, Jeffrey A. Alten, Mihir R. Atreya, David S. Cooper, Jonathan W. Byrnes, David P. Nelson, Nicholas J. Ollberding and Hector R. Wong
    Citation: Critical Care 2023 27:193
  21. The goal of hemodynamic resuscitation is to optimize the microcirculation of organs to meet their oxygen and metabolic needs. Clinicians are currently blind to what is happening in the microcirculation of orga...

    Authors: J. Duranteau, D. De Backer, K. Donadello, N. I. Shapiro, S. D. Hutchings, A. Rovas, M. Legrand, A. Harrois and C. Ince
    Citation: Critical Care 2023 27:190

    The Matters Arising to this article has been published in Critical Care 2023 27:352

  22. Sodium glucose co-transporter-2 (SGLT2) inhibitors improve long-term cardiovascular and renal outcomes in individuals with type 2 diabetes. However, the safety of SGLT2 inhibitors in ICU patients with type 2 d...

    Authors: Johan Mårtensson, Salvatore Lucio Cutuli, Eduardo A. Osawa, Fumitaka Yanase, Lisa Toh, Luca Cioccari, Nora Luethi, Akinori Maeda and Rinaldo Bellomo
    Citation: Critical Care 2023 27:189

    The Correspondence to this article has been published in Critical Care 2023 27:225

    The Correspondence to this article has been published in Critical Care 2023 27:204

  23. Intensive Care Unit (ICU) COVID-19 survivors may present long-term cognitive and emotional difficulties after hospital discharge. This study aims to characterize the neuropsychological dysfunction of COVID-19 ...

    Authors: Marta Godoy-González, Guillem Navarra-Ventura, Gemma Gomà, Candelaria de Haro, Cristina Espinal, Cristina Fortià, Natalia Ridao, Nuria Miguel Rebanal, Laia Oliveras-Furriols, Carles Subirà, Mercè Jodar, Verónica Santos-Pulpón, Leonardo Sarlabous, Rafael Fernández, Ana Ochagavía, Lluís Blanch…
    Citation: Critical Care 2023 27:188
  24. Critical illness is a continuum, but patient care is often fragmented. Value-based critical care focuses on the overall health of the patient, not on an episode of care. The “ICU without borders” model incorpo...

    Authors: Marlies Ostermann and Jean-Louis Vincent
    Citation: Critical Care 2023 27:186
  25. Sepsis-associated encephalopathy (SAE) is frequent in septic patients. Electroencephalography (EEG) is very sensitive to detect early epileptic abnormalities, such as seizures and periodic discharges (PDs), an...

    Authors: Lorenzo Ferlini, Christelle Maenhout, Ilaria Alice Crippa, Armin Alvaro Quispe-Cornejo, Jacques Creteur, Fabio Silvio Taccone and Nicolas Gaspard
    Citation: Critical Care 2023 27:179
  26. The aim of this study was to investigate the physiological impact of airway pressure release ventilation (APRV) on patients with early moderate-to-severe acute respiratory distress syndrome (ARDS) by electrica...

    Authors: Ruiting Li, Yongran Wu, Hongling Zhang, Azhen Wang, Xin Zhao, Shiying Yuan, Le Yang, Xiaojing Zou, You Shang and Zhanqi Zhao
    Citation: Critical Care 2023 27:178
  27. Electrical impedance tomography (EIT) can be used to assess ventilation/perfusion (V/Q) mismatch within the lungs. Several methods have been proposed, some of them neglecting the absolute value of alveolar ventil...

    Authors: Samuel Tuffet, Tommaso Maraffi, Matthieu Lacheny, François Perier, Anne-Fleur Haudebourg, Mohamed Ahmed Boujelben, Glasiele Alcala, Armand Mekontso-Dessap and Guillaume Carteaux
    Citation: Critical Care 2023 27:176
  28. High dose vasopressors portend poor outcome in vasodilatory shock. We aimed to evaluate the impact of baseline vasopressor dose on outcomes in patients treated with angiotensin II (AT II).

    Authors: Patrick M. Wieruszewski, Rinaldo Bellomo, Laurence W. Busse, Kealy R. Ham, Alexander Zarbock, Ashish K. Khanna, Adam M. Deane, Marlies Ostermann, Richard G. Wunderink, David W. Boldt, Stew Kroll, Chuck R. Greenfeld, Tony Hodges and Jonathan H. Chow
    Citation: Critical Care 2023 27:175

    The Comment to this article has been published in Critical Care 2023 27:210

  29. This study aims to provide an updated assessment of the efficacy of optimized enteral nutrition (EN) delivery by implementing the volume-based feeding (VBF) protocol in critically ill patients.

    Authors: Lu Wang, Yu Wang, Hua-Xin Li, Rui-peng Zhang, Li Chang, Jun Zeng and Hua Jiang
    Citation: Critical Care 2023 27:173