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  1. Triggering receptor expressed on myeloid cells-1 (TREM-1) is a pattern recognition receptor and plays a critical role in the immune response. TREM-1 activation leads to the production and release of proinflamm...

    Authors: Vivienne Theobald, Felix Carl Fabian Schmitt, Chiara Simone Middel, Lena Gaissmaier, Thorsten Brenner and Markus Alexander Weigand
    Citation: Critical Care 2024 28:17
  2. A recent large multicentre trial found no difference in clinical outcomes but identified a possibility of increased mortality rates in patients with acute kidney injury (AKI) receiving higher protein. These al...

    Authors: Zheng-Yii Lee, Ellen Dresen, Charles Chin Han Lew, Julia Bels, Aileen Hill, M. Shahnaz Hasan, Lu Ke, Arthur van Zanten, Marcel C. G. van de Poll, Daren K. Heyland and Christian Stoppe
    Citation: Critical Care 2024 28:15
  3. The impact of therapeutic plasma exchange (TPE) on short-term mortality in adult patients with sepsis-induced organ dysfunction remains uncertain. The objective of the study is to assess the effect of adjunct ...

    Authors: Vladimir Kuklin, Michael Sovershaev, Johan Bjerner, Philip Keith, L. Keith Scott, Owen Matthew Truscott Thomas, Wladimir Szpirt, Gail Rock and Bernd Stegmayr
    Citation: Critical Care 2024 28:12
  4. Authors: George Tomlinson, Ali Al-Khafaji, Steven A. Conrad, Faith N. F. Factora, Debra M. Foster, Claude Galphin, Kyle J. Gunnerson, Sobia Khan, Roopa Kohli-Seth, Paul McCarthy, Nikhil K. Meena, Ronald G. Pearl, Jean-Sebastien Rachoin, Ronald Rains, Michael Seneff, Mark Tidswell…
    Citation: Critical Care 2024 28:11

    The original article was published in Critical Care 2023 27:432

  5. In this study including 391 critically ill patients with nosocomial pneumonia due to Gram-negative pathogens, combination therapy was not associated with a reduced hazard of death at Day 28 or a greater likeli...

    Authors: François Barbier, Claire Dupuis, Niccolò Buetti, Carole Schwebel, Élie Azoulay, Laurent Argaud, Yves Cohen, Vivien Hong Tuan Ha, Marc Gainnier, Shidasp Siami, Jean-Marie Forel, Christophe Adrie, Étienne de Montmollin, Jean Reignier, Stéphane Ruckly, Jean-Ralph Zahar…
    Citation: Critical Care 2024 28:10
  6. Acute ischemic stroke (AIS) complicating an acute myocardial infarction (AMI) is not uncommon, but can severely worsen the clinical prognosis. This study aimed to investigate whether remote ischemic conditioni...

    Authors: Sijie Li, Xiurong Xing, Lanjing Wang, Jiali Xu, Changhong Ren, Yalin Li, Jing Wang, Zhi Liu, Heng Zhao, Wenbo Zhao and Xunming Ji
    Citation: Critical Care 2024 28:5
  7. Group A Streptococcus is responsible for severe and potentially lethal invasive conditions requiring intensive care unit (ICU) admission, such as streptococcal toxic shock-like syndrome (STSS). A rebound of invas...

    Authors: Arthur Orieux, Renaud Prevel, Margot Dumery, Jean-Baptiste Lascarrou, Noémie Zucman, Florian Reizine, Pierre Fillatre, Charles Detollenaere, Cédric Darreau, Nadiejda Antier, Mélanie Saint-Léger, Guillaume Schnell, Béatrice La Combe, Charlotte Guesdon, Franklin Bruna, Antoine Guillon…
    Citation: Critical Care 2024 28:4
  8. Surface electromyography (sEMG) can be used to measure the electrical activity of the respiratory muscles. The possible applications of sEMG span from patients suffering from acute respiratory failure to patie...

    Authors: A. H. Jonkman, R. S. P. Warnaar, W. Baccinelli, N. M. Carbon, R. F. D’Cruz, J. Doorduin, J. L. M. van Doorn, J. Elshof, L. Estrada-Petrocelli, J. Graßhoff, L. M. A. Heunks, A. A. Koopman, D. Langer, C. M. Moore, J. M. Nunez Silveira, E. Petersen…
    Citation: Critical Care 2024 28:2
  9. The utilization of video laryngoscopy (VL) has demonstrated superiority over direct laryngoscopy (DL) for intubation in surgical settings. However, its effectiveness in the intensive care unit and emergency de...

    Authors: Beatriz Araújo, André Rivera, Suzany Martins, Renatha Abreu, Paula Cassa, Maicon Silva and Alice Gallo de Moraes
    Citation: Critical Care 2024 28:1

    The Matters Arising to this article has been published in Critical Care 2024 28:27

  10. Epinephrine increases the chances of return of spontaneous circulation (ROSC) in out-of-hospital cardiac arrest (OHCA), especially when the initial rhythm is non-shockable. However, this drug could also worsen...

    Authors: François Javaudin, Wulfran Bougouin, Lucie Fanet, Jean-Luc Diehl, Daniel Jost, Frankie Beganton, Jean-Philippe Empana, Xavier Jouven, Frédéric Adnet, Lionel Lamhaut, Jean-Baptiste Lascarrou, Alain Cariou and Florence Dumas
    Citation: Critical Care 2023 27:496
  11. Candidemia is a high-risk complication among intensive care unit (ICU) patients. While selective digestive decontamination (SDD) has been shown to be effective in preventing ICU-acquired bacterial secondary in...

    Authors: Florian Reizine, Nicolas Massart, Vincent Joussellin, Anaïs Machut, Charles-Hervé Vacheron, Anne Savey, Arnaud Friggeri and Alain Lepape
    Citation: Critical Care 2023 27:494
  12. Intensive care unit-acquired weakness (ICU-AW) is a prevalent and severe issue among ICU patients. Resistance training and beta-hydroxy-beta-methylbutyrate (HMB) intervention have demonstrated the potential to...

    Authors: Ting-Ting Wu, Qiao-Ling Chen, Xiu-Xia Lin, Mei-Lian Xu, Xue-Xian Chen, Chen-Juan Luo, Yao-Ning Zhuang, Yue-Qing Wei, Jing-Bing Wu, Jing Xiong, Li-Li Chen and Hong Li
    Citation: Critical Care 2023 27:493
  13. Authors: Johannes Grand, Christian Hassager, Jesper Kjaergaard and Jacob E. Møller
    Citation: Critical Care 2023 27:492

    The original article was published in Critical Care 2023 27:410

    The original article was published in Critical Care 2023 27:451

  14. Brain injury is a leading cause of morbidity and mortality in patients resuscitated from cardiac arrest. Mitochondrial dysfunction contributes to brain injury following cardiac arrest; therefore, therapies tha...

    Authors: Joseph M. Wider, Erin Gruley, Paul T. Morse, Junmei Wan, Icksoo Lee, Anthony R. Anzell, Garrett M. Fogo, Jennifer Mathieu, Gerald Hish, Brian O’Neil, Robert W. Neumar, Karin Przyklenk, Maik Hüttemann and Thomas H. Sanderson
    Citation: Critical Care 2023 27:491
  15. Sepsis is defined as a life-threatening syndrome caused by an unbalanced host response to infection. The role of interleukin (IL)-36 cytokines binding to the IL-36 receptor (IL-36R) in host response during sep...

    Authors: Huachen Wang, Meixiang Wang, Junlan Chen, Hongda Hou, Zheng Guo, Hong Yang, Hua Tang and Bing Chen
    Citation: Critical Care 2023 27:490
  16. There is limited evidence to guide interventions that promote cost-effectiveness in adult intensive care units (ICU). The aim of this consensus statement is to identify globally applicable interventions for be...

    Authors: Amit Kansal, Jos M. Latour, Kay Choong See, Sumeet Rai, Maurizo Cecconi, Carl Britto, Andrew Conway Morris, Raymond Dominic Savio, Vinay M. Nadkarni, B. K. Rao and Rajesh Mishra
    Citation: Critical Care 2023 27:487
  17. Sepsis is a highly heterogeneous syndrome, which has hindered the development of effective therapies. This has prompted investigators to develop a precision medicine approach aimed at identifying biologically ...

    Authors: Jamie O. Yang, Matt S. Zinter, Matteo Pellegrini, Man Yee Wong, Kinisha Gala, Daniela Markovic, Brian Nadel, Kerui Peng, Nguyen Do, Serghei Mangul, Vinay M. Nadkarni, Aaron Karlsberg, Dhrithi Deshpande, Manish J. Butte, Lisa Asaro, Michael Agus…
    Citation: Critical Care 2023 27:486
  18. There is currently a lack of evidence on the optimal strategy to support patient recovery after critical illness. Previous research has largely focussed on rehabilitation interventions which aimed to address p...

    Authors: Jonathan Stewart, Judy Bradley, Susan Smith, Joanne McPeake, Timothy Walsh, Kimberley Haines, Nina Leggett, Nigel Hart and Danny McAuley
    Citation: Critical Care 2023 27:485
  19. Proenkephalin A 119-159 (PENK) is freely filtered in the glomerulus with plasma levels correlating with glomerular filtration rate. Therefore, PENK has been proposed as an early indicator of acute kidney injur...

    Authors: Li-Chun Lin, Min-Hsiang Chuan, Jung-Hua Liu, Hung-Wei Liao, Leong L. Ng, Martin Magnusson, Amra Jujic, Heng-Chih Pan, Vin-Cent Wu and Lui G. Forni
    Citation: Critical Care 2023 27:481
  20. Previous research indicated outcomes among refractory out-of-hospital cardiac arrest (OHCA) patients with initial shockable rhythm were different in Singapore and Osaka, Japan, possibly due to the differences ...

    Authors: Yohei Okada, Nur Shahidah, Yih Yng Ng, Michael Y. C. Chia, Han Nee Gan, Benjamin S. H. Leong, Desmond R. Mao, Wei Ming Ng, Nausheen Edwin, Takeyuki Kiguchi, Norihiro Nishioka, Tetsuhisa Kitamura, Taku Iwami and Marcus Eng Hock Ong
    Citation: Critical Care 2023 27:479
  21. Observational studies have indicated a potential association between autoimmune diseases and the occurrence of sepsis, with an increased risk of mortality among affected patients. However, whether a causal rel...

    Authors: Hui Li, Xiaojun Pan, Sheng Zhang, Xuan Shen, Wan Li, Weifeng Shang, Zhenliang Wen, Sisi Huang, Limin Chen, Xu Zhang, Dechang Chen and Jiao Liu
    Citation: Critical Care 2023 27:476
  22. The multiple roles of iron in the body have been known for decades, particularly its involvement in iron overload diseases such as hemochromatosis. More recently, compelling evidence has emerged regarding the ...

    Authors: Coralie Grange, François Lux, Thomas Brichart, Laurent David, Aymeric Couturier, David E. Leaf, Bernard Allaouchiche and Olivier Tillement
    Citation: Critical Care 2023 27:475
  23. Acute circulatory failure leads to tissue hypoperfusion. Capillary refill time (CRT) has been widely studied, but its predictive value remains debated. We conducted a meta-analysis to assess the ability of CRT...

    Authors: Matthias Jacquet-Lagrèze, Aymeric Pernollet, Eduardo Kattan, Hafid Ait-Oufella, Delphine Chesnel, Martin Ruste, Rémi Schweizer, Bernard Allaouchiche, Glenn Hernandez and Jean-Luc Fellahi
    Citation: Critical Care 2023 27:473
  24. To evaluate the potential association between early dysnatremia and 6-month functional outcome after cardiac arrest.

    Authors: Jean Baptiste Lascarrou, Cyrielle Ermel, Alain Cariou, Timo Laitio, Hans Kirkegaard, Eldar Søreide, Anders M. Grejs, Matti Reinikainen, Gwenhael Colin, Fabio Silvio Taccone, Amélie Le Gouge and Markus B. Skrifvars
    Citation: Critical Care 2023 27:472
  25. Intra-abdominal candidiasis (IAC) is difficult to predict in critically ill patients with intra-abdominal infection, leading to the overuse of antifungal treatments. Serum and peritoneal 1.3-beta-d-glucan (sBDG a...

    Authors: Emmanuel Novy, Jérémie Rivière, Maxime Nguyen, Gaëlle Arfeuille, Guillaume Louis, Bélaïd Bouhemad, Julien Pottecher, Stéphane Hecketsweiler, Adeline Germain, François-Xavier Laithier, Marie-Reine Losser, Anne Debourgogne, Yohann Bernard, Hélène Rousseau, Cédric Baumann, Amandine Luc…
    Citation: Critical Care 2023 27:470
  26. Despite the extensive volume of research published on checklists in the intensive care unit (ICU), no review has been published on the broader role of checklists within the intensive care unit, their implement...

    Authors: Ethan J. Erikson, Daniel A. Edelman, Fiona M. Brewster, Stuart D. Marshall, Maryann C. Turner, Vineet V. Sarode and David J. Brewster
    Citation: Critical Care 2023 27:468
  27. Bacteria are the main pathogens that cause sepsis. The pathogenic mechanisms of sepsis caused by gram-negative and gram-positive bacteria are completely different, and their prognostic differences in sepsis re...

    Authors: Aling Tang, Yi Shi, Qingqing Dong, Sihui Wang, Yao Ge, Chenyan Wang, Zhimin Gong, Weizhen Zhang and Wei Chen
    Citation: Critical Care 2023 27:467
  28. Monitoring respiratory effort in ventilated patients is important to balance lung and diaphragm protection. Esophageal manometry remains the gold standard for monitoring respiratory effort but is invasive and ...

    Authors: Yukie Ito, Matías G. Herrera, Justin C. Hotz, Miyako Kyogoku, Christopher J. L. Newth, Anoopindar K. Bhalla, Muneyuki Takeuchi and Robinder G. Khemani
    Citation: Critical Care 2023 27:466