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  1. Serum neuron-specific enolase (NSE) is the only recommended biomarker for multimodal prognostication in postcardiac arrest patients, but low sensitivity of absolute NSE threshold limits its utility. This study...

    Authors: Youn-Jung Kim, Yong Hwan Kim, Chun Song Youn, In Soo Cho, Su Jin Kim, Jung Hee Wee, Yoo Seok Park, Joo Suk Oh, Byung Kook Lee and Won Young Kim
    Citation: Critical Care 2023 27:313
  2. Anticoagulants are widely used but can lead to iatrogenic events such as bleeding. Limited data exists regarding the characteristics and management of patients admitted to intensive care units (ICU) for severe...

    Authors: Thomas Botrel, Sibylle Cunat, Julie Helms, Jérémie Lemarié, Jeanne Gaillon, Sébastien Préau, Raphael Favory, Arnaud W. Thille, Florence Boissier, Eric Maury, Jérémie Joffre and Hafid Ait-Oufella
    Citation: Critical Care 2023 27:312

    The Matters Arising to this article has been published in Critical Care 2023 27:356

  3. Authors: Leandro Moreira Peres, Fabio Luis-Silva, Mayra Gonçalves Menegueti, Wilson José Lovato, Douglas Alexandre do Espirito Santo, Mariana Derminio Donadel, Lucas Sato, Carolina Hunger Malek-Zadeh, Anibal Basile-Filho, Olindo Assis Martins-Filho and Maria Auxiliadora-Martins
    Citation: Critical Care 2023 27:310
  4. Conflicting findings exist regarding the influence of sex on the development, treatment, course, and outcome of status epilepticus (SE). Our study aimed to investigate sex-related disparities in adult SE patie...

    Authors: Sira M. Baumann, Pia De Stefano, Paulina S. C. Kliem, Pascale Grzonka, Caroline E. Gebhard, Oana E. Sarbu, Gian Marco De Marchis, Sabina Hunziker, Stephan Rüegg, Andreas Kleinschmidt, Jérôme Pugin, Hervé Quintard, Stephan Marsch, Margitta Seeck and Raoul Sutter
    Citation: Critical Care 2023 27:308
  5. Positive end-expiratory pressure (PEEP) individualized to a maximal respiratory system compliance directly implies minimal driving pressures with potential outcome benefits, yet, raises concerns on static and ...

    Authors: Congli Zeng, Min Zhu, Gabriel Motta-Ribeiro, David Lagier, Takuga Hinoshita, Mingyang Zang, Kira Grogg, Tilo Winkler and Marcos F. Vidal Melo
    Citation: Critical Care 2023 27:307
  6. Ventilator-free days (VFDs) are a composite endpoint increasingly used as the primary outcome in critical care trials. However, because of the skewed distribution and competitive risk between components, sampl...

    Authors: Laurent Renard Triché, Emmanuel Futier, Manuela De Carvalho, Nathalie Piñol-Domenech, Laëtitia Bodet-Contentin, Matthieu Jabaudon and Bruno Pereira
    Citation: Critical Care 2023 27:303
  7. Sepsis survivors are at elevated risk for cardiovascular disease during long-term follow-up. Whether diabetes influences cardiovascular risk after sepsis survival remains unknown. We sought to describe the ass...

    Authors: Federico Angriman, Patrick R. Lawler, Baiju R. Shah, Claudio M. Martin and Damon C. Scales
    Citation: Critical Care 2023 27:302
  8. Intensive Care Unit (ICU) survivors often experience several impairments in their physical, cognitive, and psychological health status, which are labeled as post-intensive care syndrome (PICS). The aim of this...

    Authors: Caroline Renner, Marie-Madlen Jeitziner, Monika Albert, Sabine Brinkmann, Karin Diserens, Imanuel Dzialowski, Maria-Dorothea Heidler, Martina Lück, Ricki Nusser-Müller-Busch, Peter S. Sandor, Andreas Schäfer, Bettina Scheffler, Claus Wallesch, Gudrun Zimmermann and Peter Nydahl
    Citation: Critical Care 2023 27:301
  9. Albumin infusion is the primary therapeutic strategy for septic patients with liver cirrhosis. Although recent studies have investigated the efficacy of albumin in the resuscitation stage of septic patients wi...

    Authors: Wenhan Hu, Hui Chen, Chencheng Ma, Qin Sun, Meicheng Yang, Haofei Wang, Qingyun Peng, Jinlong Wang, Chen Zhang, Wei Huang, Jianfeng Xie and Yingzi Huang
    Citation: Critical Care 2023 27:300
  10. The Netherlands introduced an opt-out donor system in 2020. While the default in (presumed) consent cases is donation, family involvement adds a crucial layer of influence when applying this default in clinica...

    Authors: Sanne P. C. van Oosterhout, Anneke G. van der Niet, W. Farid Abdo, Marianne Boenink, Thomas G. V. Cherpanath, Jelle L. Epker, Angela M. Kotsopoulos, Walther N. K. A. van Mook, Hans P. C. Sonneveld, Meint Volbeda, Gert Olthuis and Jelle L. P. van Gurp
    Citation: Critical Care 2023 27:299
  11. Prognostication is very important to clinicians and families during the early management of severe traumatic brain injury (sTBI), however, there are no gold standard biomarkers to determine prognosis in sTBI. ...

    Authors: Mohammad M. Banoei, Chel Hee Lee, James Hutchison, William Panenka, Cheryl Wellington, David S. Wishart and Brent W. Winston
    Citation: Critical Care 2023 27:295
  12. Vasopressin is a second-line vasoactive agent for refractory septic shock. Vasopressin loading is not generally performed because of the lack of evidence for its effects and safety. However, based on our previ...

    Authors: Kensuke Nakamura, Hidehiko Nakano, Daisuke Ikechi, Masaki Mochizuki, Yuji Takahashi, Yasuaki Koyama, Hideki Hashimoto, Toshikazu Abe, Mineji Hayakawa and Kazuma Yamakawa
    Citation: Critical Care 2023 27:294

    The Correspondence to this article has been published in Critical Care 2023 27:324

  13. Drowning is one of the leading causes of death worldwide and presents with a wide range of symptoms, from simple coughing to cardiac or pulmonary failure. In severe cases, extracorporeal membrane oxygenation (...

    Authors: Thomas Jasny, Jan Kloka, Oliver Old, Florian Piekarski, Gösta Lotz, Kai Zacharowski and Benjamin Friedrichson
    Citation: Critical Care 2023 27:293

    The Correspondence to this article has been published in Critical Care 2023 27:326

  14. Sepsis is a heterogenous syndrome with limited therapeutic options. Identifying immunological endotypes through gene expression patterns in septic patients may lead to targeted interventions. We investigated w...

    Authors: Jeremy A. Balch, Uan-I Chen, Oliver Liesenfeld, Petr Starostik, Tyler J. Loftus, Philip A. Efron, Scott C. Brakenridge, Timothy E. Sweeney and Lyle L. Moldawer
    Citation: Critical Care 2023 27:292
  15. To determine if neighborhood socioeconomic deprivation independently predicts 30-day mortality and readmission for patients with sepsis or critical illness after adjusting for individual poverty, demographics,...

    Authors: Jay B. Lusk, Beau Blass, Hannah Mahoney, Molly N. Hoffman, Amy G. Clark, Jonathan Bae, Deepshikha C. Ashana, Christopher E. Cox and Bradley G. Hammill
    Citation: Critical Care 2023 27:287
  16. To maintain adequate oxygenation is of utmost importance in intraoperative care. However, clinical evidence supporting specific oxygen levels in distinct surgical settings is lacking. This study aimed to compa...

    Authors: Karam Nam, Jae-Sik Nam, Hye-Bin Kim, Jaeyeon Chung, In Eob Hwang, Jae-Woo Ju, Jinyoung Bae, Seohee Lee, Youn Joung Cho, Jae-Kwang Shim, Young-Lan Kwak, Ji-Hyun Chin, In-Cheol Choi, Eun-Ho Lee and Yunseok Jeon
    Citation: Critical Care 2023 27:286
  17. Indigenous Peoples experience health inequities and racism across the continuum of health services. We performed a systematic review and meta-analysis of the incidence and outcomes of critical illness among In...

    Authors: Samantha L. Bowker, Kienan Williams, Auriele Volk, Leonard Auger, Alika Lafontaine, Paige Dumont, Aireen Wingert, Amanda Davis, Liza Bialy, Erica Wright, Richard T. Oster and Sean M. Bagshaw
    Citation: Critical Care 2023 27:285
  18. The resumption of oral feeding and free from pneumonia are important therapeutic goals for critically ill patients who have been successfully extubated after prolonged (≥ 48 h) endotracheal intubation. We aime...

    Authors: Shu-Fen Siao, Shih-Chi Ku, Wen-Hsuan Tseng, Yu-Chung Wei, Yu-Chun Chang, Tzu-Yu Hsiao, Tyng-Guey Wang and Cheryl Chia-Hui Chen
    Citation: Critical Care 2023 27:283
  19. Iatrogenic cerebral arterial gas embolism (CAGE) caused by invasive medical procedures may be treated with hyperbaric oxygen therapy (HBOT). Previous studies suggested that initiation of HBOT within 6–8 h is a...

    Authors: Raoul A. Fakkert, Noa Karlas, Patrick Schober, Nina C. Weber, Benedikt Preckel, Robert A. van Hulst and Robert P. Weenink
    Citation: Critical Care 2023 27:282
  20. Intrarenal venous flow (IRVF) patterns assessed using Doppler renal ultrasonography are real-time bedside visualizations of renal vein hemodynamics. Although this technique has the potential to detect renal co...

    Authors: Kenichiro Fujii, Izumi Nakayama, Junichi Izawa, Noriko Iida, Yoshihiro Seo, Masayoshi Yamamoto, Norimichi Uenishi, Teruhiko Terasawa and Mitsunaga Iwata
    Citation: Critical Care 2023 27:278

    The Correspondence to this article has been published in Critical Care 2023 27:335

  21. Evaluating effectiveness of speech/phrase recognition software in critically ill patients with speech impairments.

    Authors: M. Musalia, S. Laha, J. Cazalilla-Chica, J. Allan, L. Roach, J. Twamley, S. Nanda, M. Verlander, A. Williams, I. Kempe, I. I. Patel, F. Campbell-West, B. Blackwood and D. F. McAuley
    Citation: Critical Care 2023 27:277
  22. Recent evidence suggests an association of plasma Proenkephalin A 119–159 (penKid) with early and successful liberation from continuous renal replacement therapy (CRRT) in critically ill patients with acute ki...

    Authors: Thilo von Groote, Felix Albert, Melanie Meersch, Raphael Koch, Joachim Gerss, Birte Arlt, Mahan Sadjadi, Christian Porschen, Peter Pickkers and Alexander Zarbock
    Citation: Critical Care 2023 27:276
  23. The oXiris is a novel filter for continuous renal replacement therapy (CRRT) featuring an adsorption coating to adsorb endotoxins and remove inflammatory mediators. Given that no consensus has been reached on ...

    Authors: Guizhong Wang, Yuxuan He, Qingling Guo, Ying Zhao, Jie He, Yue Chen, Weijia Chen, Yi Zhou, Zichong Peng, Ke Deng, Jianbin Guan, Wenting Xie, Ping Chang and Zhanguo Liu
    Citation: Critical Care 2023 27:275

    The Correspondence to this article has been published in Critical Care 2023 27:314

    The Comment to this article has been published in Critical Care 2023 27:305

  24. This systematic review and meta-analysis aimed to investigate the clinical efficacy and safety of systemic corticosteroids in the treatment of patients with severe community-acquired pneumonia (sCAP).

    Authors: Jheng-Yan Wu, Ya-Wen Tsai, Wan-Hsuan Hsu, Ting-Hui Liu, Po-Yu Huang, Min-Hsiang Chuang, Mei-Yuan Liu and Chih-Cheng Lai
    Citation: Critical Care 2023 27:274

    The Matters Arising to this article has been published in Critical Care 2023 27:358

    The Comment to this article has been published in Critical Care 2023 27:348

    The Correspondence to this article has been published in Critical Care 2023 27:336

    The Comment to this article has been published in Critical Care 2023 27:296

  25. Airway opening pressure (AOP) detection and measurement are essential for assessing respiratory mechanics and adapting ventilation. We propose a novel approach for AOP assessment during volume assist control v...

    Authors: Anne-Fleur Haudebourg, Elsa Moncomble, Arnaud Lesimple, Flora Delamaire, Bruno Louis, Armand Mekontso Dessap, Alain Mercat, Jean-Christophe Richard, François Beloncle and Guillaume Carteaux
    Citation: Critical Care 2023 27:273
  26. In critically ill patients, measured creatinine clearance (CrCl) is the most reliable method to evaluate glomerular filtration rate in routine clinical practice and may vary subsequently on a day-to-day basis....

    Authors: Chao-Yuan Huang, Fabian Güiza, Pieter Wouters, Liese Mebis, Giorgia Carra, Jan Gunst, Philippe Meersseman, Michael Casaer, Greet Van den Berghe, Greet De Vlieger and Geert Meyfroidt
    Citation: Critical Care 2023 27:272
  27. Immune suppression has been implicated in the occurrence of pneumonia in critically ill patients. We tested the hypothesis that Intensive Care Unit (ICU)-acquired pneumonia is associated with broad host immune...

    Authors: Tjitske S. R. van Engelen, Tom D. Y. Reijnders, Fleur P. Paling, Marc J. M. Bonten, Leen Timbermont, Surbhi Malhotra-Kumar, Jan A. J. W. Kluytmans, Hessel Peters-Sengers and Tom van der Poll
    Citation: Critical Care 2023 27:269
  28. Individualised optimisation of mechanical ventilation (MV) remains cumbersome in modern intensive care medicine. Computerised, model-based support systems could help in tailoring MV settings to the complex int...

    Authors: R. S. P. Warnaar, M. P. Mulder, L. Fresiello, A. D. Cornet, L. M. A. Heunks, D. W. Donker and E. Oppersma
    Citation: Critical Care 2023 27:268
  29. To which extent trauma- induced disturbances in ionized calcium (iCa2+) levels have a linear relationship with adverse outcomes remains controversial. The goal of this study was to determine the association be...

    Authors: Dries Helsloot, Mark Fitzgerald, Rolf Lefering, Sandra Verelst and Carlo Missant
    Citation: Critical Care 2023 27:267
  30. Definitions for massive transfusion (MT) vary widely between studies, contributing to challenges in interpretation of research findings and practice evaluation. In this first systematic review, we aimed to ide...

    Authors: Victor S. Lin, Emily Sun, Serine Yau, Chathuri Abeyakoon, Georgia Seamer, Simran Bhopal, Harriet Tucker, Carolyn Doree, Susan J. Brunskill, Zoe K. McQuilten, Simon J. Stanworth, Erica M. Wood and Laura Green
    Citation: Critical Care 2023 27:265
  31. During the COVID-19 pandemic, several centers had independently reported extending prone positioning beyond 24 h. Most of these centers reported maintaining patients in prone position until significant clinica...

    Authors: Thaïs Walter and Jean-Damien Ricard
    Citation: Critical Care 2023 27:264