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  1. Severe acute brain injuries, stemming from trauma, ischemia or hemorrhage, remain a significant global healthcare concern due to their association with high morbidity and mortality rates. Accurate assessment o...

    Authors: Edith Elianna Rodriguez, Mario Zaccarelli, Elda Diletta Sterchele and Fabio Silvio Taccone
    Citation: Critical Care 2024 28:104

    The Matters Arising to this article has been published in Critical Care 2024 28:153

    The Matters Arising to this article has been published in Critical Care 2024 28:137

  2. Quality of life (QoL) is a key outcome measure in healthcare. However, the heterogeneity in its definitions presents challenges in the objective evaluation of improvement. Universal questionnaires, tailored fo...

    Authors: Johan Malmgren, Stefan Lundin, Ann-Charlotte Waldenström, Christian Rylander and Elias Johannesson
    Citation: Critical Care 2024 28:102
  3. Sepsis is characterized by organ dysfunction resulting from a dysregulated inflammatory response triggered by infection, involving multifactorial and intricate molecular mechanisms. Hypoxia-inducible factor-1α...

    Authors: Hang Ruan, Qin Zhang, You-ping Zhang, Shu-sheng Li and Xiao Ran
    Citation: Critical Care 2024 28:100
  4. Despite the high workload of cardiac intensive care unit (ICU), there is a paucity of evidence on the association between nurse workforce and mortality in patients with cardiogenic shock (CS). This study aimed...

    Authors: Ki Hong Choi, Danbee Kang, Jin Lee, Hyejeong Park, Taek Kyu Park, Joo Myung Lee, Young Bin Song, Joo-Yong Hahn, Seung-Hyuk Choi, Hyeon-Cheol Gwon, Juhee Cho and Jeong Hoon Yang
    Citation: Critical Care 2024 28:99
  5. Sepsis is a condition where the immune response to infection becomes dysregulated and life-threatening. It is not known whether lifestyle factors influence the risk of sepsis. The aim of the present study is t...

    Authors: Karl Stattin, Mikael Eriksson, Robert Frithiof, Rafael Kawati, Michael Hultström and Miklos Lipcsey
    Citation: Critical Care 2024 28:98
  6. Acute respiratory distress syndrome (ARDS) poses challenges in early identification. Exhaled breath contains metabolites reflective of pulmonary inflammation.

    Authors: Shiqi Zhang, Laura A. Hagens, Nanon F. L. Heijnen, Marry R. Smit, Paul Brinkman, Dominic Fenn, Tom van der Poll, Marcus J. Schultz, Dennis C. J. J. Bergmans, Ronny M. Schnabel and Lieuwe D. J. Bos
    Citation: Critical Care 2024 28:96
  7. Despite the growing prevalence of burn survivors, a gap persists in our understanding of the correlation between acute burn trauma and the long-term impact on psychosocial health. This study set out to investi...

    Authors: Adriana C. Panayi, Daren K. Heyland, Christian Stoppe, Marc G. Jeschke, Oliver Didzun, Dany Matar, Christian Tapking, Alen Palackic, Björn Bliesener, Leila Harhaus, Samuel Knoedler, Valentin Haug, Amir K. Bigdeli, Ulrich Kneser, Dennis P. Orgill and Gabriel Hundeshagen
    Citation: Critical Care 2024 28:95
  8. Authors:
    Citation: Critical Care 2024 28:94

    The original article was published in Critical Care 2020 24:104

    The original article was published in Critical Care 2020 24:106

    The original article was published in Critical Care 2020 24:102

    The original article was published in Critical Care 2020 24:99

    The original article was published in Critical Care 2020 24:105

    The original article was published in Critical Care 2020 24:100

    The original article was published in Critical Care 2020 24:97

    The original article was published in Critical Care 2020 24:103

    The original article was published in Critical Care 2020 24:98

    The original article was published in Critical Care 2020 24:101

  9. Acute kidney injury (AKI) often complicates sepsis and is associated with high morbidity and mortality. In recent years, several important clinical trials have improved our understanding of sepsis-associated A...

    Authors: Matthieu Legrand, Sean M. Bagshaw, Pavan K. Bhatraju, Azra Bihorac, Ellen Caniglia, Ashish K. Khanna, John A. Kellum, Jay Koyner, Michael O. Harhay, Fernando G. Zampieri, Alexander Zarbock, Kevin Chung, Kathleen Liu, Ravindra Mehta, Peter Pickkers, Abigail Ryan…
    Citation: Critical Care 2024 28:92
  10. Acute respiratory distress syndrome (ARDS) can be classified into sub-phenotypes according to different inflammatory/clinical status. Prognostic enrichment was achieved by grouping patients into hypoinflammato...

    Authors: Adrian Ceccato, Carles Forne, Lieuwe D. Bos, Marta Camprubí-Rimblas, Aina Areny-Balagueró, Elena Campaña-Duel, Sara Quero, Emili Diaz, Oriol Roca, David De Gonzalo-Calvo, Laia Fernández-Barat, Anna Motos, Ricard Ferrer, Jordi Riera, Jose A. Lorente, Oscar Peñuelas…
    Citation: Critical Care 2024 28:91
  11. In trauma systems, criteria for individualised and optimised administration of tranexamic acid (TXA), an antifibrinolytic, are yet to be established. This study used nationwide cohort data from Japan to evalua...

    Authors: Jotaro Tachino, Shigeto Seno, Hisatake Matsumoto, Tetsuhisa Kitamura, Atsushi Hirayama, Shunichiro Nakao, Yusuke Katayama, Hiroshi Ogura and Jun Oda
    Citation: Critical Care 2024 28:89
  12. Sepsis is a life-threatening condition arising from an aberrant host response to infection. Recent single-cell RNA sequencing investigations identified an immature bone-marrow-derived CD14+ monocyte phenotype wit...

    Authors: Giuseppe G. F. Leite, Justin de Brabander, Erik H. A. Michels, Joe M. Butler, Olaf L. Cremer, Brendon P. Scicluna, Timothy E. Sweeney, Miguel Reyes, Reinaldo Salomao, Hessel Peters-Sengers and Tom van der Poll
    Citation: Critical Care 2024 28:88
  13. To evaluate the effects of our self-developed endotracheal tube fixation device in mechanically ventilated patients.

    Authors: Xiaodong Zhang, Qibing Zhang, Jiqin You, Rong Xu, Zhaojie Zhang, Yunlan Shi, Chunrong Han, Shiyan Zhao, Bangtao Yao, Yan Geng and Songqiao Liu
    Citation: Critical Care 2024 28:87
  14. Considerable political, structural, environmental and epidemiological change will affect high socioeconomic index (SDI) countries over the next 25 years. These changes will impact healthcare provision and cons...

    Authors: Tobias Gauss, Mariska de Jongh, Marc Maegele, Elaine Cole and Pierre Bouzat
    Citation: Critical Care 2024 28:84
  15. Prone positioning (PP) homogenizes ventilation distribution and may limit ventilator-induced lung injury (VILI) in patients with moderate to severe acute respiratory distress syndrome (ARDS). The static and dy...

    Authors: Christoph Boesing, Joerg Krebs, Alice Marguerite Conrad, Matthias Otto, Grietje Beck, Manfred Thiel, Patricia R. M. Rocco, Thomas Luecke and Laura Schaefer
    Citation: Critical Care 2024 28:82
  16. Fluid resuscitation has long been a cornerstone of pre-hospital trauma care, yet its optimal approach remains undetermined. Although a liberal approach to fluid resuscitation has been linked with increased com...

    Authors: M. F. Bath, J. Schloer, J. Strobel, W. Rea, R. Lefering, M. Maegele, H. De’Ath and Z. B. Perkins
    Citation: Critical Care 2024 28:81
  17. Near-infrared spectroscopy regional cerebral oxygen saturation (rSO2) has gained interest as a raw parameter and as a basis for measuring cerebrovascular reactivity (CVR) due to its noninvasive nature and high sp...

    Authors: Alwyn Gomez, Logan Froese, Donald Griesdale, Eric P. Thelin, Rahul Raj, Levi van Iperenburg, Jeanette Tas, Marcel Aries, Kevin Y. Stein, Clare Gallagher, Francis Bernard, Andreas H. Kramer and Frederick A. Zeiler
    Citation: Critical Care 2024 28:78
  18. Posttraumatic stress disorder (PTSD) after a stay in the intensive care unit (ICU) can affect one in five ICU survivors. At the beginning of the coronavirus disease 2019 (COVID-19) pandemic, admission to the I...

    Authors: Pierre Kalfon, Wissam El-Hage, Marie-Agnès Geantot, Constance Favier, Laetitia Bodet-Contentin, Khaldoun Kuteifan, Pierre-Yves Olivier, Didier Thévenin, Julien Pottecher, Jullien Crozon-Clauzel, Bénédicte Mauchien, Arnaud Galbois, Roland de Varax, Sabine Valera, Philippe Estagnasie, Audrey Berric…
    Citation: Critical Care 2024 28:77
  19. A real-time model for predicting short-term mortality in critically ill patients is needed to identify patients at imminent risk. However, the performance of the model needs to be validated in various clinical...

    Authors: Leerang Lim, Ukdong Gim, Kyungjae Cho, Dongjoon Yoo, Ho Geol Ryu and Hyung-Chul Lee
    Citation: Critical Care 2024 28:76
  20. Flow starvation is a type of patient-ventilator asynchrony that occurs when gas delivery does not fully meet the patients’ ventilatory demand due to an insufficient airflow and/or a high inspiratory effort, an...

    Authors: Candelaria de Haro, Verónica Santos-Pulpón, Irene Telías, Alba Xifra-Porxas, Carles Subirà, Montserrat Batlle, Rafael Fernández, Gastón Murias, Guillermo M. Albaiceta, Sol Fernández-Gonzalo, Marta Godoy-González, Gemma Gomà, Sara Nogales, Oriol Roca, Tai Pham, Josefina López-Aguilar…
    Citation: Critical Care 2024 28:75
  21. Endotype classification may guide immunomodulatory management of patients with bacterial and viral sepsis. We aimed to identify immune endotypes and transitions associated with response to anakinra (human inte...

    Authors: Evdoxia Kyriazopoulou, Yehudit Hasin-Brumshtein, Uros Midic, Garyfallia Poulakou, Haralampos Milionis, Simeon Metallidis, Myrto Astriti, Archontoula Fragkou, Aggeliki Rapti, Eleonora Taddei, Ioannis Kalomenidis, Georgios Chrysos, Andrea Angheben, Ilias Kainis, Zoi Alexiou, Francesco Castelli…
    Citation: Critical Care 2024 28:73
  22. New onset refractory status epilepticus (NORSE) is a neurologic emergency without an immediately identifiable cause. The complicated and long ICU stay of the patients can lead to perceiving a prolongation of t...

    Authors: Federica Stretti, Stefan Yu Bögli, Francesca Casagrande, Amanda Eisele, Marian Galovic, Emanuela Keller and Giovanna Brandi
    Citation: Critical Care 2024 28:72
  23. Several bedside assessments are used to evaluate respiratory muscle function and to predict weaning from mechanical ventilation in patients on the intensive care unit. It remains unclear which assessments perf...

    Authors: Diego Poddighe, Marine Van Hollebeke, Yasir Qaiser Choudhary, Débora Ribeiro Campos, Michele R. Schaeffer, Jan Y. Verbakel, Greet Hermans, Rik Gosselink and Daniel Langer
    Citation: Critical Care 2024 28:70
  24. Chimeric antigen receptor T cells are a promising new immunotherapy for haematological malignancies. Six CAR-T cells products are currently available for adult patients with refractory or relapsed high-grade B...

    Authors: Mathieu Bellal, Jolan Malherbe, Gandhi Damaj and Damien Du Cheyron
    Citation: Critical Care 2024 28:69
  25. Molecular oxygen is typically delivered to patients via oxygen inhalation or extracorporeal membrane oxygenation (ECMO), potentially resulting in systemic hyperoxia from liberal oxygen inhalation or localized ...

    Authors: Ninan Dai, Juan Gu, Yanhong Luo, Yuanfa Tao, Yuehting Chou, Ying He, Han Qin, Tao Chen, Xiaoyun Fu, Miao Chen and Zhouxiong Xing
    Citation: Critical Care 2024 28:66
  26. SARS-CoV-2 can induce insulin resistance, which is, among others, mediated by adipose tissue dysfunction and reduced angiotensin-converting enzyme 2 (ACE2) enzymatic activity. In SARS-CoV-2-infected mice, the ...

    Authors: Erik Duijvelaar, Xiaoke Pan, Harm Jan Bogaard, Etto C. Eringa and Jurjan Aman
    Citation: Critical Care 2024 28:65
  27. After cardiac surgery, post-operative delirium (PoD) is acknowledged to have a significant negative impact on patient outcome. To date, there is no valuable and specific treatment for PoD. Critically ill patie...

    Authors: Olivier Huet, Thomas Gargadennec, Jean-Ferréol Oilleau, Bertrand Rozec, Nicolas Nesseler, Adrien Bouglé, Thomas Kerforne, Sigismond Lasocki, Vedat Eljezi, Géraldine Dessertaine, Julien Amour and Xavier Chapalain
    Citation: Critical Care 2024 28:64
  28. Acute respiratory distress syndrome (ARDS) is a life-threatening critical care syndrome commonly associated with infections such as COVID-19, influenza, and bacterial pneumonia. Ongoing research aims to improv...

    Authors: Chel Hee Lee, Mohammad M. Banoei, Mariam Ansari, Matthew P. Cheng, Francois Lamontagne, Donald Griesdale, David E. Lasry, Koray Demir, Vinay Dhingra, Karen C. Tran, Terry Lee, Kevin Burns, David Sweet, John Marshall, Arthur Slutsky, Srinivas Murthy…
    Citation: Critical Care 2024 28:63
  29. To assess the frequency, risk factors, consequences, and prevention of violence against healthcare workers in intensive care units.

    Authors: Sebastian Berger, Pascale Grzonka, Anja I. Frei, Sabina Hunziker, Sira M. Baumann, Simon A. Amacher, Caroline E. Gebhard and Raoul Sutter
    Citation: Critical Care 2024 28:61
  30. Extracorporeal cardiopulmonary resuscitation (ECPR) may reduce mortality and improve neurological outcomes in patients with cardiac arrest. We updated our existing meta-analysis and trial sequential analysis t...

    Authors: Christopher Jer Wei Low, Ryan Ruiyang Ling, Kollengode Ramanathan, Ying Chen, Bram Rochwerg, Tetsuhisa Kitamura, Taku Iwami, Marcus Eng Hock Ong and Yohei Okada
    Citation: Critical Care 2024 28:57

    The Matters Arising to this article has been published in Critical Care 2024 28:126

    The Matters Arising to this article has been published in Critical Care 2024 28:86

  31. Despite evidence associating inflammatory biomarkers with worse outcomes in hospitalized adults with COVID-19, trials of immunomodulatory therapies have met with mixed results, likely due in part to biological...

    Authors: Narges Alipanah-Lechner, James Hurst-Hopf, Kevin Delucchi, Lamorna Swigart, Andrew Willmore, Benjamin LaCombe, Robin Dewar, H. Clifford Lane, Perrine Lallemand, Kathleen D. Liu, Laura Esserman, Michael A. Matthay and Carolyn S. Calfee
    Citation: Critical Care 2024 28:56