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  1. The association of tracheostomy timing and clinical outcomes in ventilated COVID-19 patients remains controversial. We performed a meta-analysis to evaluate the impact of early tracheostomy compared to late tr...

    Authors: Yun Ji, Yumin Fang, Baoli Cheng, Libin Li and Xiangming Fang
    Citation: Critical Care 2022 26:40
  2. Non-invasive oxygenation strategies have a prominent role in the treatment of acute hypoxemic respiratory failure during the coronavirus disease 2019 (COVID-19). While the efficacy of these therapies has been ...

    Authors: Pedro David Wendel-Garcia, Arantxa Mas, Cristina González-Isern, Ricard Ferrer, Rafael Máñez, Joan-Ramon Masclans, Elena Sandoval, Paula Vera, Josep Trenado, Rafael Fernández, Josep-Maria Sirvent, Melcior Martínez, Mercedes Ibarz, Pau Garro, José Luis Lopera, María Bodí…
    Citation: Critical Care 2022 26:37
  3. The global burden of sepsis is concentrated in sub-Saharan Africa, where severe infections disproportionately affect young, HIV-infected adults and high-burden pathogens are unique. In this context, poor under...

    Authors: Matthew J. Cummings, Barnabas Bakamutumaho, Adam Price, Nicholas Owor, John Kayiwa, Joyce Namulondo, Timothy Byaruhanga, Moses Muwanga, Christopher Nsereko, Stephen Sameroff, Rafal Tokarz, Wai Wong, Shivang S. Shah, Michelle H. Larsen, W. Ian Lipkin, Julius J. Lutwama…
    Citation: Critical Care 2022 26:36
  4. Brain multimodal monitoring including intracranial pressure (ICP) and brain tissue oxygen pressure (PbtO2) is more accurate than ICP alone in detecting cerebral hypoperfusion after traumatic brain injury (TBI). N...

    Authors: Thomas Gargadennec, Gioconda Ferraro, Rudy Chapusette, Xavier Chapalain, Elisa Bogossian, Morgane Van Wettere, Lorenzo Peluso, Jacques Creteur, Olivier Huet, Niloufar Sadeghi and Fabio Silvio Taccone
    Citation: Critical Care 2022 26:35
  5. Extracorporeal membrane oxygenation (ECMO) has become an established rescue therapy for severe acute respiratory distress syndrome (ARDS) in several etiologies including influenza A H1N1 pneumonia. The benefit...

    Authors: Vito Fanelli, Marco Giani, Giacomo Grasselli, Francesco Mojoli, Gennaro Martucci, Lorenzo Grazioli, Francesco Alessandri, Silvia Mongodi, Gabriele Sales, Giorgia Montrucchio, Costanza Pizzi, Lorenzo Richiardi, Luca Lorini, Antonio Arcadipane, Antonio Pesenti, Giuseppe Foti…
    Citation: Critical Care 2022 26:34

    The Correspondence to this article has been published in Critical Care 2022 26:149

  6. Endotheliopathy is suggested as pivotal pathophysiology of sepsis and trauma-associated organ failure, but its role in acute respiratory failure is not yet determined. We investigated if endotheliopathy biomar...

    Authors: Martin Schønemann-Lund, Theis S. Itenov, Johan E. Larsson, Birgitte Lindegaard, Pär I. Johansson and Morten H. Bestle
    Citation: Critical Care 2022 26:33
  7. Whether respiratory efforts and their timing can be reliably detected during pressure support ventilation using standard ventilator waveforms is unclear. This would give the opportunity to assess and improve p...

    Authors: Francesco Mojoli, Marco Pozzi, Anita Orlando, Isabella M. Bianchi, Eric Arisi, Giorgio A. Iotti, Antonio Braschi and Laurent Brochard
    Citation: Critical Care 2022 26:32
  8. The effects of positive end-expiratory pressure (PEEP) on lung ultrasound (LUS) patterns, and their relationship with intracranial pressure (ICP) in brain injured patients have not been completely clarified. T...

    Authors: Chiara Robba, Lorenzo Ball, Denise Battaglini, Francesca Iannuzzi, Iole Brunetti, Pietro Fiaschi, Gianluigi Zona, Fabio Silvio Taccone, Antonio Messina, Silvia Mongodi and Paolo Pelosi
    Citation: Critical Care 2022 26:31
  9. Corticosteroids, in particular dexamethasone, are one of the primary treatment options for critically ill COVID-19 patients. However, there are a growing number of cases that involve COVID-19-associated pulmon...

    Authors: Rasmus Leistner, Lisa Schroeter, Thomas Adam, Denis Poddubnyy, Miriam Stegemann, Britta Siegmund, Friederike Maechler, Christine Geffers, Frank Schwab, Petra Gastmeier, Sascha Treskatsch, Stefan Angermair and Thomas Schneider
    Citation: Critical Care 2022 26:30
  10. Effective removal of pathogenic bacteria is key to improving the prognosis of sepsis. Polymorphonuclear neutrophils (PMNs) are the most important components of innate cellular immunity and play vital roles in ...

    Authors: Tingting Pan, Shaoqiong Sun, Yang Chen, Rui Tian, Erzhen Chen, Ruoming Tan, Xiaoli Wang, Zhaojun Liu, Jialin Liu and Hongping Qu
    Citation: Critical Care 2022 26:29
  11. Intravenous vitamin C administration in septic shock may have a sparing effect on vasopressor requirements, and vitamin C’s enzyme cofactor functions provide a mechanistic rationale. Our study aimed to determi...

    Authors: Patrice Rosengrave, Emma Spencer, Jonathan Williman, Jan Mehrtens, Stacey Morgan, Tara Doyle, Kymbalee Van Der Heyden, Anna Morris, Geoff Shaw and Anitra C. Carr
    Citation: Critical Care 2022 26:26
  12. Vitamin C has potential protective effects through antioxidant and anti-inflammatory properties. However, the effect of vitamin C supplementation on microvascular function and peripheral tissue perfusion in hu...

    Authors: Jean-Rémi Lavillegrand, Lisa Raia, Tomas Urbina, Geoffroy Hariri, Paul Gabarre, Vincent Bonny, Naïke Bigé, Jean-Luc Baudel, Arnaud Bruneel, Thierry Dupre, Bertrand Guidet, Eric Maury and Hafid Ait-Oufella
    Citation: Critical Care 2022 26:25
  13. Hospital and ICU structural factors are key factors affecting the quality of care as well as ICU patient outcomes. However, the data from China are scarce. This study was designed to investigate how difference...

    Authors: Zhen Li, Xudong Ma, Sifa Gao, Qi Li, Hongbo Luo, Jianhua Sun, Wei Du, Longxiang Su, Lu Wang, Qing Zhang, Zunzhu Li, Xiang Zhou and Dawei Liu
    Citation: Critical Care 2022 26:24

    The Correction to this article has been published in Critical Care 2022 26:42

  14. Parenteral lipid emulsions in critical care are traditionally based on soybean oil (SO) and rich in pro-inflammatory omega-6 fatty acids (FAs). Parenteral nutrition (PN) strategies with the aim of reducing ome...

    Authors: Quirin Notz, Zheng-Yii Lee, Johannes Menger, Gunnar Elke, Aileen Hill, Peter Kranke, Daniel Roeder, Christopher Lotz, Patrick Meybohm, Daren K. Heyland and Christian Stoppe
    Citation: Critical Care 2022 26:23
  15. Sepsis, the dysregulated host response to infection, triggers abnormal pro-coagulant and pro-inflammatory host responses. Limitations in early disease intervention highlight the need for effective diagnostic a...

    Authors: Vanessa Catenacci, Fatima Sheikh, Kush Patel and Alison E. Fox-Robichaud
    Citation: Critical Care 2022 26:21
  16. The ability of end-tidal carbon dioxide (ΔEtCO2) for predicting fluid responsiveness has been extensively studied with conflicting results. This meta-analysis aimed to explore the value of ΔEtCO2 for predictin...

    Authors: Haijun Huang, Chenxia Wu, Qinkang Shen, Yixin Fang and Hua Xu
    Citation: Critical Care 2022 26:20
  17. Timely administration of antibiotics is one of the most important interventions in reducing mortality in sepsis. However, administering antibiotics within a strict time threshold in all patients suspected with...

    Authors: Yunjoo Im, Danbee Kang, Ryoung-Eun Ko, Yeon Joo Lee, Sung Yoon Lim, Sunghoon Park, Soo Jin Na, Chi Ryang Chung, Mi Hyeon Park, Dong Kyu Oh, Chae-Man Lim and Gee Young Suh
    Citation: Critical Care 2022 26:19
  18. Proteins are an essential part of medical nutrition therapy in critically ill patients. Guidelines almost universally recommend a high protein intake without robust evidence supporting its use.

    Authors: Wolfgang H. Hartl, Philipp Kopper, Andreas Bender, Fabian Scheipl, Andrew G. Day, Gunnar Elke and Helmut Küchenhoff
    Citation: Critical Care 2022 26:7
  19. We evaluated whether the time between first respiratory support and intubation of patients receiving invasive mechanical ventilation (IMV) due to COVID-19 was associated with mortality or pulmonary sequelae.

    Authors: Jessica González, Iván D. Benítez, David de Gonzalo-Calvo, Gerard Torres, Jordi de Batlle, Silvia Gómez, Anna Moncusí-Moix, Paola Carmona, Sally Santisteve, Aida Monge, Clara Gort-Paniello, María Zuil, Ramón Cabo-Gambín, Carlos Manzano Senra, José Javier Vengoechea Aragoncillo, Rafaela Vaca…
    Citation: Critical Care 2022 26:18
  20. Despite growing interest in treatment strategies that limit oxygen exposure in ICU patients, no studies have compared conservative oxygen with standard oxygen in postsurgical patients with sepsis/septic shock,...

    Authors: Marta Martín-Fernández, María Heredia-Rodríguez, Irene González-Jiménez, Mario Lorenzo-López, Estefanía Gómez-Pesquera, Rodrigo Poves-Álvarez, F. Javier Álvarez, Pablo Jorge-Monjas, Juan Beltrán-DeHeredia, Eduardo Gutiérrez-Abejón, Francisco Herrera-Gómez, Gabriella Guzzo, Esther Gómez-Sánchez, Álvaro Tamayo-Velasco, Rocío Aller, Paolo Pelosi…
    Citation: Critical Care 2022 26:4

    The Correspondence to this article has been published in Critical Care 2022 26:177

    The Correspondence to this article has been published in Critical Care 2022 26:172

    The Comment to this article has been published in Critical Care 2022 26:67

  21. In patients with COVID-19-related acute respiratory failure (ARF), awake prone positioning (AW-PP) reduces the need for intubation in patients treated with high-flow nasal oxygen (HFNO). However, the effects o...

    Authors: Mariano Esperatti, Marina Busico, Nora Angélica Fuentes, Adrian Gallardo, Javier Osatnik, Alejandra Vitali, Elizabeth Gisele Wasinger, Matías Olmos, Jorgelina Quintana, Santiago Nicolas Saavedra, Ana Inés Lagazio, Facundo Juan Andrada, Hiromi Kakisu, Nahuel Esteban Romano, Agustin Matarrese, Mariela Adriana Mogadouro…
    Citation: Critical Care 2022 26:16
  22. Survivors of acute respiratory failure (ARF) commonly experience long-lasting physical, cognitive, and/or mental health impairments. Unmet medication needs occurring immediately after hospital discharge may ha...

    Authors: Samuel M. Brown, Victor D. Dinglas, Narjes Akhlaghi, Somnath Bose, Valerie Banner-Goodspeed, Sarah Beesley, Danielle Groat, Tom Greene, Ramona O. Hopkins, Mustafa Mir-Kasimov, Carla M. Sevin, Alison E. Turnbull, James C. Jackson and Dale M. Needham
    Citation: Critical Care 2022 26:6
  23. A biomarker describes a measurable indicator of a patient's clinical condition that can be measured accurately and reproducibly. Biomarkers offer utility for diagnosis, prognosis, early disease recognition, ri...

    Authors: Tatiana Barichello, Jaqueline S. Generoso, Mervyn Singer and Felipe Dal-Pizzol
    Citation: Critical Care 2022 26:14

    The Correspondence to this article has been published in Critical Care 2022 26:100

  24. Galectin-3 (Gal-3) is a proinflammatory and profibrotic protein especially overexpressed after Acute Kidney Injury (AKI). The early renal prognostic value of Gal-3 after AKI in critically ill patients remains ...

    Authors: L. Boutin, M. Legrand, M. Sadoune, A. Mebazaa, E. Gayat, C. E. Chadjichristos and F. Dépret
    Citation: Critical Care 2022 26:13
  25. Prone positioning (PP) reduces mortality of patients with acute respiratory distress syndrome (ARDS). The potential benefit of prone positioning maneuvers during venovenous extracorporeal membrane oxygenation ...

    Authors: Marco Giani, Emanuele Rezoagli, Christophe Guervilly, Jonathan Rilinger, Thibault Duburcq, Matthieu Petit, Laura Textoris, Bruno Garcia, Tobias Wengenmayer, Giacomo Grasselli, Antonio Pesenti, Alain Combes, Giuseppe Foti and Matthieu Schmidt
    Citation: Critical Care 2022 26:8
  26. Previous randomized trials of vitamin C, hydrocortisone, and thiamine on sepsis were limited by short-term vitamin C administration, heterogeneous populations, and the failure to evaluate each component’s effe...

    Authors: Sun-Young Jung, Min-Taek Lee, Moon Seong Baek and Won-Young Kim
    Citation: Critical Care 2022 26:3
  27. In the context of acute respiratory distress syndrome (ARDS), the response to lung recruitment maneuvers (LRMs) varies considerably from one patient to another and so is difficult to predict. The aim of the st...

    Authors: Yoann Zerbib, Alexis Lambour, Julien Maizel, Loay Kontar, Bertrand De Cagny, Thierry Soupison, Thomas Bradier, Michel Slama and Clément Brault
    Citation: Critical Care 2022 26:12
  28. Recent multicenter studies identified COVID-19 as a risk factor for invasive pulmonary aspergillosis (IPA). However, no large multicenter study has compared the incidence of IPA between COVID-19 and influenza ...

    Authors: Anahita Rouzé, Elise Lemaitre, Ignacio Martin-Loeches, Pedro Povoa, Emili Diaz, Rémy Nyga, Antoni Torres, Matthieu Metzelard, Damien Du Cheyron, Fabien Lambiotte, Fabienne Tamion, Marie Labruyere, Claire Boulle Geronimi, Charles-Edouard Luyt, Martine Nyunga, Olivier Pouly…
    Citation: Critical Care 2022 26:11
  29. Research on the duration of infectivity of ICU patients with COVID-19 has been sparse. Tests based on Reverse Transcriptase polymerase chain reaction (RT-PCR) detect both live virus and non-infectious viral RN...

    Authors: Duane J. Funk, Jared Bullard, Sylvan Lother, Gloria Vazquez Grande, Lauren Garnett, Kaylie Doan, Kerry Dust, Anand Kumar, Guillaume Poliquin and Jim Strong
    Citation: Critical Care 2022 26:10
  30. Mechanical power is a composite variable for energy transmitted to the respiratory system over time that may better capture risk for ventilator-induced lung injury than individual ventilator management compone...

    Authors: Anoopindar K. Bhalla, Margaret J. Klein, Vicent Modesto I Alapont, Guillaume Emeriaud, Martin C. J. Kneyber, Alberto Medina, Pablo Cruces, Franco Diaz, Muneyuki Takeuchi, Aline B. Maddux, Peter M. Mourani, Cristina Camilo, Benjamin R. White, Nadir Yehya, John Pappachan, Matteo Di Nardo…
    Citation: Critical Care 2022 26:2
  31. SARS-CoV-2 seems to affect the regulation of pulmonary perfusion. Hypoperfusion in areas of well-aerated lung parenchyma results in a ventilation–perfusion mismatch that can be characterized using subtraction ...

    Authors: Mario G. Santamarina, Ignacio Beddings, Felipe Martinez Lomakin, Dominique Boisier Riscal, Mónica Gutiérrez Claveria, Jaime Vidal Marambio, Nicole Retamal Báez, Cristian Pavez Novoa, César Reyes Allende, Paulina Ferreira Perey, Miguel Gutiérrez Torres, Camila Villalobos Mazza, Constanza Vergara Sagredo, Sebastian Ahumada Bermejo, Eduardo Labarca Mellado, Elizabeth Barthel Munchmeyer…
    Citation: Critical Care 2022 26:1
  32. Determining the optimal timing for extubation can be challenging in the intensive care. In this study, we aim to identify predictors for extubation failure in critically ill patients with COVID-19.

    Authors: Lucas M. Fleuren, Tariq A. Dam, Michele Tonutti, Daan P. de Bruin, Robbert C. A. Lalisang, Diederik Gommers, Olaf L. Cremer, Rob J. Bosman, Sander Rigter, Evert-Jan Wils, Tim Frenzel, Dave A. Dongelmans, Remko de Jong, Marco Peters, Marlijn J. A. Kamps, Dharmanand Ramnarain…
    Citation: Critical Care 2021 25:448
  33. Over a third of critical illness survivors suffer from mental health problems following hospitalization. Memories of delusional experiences are a major risk factor. In this project, ICU doulas delivered a uniq...

    Authors: Lioudmila V. Karnatovskaia, Katalin Varga, Alexander S. Niven, Phillip J. Schulte, Midhat Mujic, Ognjen Gajic, Brent A. Bauer, Matthew M. Clark, Roberto P. Benzo and Kemuel L. Philbrick
    Citation: Critical Care 2021 25:446
  34. Therapeutic antibiotic dose monitoring can be particularly challenging in septic patients requiring renal replacement therapy. Our aim was to conduct an exploratory population pharmacokinetic (PK) analysis on ...

    Authors: Marcus Kirwan, Reema Munshi, Hannah O’Keeffe, Conor Judge, Mary Coyle, Evelyn Deasy, Yvelynne P. Kelly, Peter J. Lavin, Maria Donnelly and Deirdre M. D’Arcy
    Citation: Critical Care 2021 25:443
  35. Inspiratory patient effort under assisted mechanical ventilation is an important quantity for assessing patient–ventilator interaction and recognizing over and under assistance. An established clinical standar...

    Authors: Jan Graßhoff, Eike Petersen, Franziska Farquharson, Max Kustermann, Hans-Joachim Kabitz, Philipp Rostalski and Stephan Walterspacher
    Citation: Critical Care 2021 25:441
  36. Oxygen (O2) toxicity remains a concern, particularly to the lung. This is mainly related to excessive production of reactive oxygen species (ROS). Supplemental O2, i.e. inspiratory O2 concentrations (FIO2) > 0.21...

    Authors: Mervyn Singer, Paul J. Young, John G. Laffey, Pierre Asfar, Fabio Silvio Taccone, Markus B. Skrifvars, Christian S. Meyhoff and Peter Radermacher
    Citation: Critical Care 2021 25:440