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  1. Management and monitoring of pain and sedation to reduce discomfort as well as side effects, such as over- and under-sedation, withdrawal syndrome and delirium, is an integral part of pediatric intensive care ...

    Authors: Marco Daverio, Florian von Borell, Anne-Sylvie Ramelet, Francesca Sperotto, Paula Pokorna, Sebastian Brenner, Maria Cristina Mondardini, Dick Tibboel, Angela Amigoni and Erwin Ista
    Citation: Critical Care 2022 26:88

    The Correction to this article has been published in Critical Care 2022 26:139

  2. Awake prone positioning (APP) improves oxygenation in coronavirus disease (COVID-19) patients and, when successful, may decrease the risk of intubation. However, factors associated with APP success remain unkn...

    Authors: Miguel Ibarra-Estrada, Jie Li, Ivan Pavlov, Yonatan Perez, Oriol Roca, Elsa Tavernier, Bairbre McNicholas, David Vines, Miguel Marín-Rosales, Alexandra Vargas-Obieta, Roxana García-Salcido, Sara A. Aguirre-Díaz, José A. López-Pulgarín, Quetzalcóatl Chávez-Peña, Julio C. Mijangos-Méndez, Guadalupe Aguirre-Avalos…
    Citation: Critical Care 2022 26:84
  3. In severe cases, SARS-CoV-2 infection leads to acute respiratory distress syndrome (ARDS), often treated by extracorporeal membrane oxygenation (ECMO). During ECMO therapy, anticoagulation is crucial to preven...

    Authors: Saskia von Stillfried, Roman David Bülow, Rainer Röhrig, Patrick Meybohm and Peter Boor
    Citation: Critical Care 2022 26:83
  4. Prone positioning in combination with the application of low tidal volume and adequate positive end-expiratory pressure (PEEP) improves survival in patients with moderate to severe acute respiratory distress s...

    Authors: Christoph Boesing, Peter T. Graf, Fabian Schmitt, Manfred Thiel, Paolo Pelosi, Patricia R. M. Rocco, Thomas Luecke and Joerg Krebs
    Citation: Critical Care 2022 26:82
  5. Delaying time to prone positioning (PP) may be associated with higher mortality in acute respiratory distress syndrome (ARDS) due to coronavirus disease 2019 (COVID-19). We evaluated the use and the impact of ...

    Authors: Christophe Le Terrier, Florian Sigaud, Said Lebbah, Luc Desmedt, David Hajage, Claude Guérin, Jérôme Pugin, Steve Primmaz and Nicolas Terzi
    Citation: Critical Care 2022 26:71
  6. Excessive inspiratory effort could translate into self-inflicted lung injury, thus worsening clinical outcomes of spontaneously breathing patients with acute respiratory failure (ARF). Although esophageal mano...

    Authors: Roberto Tonelli, Andrea Cortegiani, Alessandro Marchioni, Riccardo Fantini, Luca Tabbì, Ivana Castaniere, Emanuela Biagioni, Stefano Busani, Chiara Nani, Caterina Cerbone, Morgana Vermi, Filippo Gozzi, Giulia Bruzzi, Linda Manicardi, Maria Rosaria Pellegrino, Bianca Beghè…
    Citation: Critical Care 2022 26:70
  7. Factor XIII (FXIII) is a protein involved in blood clot stabilisation which also plays an important role in processes including trauma, wound healing, tissue repair, pregnancy, and even bone metabolism. Follow...

    Authors: Christian Kleber, Armin Sablotzki, Sebastian Casu, Martin Olivieri, Kai-Martin Thoms, Johannes Horter, Felix C. F. Schmitt, Ingvild Birschmann, Dietmar Fries, Marc Maegele, Herbert Schöchl and Michaela Wilhelmi
    Citation: Critical Care 2022 26:69
  8. Secondary nosocomial infections, which are commonly caused by carbapenem-resistant Klebsiella pneumoniae (CRKP) and vancomycin-resistant Enterococcus faecium (VRE), often develop in septic patients. This study ai...

    Authors: Sucheng Mu, Hao Xiang, Yuezhu Wang, Wei Wei, Xiangyu Long, Yi Han, Zhongshu Kuang, Yilin Yang, Feixiang Xu, Mingming Xue, Zhimin Dong, Chaoyang Tong, Huajun Zheng and Zhenju Song
    Citation: Critical Care 2022 26:68
  9. Authors: Manuel Alberto Guerrero-Gutiérrez, Javier Mancilla-Galindo, Ashuin Kammar-García, Luis Antonio Morgado-Villaseñor, Eder Iván Zamarrón-López and Orlando Rubén Pérez-Nieto
    Citation: Critical Care 2022 26:67

    The Correspondence to this article has been published in Critical Care 2022 26:177

    The original article was published in Critical Care 2022 26:4

  10. This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2022. Other selected articles can be found online at

    Authors: Joo Heung Yoon, Michael R. Pinsky and Gilles Clermont
    Citation: Critical Care 2022 26:75
  11. This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2022. Other selected articles can be found online at

    Authors: Gavin D. Perkins and Jerry P. Nolan
    Citation: Critical Care 2022 26:73
  12. Trials comparing early and delayed strategies of renal replacement therapy in patients with severe acute kidney injury may have missed differences in survival as a result of mixing together patients at heterog...

    Authors: François Grolleau, Raphaël Porcher, Saber Barbar, David Hajage, Abderrahmane Bourredjem, Jean-Pierre Quenot, Didier Dreyfuss and Stéphane Gaudry
    Citation: Critical Care 2022 26:64
  13. Infection (either community acquired or nosocomial) is a major cause of morbidity and mortality in critical care medicine. Sepsis is present in up to 30% of all ICU patients. A large fraction of sepsis cases i...

    Authors: Irene Merino, Amanda de la Fuente, Marta Domínguez-Gil, José María Eiros, Ana P. Tedim and Jesús F. Bermejo-Martín
    Citation: Critical Care 2022 26:63
  14. Obesity is highly prevalent in hospitalized patients admitted with COVID-19. Evidence based guidelines are available for COVID-19-related therapies but dosing information specific to patients with obesity is l...

    Authors: Jeffrey F. Barletta and Brian L. Erstad
    Citation: Critical Care 2022 26:60
  15. The consequences of cardiac arrest (CA) on the gastro-intestinal tract are poorly understood. We measured the incidence of ischemic injury in the upper gastro-intestinal tract after Out-of-hospital CA (OHCA) a...

    Authors: D. Grimaldi, S. Legriel, N. Pichon, P. Colardelle, S. Leblanc, F. Canouï-Poitrine, O. Ben Hadj Salem, G. Muller, N. de Prost, S. Herrmann, S. Marque, A. Baron, B. Sauneuf, J. Messika, M. Dior, J. Creteur…
    Citation: Critical Care 2022 26:59
  16. Temperature control with target temperature management (TTM) after cardiac arrest has been endorsed by expert societies and adopted in international clinical practice guidelines but recent evidence challenges ...

    Authors: Anders Aneman, Steven Frost, Michael Parr and Markus B. Skrifvars
    Citation: Critical Care 2022 26:58
  17. The ratio of partial pressure of arterial oxygen to inspired oxygen fraction (PaO2/FIO2) during invasive mechanical ventilation (MV) is used as criteria to grade the severity of respiratory failure in acute respi...

    Authors: Michael Hultström, Ola Hellkvist, Lucian Covaciu, Filip Fredén, Robert Frithiof, Miklós Lipcsey, Gaetano Perchiazzi and Mariangela Pellegrini
    Citation: Critical Care 2022 26:55
  18. Delirium is the most common cerebral dysfunction in the intensive care unit (ICU) and can be subdivided into a hypoactive, hyperactive, or mixed motor subtype based on the clinical manifestation. The aim of th...

    Authors: Kirstine N. la Cour, Nina C. Andersen-Ranberg, Sarah Weihe, Lone M. Poulsen, Camilla B. Mortensen, Cilia K. W. Kjer, Marie O. Collet, Stine Estrup and Ole Mathiesen
    Citation: Critical Care 2022 26:53
  19. Intra-abdominal hypertension (IAH) in acute pancreatitis (AP) is associated with deterioration in organ function. This trial aimed to assess the efficacy of neostigmine for IAH in patients with AP.

    Authors: Wenhua He, Peng Chen, Yupeng Lei, Liang Xia, Pi Liu, Yong Zhu, Hao Zeng, Yao Wu, Huajing Ke, Xin Huang, Wenhao Cai, Xin Sun, Wei Huang, Robert Sutton, Yin Zhu and Nonghua Lu
    Citation: Critical Care 2022 26:52
  20. Timely antimicrobial treatment and source control are strongly recommended by sepsis guidelines, however, their impact on clinical outcomes is uncertain.

    Authors: Hendrik Rüddel, Daniel O. Thomas-Rüddel, Konrad Reinhart, Friedhelm Bach, Herwig Gerlach, Matthias Lindner, John C. Marshall, Philipp Simon, Manfred Weiss, Frank Bloos and Daniel Schwarzkopf
    Citation: Critical Care 2022 26:51
  21. Increased plasma concentrations of circulating cell-free hemoglobin (CFH) are supposed to contribute to the multifactorial etiology of acute kidney injury (AKI) in critically ill patients while the CFH-scaveng...

    Authors: Jan A. Graw, Philip Hildebrandt, Alexander Krannich, Felix Balzer, Claudia Spies, Roland C. Francis, Wolfgang M. Kuebler, Steffen Weber-Carstens, Mario Menk and Oliver Hunsicker
    Citation: Critical Care 2022 26:50
  22. Trauma-induced coagulopathy includes thrombocytopenia and platelet dysfunction that impact patient outcome. Nevertheless, the role of platelet transfusion remains poorly defined. The aim of the study was 1/ to...

    Authors: S. R. Hamada, D. Garrigue, H. Nougue, A. Meyer, M. Boutonnet, E. Meaudre, A. Culver, E. Gaertner, G. Audibert, B. Vigué, J. Duranteau and A. Godier
    Citation: Critical Care 2022 26:49
  23. Severe acute respiratory syndrome coronavirus-2 (SARS–CoV-2)-induced acute respiratory distress syndrome (ARDS) causes high mortality. Umbilical cord-derived mesenchymal stromal cells (UC-MSCs) have potentiall...

    Authors: Antoine Monsel, Caroline Hauw-Berlemont, Miryam Mebarki, Nicholas Heming, Julien Mayaux, Otriv Nguekap Tchoumba, Jean-Luc Diehl, Alexandre Demoule, Djillali Annane, Clémence Marois, Sophie Demeret, Emmanuel Weiss, Guillaume Voiriot, Muriel Fartoukh, Jean-Michel Constantin, Bruno Mégarbane…
    Citation: Critical Care 2022 26:48
  24. An abrupt lung deflation in rodents results in lung injury through vascular mechanisms. Ventilator disconnections during endo-tracheal suctioning in humans often cause cardio-respiratory instability. Whether r...

    Authors: Bhushan H. Katira, Doreen Engelberts, Sheena Bouch, Jordan Fliss, Luca Bastia, Kohei Osada, Kim A. Connelly, Marcelo B. P. Amato, Niall D. Ferguson, Wolfgang M. Kuebler, Brian P. Kavanagh, Laurent J. Brochard and Martin Post
    Citation: Critical Care 2022 26:47
  25. Previous cluster-randomized controlled trials evaluating the impact of implementing evidence-based guidelines for nutrition therapy in critical illness do not consistently demonstrate patient benefits. A large...

    Authors: Lu Ke, Jiajia Lin, Gordon S. Doig, Arthur R. H. van Zanten, Yang Wang, Juan Xing, Zhongheng Zhang, Tao Chen, Lixin Zhou, Dongpo Jiang, Qindong Shi, Jiandong Lin, Jun Liu, Aibin Cheng, Yafeng Liang, Peiyang Gao…
    Citation: Critical Care 2022 26:46

    The Correction to this article has been published in Critical Care 2022 26:115

  26. Nighttime hospital admission is often associated with increased mortality risk in various diseases. This study investigated compliance rates with the Surviving Sepsis Campaign (SSC) 3-h bundle for daytime and ...

    Authors: Je Sung You, Yoo Seok Park, Sung Phil Chung, Hye Sun Lee, Soyoung Jeon, Won Young Kim, Tae Gun Shin, You Hwan Jo, Gu Hyun Kang, Sung Hyuk Choi, Gil Joon Suh, Byuk Sung Ko, Kap Su Han, Jong Hwan Shin and Taeyoung Kong
    Citation: Critical Care 2022 26:43
  27. Authors: Zhen Li, Xudong Ma, Sifa Gao, Qi Li, Hongbo Luo, Jianhua Sun, Wei Du, Longxiang Su, Lu Wang, Qing Zhang, Zunzhu Li, Xiang Zhou and Dawei Liu
    Citation: Critical Care 2022 26:42

    The original article was published in Critical Care 2022 26:24