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  1. The potential harmful effects of particle-contaminated infusions for critically ill adult patients are yet unclear. So far, only significant improved outcome in critically ill children and new-borns was demons...

    Authors: Elke Schmitt, Patrick Meybohm, Eva Herrmann, Karin Ammersbach, Raphaela Endres, Simone Lindau, Philipp Helmer, Kai Zacharowski and Holger Neb

    Citation: Critical Care 2019 23:373

    Content type: Research

    Published on:

  2. There is little descriptive data on Stenotrophomonas maltophilia hospital-acquired pneumonia (HAP) in critically ill patients. The optimal modalities of antimicrobial therapy remain to be determined. Our objectiv...

    Authors: Philippe Guerci, Hugo Bellut, Mokhtar Mokhtari, Julie Gaudefroy, Nicolas Mongardon, Claire Charpentier, Guillaume Louis, Parvine Tashk, Clément Dubost, Stanislas Ledochowski, Antoine Kimmoun, Thomas Godet, Julien Pottecher, Jean-Marc Lalot, Emmanuel Novy, David Hajage…

    Citation: Critical Care 2019 23:371

    Content type: Research

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  3. Intensive care unit (ICU)-acquired weakness (ICU-AW) and ICU-acquired diaphragm dysfunction (ICU-DD) occur frequently in mechanically ventilated (MV) patients. It is unknown whether they have different risk fa...

    Authors: Martin Dres, Boris Jung, Nicolas Molinari, Federico Manna, Bruno-Pierre Dubé, Gerald Chanques, Thomas Similowski, Samir Jaber and Alexandre Demoule

    Citation: Critical Care 2019 23:370

    Content type: Research

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  4. High inspiratory flow might damage the lungs by mechanisms not fully understood yet. We hypothesized that increasing inspiratory flow would increase lung stress, ventilation heterogeneity, and pendelluft in AR...

    Authors: Alessandro Santini, Tommaso Mauri, Francesca Dalla Corte, Elena Spinelli and Antonio Pesenti

    Citation: Critical Care 2019 23:369

    Content type: Research

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  5. Although mortality due to critical illness has fallen over decades, the number of patients with long-term functional disabilities has increased, leading to impaired quality of life and significant healthcare c...

    Authors: Arthur Raymond Hubert van Zanten, Elisabeth De Waele and Paul Edmund Wischmeyer

    Citation: Critical Care 2019 23:368

    Content type: Review

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  6. Higher inspiratory airway pressures are associated with worse outcomes in mechanically ventilated patients with the acute respiratory distress syndrome (ARDS). This relationship, however, has not been well inv...

    Authors: Sarina K. Sahetya, Christopher Mallow, Jonathan E. Sevransky, Greg S. Martin, Timothy D. Girard, Roy G. Brower and William Checkley

    Citation: Critical Care 2019 23:367

    Content type: Research

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  7. Crystalloids are the most frequently prescribed drugs in intensive care medicine and emergency medicine. Thus, even small differences in outcome may have major implications, and therefore, the choice between b...

    Authors: Charlotte L. Zwager, Pieter Roel Tuinman, Harm-Jan de Grooth, Jos Kooter, Hans Ket, Lucas M. Fleuren and Paul W. G. Elbers

    Citation: Critical Care 2019 23:366

    Content type: Research

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  8. Multiple trauma scores have been developed and validated, including the Revised Trauma Score (RTS) and the Mechanism, Glasgow Coma Scale, Age, and Arterial Pressure (MGAP) score. However, these scores are comp...

    Authors: Atsushi Shiraishi, Yasuhiro Otomo, Shunsuke Yoshikawa, Koji Morishita, Ian Roberts and Hiroki Matsui

    Citation: Critical Care 2019 23:365

    Content type: Research

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  9. Continuous, reliable evaluation of left ventricular (LV) contractile function in patients with advanced heart failure requiring intensive care remains challenging. Continual monitoring of dP/dtmax from the arteri...

    Authors: Petr Ostadal, Dagmar Vondrakova, Andreas Krüger, Marek Janotka and Jan Naar

    Citation: Critical Care 2019 23:364

    Content type: Research

    Published on:

  10. Bloodstream infections are associated with high morbidity and mortality, both of which contribute substantially to healthcare costs. The effects of early administration of appropriate antimicrobials on the pro...

    Authors: Ching-Chi Lee, Chung-Hsun Lee, Chao-Yung Yang, Chih-Chia Hsieh, Hung-Jen Tang and Wen-Chien Ko

    Citation: Critical Care 2019 23:363

    Content type: Research

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  11. Time to antibiotic administration is a key element in sepsis care; however, it is difficult to implement sepsis care bundles. Additionally, sepsis is different from other emergent conditions including acute co...

    Authors: Toshikazu Abe, Shigeki Kushimoto, Yasuharu Tokuda, Gary S. Phillips, Andrew Rhodes, Takehiro Sugiyama, Akira Komori, Hiroki Iriyama, Hiroshi Ogura, Seitaro Fujishima, Atsushi Shiraishi, Daizoh Saitoh, Toshihiko Mayumi, Toshio Naito, Kiyotsugu Takuma, Taka-aki Nakada…

    Citation: Critical Care 2019 23:360

    Content type: Research

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    The Letter to this article has been published in Critical Care 2020 24:17

  12. Few studies have reported left ventricular wall findings in contrast-enhanced computed tomography (CE-CT) after extracorporeal cardiopulmonary resuscitation (ECPR). This study examined left ventricular wall CE...

    Authors: Kazuhiro Sugiyama, Masamichi Takahashi, Kazuki Miyazaki, Takuto Ishida, Mioko Kobayashi and Yuichi Hamabe

    Citation: Critical Care 2019 23:357

    Content type: Research

    Published on:

  13. Sepsis is an increasingly significant challenge throughout the world as one of the major causes of patient morbidity and mortality. Central to the host immunologic response to sepsis is the increase in circula...

    Authors: McKenzie K. Hollen, Julie A. Stortz, Dijoia Darden, Marvin L. Dirain, Dina C. Nacionales, Russell B. Hawkins, Michael C. Cox, Maria-Cecilia Lopez, Jaimar C. Rincon, Ricardo Ungaro, Zhongkai Wang, Quran Wu, Babette Brumback, Marie-Pierre L. Gauthier, Michael Kladde, Christiaan Leeuwenburgh…

    Citation: Critical Care 2019 23:355

    Content type: Research

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  14. Hypercapnia improves gastric microcirculatory oxygenation (μHbO2) and increases vasopressin plasma levels, whereas V1A receptor blockade abolishes the increase of μHbO2. The aim of this study was to evaluate the ...

    Authors: Richard Truse, Steven Grewe, Anna Herminghaus, Jan Schulz, Andreas P. M. Weber, Tabea Mettler-Altmann, Inge Bauer, Olaf Picker and Christian Vollmer

    Citation: Critical Care 2019 23:353

    Content type: Research

    Published on:

  15. Acute respiratory distress syndrome (ARDS) survivors experience a high prevalence of cognitive impairment with concomitantly impaired functional status and quality of life, often persisting months after hospit...

    Authors: Cina Sasannejad, E. Wesley Ely and Shouri Lahiri

    Citation: Critical Care 2019 23:352

    Content type: Review

    Published on:

    The Letter to this article has been published in Critical Care 2020 24:30

  16. For patients who survive a critical illness and have their oral endotracheal tube removed, dysphagia is highly prevalent, and without intervention, it may persist far beyond hospital discharge. This pre- and p...

    Authors: Chung-Pei Wu, Yu-Juan Xu, Tyng-Guey Wang, Shih-Chi Ku, Ding-Cheng Chan, Jang-Jaer Lee, Yu-Chung Wei, Tzu-Yu Hsiao and Cheryl Chia-Hui Chen

    Citation: Critical Care 2019 23:350

    Content type: Research

    Published on:

  17. Extracorporeal carbon dioxide removal (ECCO2R) uses an extracorporeal circuit to directly remove carbon dioxide from the blood either in lieu of mechanical ventilation or in combination with it. While the potenti...

    Authors: Sascha Gross-Hardt, Felix Hesselmann, Jutta Arens, Ulrich Steinseifer, Leen Vercaemst, Wolfram Windisch, Daniel Brodie and Christian Karagiannidis

    Citation: Critical Care 2019 23:348

    Content type: Research

    Published on:

  18. Although tranexamic acid is widely used in patients with haemoptysis, whether it improves mortality has not been well investigated. The aim of this study was to evaluate the effect of tranexamic acid on in-hos...

    Authors: Takahiro Kinoshita, Hiroyuki Ohbe, Hiroki Matsui, Kiyohide Fushimi, Hiroshi Ogura and Hideo Yasunaga

    Citation: Critical Care 2019 23:347

    Content type: Research

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  19. Excessive respiratory muscle effort during mechanical ventilation may cause patient self-inflicted lung injury and load-induced diaphragm myotrauma, but there are no non-invasive methods to reliably detect ele...

    Authors: Michele Bertoni, Irene Telias, Martin Urner, Michael Long, Lorenzo Del Sorbo, Eddy Fan, Christer Sinderby, Jennifer Beck, Ling Liu, Haibo Qiu, Jenna Wong, Arthur S. Slutsky, Niall D. Ferguson, Laurent J. Brochard and Ewan C. Goligher

    Citation: Critical Care 2019 23:346

    Content type: Research

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  20. Adaptive mechanical ventilation automatically adjusts respiratory rate (RR) and tidal volume (VT) to deliver the clinically desired minute ventilation, selecting RR and VT based on Otis’ equation on least work of...

    Authors: Tobias Becher, Anna Adelmeier, Inéz Frerichs, Norbert Weiler and Dirk Schädler

    Citation: Critical Care 2019 23:338

    Content type: Research

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  21. Few viruses have shaped the course of human history more than influenza viruses. A century since the 1918–1919 Spanish influenza pandemic—the largest and deadliest influenza pandemic in recorded history—we hav...

    Authors: Taylor Kain and Robert Fowler

    Citation: Critical Care 2019 23:337

    Content type: Review

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  22. The performance of blood biomarkers (mid-regional proadrenomedullin (MR-proADM), procalcitonin (PCT), C-reactive protein (CRP), and lactate) and clinical scores (Sequential Organ Failure Assessment (SOFA), Nat...

    Authors: Juan Gonzalez del Castillo, Darius Cameron Wilson, Carlota Clemente-Callejo, Francisco Román, Ignasi Bardés-Robles, Inmaculada Jiménez, Eva Orviz, Macarena Dastis-Arias, Begoña Espinosa, Fernando Tornero-Romero, Jordi Giol-Amich, Veronica González and Ferran Llopis-Roca

    Citation: Critical Care 2019 23:335

    Content type: Research

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  23. The concept of personalized cardiopulmonary resuscitation (CPR) requires a parameter that reflects its hemodynamic efficiency. While intra-arrest ultrasound is increasingly implemented into the advanced life s...

    Authors: Roman Skulec, Petr Vojtisek and Vladimir Cerny

    Citation: Critical Care 2019 23:334

    Content type: Research

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    The Letter to this article has been published in Critical Care 2020 24:51

  24. The interactive effect of cumulative input and output on achieving optimal fluid balance has not been well elucidated in patients with acute kidney injury (AKI) requiring continuous renal replacement therapy (...

    Authors: Jong Hyun Jhee, Hye Ah Lee, Seonmi Kim, Youn Kyung Kee, Ji Eun Lee, Shina Lee, Seung-Jung Kim, Duk-Hee Kang, Kyu Bok Choi, Hyung Jung Oh and Dong-Ryeol Ryu

    Citation: Critical Care 2019 23:329

    Content type: Research

    Published on:

  25. In the publication of this article [1], there was an error in a contributors Family Name. This has now been updated in the original article.

    Authors: Luca Cabrini, Giovanni Landoni, Martina Baiardo Redaelli, Omar Saleh, Carmine D. Votta, Evgeny Fominskiy, Alessandro Putzu, Cézar Daniel Snak de Souza, Massimo Antonelli, Rinaldo Bellomo, Paolo Pelosi and Alberto Zangrillo

    Citation: Critical Care 2019 23:325

    Content type: Correction

    Published on:

    The original article was published in Critical Care 2018 22:6

  26. Antibiotic-associated diarrhea (AAD) is a risk factor for exacerbating the outcome of critically ill patients. Dysbiosis induced by the exposure to antibiotics reveals the potential therapeutic role of fecal m...

    Authors: Min Dai, Yafei Liu, Wei Chen, Heena Buch, Yi Shan, Liuhui Chang, Yong Bai, Chen Shen, Xiaoyin Zhang, Yufeng Huo, Dian Huang, Zhou Yang, Zhihang Hu, Xuwei He, Junyu Pan, Lili Hu…

    Citation: Critical Care 2019 23:324

    Content type: Research

    Published on:

  27. Most deaths of comatose survivors of out-of-hospital sudden cardiac arrest result from withdrawal of life-sustaining treatment (WLST) decisions based on poor neurological prognostication and the family’s inten...

    Authors: Hiroshi Endoh, Natuo Kamimura, Hiroyuki Honda and Masakazu Nitta

    Citation: Critical Care 2019 23:323

    Content type: Research

    Published on: