Articles

Rapid establishment of an ICU using anesthesia ventilators during COVID-19 pandemic: lessons learned

Authors: Amanda S. Xi, Marvin G. Chang and Edward A. Bittner

Significance of body temperature in elderly patients with sepsis

Elderly patients have a blunted host response, which may influence vital signs and clinical outcomes of sepsis. This study was aimed to investigate whether the associations between the vital signs and mortalit...

Authors: Takashi Shimazui, Taka-aki Nakada, Keith R. Walley, Taku Oshima, Toshikazu Abe, Hiroshi Ogura, Atsushi Shiraishi, Shigeki Kushimoto, Daizoh Saitoh, Seitaro Fujishima, Toshihiko Mayumi, Yasukazu Shiino, Takehiko Tarui, Toru Hifumi, Yasuhiro Otomo, Kohji Okamoto…

Hospital preparedness for mass critical care during SARS-CoV-2 pandemic

Mass critical care caused by the severe acute respiratory syndrome corona virus 2 pandemic poses an extreme challenge to hospitals. The primary goal of hospital disaster preparedness and response is to maintai...

Authors: Thomas Wurmb, Katja Scholtes, Felix Kolibay, Nora Schorscher, Georg Ertl, Ralf-Ingo Ernestus, Ulrich Vogel, Axel Franke and Barbara Kowalzik

Brain tight junction protein expression in sepsis in an autopsy series

Neuroinflammation often develops in sepsis along with increasing permeability of the blood-brain barrier (BBB), which leads to septic encephalopathy. The barrier is formed by tight junction structures between ...

Authors: Kristo Erikson, Hannu Tuominen, Merja Vakkala, Janne Henrik Liisanantti, Tuomo Karttunen, Hannu Syrjälä and Tero Ilmari Ala-Kokko

Long-term survival of elderly patients after intensive care unit admission for acute respiratory infection: a population-based, propensity score-matched cohort study

Intensive care unit (ICU) hospitalisations of elderly patients with acute respiratory infection have increased, yet the long-term effects of ICU admission among elderly individuals remain unknown. We examined ...

Authors: Antoine Guillon, Coralie Hermetet, Kimberly A. Barker, Youenn Jouan, Christophe Gaborit, Stephan Ehrmann, Yannick Le Manach, Pierre-François Dequin and Leslie Grammatico-Guillon

Update of the treatment of nosocomial pneumonia in the ICU

In accordance with the recommendations of, amongst others, the Surviving Sepsis Campaign and the recently published European treatment guidelines for hospital-acquired pneumonia (HAP) and ventilator-associated pn...

Authors: Rafael Zaragoza, Pablo Vidal-Cortés, Gerardo Aguilar, Marcio Borges, Emili Diaz, Ricard Ferrer, Emilio Maseda, Mercedes Nieto, Francisco Xavier Nuvials, Paula Ramirez, Alejandro Rodriguez, Cruz Soriano, Javier Veganzones and Ignacio Martín-Loeches

Biofilm formation on three different endotracheal tubes: a prospective clinical trial

Biofilm formation on endotracheal tubes (ETTs) is an early and frequent event in mechanically ventilated patients. The biofilm is believed to act as a reservoir for infecting microorganisms and thereby contrib...

Authors: Hulda R. Thorarinsdottir, Thomas Kander, Anna Holmberg, Sarunas Petronis and Bengt Klarin

Italian pulmonologist units and COVID-19 outbreak: “mind the gap”!

Authors: Raffaele Scala, Teresa Renda, Antonio Corrado and Adriano Vaghi

Platelet-derived exosomes promote neutrophil extracellular trap formation during septic shock

Platelets have been demonstrated to be potent activators of neutrophil extracellular trap (NET) formation during sepsis. However, the mediators and molecular pathways involved in human platelet-mediated NET ge...

Authors: Yang Jiao, Weiwei Li, Wei Wang, Xingyu Tong, Ran Xia, Jie Fan, Jianer Du, Chengmi Zhang and Xueyin Shi

Multimodal non-invasive assessment of intracranial hypertension: an observational study

Although placement of an intra-cerebral catheter remains the gold standard method for measuring intracranial pressure (ICP), several non-invasive techniques can provide useful estimates. The aim of this study ...

Authors: Chiara Robba, Selene Pozzebon, Bedrana Moro, Jean-Louis Vincent, Jacques Creteur and Fabio Silvio Taccone

Usefulness of point-of-care multiplex PCR to rapidly identify pathogens responsible for ventilator-associated pneumonia and their resistance to antibiotics: an observational study

The use of multiplex PCR to shorten time to identification of pathogens and their resistance mechanisms for patients with ventilator-associated pneumonia (VAP) is attractive, but poorly studied. The multiplex ...

Authors: Charles-Edouard Luyt, Guillaume Hékimian, Isabelle Bonnet, Nicolas Bréchot, Matthieu Schmidt, Jérôme Robert, Alain Combes and Alexandra Aubry

Correction to: The role of high load herpes simplex virus in patients with mechanical ventilation: a real hospital acquired viral lung infection needs antiviral therapy?

An amendment to this paper has been published and can be accessed via the original article.

Authors: Heyan Wang and Hangyong He

Mobilization practices in critically ill children: a European point prevalence study (EU PARK-PICU)

Early mobilization of adults receiving intensive care improves health outcomes, yet little is known about mobilization practices in paediatric intensive care units (PICUs). We aimed to determine the prevalence...

Authors: Erwin Ista, Barnaby R. Scholefield, Joseph C. Manning, Irene Harth, Orsola Gawronski, Alicja Bartkowska-Śniatkowska, Anne-Sylvie Ramelet and Sapna R. Kudchadkar

Correction to: The effect of corticosteroids on the mortality of patients with influenza pneumonia: a systematic review and meta-analysis

An amendment to this paper has been published and can be accessed via the original article.

Authors: Yue-Nan Ni, Guo Chen, Jiankui Sun, Bin-Miao Liang and Zong-An Liang

COVID-19: ICU delirium management during SARS-CoV-2 pandemic—pharmacological considerations

Authors: Lauren J. Andrews and Scott T. Benken

Correction to: How to measure blood pressure using an arterial catheter: a systematic 5-step approach

An amendment to this paper has been published and can be accessed via the original article.

Authors: Bernd Saugel, Karim Kouz, Agnes S. Meidert, Leonie Schulte-Uentrop and Stefano Romagnoli

VEGF-D: a novel biomarker for detection of COVID-19 progression

Authors: Yaxian Kong, Junyan Han, Xueying Wu, Hui Zeng, Jingyuan Liu and Henghui Zhang

Learning from cubism to understand the reality of hemodynamics

Authors: Jason Stankiewicz, Maniraj Jeyaraju and Michael T. McCurdy

Protocol for awake prone positioning in COVID-19 patients: to do it earlier, easier, and longer

Authors: Guy Bower and Hangyong He

Preventive use of respiratory support after scheduled extubation in critically ill medical patients—a network meta-analysis of randomized controlled trials

Respiratory support has been increasingly used after extubation for the prevention of re-intubation and improvement of prognosis in critically ill medical patients. However, the optimal respiratory support met...

Authors: Xiaoyang Zhou, Shengmi Yao, Pingping Dong, Bixin Chen, Zhaojun Xu and Hua Wang

Using indirect calorimetry in place of fixed energy prescription was feasible and energy targets were more closely met: do not forget an important limitation

Authors: Patrick M. Honore, Leonel Barreto Gutierrez, Luc Kugener, Sebastien Redant, Rachid Attou, Andrea Gallerani and David De Bels

Screening for low testosterone is needed for early identification and treatment of men at high risk of mortality from Covid-19

Authors: Simon Peter Rowland and Elizabeth O’Brien Bergin

Performance and impact of a multiplex PCR in ICU patients with ventilator-associated pneumonia or ventilated hospital-acquired pneumonia

Early appropriate antibiotic therapy reduces morbidity and mortality of severe pneumonia. However, the emergence of bacterial resistance requires the earliest use of antibiotics with the narrowest possible spe...

Authors: Nathan Peiffer-Smadja, Lila Bouadma, Vincent Mathy, Kahina Allouche, Juliette Patrier, Martin Reboul, Philippe Montravers, Jean-François Timsit and Laurence Armand-Lefevre

“War to the knife” against thromboinflammation to protect endothelial function of COVID-19 patients

In this viewpoint, we summarize the relevance of thromboinflammation in COVID-19 and discuss potential mechanisms of endothelial injury as a key point for the development of lung and distant organ dysfunction,...

Authors: Gabriele Guglielmetti, Marco Quaglia, Pier Paolo Sainaghi, Luigi Mario Castello, Rosanna Vaschetto, Mario Pirisi, Francesco Della Corte, Gian Carlo Avanzi, Piero Stratta and Vincenzo Cantaluppi

Prevention of thrombotic risk in hospitalized patients with COVID-19 and hemostasis monitoring

COVID-19 is an infection induced by the SARS-CoV-2 coronavirus, and severe forms can lead to acute respiratory distress syndrome (ARDS) requiring intensive care unit (ICU) management. Severe forms are associat...

Authors: Sophie Susen, Charles Ambroise Tacquard, Alexandre Godon, Alexandre Mansour, Delphine Garrigue, Philippe Nguyen, Anne Godier, Sophie Testa, Jerrold H. Levy, Pierre Albaladejo and Yves Gruel

First do no harm—beware the risk of therapeutic plasma exchange in severe COVID-19

Authors: Klaus Stahl, Christian Bode and Sascha David

High doses of ketamine to improve neuronal edema in subarachnoid hemorrhage: we should consider other undesirable organ targets

Authors: Patrick M. Honore, Aude Mugisha, Luc Kugener, Sebastien Redant, Rachid Attou, Andrea Gallerani and David De Bels

Bedside rapid placement of nasointestinal feeding tube via ultrasound-guided stylet positioning in critical COVID-19 patients

Authors: Chuan-xi Chen, Zheng-deng Wei, Yong-jun Liu, Shou-zhen Cheng and Xiang-dong Guan

The unique characteristics of COVID-19 coagulopathy

Thrombotic complications and coagulopathy frequently occur in COVID-19. However, the characteristics of COVID-19-associated coagulopathy (CAC) are distinct from those seen with bacterial sepsis-induced coagulo...

Authors: Toshiaki Iba, Jerrold H. Levy, Jean Marie Connors, Theodore E. Warkentin, Jecko Thachil and Marcel Levi

Can augmented renal clearance be detected using estimators of glomerular filtration rate?

Authors: Matthias Gijsen, Alexander Wilmer, Geert Meyfroidt, Joost Wauters and Isabel Spriet

Compassionate use of others’ immunity — understanding gut microbiome in Covid-19

Authors: Prashanth Thalanayar Muthukrishnan and Robert Faillace

Single ventilator for multiple patients during COVID19 surge: matching and balancing patients

Authors: Lonnie G. Petersen, James Friend and Sidney Merritt

Prevalence and impact of acute renal impairment on COVID-19: a systematic review and meta-analysis

The aim of this study is to assess the prevalence of abnormal urine analysis and kidney dysfunction in COVID-19 patients and to determine the association of acute kidney injury (AKI) with the severity and prog...

Authors: Xianghong Yang, Yiyang Jin, Ranran Li, Zhongheng Zhang, Renhua Sun and Dechang Chen

Immortal time bias: a possible explanation for “Impact of acyclovir use on survival of patients with ventilator-associated pneumonia and high load herpes simplex virus replication”

Authors: Magnus Glindvad Ahlström, Lars Haukali Omland, Andreas Ronit and Niels Obel

Hypertonic sodium lactate improves microcirculation, cardiac function, and inflammation in a rat model of sepsis

Hypertonic sodium lactate (HSL) may be of interest during inflammation. We aimed to evaluate its effects during experimental sepsis in rats (cecal ligation and puncture (CLP)).

Authors: Emmanuel Besnier, David Coquerel, Geoffrey Kouadri, Thomas Clavier, Raphael Favory, Thibault Duburcq, Olivier Lesur, Soumeya Bekri, Vincent Richard, Paul Mulder and Fabienne Tamion

The vascular endothelium: the cornerstone of organ dysfunction in severe SARS-CoV-2 infection

In severe SARS-CoV-2 infections, emerging data including recent histopathological studies have emphasized the crucial role of endothelial cells (ECs) in vascular dysfunction, immunothrombosis, and inflammation.

Authors: Stéphanie Pons, Sofiane Fodil, Elie Azoulay and Lara Zafrani

Liver injury without liver failure in COVID-19 patients: how to explain, in some cases, elevated ammonia without hepatic decompensation

Authors: Patrick M. Honore, Leonel Barreto Gutierrez, Luc Kugener, Sebastien Redant, Rachid Attou, Andrea Gallerani and David De Bels

The ARDSnet protocol may be detrimental in COVID-19

Authors: Vasiliki Tsolaki, George E. Zakynthinos and Dimosthenis Makris

Paediatric and adult critical care medicine: joining forces against Covid-19

Authors: Martin C. J. Kneyber, Bernadette Engels and Peter H. J. van der Voort

Micronutrient status of COVID-19 patients: a critical consideration

Authors: Anitra C. Carr

Invasive mechanical ventilation in COVID-19 patient management: the experience with 469 patients in Wuhan

Authors: Jing Hua, Chenchen Qian, Zhibing Luo, Qiang Li and Feilong Wang

Health-related quality of life of children and their parents 2 years after critical illness: pre-planned follow-up of the PEPaNIC international, randomized, controlled trial

Pediatric intensive care unit (PICU) survivors are at risk for prolonged morbidities interfering with daily life. The current study examined parent-reported health-related quality of life (HRQoL) in former cri...

Authors: José Hordijk, Sascha Verbruggen, Ilse Vanhorebeek, Fabian Güiza, Pieter Wouters, Greet Van den Berghe, Koen Joosten and Karolijn Dulfer

Incidence of acute kidney injury in COVID-19 infection: a systematic review and meta-analysis

Authors: Yih-Ting Chen, Shih-Chieh Shao, Cheng-Kai Hsu, I-Wen Wu, Ming-Jui Hung and Yung-Chang Chen

Response to “COVID-19: room for treating T cell exhaustion?”

Authors: Anne M. Drewry, Richard Hotchkiss and Erik Kulstad

Success and complications by team composition for prehospital pediatric intubation: children also need physicians!

Authors: Romain Jouffroy, Stéphanie Fogel, Peter Jones and Benoît Vivien

Optic nerve sheath diameter in critically ill patients: nuances and interpretation

Authors: Amos Lal, Kamal Kant Sahu, Ajay Kumar Mishra and Jamal Akhtar

Early rehabilitation with dedicated use of belt-type electrical muscle stimulation for severe COVID-19 patients

Authors: Kensuke Nakamura, Hidehiko Nakano, Hiromu Naraba, Masaki Mochizuki and Hideki Hashimoto

Beta-2-glycoprotein I as a biomarker for sepsis in critically ill patients in the intensive care unit: a prospective cohort study

Authors: Irene T. Schrijver, Hans Kemperman, Mark Roest, Jozef Kesecioglu and Dylan W. de Lange

Clinical features and outcomes of COVID-19 patients with gastrointestinal symptoms

Authors: Chao Cao, Meiping Chen, Li He, Jiao Xie and Xiaomin Chen

COVID-19 targets the right lung

Authors: Jingwen Li, Xiaxia Yu, Shaoping Hu, Zhicheng Lin, Nian Xiong and Yi Gao