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  1. Elderly patients have a blunted host response, which may influence vital signs and clinical outcomes of sepsis. This study was aimed to investigate whether the associations between the vital signs and mortalit...

    Authors: Takashi Shimazui, Taka-aki Nakada, Keith R. Walley, Taku Oshima, Toshikazu Abe, Hiroshi Ogura, Atsushi Shiraishi, Shigeki Kushimoto, Daizoh Saitoh, Seitaro Fujishima, Toshihiko Mayumi, Yasukazu Shiino, Takehiko Tarui, Toru Hifumi, Yasuhiro Otomo, Kohji Okamoto…

    Citation: Critical Care 2020 24:387

    Content type: Research

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  2. Mass critical care caused by the severe acute respiratory syndrome corona virus 2 pandemic poses an extreme challenge to hospitals. The primary goal of hospital disaster preparedness and response is to maintai...

    Authors: Thomas Wurmb, Katja Scholtes, Felix Kolibay, Nora Schorscher, Georg Ertl, Ralf-Ingo Ernestus, Ulrich Vogel, Axel Franke and Barbara Kowalzik

    Citation: Critical Care 2020 24:386

    Content type: Viewpoint

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  3. Neuroinflammation often develops in sepsis along with increasing permeability of the blood-brain barrier (BBB), which leads to septic encephalopathy. The barrier is formed by tight junction structures between ...

    Authors: Kristo Erikson, Hannu Tuominen, Merja Vakkala, Janne Henrik Liisanantti, Tuomo Karttunen, Hannu Syrjälä and Tero Ilmari Ala-Kokko

    Citation: Critical Care 2020 24:385

    Content type: Research

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  4. Intensive care unit (ICU) hospitalisations of elderly patients with acute respiratory infection have increased, yet the long-term effects of ICU admission among elderly individuals remain unknown. We examined ...

    Authors: Antoine Guillon, Coralie Hermetet, Kimberly A. Barker, Youenn Jouan, Christophe Gaborit, Stephan Ehrmann, Yannick Le Manach, Pierre-François Dequin and Leslie Grammatico-Guillon

    Citation: Critical Care 2020 24:384

    Content type: Research

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  5. In accordance with the recommendations of, amongst others, the Surviving Sepsis Campaign and the recently published European treatment guidelines for hospital-acquired pneumonia (HAP) and ventilator-associated pn...

    Authors: Rafael Zaragoza, Pablo Vidal-Cortés, Gerardo Aguilar, Marcio Borges, Emili Diaz, Ricard Ferrer, Emilio Maseda, Mercedes Nieto, Francisco Xavier Nuvials, Paula Ramirez, Alejandro Rodriguez, Cruz Soriano, Javier Veganzones and Ignacio Martín-Loeches

    Citation: Critical Care 2020 24:383

    Content type: Review

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  6. Biofilm formation on endotracheal tubes (ETTs) is an early and frequent event in mechanically ventilated patients. The biofilm is believed to act as a reservoir for infecting microorganisms and thereby contrib...

    Authors: Hulda R. Thorarinsdottir, Thomas Kander, Anna Holmberg, Sarunas Petronis and Bengt Klarin

    Citation: Critical Care 2020 24:382

    Content type: Research

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  7. Platelets have been demonstrated to be potent activators of neutrophil extracellular trap (NET) formation during sepsis. However, the mediators and molecular pathways involved in human platelet-mediated NET ge...

    Authors: Yang Jiao, Weiwei Li, Wei Wang, Xingyu Tong, Ran Xia, Jie Fan, Jianer Du, Chengmi Zhang and Xueyin Shi

    Citation: Critical Care 2020 24:380

    Content type: Research

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  8. Although placement of an intra-cerebral catheter remains the gold standard method for measuring intracranial pressure (ICP), several non-invasive techniques can provide useful estimates. The aim of this study ...

    Authors: Chiara Robba, Selene Pozzebon, Bedrana Moro, Jean-Louis Vincent, Jacques Creteur and Fabio Silvio Taccone

    Citation: Critical Care 2020 24:379

    Content type: Research

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  9. The use of multiplex PCR to shorten time to identification of pathogens and their resistance mechanisms for patients with ventilator-associated pneumonia (VAP) is attractive, but poorly studied. The multiplex ...

    Authors: Charles-Edouard Luyt, Guillaume Hékimian, Isabelle Bonnet, Nicolas Bréchot, Matthieu Schmidt, Jérôme Robert, Alain Combes and Alexandra Aubry

    Citation: Critical Care 2020 24:378

    Content type: Research

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  10. Early mobilization of adults receiving intensive care improves health outcomes, yet little is known about mobilization practices in paediatric intensive care units (PICUs). We aimed to determine the prevalence...

    Authors: Erwin Ista, Barnaby R. Scholefield, Joseph C. Manning, Irene Harth, Orsola Gawronski, Alicja Bartkowska-Śniatkowska, Anne-Sylvie Ramelet and Sapna R. Kudchadkar

    Citation: Critical Care 2020 24:368

    Content type: Research

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  11. Respiratory support has been increasingly used after extubation for the prevention of re-intubation and improvement of prognosis in critically ill medical patients. However, the optimal respiratory support met...

    Authors: Xiaoyang Zhou, Shengmi Yao, Pingping Dong, Bixin Chen, Zhaojun Xu and Hua Wang

    Citation: Critical Care 2020 24:370

    Content type: Research

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  12. Early appropriate antibiotic therapy reduces morbidity and mortality of severe pneumonia. However, the emergence of bacterial resistance requires the earliest use of antibiotics with the narrowest possible spe...

    Authors: Nathan Peiffer-Smadja, Lila Bouadma, Vincent Mathy, Kahina Allouche, Juliette Patrier, Martin Reboul, Philippe Montravers, Jean-François Timsit and Laurence Armand-Lefevre

    Citation: Critical Care 2020 24:366

    Content type: Research

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  13. In this viewpoint, we summarize the relevance of thromboinflammation in COVID-19 and discuss potential mechanisms of endothelial injury as a key point for the development of lung and distant organ dysfunction,...

    Authors: Gabriele Guglielmetti, Marco Quaglia, Pier Paolo Sainaghi, Luigi Mario Castello, Rosanna Vaschetto, Mario Pirisi, Francesco Della Corte, Gian Carlo Avanzi, Piero Stratta and Vincenzo Cantaluppi

    Citation: Critical Care 2020 24:365

    Content type: Viewpoint

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  14. COVID-19 is an infection induced by the SARS-CoV-2 coronavirus, and severe forms can lead to acute respiratory distress syndrome (ARDS) requiring intensive care unit (ICU) management. Severe forms are associat...

    Authors: Sophie Susen, Charles Ambroise Tacquard, Alexandre Godon, Alexandre Mansour, Delphine Garrigue, Philippe Nguyen, Anne Godier, Sophie Testa, Jerrold H. Levy, Pierre Albaladejo and Yves Gruel

    Citation: Critical Care 2020 24:364

    Content type: Review

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  15. Thrombotic complications and coagulopathy frequently occur in COVID-19. However, the characteristics of COVID-19-associated coagulopathy (CAC) are distinct from those seen with bacterial sepsis-induced coagulo...

    Authors: Toshiaki Iba, Jerrold H. Levy, Jean Marie Connors, Theodore E. Warkentin, Jecko Thachil and Marcel Levi

    Citation: Critical Care 2020 24:360

    Content type: Review

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  16. The aim of this study is to assess the prevalence of abnormal urine analysis and kidney dysfunction in COVID-19 patients and to determine the association of acute kidney injury (AKI) with the severity and prog...

    Authors: Xianghong Yang, Yiyang Jin, Ranran Li, Zhongheng Zhang, Renhua Sun and Dechang Chen

    Citation: Critical Care 2020 24:356

    Content type: Research

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  17. Hypertonic sodium lactate (HSL) may be of interest during inflammation. We aimed to evaluate its effects during experimental sepsis in rats (cecal ligation and puncture (CLP)).

    Authors: Emmanuel Besnier, David Coquerel, Geoffrey Kouadri, Thomas Clavier, Raphael Favory, Thibault Duburcq, Olivier Lesur, Soumeya Bekri, Vincent Richard, Paul Mulder and Fabienne Tamion

    Citation: Critical Care 2020 24:354

    Content type: Research

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  18. Pediatric intensive care unit (PICU) survivors are at risk for prolonged morbidities interfering with daily life. The current study examined parent-reported health-related quality of life (HRQoL) in former cri...

    Authors: José Hordijk, Sascha Verbruggen, Ilse Vanhorebeek, Fabian Güiza, Pieter Wouters, Greet Van den Berghe, Koen Joosten and Karolijn Dulfer

    Citation: Critical Care 2020 24:347

    Content type: Research

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