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  1. Oesophageal pressure (PES) is used for calculation of lung and chest wall mechanics and transpulmonary pressure during mechanical ventilation. Measurements performed with a balloon catheter are suggested as a ...

    Authors: Per Persson, Rebecca Ahlstrand, Magni Gudmundsson, Alex de Leon and Stefan Lundin

    Citation: Critical Care 2019 23:217

    Content type: Research

    Published on:

  2. As more patients are surviving intensive care, mental health concerns in survivors have become a research priority. Among these, post-traumatic stress disorder (PTSD) can have an important impact on the qualit...

    Authors: Cássia Righy, Regis Goulart Rosa, Rodrigo Teixeira Amancio da Silva, Renata Kochhann, Celina Borges Migliavaca, Caroline Cabral Robinson, Stefania Pigatto Teche, Cassiano Teixeira, Fernando Augusto Bozza and Maicon Falavigna

    Citation: Critical Care 2019 23:213

    Content type: Research

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  3. Mottling score, a tissue perfusion parameter, is correlated with outcome in septic shock patients. However, its predictive value on mortality according to prognostic covariates such as vasopressor dose and oth...

    Authors: Guillaume Dumas, Jean-Rémi Lavillegrand, Jérémie Joffre, Naïke Bigé, Edmilson Bastos de-Moura, Jean-Luc Baudel, Sylvie Chevret, Bertrand Guidet, Eric Maury, Fabio Amorim and Hafid Ait-Oufella

    Citation: Critical Care 2019 23:211

    Content type: Research

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    The Letter to this article has been published in Critical Care 2019 23:268

  4. Malignant stroke occurs in a subgroup of patients suffering from ischemic cerebral infarction and is characterized by neurological deterioration due to progressive edema, raised intracranial pressure, and cere...

    Authors: Thomas Beez, Christopher Munoz-Bendix, Hans-Jakob Steiger and Kerim Beseoglu

    Citation: Critical Care 2019 23:209

    Content type: Review

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  5. The long-term ecological effects on the emergence of antimicrobial resistance at the ICU level during selective decontamination of the digestive tract (SDD) are unknown. We determined the incidence of newly ac...

    Authors: Sophie Buitinck, Rogier Jansen, Saskia Rijkenberg, Jos P. J. Wester, Rob J. Bosman, Nardo J. M. van der Meer and Peter H. J. van der Voort

    Citation: Critical Care 2019 23:208

    Content type: Research

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  6. Known colloquially as the “weekend effect,” the association between weekend admissions and increased mortality within hospital settings has become a highly contested topic over the last two decades. Drawing in...

    Authors: Louis Faust, Keith Feldman and Nitesh V. Chawla

    Citation: Critical Care 2019 23:207

    Content type: Research

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    The Letter to this article has been published in Critical Care 2019 23:345

  7. The population pharmacokinetics of total and unbound posaconazole following intravenous administration has not yet been described for the critically ill patient population. The aim of this work was, therefore,...

    Authors: Fekade B. Sime, Catherine J. Byrne, Suzanne Parker, Janine Stuart, Jenie Butler, Therese Starr, Saurabh Pandey, Steven C. Wallis, Jeffrey Lipman and Jason A. Roberts

    Citation: Critical Care 2019 23:205

    Content type: Research

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  8. Rapid detection, early resuscitation, and appropriate antibiotic use are crucial for sepsis care. Accurate identification of the site of infection may facilitate a timely provision of appropriate care. We aime...

    Authors: Toshikazu Abe, Yasuharu Tokuda, Atsushi Shiraishi, Seitaro Fujishima, Toshihiko Mayumi, Takehiro Sugiyama, Gautam A. Deshpande, Yasukazu Shiino, Toru Hifumi, Yasuhiro Otomo, Kohji Okamoto, Joji Kotani, Yuichiro Sakamoto, Junichi Sasaki, Shin-ichiro Shiraishi, Kiyotsugu Takuma…

    Citation: Critical Care 2019 23:202

    Content type: Research

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    The Letter to this article has been published in Critical Care 2019 23:294

  9. Vitamin D supplementation has shown promise for reducing mortality in the intensive care setting. As a steroid prohormone with pleiotropic effects, there may be a lag between administration and observing clini...

    Authors: Gennaro Martucci, Dayre McNally, Dhruv Parekh, Paul Zajic, Fabio Tuzzolino, Antonio Arcadipane, Kenneth B. Christopher, Harald Dobnig and Karin Amrein

    Citation: Critical Care 2019 23:200

    Content type: Research

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  10. In recent years, argon has been shown to exert neuroprotective effects in an array of models. However, the mechanisms by which argon exerts its neuroprotective characteristics remain unclear. Accumulating evid...

    Authors: Jingjin Liu, Kay Nolte, Gary Brook, Lisa Liebenstund, Agnieszka Weinandy, Anke Höllig, Michael Veldeman, Antje Willuweit, Karl-Josef Langen, Rolf Rossaint and Mark Coburn

    Citation: Critical Care 2019 23:198

    Content type: Research

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  11. Septic shock is the most severe form of sepsis, in which profound underlying abnormalities in circulatory and cellular/metabolic parameters lead to substantially increased mortality. A clear understanding and ...

    Authors: Jean-Louis Vincent, Gabriel Jones, Sholto David, Elena Olariu and Kevin K. Cadwell

    Citation: Critical Care 2019 23:196

    Content type: Research

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  12. Despite the essential functions of the intestinal microbiota in human physiology, little has been reported about the microbiome in neurocritically ill patients. This investigation aimed to evaluate the charact...

    Authors: Ruoting Xu, Chuhong Tan, Jiajia Zhu, Xiuli Zeng, Xuxuan Gao, Qiheng Wu, Qiong Chen, Huidi Wang, Hongwei Zhou, Yan He, Suyue Pan and Jia Yin

    Citation: Critical Care 2019 23:195

    Content type: Research

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    The Letter to this article has been published in Critical Care 2019 23:403

  13. Quantification of intrinsic PEEP (PEEPi) has important implications for patients subjected to invasive mechanical ventilation. A new non-invasive breath-by-breath method (etCO2D) for determination of PEEPi is eva...

    Authors: Sarah Heili-Frades, Fernando Suarez-Sipmann, Arnoldo Santos, Maria Pilar Carballosa, Alba Naya-Prieto, Carlos Castilla-Reparaz, Maria Jesús Rodriguez-Nieto, Nicolás González-Mangado and German Peces -Barba

    Citation: Critical Care 2019 23:192

    Content type: Research

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  14. Optimal infusion rate of colloids in patients with suspected hypovolemia is unknown, and the primary objective of the present study was to test if plasma volume expansion by 5% albumin is greater if fluid is a...

    Authors: Svajunas Statkevicius, Johan Bonnevier, Jane Fisher, Björn P. Bark, Erik Larsson, Carl M. Öberg, Päivi Kannisto, Bobby Tingstedt and Peter Bentzer

    Citation: Critical Care 2019 23:191

    Content type: Research

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  15. Procalcitonin (PCT) is a biomarker used to assess systemic inflammation, infection, and sepsis and to optimize antimicrobial therapies. Its role in the in the differential diagnosis between candidemia and bact...

    Authors: Andrea Cortegiani, Giovanni Misseri, Mariachiara Ippolito, Matteo Bassetti, Antonino Giarratano, Ignacio Martin-Loeches and Sharon Einav

    Citation: Critical Care 2019 23:190

    Content type: Research

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    The Correction to this article has been published in Critical Care 2019 23:322

    The Letter to this article has been published in Critical Care 2019 23:271

  16. Intensive care survivors suffer chronic and potentially life-changing physical, psychosocial and cognitive sequelae, and supporting recovery is an international priority. As survivors’ transition from the inte...

    Authors: J. King, B. O’Neill, P. Ramsay, M. A. Linden, A. Darweish Medniuk, J. Outtrim and B. Blackwood

    Citation: Critical Care 2019 23:187

    Content type: Research

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  17. Multiple organ dysfunction is a common cause of morbidity and mortality in intensive care units (ICUs). Original development of the Sequential Organ Failure Assessment (SOFA) score was not to predict outcome, ...

    Authors: Andrea Soo, Danny J. Zuege, Gordon H. Fick, Daniel J. Niven, Luc R. Berthiaume, Henry T. Stelfox and Christopher J. Doig

    Citation: Critical Care 2019 23:186

    Content type: Research

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  18. Antibiotic exposure in intensive care patients with sepsis is frequently inadequate and is associated with poorer outcomes. Antibiotic dosing is challenging in the intensive care, as critically ill patients ha...

    Authors: Lucas M. Fleuren, Luca F. Roggeveen, Tingjie Guo, Petr Waldauf, Peter H. J. van der Voort, Rob J. Bosman, Eleonora L. Swart, Armand R. J. Girbes and Paul W. G. Elbers

    Citation: Critical Care 2019 23:185

    Content type: Research

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  19. Sepsis remains one of the most important causes of morbidity and mortality worldwide. In approximately 30–50% of cases of suspected sepsis, no pathogen is isolated, disabling the clinician to treat the patient...

    Authors: Rishi S. Nannan Panday, Eline M. J. Lammers, Nadia Alam and Prabath W. B. Nanayakkara

    Citation: Critical Care 2019 23:182

    Content type: Research

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    The Letter to this article has been published in Critical Care 2019 23:332

  20. The effect of high-flow nasal cannula (HFNC) therapy in patients after planned extubation remains inconclusive. We aimed to perform a rigorous and comprehensive systematic meta-analysis to robustly quantify th...

    Authors: Youfeng Zhu, Haiyan Yin, Rui Zhang, Xiaoling Ye and Jianrui Wei

    Citation: Critical Care 2019 23:180

    Content type: Research

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    The Letter to this article has been published in Critical Care 2019 23:344

  21. Fluid challenge (FC) is one of the most common practices in Intensive Care Unit (ICU). The present study aimed to evaluate whether echocardiographic assessment of the response to FC at the end of the infusion ...

    Authors: Claire Roger, Laurent Zieleskiewicz, Christophe Demattei, Karim Lakhal, Gael Piton, Benjamin Louart, Jean-Michel Constantin, Russell Chabanne, Jean-Sébastien Faure, Yazine Mahjoub, Isabelle Desmeulles, Hervé Quintard, Jean-Yves Lefrant and Laurent Muller

    Citation: Critical Care 2019 23:179

    Content type: Research

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  22. Timely initiation of physical, occupational, and speech therapy in critically ill patients is crucial to reduce morbidity and improve outcomes. Over a 5-year time interval, we sought to determine the utilizati...

    Authors: Clare C. Prohaska, Peter D. Sottile, Amy Nordon-Craft, Matt D. Gallagher, Ellen L. Burnham, Brendan J. Clark, Michael Ho, Tyree H. Kiser, R. William Vandivier, Wenhui Liu, Margaret Schenkman and Marc Moss

    Citation: Critical Care 2019 23:175

    Content type: Research

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  23. We aimed to examine recent trends in patient characteristics and mortality in patients with acute kidney injury (AKI) receiving renal replacement therapy (RRT), including continuous RRT (CRRT) and intermittent...

    Authors: Yoshihisa Miyamoto, Masao Iwagami, Shotaro Aso, Hideo Yasunaga, Hiroki Matsui, Kiyohide Fushimi, Yoshifumi Hamasaki, Masaomi Nangaku and Kent Doi

    Citation: Critical Care 2019 23:172

    Content type: Research

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  24. Cerebral hypoperfusion may aggravate neurological damage after cardiac arrest. Near-infrared spectroscopy (NIRS) provides information on cerebral oxygenation but its relevance during post-resuscitation care is...

    Authors: Pekka Jakkula, Johanna Hästbacka, Matti Reinikainen, Ville Pettilä, Pekka Loisa, Marjaana Tiainen, Erika Wilkman, Stepani Bendel, Thomas Birkelund, Anni Pulkkinen, Minna Bäcklund, Sirkku Heino, Sari Karlsson, Hiski Kopponen and Markus B. Skrifvars

    Citation: Critical Care 2019 23:171

    Content type: Research

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  25. Extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-E) are disseminating worldwide leading to increased hospital length of stay and mortality in intensive care units (ICU). ESBL-E dissemination wa...

    Authors: Renaud Prevel, Alexandre Boyer, Fatima M’Zali, Agnès Lasheras, Jean-Ralph Zahar, Anne-Marie Rogues and Didier Gruson

    Citation: Critical Care 2019 23:170

    Content type: Research

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  26. Septic shock is the most severe phase of sepsis and is associated with high rates of mortality. However, early stage prediction of septic shock outcomes remains difficult. Metabolomic techniques have emerged a...

    Authors: Zhicheng Liu, Mohamed N. Triba, Roland Amathieu, Xiangping Lin, Nadia Bouchemal, Edith Hantz, Laurence Le Moyec and Philippe Savarin

    Citation: Critical Care 2019 23:169

    Content type: Research

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  27. Catecholamines, especially norepinephrine, are the most frequently used vasopressors for treating patients with septic shock. During the recent decades, terlipressin, vasopressin V1A agonist, and even Ca2+ sensit...

    Authors: Lu Cheng, Jing Yan, Shutang Han, Qiuhua Chen, Mingqi Chen, Hua Jiang and Jun Lu

    Citation: Critical Care 2019 23:168

    Content type: Research

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