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  1. Calcium release-activated calcium (CRAC) channel inhibitors block proinflammatory cytokine release, preserve endothelial integrity and may effectively treat patients with severe COVID-19 pneumonia.

    Authors: Charles Bruen, Mukhtar Al-Saadi, Edward A. Michelson, Maged Tanios, Raul Mendoza-Ayala, Joseph Miller, Jeffrey Zhang, Kenneth Stauderman, Sudarshan Hebbar and Peter C. Hou
    Citation: Critical Care 2022 26:101
    Content type: Research Published on:

  2. Post-extubation dysphagia (PED) is recognized as a common complication in the intensive care unit (ICU). Speech and language therapy (SLT) can potentially help improve PED; however, the impact of the timing of...

    Authors: Takashi Hongo, Ryohei Yamamoto, Keibun Liu, Takahiko Yaguchi, Hisashi Dote, Ryusuke Saito, Tomoyuki Masuyama, Kosuke Nakatsuka, Shinichi Watanabe, Takahiro Kanaya, Tomoya Yamaguchi, Tetsuya Yumoto, Hiromichi Naito and Atsunori Nakao
    Citation: Critical Care 2022 26:98
    Content type: Research Published on:

  3. In Poland, the clinical characteristics and outcomes of patients with COVID-19 requiring extracorporeal membrane oxygenation (ECMO) remain unknown. This study aimed to answer these unknowns by analyzing data c...

    Authors: Ewa Trejnowska, Dominik Drobiński, Piotr Knapik, Marta Wajda-Pokrontka, Konstanty Szułdrzyński, Jakub Staromłyński, Wojciech Nowak, Maciej Urlik, Marek Ochman, Waldemar Goździk, Wojciech Serednicki, Jakub Śmiechowicz, Jakub Brączkowski, Wojciech Bąkowski, Anna Kwinta, Michał O. Zembala…
    Citation: Critical Care 2022 26:97
    Content type: Research Published on:

  4. Amniotic fluid embolism (AFE) is a rare but often catastrophic complication of pregnancy that leads to cardiopulmonary dysfunction and severe disseminated intravascular coagulopathy (DIC). Although few case re...

    Authors: Sarah Aissi James, Thomas Klein, Guillaume Lebreton, Jacky Nizard, Juliette Chommeloux, Nicolas Bréchot, Marc Pineton de Chambrun, Guillaume Hékimian, Charles-Edouard Luyt, Bruno Levy, Antoine Kimmoun, Alain Combes and Matthieu Schmidt
    Citation: Critical Care 2022 26:96
    Content type: Research Published on:

  5. To compare old patients hospitalized in ICU for respiratory distress due to COVID-19 with old patients hospitalized in ICU for a non-COVID-19-related reason in terms of autonomy and quality of life.

    Authors: Fabrice Thiolliere, Claire Falandry, Bernard Allaouchiche, Victor Geoffray, Laurent Bitker, Jean Reignier, Paul Abraham, Stephanie Malaquin, Baptiste Balança, Hélène Boyer, Philippe Seguin, Céline Guichon, Marie Simon, Arnaud Friggeri and Charles-Hervé Vacheron
    Citation: Critical Care 2022 26:94
    Content type: Research Published on:

  6. Intermittent hemodialysis (IHD) and continuous renal replacement therapy (CRRT) are the two main RRT modalities in patients with severe acute kidney injury (AKI). Meta-analyses conducted more than 10 years ago...

    Authors: Stéphane Gaudry, François Grolleau, Saber Barbar, Laurent Martin-Lefevre, Bertrand Pons, Éric Boulet, Alexandre Boyer, Guillaume Chevrel, Florent Montini, Julien Bohe, Julio Badie, Jean-Philippe Rigaud, Christophe Vinsonneau, Raphaël Porcher, Jean-Pierre Quenot and Didier Dreyfuss
    Citation: Critical Care 2022 26:93
    Content type: Research Published on:

  7. Non-occlusive mesenteric ischemia (NOMI) is a life-threatening condition occurring in patients with shock and is characterized by vasoconstriction of the mesenteric arteries leading to intestinal ischemia and ...

    Authors: Nina Rittgerodt, Thorben Pape, Markus Busch, Lena S. Becker, Andrea Schneider, Heiner Wedemeyer, Benjamin Seeliger, Julius Schmidt, Anna Maria Hunkemöller, Jan Fuge, Wolfgang Knitsch, Christine Fegbeutel, Hans-Jörg Gillmann, Bernhard C. Meyer, Marius M. Hoeper, Jan B. Hinrichs…
    Citation: Critical Care 2022 26:92
    Content type: Research Published on:

  8. The importance or necessity of a loading dose when prescribing intravenous colistin has not been well established in clinical practice, and approximate one-third to half of patients with carbapenem-resistant g...

    Authors: Sheng-Huei Wang, Kuang-Yao Yang, Chau-Chyun Sheu, Wei-Cheng Chen, Ming-Cheng Chan, Jia-Yih Feng, Chia-Min Chen, Biing-Ru Wu, Zhe-Rong Zheng, Yu-Ching Chou and Chung-Kan Peng
    Citation: Critical Care 2022 26:91
    Content type: Research Published on:

  9. Dopamine is used to treat patients with shock in intensive care units (ICU) throughout the world, despite recent evidence against its use. The aim of this study was to identify the latest practice of dopamine ...

    Authors: Reina Suzuki, Shigehiko Uchino, Yusuke Sasabuchi, Alan Kawarai Lefor and Masamitsu Sanui
    Citation: Critical Care 2022 26:90
    Content type: Research Published on:

  10. Description of all consecutive critically ill COVID 19 patients hospitalized in ICU in University Hospital of Guadeloupe and outcome according to delay between steroid therapy initiation and mechanical ventila...

    Authors: Laurent Camous, Jean-David Pommier, Frederic Martino, Benoît Tressieres, Alexandre Demoule and Marc Valette
    Citation: Critical Care 2022 26:89
    Content type: Brief Report Published on:

    The Correspondence to this article has been published in Critical Care 2022 26:212

  11. Management and monitoring of pain and sedation to reduce discomfort as well as side effects, such as over- and under-sedation, withdrawal syndrome and delirium, is an integral part of pediatric intensive care ...

    Authors: Marco Daverio, Florian von Borell, Anne-Sylvie Ramelet, Francesca Sperotto, Paula Pokorna, Sebastian Brenner, Maria Cristina Mondardini, Dick Tibboel, Angela Amigoni and Erwin Ista
    Citation: Critical Care 2022 26:88
    Content type: Research Published on:

    The Correction to this article has been published in Critical Care 2022 26:139

  15. Awake prone positioning (APP) improves oxygenation in coronavirus disease (COVID-19) patients and, when successful, may decrease the risk of intubation. However, factors associated with APP success remain unkn...

    Authors: Miguel Ibarra-Estrada, Jie Li, Ivan Pavlov, Yonatan Perez, Oriol Roca, Elsa Tavernier, Bairbre McNicholas, David Vines, Miguel Marín-Rosales, Alexandra Vargas-Obieta, Roxana García-Salcido, Sara A. Aguirre-Díaz, José A. López-Pulgarín, Quetzalcóatl Chávez-Peña, Julio C. Mijangos-Méndez, Guadalupe Aguirre-Avalos…
    Citation: Critical Care 2022 26:84
    Content type: Research Published on:

  16. In severe cases, SARS-CoV-2 infection leads to acute respiratory distress syndrome (ARDS), often treated by extracorporeal membrane oxygenation (ECMO). During ECMO therapy, anticoagulation is crucial to preven...

    Authors: Saskia von Stillfried, Roman David Bülow, Rainer Röhrig, Patrick Meybohm and Peter Boor
    Citation: Critical Care 2022 26:83
    Content type: Brief Report Published on:

  17. Prone positioning in combination with the application of low tidal volume and adequate positive end-expiratory pressure (PEEP) improves survival in patients with moderate to severe acute respiratory distress s...

    Authors: Christoph Boesing, Peter T. Graf, Fabian Schmitt, Manfred Thiel, Paolo Pelosi, Patricia R. M. Rocco, Thomas Luecke and Joerg Krebs
    Citation: Critical Care 2022 26:82
    Content type: Research Published on:

  19. Delaying time to prone positioning (PP) may be associated with higher mortality in acute respiratory distress syndrome (ARDS) due to coronavirus disease 2019 (COVID-19). We evaluated the use and the impact of ...

    Authors: Christophe Le Terrier, Florian Sigaud, Said Lebbah, Luc Desmedt, David Hajage, Claude Guérin, Jérôme Pugin, Steve Primmaz and Nicolas Terzi
    Citation: Critical Care 2022 26:71
    Content type: Research Published on:

  20. Excessive inspiratory effort could translate into self-inflicted lung injury, thus worsening clinical outcomes of spontaneously breathing patients with acute respiratory failure (ARF). Although esophageal mano...

    Authors: Roberto Tonelli, Andrea Cortegiani, Alessandro Marchioni, Riccardo Fantini, Luca Tabbì, Ivana Castaniere, Emanuela Biagioni, Stefano Busani, Chiara Nani, Caterina Cerbone, Morgana Vermi, Filippo Gozzi, Giulia Bruzzi, Linda Manicardi, Maria Rosaria Pellegrino, Bianca Beghè…
    Citation: Critical Care 2022 26:70
    Content type: Research Published on:

  21. Secondary nosocomial infections, which are commonly caused by carbapenem-resistant Klebsiella pneumoniae (CRKP) and vancomycin-resistant Enterococcus faecium (VRE), often develop in septic patients. This study ai...

    Authors: Sucheng Mu, Hao Xiang, Yuezhu Wang, Wei Wei, Xiangyu Long, Yi Han, Zhongshu Kuang, Yilin Yang, Feixiang Xu, Mingming Xue, Zhimin Dong, Chaoyang Tong, Huajun Zheng and Zhenju Song
    Citation: Critical Care 2022 26:68
    Content type: Research Published on:

  22. Authors: Manuel Alberto Guerrero-Gutiérrez, Javier Mancilla-Galindo, Ashuin Kammar-García, Luis Antonio Morgado-Villaseñor, Eder Iván Zamarrón-López and Orlando Rubén Pérez-Nieto
    Citation: Critical Care 2022 26:67
    Content type: Comment Published on:

    The Correspondence to this article has been published in Critical Care 2022 26:177

    The original article was published in Critical Care 2022 26:4

  29. This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2022. Other selected articles can be found online at

    Authors: Joo Heung Yoon, Michael R. Pinsky and Gilles Clermont
    Citation: Critical Care 2022 26:75
    Content type: Review Published on:

  31. This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2022. Other selected articles can be found online at

    Authors: Gavin D. Perkins and Jerry P. Nolan
    Citation: Critical Care 2022 26:73
    Content type: Review Published on:

  35. Trials comparing early and delayed strategies of renal replacement therapy in patients with severe acute kidney injury may have missed differences in survival as a result of mixing together patients at heterog...

    Authors: François Grolleau, Raphaël Porcher, Saber Barbar, David Hajage, Abderrahmane Bourredjem, Jean-Pierre Quenot, Didier Dreyfuss and Stéphane Gaudry
    Citation: Critical Care 2022 26:64
    Content type: Research Published on:

  36. Infection (either community acquired or nosocomial) is a major cause of morbidity and mortality in critical care medicine. Sepsis is present in up to 30% of all ICU patients. A large fraction of sepsis cases i...

    Authors: Irene Merino, Amanda de la Fuente, Marta Domínguez-Gil, José María Eiros, Ana P. Tedim and Jesús F. Bermejo-Martín
    Citation: Critical Care 2022 26:63
    Content type: Review Published on:

  38. Obesity is highly prevalent in hospitalized patients admitted with COVID-19. Evidence based guidelines are available for COVID-19-related therapies but dosing information specific to patients with obesity is l...

    Authors: Jeffrey F. Barletta and Brian L. Erstad
    Citation: Critical Care 2022 26:60
    Content type: Review Published on:

  39. The consequences of cardiac arrest (CA) on the gastro-intestinal tract are poorly understood. We measured the incidence of ischemic injury in the upper gastro-intestinal tract after Out-of-hospital CA (OHCA) a...

    Authors: D. Grimaldi, S. Legriel, N. Pichon, P. Colardelle, S. Leblanc, F. Canouï-Poitrine, O. Ben Hadj Salem, G. Muller, N. de Prost, S. Herrmann, S. Marque, A. Baron, B. Sauneuf, J. Messika, M. Dior, J. Creteur…
    Citation: Critical Care 2022 26:59
    Content type: Research Published on:

  40. Temperature control with target temperature management (TTM) after cardiac arrest has been endorsed by expert societies and adopted in international clinical practice guidelines but recent evidence challenges ...

    Authors: Anders Aneman, Steven Frost, Michael Parr and Markus B. Skrifvars
    Citation: Critical Care 2022 26:58
    Content type: Research Published on:

  43. The ratio of partial pressure of arterial oxygen to inspired oxygen fraction (PaO2/FIO2) during invasive mechanical ventilation (MV) is used as criteria to grade the severity of respiratory failure in acute respi...

    Authors: Michael Hultström, Ola Hellkvist, Lucian Covaciu, Filip Fredén, Robert Frithiof, Miklós Lipcsey, Gaetano Perchiazzi and Mariangela Pellegrini
    Citation: Critical Care 2022 26:55
    Content type: Correspondence Published on:

  45. Delirium is the most common cerebral dysfunction in the intensive care unit (ICU) and can be subdivided into a hypoactive, hyperactive, or mixed motor subtype based on the clinical manifestation. The aim of th...

    Authors: Kirstine N. la Cour, Nina C. Andersen-Ranberg, Sarah Weihe, Lone M. Poulsen, Camilla B. Mortensen, Cilia K. W. Kjer, Marie O. Collet, Stine Estrup and Ole Mathiesen
    Citation: Critical Care 2022 26:53
    Content type: Research Published on:

  46. Intra-abdominal hypertension (IAH) in acute pancreatitis (AP) is associated with deterioration in organ function. This trial aimed to assess the efficacy of neostigmine for IAH in patients with AP.

    Authors: Wenhua He, Peng Chen, Yupeng Lei, Liang Xia, Pi Liu, Yong Zhu, Hao Zeng, Yao Wu, Huajing Ke, Xin Huang, Wenhao Cai, Xin Sun, Wei Huang, Robert Sutton, Yin Zhu and Nonghua Lu
    Citation: Critical Care 2022 26:52
    Content type: Research Published on:

  47. Timely antimicrobial treatment and source control are strongly recommended by sepsis guidelines, however, their impact on clinical outcomes is uncertain.

    Authors: Hendrik Rüddel, Daniel O. Thomas-Rüddel, Konrad Reinhart, Friedhelm Bach, Herwig Gerlach, Matthias Lindner, John C. Marshall, Philipp Simon, Manfred Weiss, Frank Bloos and Daniel Schwarzkopf
    Citation: Critical Care 2022 26:51
    Content type: Research Published on:

  48. Increased plasma concentrations of circulating cell-free hemoglobin (CFH) are supposed to contribute to the multifactorial etiology of acute kidney injury (AKI) in critically ill patients while the CFH-scaveng...

    Authors: Jan A. Graw, Philip Hildebrandt, Alexander Krannich, Felix Balzer, Claudia Spies, Roland C. Francis, Wolfgang M. Kuebler, Steffen Weber-Carstens, Mario Menk and Oliver Hunsicker
    Citation: Critical Care 2022 26:50
    Content type: Research Published on:

  49. Trauma-induced coagulopathy includes thrombocytopenia and platelet dysfunction that impact patient outcome. Nevertheless, the role of platelet transfusion remains poorly defined. The aim of the study was 1/ to...

    Authors: S. R. Hamada, D. Garrigue, H. Nougue, A. Meyer, M. Boutonnet, E. Meaudre, A. Culver, E. Gaertner, G. Audibert, B. Vigué, J. Duranteau and A. Godier
    Citation: Critical Care 2022 26:49
    Content type: Research Published on:

  50. Severe acute respiratory syndrome coronavirus-2 (SARS–CoV-2)-induced acute respiratory distress syndrome (ARDS) causes high mortality. Umbilical cord-derived mesenchymal stromal cells (UC-MSCs) have potentiall...

    Authors: Antoine Monsel, Caroline Hauw-Berlemont, Miryam Mebarki, Nicholas Heming, Julien Mayaux, Otriv Nguekap Tchoumba, Jean-Luc Diehl, Alexandre Demoule, Djillali Annane, Clémence Marois, Sophie Demeret, Emmanuel Weiss, Guillaume Voiriot, Muriel Fartoukh, Jean-Michel Constantin, Bruno Mégarbane…
    Citation: Critical Care 2022 26:48
    Content type: Research Published on:
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  • ISSN: 1364-8535 (electronic)

Critical Care

ISSN: 1364-8535