Articles

Impact of treating iron deficiency, diagnosed according to hepcidin quantification, on outcomes after a prolonged ICU stay compared to standard care: a multicenter, randomized, single-blinded trial

Anemia is a significant problem in patients on ICU. Its commonest cause, iron deficiency (ID), is difficult to diagnose in the context of inflammation. Hepcidin is a new marker of ID. We aimed to assess whethe...

Authors: Sigismond Lasocki, Pierre Asfar, Samir Jaber, Martine Ferrandiere, Thomas Kerforne, Karim Asehnoune, Philippe Montravers, Philippe Seguin, Katell Peoc’h, Soizic Gergaud, Nicolas Nagot, Thibaud Lefebvre and Sylvain Lehmann

Monitoring circulating dipeptidyl peptidase 3 (DPP3) predicts improvement of organ failure and survival in sepsis: a prospective observational multinational study

Dipeptidyl peptidase 3 (DPP3) is a cytosolic enzyme involved in the degradation of various cardiovascular and endorphin mediators. High levels of circulating DPP3 (cDPP3) indicate a high risk of organ dysfunct...

Authors: Alice Blet, Benjamin Deniau, Karine Santos, Dirk P. T. van Lier, Feriel Azibani, Xavier Wittebole, Benjamin G. Chousterman, Etienne Gayat, Oliver Hartmann, Joachim Struck, Andreas Bergmann, Massimo Antonelli, Albertus Beishuizen, Jean-Michel Constantin, Charles Damoisel, Nicolas Deye…

Automated detection and quantification of reverse triggering effort under mechanical ventilation

Reverse triggering (RT) is a dyssynchrony defined by a respiratory muscle contraction following a passive mechanical insufflation. It is potentially harmful for the lung and the diaphragm, but its detection is...

Authors: Tài Pham, Jaume Montanya, Irene Telias, Thomas Piraino, Rudys Magrans, Rémi Coudroy, L. Felipe Damiani, Ricard Mellado Artigas, Matías Madorno, Lluis Blanch and Laurent Brochard

Airway Pseudomonas aeruginosa density in mechanically ventilated patients: clinical impact and relation to therapeutic efficacy of antibiotics

The bacterial density of Pseudomonas aeruginosa is closely related to its pathogenicity. We evaluated the effect of airway P. aeruginosa density on the clinical course of mechanically ventilated patients and the ...

Authors: Yohei Migiyama, Shinya Sakata, Shinji Iyama, Kentaro Tokunaga, Koichi Saruwatari, Yusuke Tomita, Sho Saeki, Shinichiro Okamoto, Hidenori Ichiyasu and Takuro Sakagami

High-flow nasal oxygen in patients with COVID-19-associated acute respiratory failure

Whether the use of high-flow nasal oxygen in adult patients with COVID-19 associated acute respiratory failure improves clinically relevant outcomes remains unclear. We thus sought to assess the effect of high...

Authors: Ricard Mellado-Artigas, Bruno L. Ferreyro, Federico Angriman, María Hernández-Sanz, Egoitz Arruti, Antoni Torres, Jesús Villar, Laurent Brochard and Carlos Ferrando

Renal dysfunction improves risk stratification and may call for a change in the management of intermediate- and high-risk acute pulmonary embolism: results from a multicenter cohort study with external validation

Renal dysfunction influences outcomes after pulmonary embolism (PE). We aimed to determine the incremental value of adding renal dysfunction, defined by estimated glomerular filtration rate (eGFR), on top of t...

Authors: Romain Chopard, David Jimenez, Guillaume Serzian, Fiona Ecarnot, Nicolas Falvo, Elsa Kalbacher, Benjamin Bonnet, Gilles Capellier, François Schiele, Laurent Bertoletti, Manuel Monreal and Nicolas Meneveau

Septic shock, noradrenaline requirements and alpha-2 agonists: Fishing in the right pond?

Authors: Auguste Dargent, Luc Quintin and Jean-Pierre Quenot

Letter on “(1,3)-β-d-Glucan-based empirical antifungal interruption in suspected invasive candidiasis: a randomized trial”

Authors: Antonios Kritikos and Frederic Lamoth

Characterization of esophageal motor activity, gastroesophageal reflux, and evaluation of prokinetic effectiveness in mechanically ventilated critically ill patients: a high-resolution impedance manometry study

Motility disorders of upper gastrointestinal tract are common in critical illness and associated with significant clinical consequences. However, detailed quantitative and qualitative analyses of esophageal mo...

Authors: Karel Balihar, Jan Kotyza, Lucie Zdrhova, Jana Kozeluhova, Michal Krcma and Martin Matejovic

SARS-CoV-2 pneumonia—receptor binding and lung immunopathology: a narrative review

The current pandemic of COVID-19 caused thousands of deaths and healthcare professionals struggle to properly manage infected patients. This review summarizes information about SARS-CoV-2 receptor binding dyna...

Authors: Maria Clara Saad Menezes, Diego Vinicius Santinelli Pestana, Gustavo Rosa Gameiro, Luiz Fernando Ferraz da Silva, Ėlodie Baron, Jean-Jacques Rouby and José Otavio Costa Auler Jr

Static compliance of the respiratory system in COVID-19 related ARDS: an international multicenter study

Controversies exist on the nature of COVID-19 related acute respiratory distress syndrome (ARDS) in particular on the static compliance of the respiratory system (Crs). We aimed to analyze the association of C...

Authors: Benoit Vandenbunder, Stephan Ehrmann, Michael Piagnerelli, Bertrand Sauneuf, Nicolas Serck, Thibaud Soumagne, Julien Textoris, Christophe Vinsonneau, Nadia Aissaoui, Gauthier Blonz, Giuseppe Carbutti, Romain Courcelle, Alain D’hondt, Stephane Gaudry, Julien Higny, Geoffroy Horlait…

Carboxypeptidase B blocks ex vivo activation of the anaphylatoxin-neutrophil extracellular trap axis in neutrophils from COVID-19 patients

Thrombosis and coagulopathy are highly prevalent in critically ill patients with COVID-19 and increase the risk of death. Immunothrombosis has recently been demonstrated to contribute to the thrombotic events ...

Authors: Yue Zhang, Kai Han, Chunjing Du, Rui Li, Jingyuan Liu, Hui Zeng, Liuluan Zhu and Ang Li

Identification and characterization of neutrophil heterogeneity in sepsis

Although the immune function of neutrophils in sepsis has been well described, the heterogeneity of neutrophils remains unclear during the process of sepsis.

Authors: Xinxin Qi, Yao Yu, Ran Sun, Jiamin Huang, Lu Liu, Yunxi Yang, Tao Rui and Bingwei Sun

Acute cholangitis in intensive care units: clinical, biological, microbiological spectrum and risk factors for mortality: a multicenter study

Little is known on the outcome and risk factors for mortality of patients admitted in Intensive Care units (ICUs) for Acute cholangitis (AC).

Authors: Jean-Rémi Lavillegrand, Emmanuelle Mercier-Des-Rochettes, Elodie Baron, Frédéric Pène, Damien Contou, Raphael Favory, Sébastien Préau, Arnaud Galbois, Chloé Molliere, Arnaud-Félix Miailhe, Jean Reignier, Mehran Monchi, Claire Pichereau, Sara Thietart, Thibault Vieille, Gael Piton…

Angiopoietin-2 outperforms other endothelial biomarkers associated with severe acute kidney injury in patients with severe sepsis and respiratory failure

Endothelial dysfunction and injury is a major pathophysiologic feature of sepsis. Sepsis is also the most frequent cause of acute kidney injury (AKI) in critically ill patients. Though most studies of AKI in s...

Authors: Wen-Kuang Yu, J. Brennan McNeil, Nancy E. Wickersham, Ciara M. Shaver, Julie A. Bastarache and Lorraine B. Ware

Use of the lung ultrasound score in monitoring COVID-19 patients: it’s time for a reappraisal

Authors: Luigi Vetrugno, Daniele Orso, Cristian Deana, Flavio Bassi, Gianmaria Cammarota and Tiziana Bove

Utility of AI models in critical care: union of man and the machine

Authors: Amos Lal, Vitaly Herasevich and Ognjen Gajic

Incidence and management of metabolic acidosis with sodium bicarbonate in the ICU: An international observational study

Metabolic acidosis is a major complication of critical illness. However, its current epidemiology and its treatment with sodium bicarbonate given to correct metabolic acidosis in the ICU are poorly understood.

Authors: Tomoko Fujii, Andrew A. Udy, Alistair Nichol, Rinaldo Bellomo, Adam M. Deane, Khaled El-Khawas, Naorungroj Thummaporn, Ary Serpa Neto, Hannah Bergin, Robert Short-Burchell, Chin-Ming Chen, Kuang-Hua Cheng, Kuo-Chen Cheng, Clemente Chia, Feng-Fan Chiang, Nai-Kuan Chou…

The epidemiology and clinical outcomes of ventilator-associated events among 20,769 mechanically ventilated patients at intensive care units: an observational study

Ventilator-associated pneumonia (VAP) is the most common hospital-acquired infection (HAI) in intensive care units (ICUs). Ventilator-associated event (VAE), a more objective definition, has replaced tradition...

Authors: Qiao He, Wen Wang, Shichao Zhu, Mingqi Wang, Yan Kang, Rui Zhang, Kang Zou, Zhiyong Zong and Xin Sun

Association between perioperative fluid administration and postoperative outcomes: a 20-year systematic review and a meta-analysis of randomized goal-directed trials in major visceral/noncardiac surgery

Appropriate perioperative fluid management is of pivotal importance to reduce postoperative complications, which impact on early and long-term patient outcome. The so-called perioperative goal-directed therapy...

Authors: Antonio Messina, Chiara Robba, Lorenzo Calabrò, Daniel Zambelli, Francesca Iannuzzi, Edoardo Molinari, Silvia Scarano, Denise Battaglini, Marta Baggiani, Giacomo De Mattei, Laura Saderi, Giovanni Sotgiu, Paolo Pelosi and Maurizio Cecconi

The feasibility and reliability of actigraphy to monitor sleep in intensive care patients: an observational study

Sleep amongst intensive care patients is reduced and highly fragmented which may adversely impact on recovery. The current challenge for Intensive Care clinicians is identifying feasible and accurate assessmen...

Authors: L. J. Delaney, E. Litton, K. L. Melehan, H.-C. C. Huang, V. Lopez and F. Van Haren

Blood purification with a cytokine adsorber for the elimination of myoglobin in critically ill patients with severe rhabdomyolysis

Rhabdomyolysis is frequently occurring in critically ill patients, resulting in a high risk of acute kidney injury (AKI) and potentially permanent kidney damage due to increased myoglobin levels. The extracorp...

Authors: Christina Scharf, Uwe Liebchen, Michael Paal, Michael Irlbeck, Michael Zoller and Ines Schroeder

COVID-19: What we’ve done well and what we could or should have done better—the 4 Ps

The current coronavirus pandemic has impacted heavily on ICUs worldwide. Although many hospitals and healthcare systems had plans in place to manage multiple casualties as a result of major natural disasters o...

Authors: Jean-Louis Vincent, Julia Wendon, Greg S. Martin, Nicole P. Juffermans, Jacques Creteur and Maurizio Cecconi

Clearance of inflammatory cytokines in patients with septic acute kidney injury during renal replacement therapy using the EMiC2 filter (Clic-AKI study)

The EMiC2 membrane is a medium cut-off haemofilter (45 kiloDalton). Little is known regarding its efficacy in eliminating medium-sized cytokines in sepsis. This study aimed to explore the effects of continuous...

Authors: Nuttha Lumlertgul, Anna Hall, Luigi Camporota, Siobhan Crichton and Marlies Ostermann

Insight into ECMO, mortality and ARDS: a nationwide analysis of 45,647 ECMO runs

Extracorporeal life support (ECLS) has become an integral part of modern intensive therapy. The choice of support mode depends largely on the indication. Patients with respiratory failure are predominantly tre...

Authors: Benjamin Friedrichson, Haitham Mutlak, Kai Zacharowski and Florian Piekarski

Severe acute kidney injury associated with progression of chronic kidney disease after critical COVID-19

Authors: Michael Hultström, Miklos Lipcsey, Ewa Wallin, Ing-Marie Larsson, Anders Larsson and Robert Frithiof

Sepsis is associated with mitochondrial DNA damage and a reduced mitochondrial mass in the kidney of patients with sepsis-AKI

Sepsis is a life-threatening condition accompanied by organ dysfunction subsequent to a dysregulated host response to infection. Up to 60% of patients with sepsis develop acute kidney injury (AKI), which is as...

Authors: Elisabeth C. van der Slikke, Bastiaan S. Star, Matijs van Meurs, Robert H. Henning, Jill Moser and Hjalmar R. Bouma

Lung ultrasound can predict response to the prone position in awake non-intubated patients with COVID‑19 associated acute respiratory distress syndrome

Authors: Sergey N. Avdeev, Galina V. Nekludova, Natalia V. Trushenko, Natalia A. Tsareva, Andrey I. Yaroshetskiy and Djuro Kosanovic

Bedside POCUS during ward emergencies is associated with improved diagnosis and outcome: an observational, prospective, controlled study

Rapid response teams are intended to improve early diagnosis and intervention in ward patients who develop acute respiratory or circulatory failure. A management protocol including the use of a handheld ultras...

Authors: Laurent Zieleskiewicz, Alexandre Lopez, Sami Hraiech, Karine Baumstarck, Bruno Pastene, Mathieu Di Bisceglie, Benjamin Coiffard, Gary Duclos, Alain Boussuges, Xavier Bobbia, Sharon Einav, Laurent Papazian and Marc Leone

Rate control in atrial fibrillation using Landiolol is safe in critically ill Covid-19 patients

Authors: Geoffroy Hariri, Tomas Urbina, Sandie Mazerand, Naike Bige, Jean-Luc Baudel and Hafid Ait-Oufella

Serum neurofilament measurement improves clinical risk scores for outcome prediction after cardiac arrest: results of a prospective study

A recent study found serum neurofilament light chain (NfL) levels to be strongly associated with poor neurological outcome in patients after cardiac arrest. Our aim was to confirm these findings in an independ...

Authors: Sabina Hunziker, Adrian Quinto, Maja Ramin-Wright, Christoph Becker, Katharina Beck, Alessia Vincent, Kai Tisljar, Giulio Disanto, Pascal Benkert, David Leppert, Hans Pargger, Stephan Marsch, Raoul Sutter, Nils Peters and Jens Kuhle

Semi-elemental versus polymeric formula for enteral nutrition in brain-injured critically ill patients: a randomized trial

The properties of semi-elemental enteral nutrition might theoretically improve gastrointestinal tolerance in brain-injured patients, known to suffer gastroparesis. The purpose of this study was to compare the ...

Authors: Laurent Carteron, Emmanuel Samain, Hadrien Winiszewski, Gilles Blasco, Anne-Sophie Balon, Camille Gilli, Gael Piton, Gilles Capellier, Sebastien Pili-Floury and Guillaume Besch

Can prone positioning be a safe procedure in patients with acute brain injury and moderate-to-severe acute respiratory distress syndrome?

Authors: Pauline Bernon, Ségolène Mrozek, Guillaume Dupont, Frédéric Dailler, Anne-Claire Lukaszewicz and Baptiste Balança

Development and validation of new poisoning mortality score system for patients with acute poisoning at the emergency department

A prediction model of mortality for patients with acute poisoning has to consider both poisoning-related characteristics and patients’ physiological conditions; moreover, it must be applicable to patients of a...

Authors: Kap Su Han, Su Jin Kim, Eui Jung Lee, Joong Ho Shin, Ji Sung Lee and Sung Woo Lee

Hospital networks and patient transport capacity during the COVID-19 pandemic when intensive care resources become scarce

Authors: Alexander Supady, Dawid Staudacher, Christoph Bode, Guido Michels and Tobias Wengenmayer

Incidence, prognostic factors, and outcomes of venous thromboembolism in critically ill patients: data from two prospective cohort studies

The objective of this study was to describe the prevalence, incidence, prognostic factors, and outcomes of venous thromboembolism in critically ill patients receiving contemporary thrombosis prophylaxis.

Authors: Ruben J. Eck, Lisa Hulshof, Renske Wiersema, Chris H. L. Thio, Bart Hiemstra, Niels C. Gritters van den Oever, Reinold O. B. Gans, Iwan C. C. van der Horst, Karina Meijer and Frederik Keus

Duration of diaphragmatic inactivity after endotracheal intubation of critically ill patients

In patients intubated for mechanical ventilation, prolonged diaphragm inactivity could lead to weakness and poor outcome. Time to resume a minimal diaphragm activity may be related to sedation practice and pat...

Authors: Michael Chaim Sklar, Fabiana Madotto, Annemijn Jonkman, Michela Rauseo, Ibrahim Soliman, L. Felipe Damiani, Irene Telias, Sebastian Dubo, Lu Chen, Nuttapol Rittayamai, Guang-Qiang Chen, Ewan C. Goligher, Martin Dres, Remi Coudroy, Tai Pham, Ricard M. Artigas…

Ventilator-associated pneumonia in critically ill patients with COVID-19

Pandemic COVID-19 caused by the coronavirus SARS-CoV-2 has a high incidence of patients with severe acute respiratory syndrome (SARS). Many of these patients require admission to an intensive care unit (ICU) f...

Authors: Mailis Maes, Ellen Higginson, Joana Pereira-Dias, Martin D. Curran, Surendra Parmar, Fahad Khokhar, Delphine Cuchet-Lourenço, Janine Lux, Sapna Sharma-Hajela, Benjamin Ravenhill, Islam Hamed, Laura Heales, Razeen Mahroof, Amelia Soderholm, Sally Forrest, Sushmita Sridhar…

Burden of pneumococcal pneumonia requiring ICU admission in France: 1-year prognosis, resources use, and costs

Community-acquired pneumonia (CAP), especially pneumococcal CAP (P-CAP), is associated with a heavy burden of illness as evidenced by high rates of intensive care unit (ICU) admission, mortality, and costs. Al...

Authors: Claire Dupuis, Ayman Sabra, Juliette Patrier, Gwendoline Chaize, Amine Saighi, Céline Féger, Alexandre Vainchtock, Jacques Gaillat and Jean-François Timsit

Alveolar compartmentalization of inflammatory and immune cell biomarkers in pneumonia-related ARDS

Biomarkers of disease severity might help individualizing the management of patients with the acute respiratory distress syndrome (ARDS). Whether the alveolar compartmentalization of biomarkers has a clinical ...

Authors: Inès Bendib, Asma Beldi-Ferchiou, Frédéric Schlemmer, Mathieu Surenaud, Bernard Maitre, Anne Plonquet, Guillaume Carteaux, Keyvan Razazi, Veronique Godot, Sophie Hüe, Armand Mekontso Dessap and Nicolas de Prost

Knowledge translation tools to guide care of non-intubated patients with acute respiratory illness during the COVID-19 Pandemic

Providing optimal care to patients with acute respiratory illness while preventing hospital transmission of COVID-19 is of paramount importance during the pandemic; the challenge lies in achieving both goals s...

Authors: David Leasa, Paul Cameron, Kimia Honarmand, Tina Mele and Karen J. Bosma

Hemodynamic and anti-inflammatory effects of early esmolol use in hyperkinetic septic shock: a pilot study

Several studies have shown that heart rate control with selective beta-1 blockers in septic shock is safe. In these trials, esmolol was administered 24 h after onset of septic shock in patients who remained ta...

Authors: Bruno Levy, Caroline Fritz, Caroline Piona, Kevin Duarte, Andrea Morelli, Philippe Guerci, Antoine Kimmoun and Nicolas Girerd

The immune modulatory effects of mitochondrial transplantation on cecal slurry model in rat

Sepsis has a high mortality rate, but no specific drug has been proven effective, prompting the development of new drugs. Immunologically, sepsis can involve hyperinflammation, immune paralysis, or both, which...

Authors: Jung Wook Hwang, Min Ji Lee, Tae Nyoung Chung, Han A. Reum Lee, Jung Ho Lee, Seo Yoon Choi, Ye Jin Park, Chul Hee Kim, Isom Jin, Seong Hoon Kim, Hyo-Bum Kwak, Jun-Won Heo, Kwangmin Na, Sangchun Choi, Yong-Soo Choi and Kyuseok Kim

Ketamine in acute phase of severe traumatic brain injury “an old drug for new uses?”

Maintaining an adequate level of sedation and analgesia plays a key role in the management of traumatic brain injury (TBI). To date, it is unclear which drug or combination of drugs is most effective in achiev...

Authors: Daniel Agustin Godoy, Rafael Badenes, Paolo Pelosi and Chiara Robba

A randomized trial of albumin infusion to prevent intradialytic hypotension in hospitalized hypoalbuminemic patients

Intradialytic hypotension (IDH) is a frequent complication of intermittent hemodialysis (IHD), occurring from 15 to 50% of ambulatory sessions, and is more frequent among hospitalized patients with hypoalbumin...

Authors: Etienne Macedo, Bethany Karl, Euyhyun Lee and Ravindra L. Mehta

Systematic early versus late mobilization or standard early mobilization in mechanically ventilated adult ICU patients: systematic review and meta-analysis

This systematic review and meta-analysis aimed to determine the effectiveness of systematic early mobilization in improving muscle strength and physical function in mechanically ventilated intensive care unit ...

Authors: Dominik Menges, Bianca Seiler, Yuki Tomonaga, Matthias Schwenkglenks, Milo A. Puhan and Henock G. Yebyo

Endotracheal aspirates contain a limited number of lower respiratory tract immune cells

Authors: Marika Orlov, Eric D. Morrell, Victoria Dmyterko, Jessica A. Hamerman, Mark M. Wurfel and Carmen Mikacenic

Characteristics and clinical outcomes of culture-negative and culture-positive septic shock: a single-center retrospective cohort study

We evaluated the characteristics and outcomes of culture-negative versus culture-positive septic shock.

Authors: June-sung Kim, Youn-Jung Kim and Won Young Kim

Problems in care and avoidability of death after discharge from intensive care: a multi-centre retrospective case record review study

Over 138,000 patients are discharged to hospital wards from intensive care units (ICUs) in England, Wales and Northern Ireland annually. More than 8000 die before leaving hospital. In hospital-wide populations...

Authors: Sarah Vollam, Owen Gustafson, J. Duncan Young, Benjamin Attwood, Liza Keating and Peter Watkinson

Venoarterial extracorporeal membrane oxygenation induces early immune alterations

Venoarterial extracorporeal membrane oxygenation (VA-ECMO) provides heart mechanical support in critically ill patients with cardiogenic shock. Despite important progresses in the management of patients under ...

Authors: Aurélien Frerou, Mathieu Lesouhaitier, Murielle Gregoire, Fabrice Uhel, Arnaud Gacouin, Florian Reizine, Caroline Moreau, Aurélie Loirat, Adel Maamar, Nicolas Nesseler, Amedeo Anselmi, Erwan Flecher, Jean-Philippe Verhoye, Yves Le Tulzo, Michel Cogné, Mikael Roussel…