Articles
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Citation: Critical Care 2023 27:281
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Magic mirror on the wall, which is the best meta-analysis one of all?
Citation: Critical Care 2023 27:280 -
Harmful effects of propofol? The Editor’s standpoint
Citation: Critical Care 2023 27:279 -
Association between intrarenal venous flow from Doppler ultrasonography and acute kidney injury in patients with sepsis in critical care: a prospective, exploratory observational study
Intrarenal venous flow (IRVF) patterns assessed using Doppler renal ultrasonography are real-time bedside visualizations of renal vein hemodynamics. Although this technique has the potential to detect renal co...
Citation: Critical Care 2023 27:278 -
A user evaluation of speech/phrase recognition software in critically ill patients: a DECIDE-AI feasibility study
Evaluating effectiveness of speech/phrase recognition software in critically ill patients with speech impairments.
Citation: Critical Care 2023 27:277 -
Evaluation of Proenkephalin A 119–159 for liberation from renal replacement therapy: an external, multicenter pilot study in critically ill patients with acute kidney injury
Recent evidence suggests an association of plasma Proenkephalin A 119–159 (penKid) with early and successful liberation from continuous renal replacement therapy (CRRT) in critically ill patients with acute ki...
Citation: Critical Care 2023 27:276 -
Continuous renal replacement therapy with the adsorptive oXiris filter may be associated with the lower 28-day mortality in sepsis: a systematic review and meta-analysis
The oXiris is a novel filter for continuous renal replacement therapy (CRRT) featuring an adsorption coating to adsorb endotoxins and remove inflammatory mediators. Given that no consensus has been reached on ...
Citation: Critical Care 2023 27:275 -
Efficacy and safety of adjunctive corticosteroids in the treatment of severe community-acquired pneumonia: a systematic review and meta-analysis of randomized controlled trials
This systematic review and meta-analysis aimed to investigate the clinical efficacy and safety of systemic corticosteroids in the treatment of patients with severe community-acquired pneumonia (sCAP).
Citation: Critical Care 2023 27:274 -
A novel method for assessment of airway opening pressure without the need for low-flow insufflation
Airway opening pressure (AOP) detection and measurement are essential for assessing respiratory mechanics and adapting ventilation. We propose a novel approach for AOP assessment during volume assist control v...
Citation: Critical Care 2023 27:273 -
Development and validation of the creatinine clearance predictor machine learning models in critically ill adults
In critically ill patients, measured creatinine clearance (CrCl) is the most reliable method to evaluate glomerular filtration rate in routine clinical practice and may vary subsequently on a day-to-day basis....
Citation: Critical Care 2023 27:272 -
How artificial intelligence will affect the future of medical publishing
Citation: Critical Care 2023 27:271 -
Artificial intelligence is the new chief editor of Critical Care (maybe?)
Citation: Critical Care 2023 27:270 -
Plasma protein biomarkers reflective of the host response in patients developing Intensive Care Unit-acquired pneumonia
Immune suppression has been implicated in the occurrence of pneumonia in critically ill patients. We tested the hypothesis that Intensive Care Unit (ICU)-acquired pneumonia is associated with broad host immune...
Citation: Critical Care 2023 27:269 -
Computational physiological models for individualised mechanical ventilation: a systematic literature review focussing on quality, availability, and clinical readiness
Individualised optimisation of mechanical ventilation (MV) remains cumbersome in modern intensive care medicine. Computerised, model-based support systems could help in tailoring MV settings to the complex int...
Citation: Critical Care 2023 27:268 -
Trauma-induced disturbances in ionized calcium levels correlate parabolically with coagulopathy, transfusion, and mortality: a multicentre cohort analysis from the TraumaRegister DGU®
To which extent trauma- induced disturbances in ionized calcium (iCa2+) levels have a linear relationship with adverse outcomes remains controversial. The goal of this study was to determine the association be...
Citation: Critical Care 2023 27:267 -
Moderate exercise-induced dynamics on key sepsis-associated signaling pathways in the liver
There is a clear relationship between quantitative measures of fitness (e.g., VO2 max) and outcomes after surgical procedures. Whether or not fitness is a modifiable risk factor and what underlying biological pro...
Citation: Critical Care 2023 27:266 -
Definitions of massive transfusion in adults with critical bleeding: a systematic review
Definitions for massive transfusion (MT) vary widely between studies, contributing to challenges in interpretation of research findings and practice evaluation. In this first systematic review, we aimed to ide...
Citation: Critical Care 2023 27:265 -
Extended prone positioning for intubated ARDS: a review
During the COVID-19 pandemic, several centers had independently reported extending prone positioning beyond 24 h. Most of these centers reported maintaining patients in prone position until significant clinica...
Citation: Critical Care 2023 27:264 -
A targeted metabolomics approach for sepsis-induced ARDS and its subphenotypes
Acute respiratory distress syndrome (ARDS) is etiologically and clinically a heterogeneous disease. Its diagnostic characteristics and subtype classification, and the application of these features to treatment...
Citation: Critical Care 2023 27:263 -
A new reservoir-based CPAP with low oxygen consumption: the Bag-CPAP
Several noninvasive ventilatory supports rely in their design on high oxygen consumption which may precipitate oxygen shortage, as experienced during the COVID-19 pandemic. In this bench-to-bedside study, we a...
Citation: Critical Care 2023 27:262 -
Personalized nutrition therapy in critical care: 10 expert recommendations
Personalization of ICU nutrition is essential to future of critical care. Recommendations from American/European guidelines and practice suggestions incorporating recent literature are presented. Low-dose ente...
Citation: Critical Care 2023 27:261 -
Prognostic and predictive value of endothelial dysfunction biomarkers in sepsis-associated acute kidney injury: risk-stratified analysis from a prospective observational cohort of pediatric septic shock
Sepsis-associated acute kidney injury (SA-AKI) is associated with high morbidity, with no current therapies available beyond continuous renal replacement therapy (CRRT). Systemic inflammation and endothelial d...
Citation: Critical Care 2023 27:260 -
Acute-on-chronic liver failure: far to go—a review
Acute-on-chronic liver failure (ACLF) has been recognized as a severe clinical syndrome based on the acute deterioration of chronic liver disease and is characterized by organ failure and high short-term morta...
Citation: Critical Care 2023 27:259 -
How to avoid harm with feeding critically ill patients: a synthesis of viewpoints of a basic scientist, dietitian and intensivist
The optimal feeding strategy in critically ill patients is a matter of debate, with current guidelines recommending different strategies regarding energy and protein targets. Several recent trials have added t...
Citation: Critical Care 2023 27:258 -
Clinical benefit of AI-assisted lung ultrasound in a resource-limited intensive care unit
Interpreting point-of-care lung ultrasound (LUS) images from intensive care unit (ICU) patients can be challenging, especially in low- and middle- income countries (LMICs) where there is limited training avail...
Citation: Critical Care 2023 27:257 -
Telemedical support for prehospital emergency medical service in severe emergencies: an open-label randomised non-inferiority clinical trial
A tele-emergency medical service with a remote emergency physician for severe prehospital emergencies may overcome the increasing number of emergency calls and shortage of emergency medical service providers. ...
Citation: Critical Care 2023 27:256 -
Authors’ reply to the comment from Benavides-Zora et al.
Citation: Critical Care 2023 27:255 -
Human-centered visualization technologies for patient monitoring are the future: a narrative review
Medical technology innovation has improved patient monitoring in perioperative and intensive care medicine and continuous improvement in the technology is now a central focus in this field. Because data densit...
Citation: Critical Care 2023 27:254 -
A tribute to Paolo Pelosi
Citation: Critical Care 2023 27:253 -
Prevalence, reasons, and timing of decisions to withhold/withdraw life-sustaining therapy for out-of-hospital cardiac arrest patients with extracorporeal cardiopulmonary resuscitation
Extracorporeal cardiopulmonary resuscitation (ECPR) is rapidly becoming a common treatment strategy for patients with refractory cardiac arrest. Despite its benefits, ECPR raises a variety of ethical concerns ...
Citation: Critical Care 2023 27:252 -
The association of hypoglycemia with outcome of critically ill children in relation to nutritional and blood glucose control strategies
Withholding parenteral nutrition (PN) until one week after PICU admission facilitated recovery from critical illness and protected against emotional and behavioral problems 4 years later. However, the interven...
Citation: Critical Care 2023 27:251 -
Detrimental effects of PCSK9 loss-of-function in the pediatric host response to sepsis are mediated through independent influence on Angiopoietin-1
Sepsis is associated with significant mortality. Yet, there are no efficacious therapies beyond antibiotics. PCSK9 loss-of-function (LOF) and inhibition, through enhanced low-density lipoprotein receptor (LDLR) m...
Citation: Critical Care 2023 27:250 -
Cerebral apolipoprotein E and amyloid precursor-like protein 1 as risk factors for chronic neurodegeneration after non-traumatic acute brain injury (ABI)
Citation: Critical Care 2023 27:249 -
Incidence and clinical features of HHV-7 detection in lower respiratory tract in patients with severe pneumonia: a multicenter, retrospective study
The significance of detecting human herpesvirus 7 (HHV-7) in the lower respiratory tract of patients with severe pneumonia is unclear. This study aims to evaluate the clinical characteristics and prognosis of ...
Citation: Critical Care 2023 27:248 -
Respiratory challenges and ventilatory management in different types of acute brain-injured patients
Acute brain injury (ABI) covers various clinical entities that may require invasive mechanical ventilation (MV) in the intensive care unit (ICU). The goal of MV, which is to protect the lung and the brain from...
Citation: Critical Care 2023 27:247 -
The absolute value of recruitment-to-inflation ratio does not correlate with the recruited volume
Citation: Critical Care 2023 27:246 -
Targeted therapy using polymyxin B hemadsorption in patients with sepsis: a post-hoc analysis of the JSEPTIC-DIC study and the EUPHRATES trial
Polymyxin B hemadsorption (PMX-HA) reduces blood endotoxin levels, but characteristics of patients with sepsis likely to benefit from PMX-HA are not well known. We sought to identify patient subgroups likely t...
Citation: Critical Care 2023 27:245 -
Modifications of lung microbiota structure in traumatic brain injury ventilated patients according to time and enteral feeding formulas: a prospective randomized study
Specialized diets enriched with immune nutrients could be an important supplement in patients (pts) with acute traumatic brain injury (TBI). Omega-3 and arginine may interact with immune response and microbiot...
Citation: Critical Care 2023 27:244 -
Extracorporeal hemoadsorption in critically ill COVID-19 patients on VV ECMO: the CytoSorb therapy in COVID-19 (CTC) registry
The CytoSorb therapy in COVID-19 (CTC) registry evaluated the clinical performance and treatment parameters of extracorporeal hemoadsorption integrated with veno-venous extracorporeal membrane oxygenation (VV ...
Citation: Critical Care 2023 27:243 -
Volume of oxygen administered during mechanical ventilation predicts mortality in ICU patients
Citation: Critical Care 2023 27:242 -
International survey of antibiotic dosing and monitoring in adult intensive care units
In recent years, numerous dosing studies have been conducted to optimize therapeutic antibiotic exposures in patients with serious infections. These studies have led to the inclusion of dose optimization recom...
Citation: Critical Care 2023 27:241 -
Prone position versus usual care in hypoxemic COVID-19 patients in medical wards: a randomised controlled trial
Benefit of early awake prone positioning for COVID-19 patients hospitalised in medical wards and who need oxygen therapy remains to be demonstrated. The question was considered at the time of COVID-19 pandemic...
Citation: Critical Care 2023 27:240 -
A long-lasting porcine model of ARDS caused by pneumonia and ventilator-induced lung injury
Animal models of acute respiratory distress syndrome (ARDS) do not completely resemble human ARDS, struggling translational research. We aimed to characterize a porcine model of ARDS induced by pneumonia—the m...
Citation: Critical Care 2023 27:239 -
“Under pressure”: should we use diaphragm excursion to predict weaning success in patients receiving pressure support ventilation?
Citation: Critical Care 2023 27:238 -
Comment to: “Propofol and survival: an updated meta-analysis of randomized clinical trials”: authors’ reply
Citation: Critical Care 2023 27:237 -
Time to treatment and mortality for clinical sepsis subtypes
Sepsis is common, deadly, and heterogenous. Prior analyses of patients with sepsis and septic shock in New York State showed a risk-adjusted association between more rapid antibiotic administration and bundled...
Citation: Critical Care 2023 27:236 -
The oxygen reactivity index indicates disturbed local perfusion regulation after aneurysmal subarachnoid hemorrhage: an observational cohort study
Cerebral autoregulation (CA) can be impaired in patients with delayed cerebral ischemia (DCI) after aneurysmal subarachnoid hemorrhage (aSAH). The Pressure Reactivity Index (PRx, correlation of blood pressure and...
Citation: Critical Care 2023 27:235 -
Early plasma angiopoietin-2 is prognostic for ARDS and mortality among critically ill patients with sepsis
Angiopoietin-2 (Ang-2) is associated with vascular endothelial injury and permeability in the acute respiratory distress syndrome (ARDS) and sepsis. Elevated circulating Ang-2 levels may identify critically il...
Citation: Critical Care 2023 27:234 -
Tidal lung hysteresis to interpret PEEP-induced changes in compliance in ARDS patients
In ARDS, the PEEP level associated with the best respiratory system compliance is often selected; however, intra-tidal recruitment can increase compliance, falsely suggesting improvement in baseline mechanics....
Citation: Critical Care 2023 27:233 -
Polymyxin B therapy based on therapeutic drug monitoring in carbapenem-resistant organisms sepsis: the PMB-CROS randomized clinical trial
The appropriate administration regimen of polymyxin B is yet controversial. The present study aimed to explore the optimal dose of polymyxin B under therapeutic drug monitoring (TDM) guidance.
Citation: Critical Care 2023 27:232
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- ISSN: 1364-8535 (electronic)