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  1. Content type: Research

    The association of plasma interleukin-8 (IL-8), or IL-8 genetic variants, with pediatric acute respiratory distress syndrome (PARDS) in children with acute respiratory failure at risk for PARDS has not been ex...

    Authors: Heidi Flori, Anil Sapru, Michael W. Quasney, Ginny Gildengorin, Martha A. Q. Curley, Michael A. Matthay and Mary K. Dahmer

    Citation: Critical Care 2019 23:128

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  2. Content type: Research

    Diaphragm weakness occurs rapidly in adult animals treated with mechanical ventilation (MV), but the effects of MV on the neonatal diaphragm have not been determined. Furthermore, it is unknown whether co-exis...

    Authors: Feng Liang, Guillaume Emeriaud, Dilson E. Rassier, Dong Shang, Ekaterina Gusev, Sabah N. A. Hussain, Michael Sage, Benjamin Crulli, Etienne Fortin-Pellerin, Jean-Paul Praud and Basil J. Petrof

    Citation: Critical Care 2019 23:123

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  3. Content type: Research

    The pressure-volume (P-V) curve has been suggested as a bedside tool to set mechanical ventilation; however, it reflects a global behavior of the lung without giving information on the regional mechanical propert...

    Authors: Gaetano Scaramuzzo, Savino Spadaro, Andreas D. Waldmann, Stephan H. Böhm, Riccardo Ragazzi, Elisabetta Marangoni, Valentina Alvisi, Elena Spinelli, Tommaso Mauri and Carlo Alberto Volta

    Citation: Critical Care 2019 23:119

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  4. Content type: Research

    Endothelial hyperpermeability following cardiopulmonary bypass (CPB) contributes to microcirculatory perfusion disturbances and postoperative complications after cardiac surgery. We investigated the postoperat...

    Authors: Nicole A. M. Dekker, Anoek L. I. van Leeuwen, Willem W. J. van Strien, Jisca Majolée, Robert Szulcek, Alexander B. A. Vonk, Peter L. Hordijk, Christa Boer and Charissa E. van den Brom

    Citation: Critical Care 2019 23:117

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  5. Content type: Research

    In critically ill patients, changes in the velocity-time integral (VTI) of the left ventricular outflow tract, measured by transthoracic echocardiography (TTE), are often used to non-invasively assess the resp...

    Authors: Mathieu Jozwiak, Pablo Mercado, Jean-Louis Teboul, Anouar Benmalek, Julia Gimenez, François Dépret, Christian Richard and Xavier Monnet

    Citation: Critical Care 2019 23:116

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  6. Content type: Research

    Neutrophil extracellular traps (NETs) are innate defense mechanisms that are also implicated in the pathogenesis of organ dysfunction. However, the role of NETs in pediatric sepsis is unknown.

    Authors: David F. Colón, Carlos W. Wanderley, Marcelo Franchin, Camila M. Silva, Carlos H. Hiroki, Fernanda V. S. Castanheira, Paula B. Donate, Alexandre H. Lopes, Leila C. Volpon, Silvia K. Kavaguti, Vanessa F. Borges, Cesar A. Speck-Hernandez, Fernando Ramalho, Ana P. Carlotti, Fabio Carmona, Jose C. Alves-Filho…

    Citation: Critical Care 2019 23:113

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  7. Content type: Research

    Microaspiration of gastric and oropharyngeal secretions is the main mechanism of entry of bacteria into the lower respiratory tract in intubated critically ill patients. The aim of this study is to determine t...

    Authors: Saad Nseir, Amélie Le Gouge, Jean-Baptiste Lascarrou, Jean-Claude Lacherade, Emmanuelle Jaillette, Jean-Paul Mira, Emmanuelle Mercier, Pierre-Louis Declercq, Michel Sirodot, Gaël Piton, François Tinturier, Elisabeth Coupez, Stéphane Gaudry, Michel Djibré, Didier Thevenin, Jeremy Pasco…

    Citation: Critical Care 2019 23:111

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  8. Content type: Research

    CAP (Community acquired pneumonia) is frequent, with a high mortality rate and a high burden on health care systems. Development of predictive biomarkers, new therapeutic concepts, and epidemiologic research r...

    Authors: Peter Ahnert, Petra Creutz, Katrin Horn, Fabian Schwarzenberger, Michael Kiehntopf, Hamid Hossain, Michael Bauer, Frank Martin Brunkhorst, Konrad Reinhart, Uwe Völker, Trinad Chakraborty, Martin Witzenrath, Markus Löffler, Norbert Suttorp and Markus Scholz

    Citation: Critical Care 2019 23:110

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  9. Content type: Research

    Cardiopulmonary bypass (CPB) is often associated with degrees of complex inflammatory response mediated by various cytokines. This response can, in severe cases, lead to systemic hypotension and organ dysfunct...

    Authors: Elettra C Poli, Lorenzo Alberio, Anna Bauer-Doerries, Carlo Marcucci, Aurélien Roumy, Matthias Kirsch, Eleonora De Stefano, Lucas Liaudet and Antoine G Schneider

    Citation: Critical Care 2019 23:108

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  10. Content type: Research

    In patients who recover consciousness after cardiac arrest (CA), a subsequent death from non-neurological causes may confound the assessment of long-term neurological outcome. We investigated the prevalence an...

    Authors: Fabio Silvio Taccone, Janneke Horn, Christian Storm, Alain Cariou, Claudio Sandroni, Hans Friberg, Cornelia Astrid Hoedemaekers and Mauro Oddo

    Citation: Critical Care 2019 23:107

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    The Commentary to this article has been published in Critical Care 2019 23:246

  11. Content type: Research

    Underfeeding in critical illness is common and associated with poor outcomes. According to large prospective hospital studies, volume-based feeding (VBF) safely and effectively improves energy and protein deli...

    Authors: Sue Brierley-Hobson, Graham Clarke and Vincent O’Keeffe

    Citation: Critical Care 2019 23:105

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  12. Content type: Review

    Beta-lactam antibiotics (βLA) are the most commonly used antibiotics in the intensive care unit (ICU). ICU patients present many pathophysiological features that cause pharmacokinetic (PK) and pharmacodynamic ...

    Authors: Romain Guilhaumou, Sihem Benaboud, Youssef Bennis, Claire Dahyot-Fizelier, Eric Dailly, Peggy Gandia, Sylvain Goutelle, Sandrine Lefeuvre, Nicolas Mongardon, Claire Roger, Julien Scala-Bertola, Florian Lemaitre and Marc Garnier

    Citation: Critical Care 2019 23:104

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  13. Content type: Research

    Mechanical ventilation can lead to ventilator-induced lung injury (VILI). In addition to the well-known mechanical forces of volutrauma, barotrauma, and atelectrauma, non-mechanical mechanisms have recently be...

    Authors: Stefan Boehme, Erik K. Hartmann, Thomas Tripp, Serge C. Thal, Matthias David, Dietmar Abraham, James E. Baumgardner, Klaus Markstaller and Klaus U. Klein

    Citation: Critical Care 2019 23:102

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  14. Content type: Research

    The benefits of early epinephrine administration in pediatric with nontraumatic out-of-hospital cardiac arrest (OHCA) have been reported; however, the effects in pediatric cases of traumatic OHCA are unclear. ...

    Authors: Yan-Ren Lin, Meng-Huan Wu, Tren-Yi Chen, Yuan-Jhen Syue, Mei-Chueh Yang, Tsung-Han Lee, Chih-Ming Lin, Chu-Chung Chou, Chin-Fu Chang and Chao-Jui Li

    Citation: Critical Care 2019 23:101

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  15. Content type: Research

    The effect of corticosteroids on clinical outcomes in patients with influenza pneumonia remains controversial. We aimed to further evaluate the influence of corticosteroids on mortality in adult patients with ...

    Authors: Yue-Nan Ni, Guo Chen, Jiankui Sun, Bin-Miao Liang and Zong-An Liang

    Citation: Critical Care 2019 23:99

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  16. Content type: Research

    Severe traumatic injury continues to present challenges to healthcare systems around the world, and post-traumatic bleeding remains a leading cause of potentially preventable death among injured patients. Now ...

    Authors: Donat R. Spahn, Bertil Bouillon, Vladimir Cerny, Jacques Duranteau, Daniela Filipescu, Beverley J. Hunt, Radko Komadina, Marc Maegele, Giuseppe Nardi, Louis Riddez, Charles-Marc Samama, Jean-Louis Vincent and Rolf Rossaint

    Citation: Critical Care 2019 23:98

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  17. Content type: Research

    We aimed to develop a set of quality indicators for patients with traumatic brain injury (TBI) in intensive care units (ICUs) across Europe and to explore barriers and facilitators for implementation of these ...

    Authors: Jilske A. Huijben, Eveline J. A. Wiegers, Nicolette F. de Keizer, Andrew I. R. Maas, David Menon, Ari Ercole, Giuseppe Citerio, Fiona Lecky, Lindsay Wilson, Maryse C. Cnossen, Suzanne Polinder, Ewout W. Steyerberg, Mathieu van der Jagt and Hester F. Lingsma

    Citation: Critical Care 2019 23:95

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  18. Content type: Research

    Sepsis results from a dysregulated host response to an infection that is associated with an imbalance between pro- and anti-inflammatory cytokines. This imbalance is hypothesized to be a driver of patient mort...

    Authors: Mallory Sheth, Corey M. Benedum, Leo Anthony Celi, Roger G. Mark and Natasha Markuzon

    Citation: Critical Care 2019 23:93

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  19. Content type: Research

    Anemia is frequent among patients with traumatic brain injury (TBI) and is associated with an increased risk of poor outcome. The optimal hemoglobin concentration to trigger red blood cell (RBC) transfusion in...

    Authors: André L. N. Gobatto, Milena A. Link, Davi J. Solla, Estevão Bassi, Paulo F. Tierno, Wellingson Paiva, Fabio S. Taccone and Luiz M. Malbouisson

    Citation: Critical Care 2019 23:89

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    The Letter to this article has been published in Critical Care 2019 23:189

  20. Content type: Research

    Continuous coordination among organ systems is necessary to maintain biological stability in humans. Organ system network analysis in addition to organ-oriented medicine is expected to improve patient outcomes...

    Authors: Toshifumi Asada, Kent Doi, Ryota Inokuchi, Naoki Hayase, Miyuki Yamamoto and Naoto Morimura

    Citation: Critical Care 2019 23:83

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  21. Content type: Review

    This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2019. Other selected articles can be found online at

    Authors: Irene Telias and Mary Elizabeth Wilcox

    Citation: Critical Care 2019 23:82

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