Articles

Benefits of red blood cell transfusion in patients with traumatic brain injury

Authors: Weimin Zhang, Kailei Du and Xuping Chen

Detailed measurements of oesophageal pressure during mechanical ventilation with an advanced high-resolution manometry catheter

Oesophageal pressure (PES) is used for calculation of lung and chest wall mechanics and transpulmonary pressure during mechanical ventilation. Measurements performed with a balloon catheter are suggested as a ...

Authors: Per Persson, Rebecca Ahlstrand, Magni Gudmundsson, Alex de Leon and Stefan Lundin

How to achieve nutrition goals by actual nutrition guidelines

Authors: Christian Stoppe, Jean-Charles Preiser and Daren Heyland

Influenza virus-related critical illness: prevention, diagnosis, treatment

Annual seasonal influenza epidemics of variable severity result in significant morbidity and mortality in the United States (U.S.) and worldwide. In temperate climate countries, including the U.S., influenza a...

Authors: Eric J. Chow, Joshua D. Doyle and Timothy M. Uyeki

Prevalence of post-traumatic stress disorder symptoms in adult critical care survivors: a systematic review and meta-analysis

As more patients are surviving intensive care, mental health concerns in survivors have become a research priority. Among these, post-traumatic stress disorder (PTSD) can have an important impact on the qualit...

Authors: Cássia Righy, Regis Goulart Rosa, Rodrigo Teixeira Amancio da Silva, Renata Kochhann, Celina Borges Migliavaca, Caroline Cabral Robinson, Stefania Pigatto Teche, Cassiano Teixeira, Fernando Augusto Bozza and Maicon Falavigna

Aetiology and outcomes of sepsis in adults in sub-Saharan Africa: a systematic review and meta-analysis

Aetiology and outcomes of sepsis in sub-Saharan Africa (sSA) are poorly described; we performed a systematic review and meta-analysis to summarise the available data.

Authors: Joseph M. Lewis, Nicholas A. Feasey and Jamie Rylance

Mottling score is a strong predictor of 14-day mortality in septic patients whatever vasopressor doses and other tissue perfusion parameters

Mottling score, a tissue perfusion parameter, is correlated with outcome in septic shock patients. However, its predictive value on mortality according to prognostic covariates such as vasopressor dose and oth...

Authors: Guillaume Dumas, Jean-Rémi Lavillegrand, Jérémie Joffre, Naïke Bigé, Edmilson Bastos de-Moura, Jean-Luc Baudel, Sylvie Chevret, Bertrand Guidet, Eric Maury, Fabio Amorim and Hafid Ait-Oufella

Interventions to improve cardiopulmonary resuscitation: a review of meta-analyses and future agenda

Authors: Athanasios Chalkias and John P. A. Ioannidis

Decompressive craniectomy for acute ischemic stroke

Malignant stroke occurs in a subgroup of patients suffering from ischemic cerebral infarction and is characterized by neurological deterioration due to progressive edema, raised intracranial pressure, and cere...

Authors: Thomas Beez, Christopher Munoz-Bendix, Hans-Jakob Steiger and Kerim Beseoglu

The ecological effects of selective decontamination of the digestive tract (SDD) on antimicrobial resistance: a 21-year longitudinal single-centre study

The long-term ecological effects on the emergence of antimicrobial resistance at the ICU level during selective decontamination of the digestive tract (SDD) are unknown. We determined the incidence of newly ac...

Authors: Sophie Buitinck, Rogier Jansen, Saskia Rijkenberg, Jos P. J. Wester, Rob J. Bosman, Nardo J. M. van der Meer and Peter H. J. van der Voort

Examining the weekend effect across ICU performance metrics

Known colloquially as the “weekend effect,” the association between weekend admissions and increased mortality within hospital settings has become a highly contested topic over the last two decades. Drawing in...

Authors: Louis Faust, Keith Feldman and Nitesh V. Chawla

Reversal of oral anticoagulation in patients with acute intracerebral hemorrhage

In light of an aging population with increased cardiovascular comorbidity, the use of oral anticoagulation (OAC) is steadily expanding. A variety of pharmacological alternatives to vitamin K antagonists (VKA) ...

Authors: Joji B. Kuramatsu, Jochen A. Sembill and Hagen B. Huttner

Population pharmacokinetics of total and unbound concentrations of intravenous posaconazole in adult critically ill patients

The population pharmacokinetics of total and unbound posaconazole following intravenous administration has not yet been described for the critically ill patient population. The aim of this work was, therefore,...

Authors: Fekade B. Sime, Catherine J. Byrne, Suzanne Parker, Janine Stuart, Jenie Butler, Therese Starr, Saurabh Pandey, Steven C. Wallis, Jeffrey Lipman and Jason A. Roberts

ELS (Ethical Life Support): a new teaching tool for medical ethics

Authors: Marco Vergano, Giuseppe Naretto, Fabrizio Elia, Enrico Gandolfo, Chiara Nebris Calliera and Giuseppe R. Gristina

In-hospital mortality associated with the misdiagnosis or unidentified site of infection at admission

Rapid detection, early resuscitation, and appropriate antibiotic use are crucial for sepsis care. Accurate identification of the site of infection may facilitate a timely provision of appropriate care. We aime...

Authors: Toshikazu Abe, Yasuharu Tokuda, Atsushi Shiraishi, Seitaro Fujishima, Toshihiko Mayumi, Takehiro Sugiyama, Gautam A. Deshpande, Yasukazu Shiino, Toru Hifumi, Yasuhiro Otomo, Kohji Okamoto, Joji Kotani, Yuichiro Sakamoto, Junichi Sasaki, Shin-ichiro Shiraishi, Kiyotsugu Takuma…

Effect of high-flow nasal therapy on dyspnea, comfort, and respiratory rate

Authors: Andrea Cortegiani, Claudia Crimi, Alberto Noto, Yigal Helviz, Antonino Giarratano, Cesare Gregoretti and Sharon Einav

Trying to identify who may benefit most from future vitamin D intervention trials: a post hoc analysis from the VITDAL-ICU study excluding the early deaths

Vitamin D supplementation has shown promise for reducing mortality in the intensive care setting. As a steroid prohormone with pleiotropic effects, there may be a lag between administration and observing clini...

Authors: Gennaro Martucci, Dayre McNally, Dhruv Parekh, Paul Zajic, Fabio Tuzzolino, Antonio Arcadipane, Kenneth B. Christopher, Harald Dobnig and Karin Amrein

Short-term assist devices in postcardiotomy cardiogenic shock

Authors: Hasan Iner, Nihan Karakas Yesilkaya, Yuksel Besir, Gamze Gokalp, Orhan Gokalp, Levent Yilik and Ali Gurbuz

Post-stroke treatment with argon attenuated brain injury, reduced brain inflammation and enhanced M2 microglia/macrophage polarization: a randomized controlled animal study

In recent years, argon has been shown to exert neuroprotective effects in an array of models. However, the mechanisms by which argon exerts its neuroprotective characteristics remain unclear. Accumulating evid...

Authors: Jingjin Liu, Kay Nolte, Gary Brook, Lisa Liebenstund, Agnieszka Weinandy, Anke Höllig, Michael Veldeman, Antje Willuweit, Karl-Josef Langen, Rolf Rossaint and Mark Coburn

Frequency and mortality of septic shock in Europe and North America: a systematic review and meta-analysis

Septic shock is the most severe form of sepsis, in which profound underlying abnormalities in circulatory and cellular/metabolic parameters lead to substantially increased mortality. A clear understanding and ...

Authors: Jean-Louis Vincent, Gabriel Jones, Sholto David, Elena Olariu and Kevin K. Cadwell

Dysbiosis of the intestinal microbiota in neurocritically ill patients and the risk for death

Despite the essential functions of the intestinal microbiota in human physiology, little has been reported about the microbiome in neurocritically ill patients. This investigation aimed to evaluate the charact...

Authors: Ruoting Xu, Chuhong Tan, Jiajia Zhu, Xiuli Zeng, Xuxuan Gao, Qiheng Wu, Qiong Chen, Huidi Wang, Hongwei Zhou, Yan He, Suyue Pan and Jia Yin

Automated continuous noninvasive ward monitoring: future directions and challenges

Automated continuous noninvasive ward monitoring may enable subtle changes in vital signs to be recognized. There is already some evidence that automated ward monitoring can improve patient outcome. Before aut...

Authors: Ashish K. Khanna, Phillip Hoppe and Bernd Saugel

Acute kidney injury after cardiac arrest: the role of coronary angiography and temperature management

Authors: Angélique M. E. Spoelstra-de Man and Heleen M. Oudemans-van Straaten

Continuous monitoring of intrinsic PEEP based on expired CO₂ kinetics: an experimental validation study

Quantification of intrinsic PEEP (PEEPi) has important implications for patients subjected to invasive mechanical ventilation. A new non-invasive breath-by-breath method (etCO₂D) for determination of PEEPi is eva...

Authors: Sarah Heili-Frades, Fernando Suarez-Sipmann, Arnoldo Santos, Maria Pilar Carballosa, Alba Naya-Prieto, Carlos Castilla-Reparaz, Maria Jesús Rodriguez-Nieto, Nicolás González-Mangado and German Peces -Barba

Albumin infusion rate and plasma volume expansion: a randomized clinical trial in postoperative patients after major surgery

Optimal infusion rate of colloids in patients with suspected hypovolemia is unknown, and the primary objective of the present study was to test if plasma volume expansion by 5% albumin is greater if fluid is a...

Authors: Svajunas Statkevicius, Johan Bonnevier, Jane Fisher, Björn P. Bark, Erik Larsson, Carl M. Öberg, Päivi Kannisto, Bobby Tingstedt and Peter Bentzer

Procalcitonin levels in candidemia versus bacteremia: a systematic review

Procalcitonin (PCT) is a biomarker used to assess systemic inflammation, infection, and sepsis and to optimize antimicrobial therapies. Its role in the in the differential diagnosis between candidemia and bact...

Authors: Andrea Cortegiani, Giovanni Misseri, Mariachiara Ippolito, Matteo Bassetti, Antonino Giarratano, Ignacio Martin-Loeches and Sharon Einav

Red blood cell transfusion may be more detrimental than anemia for the clinical outcome of patients with severe traumatic brain injury

Authors: Santiago R. Leal-Noval, María D. Rincón-Ferrari and Manuel Múñoz-Gómez

Letter on “Sigh maneuver to enhance assessment of fluid responsiveness during pressure support ventilation”

Authors: Khaoula Meddeb and Mohamed Boussarsar

Identifying patients’ support needs following critical illness: a scoping review of the qualitative literature

Intensive care survivors suffer chronic and potentially life-changing physical, psychosocial and cognitive sequelae, and supporting recovery is an international priority. As survivors’ transition from the inte...

Authors: J. King, B. O’Neill, P. Ramsay, M. A. Linden, A. Darweish Medniuk, J. Outtrim and B. Blackwood

Describing organ dysfunction in the intensive care unit: a cohort study of 20,000 patients

Multiple organ dysfunction is a common cause of morbidity and mortality in intensive care units (ICUs). Original development of the Sequential Organ Failure Assessment (SOFA) score was not to predict outcome, ...

Authors: Andrea Soo, Danny J. Zuege, Gordon H. Fick, Daniel J. Niven, Luc R. Berthiaume, Henry T. Stelfox and Christopher J. Doig

Clinically relevant pharmacokinetic knowledge on antibiotic dosing among intensive care professionals is insufficient: a cross-sectional study

Antibiotic exposure in intensive care patients with sepsis is frequently inadequate and is associated with poorer outcomes. Antibiotic dosing is challenging in the intensive care, as critically ill patients ha...

Authors: Lucas M. Fleuren, Luca F. Roggeveen, Tingjie Guo, Petr Waldauf, Peter H. J. van der Voort, Rob J. Bosman, Eleonora L. Swart, Armand R. J. Girbes and Paul W. G. Elbers

Endocan removal during continuous renal replacement therapy: does it affect the reliability of this biomarker?

Authors: Patrick M. Honore, David De Bels, Rachid Attou, Sebastien Redant, Andrea Gallerani and Kianoush Kashani

How to treat combined respiratory and metabolic acidosis after extracorporeal cardiopulmonary resuscitation?

Authors: Xavier Bemtgen, Florentine Schroth, Tobias Wengenmayer, Paul M. Biever, Daniel Duerschmied, Christoph Benk, Christoph Bode and Dawid L. Staudacher

An overview of positive cultures and clinical outcomes in septic patients: a sub-analysis of the Prehospital Antibiotics Against Sepsis (PHANTASi) trial

Sepsis remains one of the most important causes of morbidity and mortality worldwide. In approximately 30–50% of cases of suspected sepsis, no pathogen is isolated, disabling the clinician to treat the patient...

Authors: Rishi S. Nannan Panday, Eline M. J. Lammers, Nadia Alam and Prabath W. B. Nanayakkara

Response

Authors: Huoyan Liang, Xianfei Ding and Tongwen Sun

High-flow nasal cannula oxygen therapy versus conventional oxygen therapy in patients after planned extubation: a systematic review and meta-analysis

The effect of high-flow nasal cannula (HFNC) therapy in patients after planned extubation remains inconclusive. We aimed to perform a rigorous and comprehensive systematic meta-analysis to robustly quantify th...

Authors: Youfeng Zhu, Haiyan Yin, Rui Zhang, Xiaoling Ye and Jianrui Wei

Time course of fluid responsiveness in sepsis: the fluid challenge revisiting (FCREV) study

Fluid challenge (FC) is one of the most common practices in Intensive Care Unit (ICU). The present study aimed to evaluate whether echocardiographic assessment of the response to FC at the end of the infusion ...

Authors: Claire Roger, Laurent Zieleskiewicz, Christophe Demattei, Karim Lakhal, Gael Piton, Benjamin Louart, Jean-Michel Constantin, Russell Chabanne, Jean-Sébastien Faure, Yazine Mahjoub, Isabelle Desmeulles, Hervé Quintard, Jean-Yves Lefrant and Laurent Muller

Are we really preventing lung collapse with APRV?

Authors: Ryota Sato, Natsumi Hamahata and Ehab G. Daoud

How I manage a difficult intubation

Authors: Jonathan D. Casey, Matthew W. Semler, Kevin High and Wesley H. Self

How I ventilate an obese patient

Authors: Lorenzo Ball and Paolo Pelosi

Patterns of utilization and effects of hospital-specific factors on physical, occupational, and speech therapy for critically ill patients with acute respiratory failure in the USA: results of a 5-year sample

Timely initiation of physical, occupational, and speech therapy in critically ill patients is crucial to reduce morbidity and improve outcomes. Over a 5-year time interval, we sought to determine the utilizati...

Authors: Clare C. Prohaska, Peter D. Sottile, Amy Nordon-Craft, Matt D. Gallagher, Ellen L. Burnham, Brendan J. Clark, Michael Ho, Tyree H. Kiser, R. William Vandivier, Wenhui Liu, Margaret Schenkman and Marc Moss

Should ECMO be used in cardiogenic shock?

Authors: Orhan Gokalp, Koksal Donmez, Hasan Iner, Gamze Gokalp, Yuksel Besir, Nihan Karakas Yesilkaya, Levent Yilik and Ali Gurbuz

The challenge of removal of sepsis markers by continuous hemofiltration

Authors: Patrick M. Honore, David De Bels, Rachid Attou, Sebastien Redant and Kianoush Kashani

Temporal change in characteristics and outcomes of acute kidney injury on renal replacement therapy in intensive care units: analysis of a nationwide administrative database in Japan, 2007–2016

We aimed to examine recent trends in patient characteristics and mortality in patients with acute kidney injury (AKI) receiving renal replacement therapy (RRT), including continuous RRT (CRRT) and intermittent...

Authors: Yoshihisa Miyamoto, Masao Iwagami, Shotaro Aso, Hideo Yasunaga, Hiroki Matsui, Kiyohide Fushimi, Yoshifumi Hamasaki, Masaomi Nangaku and Kent Doi

Near-infrared spectroscopy after out-of-hospital cardiac arrest

Cerebral hypoperfusion may aggravate neurological damage after cardiac arrest. Near-infrared spectroscopy (NIRS) provides information on cerebral oxygenation but its relevance during post-resuscitation care is...

Authors: Pekka Jakkula, Johanna Hästbacka, Matti Reinikainen, Ville Pettilä, Pekka Loisa, Marjaana Tiainen, Erika Wilkman, Stepani Bendel, Thomas Birkelund, Anni Pulkkinen, Minna Bäcklund, Sirkku Heino, Sari Karlsson, Hiski Kopponen and Markus B. Skrifvars

Is systematic fecal carriage screening of extended-spectrum beta-lactamase-producing Enterobacteriaceae still useful in intensive care unit: a systematic review

Extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-E) are disseminating worldwide leading to increased hospital length of stay and mortality in intensive care units (ICU). ESBL-E dissemination wa...

Authors: Renaud Prevel, Alexandre Boyer, Fatima M’Zali, Agnès Lasheras, Jean-Ralph Zahar, Anne-Marie Rogues and Didier Gruson

Nuclear magnetic resonance-based serum metabolomic analysis reveals different disease evolution profiles between septic shock survivors and non-survivors

Septic shock is the most severe phase of sepsis and is associated with high rates of mortality. However, early stage prediction of septic shock outcomes remains difficult. Metabolomic techniques have emerged a...

Authors: Zhicheng Liu, Mohamed N. Triba, Roland Amathieu, Xiangping Lin, Nadia Bouchemal, Edith Hantz, Laurence Le Moyec and Philippe Savarin

Comparative efficacy of vasoactive medications in patients with septic shock: a network meta-analysis of randomized controlled trials

Catecholamines, especially norepinephrine, are the most frequently used vasopressors for treating patients with septic shock. During the recent decades, terlipressin, vasopressin V1A agonist, and even Ca²⁺ sensit...

Authors: Lu Cheng, Jing Yan, Shutang Han, Qiuhua Chen, Mingqi Chen, Hua Jiang and Jun Lu

Letter in response to “Vascular endothelial cadherin shedding is more severe in sepsis patients with severe acute kidney injury”

Authors: Richard W Pierce

Inducible metabolic pathway for citrate metabolism in case of major liver dysfunction: fact or fiction?

Authors: Patrick M. Honore, David De Bels, Sebastien Redant, Rachid Attou, Luc Kugener and Willem Boer