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  1. Acute kidney injury (AKI) occurs commonly in pediatric septic shock and increases morbidity and mortality. Early identification of high-risk patients can facilitate targeted intervention to improve outcomes. W...

    Authors: Natalja L. Stanski, Rajit K. Basu, Natalie Z. Cvijanovich, Julie C. Fitzgerald, Michael T. Bigham, Parag N. Jain, Adam J. Schwarz, Riad Lutfi, Neal J. Thomas, Torrey Baines, Bereketeab Haileselassie, Scott L. Weiss, Mihir R. Atreya, Andrew J. Lautz, Basilia Zingarelli, Stephen W. Standage…
    Citation: Critical Care 2023 27:463
  2. Prone position has been shown to improve oxygenation and survival in patients with early acute respiratory distress syndrome (ARDS). These beneficial effects are partly mediated by improved ventilation/perfusi...

    Authors: Xueyan Yuan, Zhanqi Zhao, Yali Chao, Dongyu Chen, Hui Chen, Rui Zhang, Songqiao Liu, Jianfeng Xie, Yi Yang, Haibo Qiu, Leo Heunks and Ling Liu
    Citation: Critical Care 2023 27:462

    The Matters Arising to this article has been published in Critical Care 2024 28:129

  3. ICU survival is improving. However, many patients leave ICU with ongoing cognitive, physical, and/or psychological impairments and reduced quality of life. Many of the reasons for these ongoing problems are un...

    Authors: Oystein Tronstad, Dylan Flaws, Sue Patterson, Robert Holdsworth, Veronica Garcia-Hansen, Francisca Rodriguez Leonard, Ruth Ong, Stephanie Yerkovich and John F. Fraser
    Citation: Critical Care 2023 27:461
  4. Recent clinical and research efforts in cardiogenic shock (CS) have largely focussed on the restoration of the low cardiac output state that is the conditio sine qua non of the clinical syndrome. This approach ha...

    Authors: Marie Buckel, Patrick Maclean, Julian C. Knight, Patrick R. Lawler and Alastair G. Proudfoot
    Citation: Critical Care 2023 27:460
  5. Burn inhalation injury (BII) is a major cause of burn-related mortality and morbidity. Despite published practice guidelines, no consensus exists for the best strategies regarding diagnosis and management of B...

    Authors: Helena Milton-Jones, Sabri Soussi, Roger Davies, Emmanuel Charbonney, Walton N. Charles, Heather Cleland, Ken Dunn, Dashiell Gantner, Julian Giles, Marc Jeschke, Nicole Lee, Matthieu Legrand, Joanne Lloyd, Ignacio Martin-Loeches, Olivier Pantet, Mark Samaan…
    Citation: Critical Care 2023 27:459
  6. Extracellular histones have been associated with severity and outcome in sepsis. The aim of the present study was to assess the effects of sodium-β-O-Methyl cellobioside sulfate (mCBS), a histone-neutralizing ...

    Authors: Bruno Garcia, Fuhong Su, Laurence Dewachter, Yong Wang, Ning Li, Myriam Remmelink, Marie Van Eycken, Amina Khaldi, Raphaël Favory, Antoine Herpain, Anthony Moreau, Alexander Moiroux-Sahraoui, Francesca Manicone, Filippo Annoni, Lin Shi, Jean-Louis Vincent…
    Citation: Critical Care 2023 27:458
  7. In the acute distress respiratory syndrome (ARDS), specific lung regions can be exposed to excessive strain due to heterogeneous disease, gravity-dependent lung collapse and injurious mechanical ventilation. C...

    Authors: Roberto Brito, Caio C. A. Morais, Marioli T. Lazo, Dannette V. Guiñez, Abraham I. J. Gajardo, Daniel H. Arellano, Marcelo B. P. Amato and Rodrigo A. Cornejo
    Citation: Critical Care 2023 27:457
  8. Cardiac complications due to non-traumatic subarachnoid hemorrhage (SAH) are usually described using classical echocardiographic evaluation. Strain imaging appears to have better sensitivity than standard echo...

    Authors: Hugues de Courson, Grégoire Chadefaux, Alexandre Loiseau, Delphine Georges and Matthieu Biais
    Citation: Critical Care 2023 27:455

    The Matters Arising to this article has been published in Critical Care 2024 28:103

    The Matters Arising to this article has been published in Critical Care 2024 28:21

  9. Authors: Bruno Caldeira Antônio, Maiara Sulzbach Denardin, Henrique Alexsander Ferreira Neves and Eduardo Messias Hirano Padrao
    Citation: Critical Care 2023 27:454

    The original article was published in Critical Care 2023 27:422

  10. The renin–angiotensin system (RAS) plays a crucial role in regulating blood pressure and the cardio-renal system. The classical RAS, mainly mediated by angiotensin I, angiotensin-converting enzyme, and angiote...

    Authors: Bruno Garcia, Alexander Zarbock, Rinaldo Bellomo and Matthieu Legrand
    Citation: Critical Care 2023 27:453
  11. CONCISE is an internationally agreed minimum set of outcomes for use in nutritional and metabolic clinical research in critically ill adults. Clinicians and researchers need to be aware of the clinimetric prop...

    Authors: T. W. Davies, E. Kelly, R. J. J. van Gassel, M. C. G. van de Poll, J. Gunst, M. P. Casaer, K. B. Christopher, J. C. Preiser, A. Hill, K. Gundogan, A. Reintam-Blaser, A.-F. Rousseau, C. Hodgson, D. M. Needham, S. J. Schaller, T. McClelland…
    Citation: Critical Care 2023 27:450
  12. Intra-abdominal candidiasis (IAC) is one of the most common of invasive candidiasis observed in critically ill patients. It is associated with high mortality, with up to 50% of deaths attributable to delays in...

    Authors: Emmanuel Novy, Claire Roger, Jason A. Roberts and Menino Osbert Cotta
    Citation: Critical Care 2023 27:449
  13. Traumatic spinal cord injury (SCI) leads to profound neurologic sequelae, and the provision of life-supporting treatment serves great importance among this patient population. The decision for withdrawal of li...

    Authors: Husain Shakil, Armaan K. Malhotra, Rachael H. Jaffe, Christopher W. Smith, Erin M. Harrington, Alick P. Wang, Eva Y. Yuan, Yingshi He, Karim Ladha, Duminda N. Wijeysundera, Avery B. Nathens, Jefferson R. Wilson and Christopher D. Witiw
    Citation: Critical Care 2023 27:448
  14. Midline shift and mass lesions may occur with traumatic brain injury (TBI) and are associated with higher mortality and morbidity. The shape of intracranial pressure (ICP) pulse waveform reflects the state of ...

    Authors: Agnieszka Kazimierska, Agnieszka Uryga, Cyprian Mataczyński, Marek Czosnyka, Erhard W. Lang and Magdalena Kasprowicz
    Citation: Critical Care 2023 27:447
  15. Sepsis is a medical emergency with potentially life-threatening consequences. Patients play a crucial role in preventing and recognizing sepsis at an early stage. The understanding of risk groups’ sepsis knowl...

    Authors: Sebastian Born, Carolin Fleischmann-Struzek, Wiltrud Abels, Silke Piedmont, Edmund Neugebauer, Konrad Reinhart, Evjenia Toubekis, Odette Wegwarth and Daniel Schwarzkopf
    Citation: Critical Care 2023 27:446
  16. Sepsis survivors commonly experience functional impairment, which may limit return to work. We investigated return to work (RTW) of patients hospitalized with sepsis and the associations with patient and clini...

    Authors: Nina Vibeche Skei, Karoline Moe, Tom Ivar Lund Nilsen, Lene Aasdahl, Hallie C. Prescott, Jan Kristian Damås and Lise Tuset Gustad
    Citation: Critical Care 2023 27:443
  17. Extracorporeal cardiopulmonary resuscitation (ECPR) has been proposed as a rescue therapy for patients with refractory cardiac arrest. This study aimed to evaluate the association between ECPR and clinical out...

    Authors: Yohei Okada, Sho Komukai, Taro Irisawa, Tomoki Yamada, Kazuhisa Yoshiya, Changhwi Park, Tetsuro Nishimura, Takuya Ishibe, Hitoshi Kobata, Takeyuki Kiguchi, Masafumi Kishimoto, Sung-Ho Kim, Yusuke Ito, Taku Sogabe, Takaya Morooka, Haruko Sakamoto…
    Citation: Critical Care 2023 27:442
  18. Although the stretch that generates ventilator-induced lung injury (VILI) occurs within the peripheral tissue that encloses the alveolar space, airway pressures and volumes monitor the gas within the interior cor...

    Authors: John J. Marini, Lauren T. Thornton, Patricia R. M. Rocco and Philip S. Crooke
    Citation: Critical Care 2023 27:441
  19. The mortality benefit of VV-ECMO in ARDS has been extensively studied, but the impact on long-term functional outcomes of survivors is poorly defined. We aimed to assess the association between ECMO and functi...

    Authors: Mackenzie Snyder, Binta Y. Njie, Ilana Grabenstein, Sara Viola, Hatoon Abbas, Waqas Bhatti, Ryan Lee, Rosalie Traficante, Siu Yan Amy Yeung, Jonathan H. Chow, Ali Tabatabai, Bradley S. Taylor, Siamak Dahi, Thomas Scalea, Joseph Rabin, Alison Grazioli…
    Citation: Critical Care 2023 27:440
  20. Severe weakness associated with critical illness (CIW) is common. This narrative review summarizes the latest scientific insights and proposes a guide for clinicians to optimize the diagnosis and management of...

    Authors: Nicola Latronico, Frank A. Rasulo, Matthias Eikermann and Simone Piva
    Citation: Critical Care 2023 27:439

    The Publisher Correction to this article has been published in Critical Care 2023 27:469

  21. Individuals who survive sepsis are at high risk of chronic sequelae, resulting in significant health-economic costs. Several studies have focused on aspects of healthcare pathways of sepsis survivors but compr...

    Authors: Fanny Pandolfi, Christian Brun-Buisson, Didier Guillemot and Laurence Watier
    Citation: Critical Care 2023 27:438
  22. The phase II CIGMA trial performed in 160 patients with severe community-acquired pneumonia (sCAP) found treatment with trimodulin (human polyvalent immunoglobulin [Ig]: ~ 23% IgM, ~ 21% IgA, ~ 56% IgG) was as...

    Authors: Mervyn Singer, Antoni Torres, Corina C. Heinz, Sabrina Weißmüller, Alexander Staus, Steffen Kistner, Ksenia Jakubczyk, Thomas Häder, Patrick Langohr, Andrea Wartenberg-Demand, Jörg Schüttrumpf, Jean-Louis Vincent and Tobias Welte
    Citation: Critical Care 2023 27:436
  23. Drug-induced kidney disease (DIKD) accounts for about one-fourth of all cases of acute kidney injury (AKI) in hospitalized patients, especially in critically ill setting. There is no standard definition or cla...

    Authors: Iman Karimzadeh, Erin F. Barreto, John A. Kellum, Linda Awdishu, Patrick T. Murray, Marlies Ostermann, Azra Bihorac, Ravindra L. Mehta, Stuart L. Goldstein, Kianoush B. Kashani and Sandra L. Kane-Gill
    Citation: Critical Care 2023 27:435
  24. While venoarterial extracorporeal membrane oxygenation (V-A ECMO) provides lifesaving support for cardiopulmonary failure, complications may increase mortality, with few studies focusing on ischemic/hemorrhagi...

    Authors: Jaeho Hwang, Andrew Kalra, Benjamin L. Shou, Glenn Whitman, Christopher Wilcox, Daniel Brodie, Akram M. Zaaqoq, Roberto Lorusso, Ken Uchino and Sung-Min Cho
    Citation: Critical Care 2023 27:433
  25. Given the success of recent platform trials for COVID-19, Bayesian statistical methods have become an option for complex, heterogenous syndromes like sepsis. However, study design will require careful consider...

    Authors: George Tomlinson, Ali Al-Khafaji, Steven A. Conrad, Faith N. F. Factora, Debra M. Foster, Claude Galphin, Kyle J. Gunnerson, Sobia Khan, Roopa Kohli-Seth, Paul McCarthy, Nikhil K. Meena, Ronald G. Pearl, Jean-Sebastien Rachoin, Ronald Rains, Michael Seneff, Mark Tidswell…
    Citation: Critical Care 2023 27:432

    The Correction to this article has been published in Critical Care 2024 28:11

  26. Pulse pressure and stroke volume variation (PPV and SVV) have been widely used in surgical patients as predictors of fluid challenge (FC) response. Several factors may affect the reliability of these indices i...

    Authors: Antonio Messina, Mariagiovanna Caporale, Lorenzo Calabrò, Giulia Lionetti, Daniele Bono, Guia Margherita Matronola, Andrea Brunati, Luciano Frassanito, Emanuela Morenghi, Massimo Antonelli, Michelle S. Chew and Maurizio Cecconi
    Citation: Critical Care 2023 27:431

    The Matters Arising to this article has been published in Critical Care 2024 28:22

    The Matters Arising to this article has been published in Critical Care 2023 27:482

  27. The assessment of post-intensive care syndrome (PICS) is challenging due to the numerous types of instruments. We herein attempted to identify and propose recommendations for instruments to assess PICS in inte...

    Authors: Nobuto Nakanishi, Keibun Liu, Akira Kawauchi, Masatsugu Okamura, Kohei Tanaka, Sho Katayama, Yuki Mitani, Kohei Ota, Shunsuke Taito, Kenichi Fudeyasu, Yuki Masuka, Shodai Yoshihiro, Shu Utsumi, Mitsuaki Nishikimi, Mamoru Masuda, Yuki Iida…
    Citation: Critical Care 2023 27:430
  28. Capillary refill time (CRT) has been suggested as a variable to follow during the course of septic shock. We systematically investigated the effects on CRT of volume expansion and norepinephrine.

    Authors: Nicolas Fage, Francesca Moretto, Daniela Rosalba, Rui Shi, Christopher Lai, Jean-Louis Teboul and Xavier Monnet
    Citation: Critical Care 2023 27:429
  29. Critically ill patients suffer from acute muscle wasting, which is associated with significant physical functional impairment. We describe data from nested muscle biopsy studies from two trials of functional e...

    Authors: T. S. O. Jameson, M. K. Caldow, F. Stephens, L. Denehy, G. S. Lynch, R. Koopman, A. Krajcova, T. Urban, S. Berney, F. Duska and Z. Puthucheary
    Citation: Critical Care 2023 27:428

    The Matters Arising to this article has been published in Critical Care 2024 28:8

  30. It is yet to be better understood how outcomes during and after the critical illness potentially differ between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants from other lower respirator...

    Authors: Pontus Hedberg, Nicholas Baltzer, Fredrik Granath, Michael Fored, Johan Mårtensson and Pontus Nauclér
    Citation: Critical Care 2023 27:427
  31. Intention-to-treat analyses of POINCARE-2 trial led to inconclusive results regarding the effect of a conservative fluid balance strategy on mortality in critically ill patients. The present as-treated analysi...

    Authors: Adil Mansouri, Marie Buzzi, Sébastien Gibot, Claire Charpentier, Francis Schneider, Guillaume Louis, Hervé Outin, Alexandra Monnier, Jean-Pierre Quenot, Julio Badie, Laurent Argaud, Cédric Bruel, Marc Soudant and Nelly Agrinier
    Citation: Critical Care 2023 27:426
  32. Natural language processing (NLP) may help evaluate the characteristics, prevalence, trajectory, treatment, and outcomes of behavioural disturbance phenotypes in critically ill patients.

    Authors: Marcus Young, Natasha E. Holmes, Kartik Kishore, Sobia Amjad, Michele Gaca, Ary Serpa Neto, Michael C. Reade and Rinaldo Bellomo
    Citation: Critical Care 2023 27:425
  33. Acute cor pulmonale (ACP) is prognostic in patients with acute respiratory distress syndrome (ARDS). Identification of paradoxical septal motion (PSM) using two-dimensional echocardiography is highly subjectiv...

    Authors: Bruno Evrard, Jean-Baptiste Woillard, Annick Legras, Misylias Bouaoud, Maeva Gourraud, Antoine Humeau, Marine Goudelin and Philippe Vignon
    Citation: Critical Care 2023 27:424
  34. Trauma-induced coagulopathy (TIC) is common in trauma patients with major hemorrhage. Prothrombin complex concentrate (PCC) is used as a potential treatment for the correction of TIC, but the efficacy, timing,...

    Authors: Ioannis Hannadjas, Arthur James, Ross Davenport, Charlotte Lindsay, Karim Brohi and Elaine Cole
    Citation: Critical Care 2023 27:422

    The Matters Arising to this article has been published in Critical Care 2023 27:454

  35. Authors: Tjitske S. R. van Engelen, Tom D. Y. Reijnders, Fleur P. Paling, Marc J. M. Bonten, Leen Timbermont, Surbhi Malhotra-Kumar, Jan A. J. W. Kluytmans, Hessel Peters-Sengers and Tom van der Poll
    Citation: Critical Care 2023 27:420

    The original article was published in Critical Care 2023 27:269

  36. Acute respiratory distress syndrome (ARDS) subphenotypes differ in outcomes and treatment responses. Subphenotypes in high-flow nasal oxygen (HFNO)-treated ARDS patients have not been investigated.

    Authors: Pierre-Louis Blot, Benjamin G. Chousterman, Manel Santafè, Jérôme Cartailler, Andrés Pacheco, Mònica Magret, Joan R. Masclans, Antoni Artigas, Oriol Roca and Marina García-de-Acilu
    Citation: Critical Care 2023 27:419
  37. Despite cefoxitin's in vitro resistance to hydrolysis by extended-spectrum beta-lactamases (ESBL), treatment of ESBL-producing Klebsiella pneumoniae (KP) infections with cefoxitin remains controversial. The aim o...

    Authors: Tanguy Dequidt, Sylvaine Bastian, Mathieu Nacher, Sébastien Breurec, Michel Carles, Guillaume Thiery, Laurent Camous, Benoit Tressieres, Marc Valette and Jean-David Pommier
    Citation: Critical Care 2023 27:418
  38. Sepsis is one of the leading causes of death. Treatment attempts targeting the immune response regularly fail in clinical trials. As HCMV latency can modulate the immune response and changes the immune cell co...

    Authors: M. Unterberg, S. F. Ehrentraut, T. Bracht, A. Wolf, H. Haberl, A. von Busch, K. Rump, D. Ziehe, M. Bazzi, P. Thon, B. Sitek, K. Marcus, M. Bayer, K. Schork, M. Eisenacher, B. Ellger…
    Citation: Critical Care 2023 27:417

    The Matters Arising to this article has been published in Critical Care 2023 27:464

    The Matters Arising to this article has been published in Critical Care 2023 27:445

  39. Although the defining elements of “acute respiratory distress syndrome” (ARDS) have been known for over a century, the syndrome was first described in 1967. Since then, despite several revisions of its concept...

    Authors: Jesús Villar, Tamas Szakmany, Giacomo Grasselli and Luigi Camporota
    Citation: Critical Care 2023 27:416
  40. The results of clinical and weaning readiness tests and the spontaneous breathing trial (SBT) are used to predict the success of the weaning process and extubation.

    Authors: Fabio Varón-Vega, Luis F. Giraldo-Cadavid, Ana María Uribe, Adriana Rincón, Jonathan Palacios, Stephanie Crevoisier, Eduardo Tuta-Quintero, Lina Ordoñez, Natalia Boada, Paola Rincón, Marcela Poveda and Pablo Monedero
    Citation: Critical Care 2023 27:414