Articles

An overview of positive cultures and clinical outcomes in septic patients: a sub-analysis of the Prehospital Antibiotics Against Sepsis (PHANTASi) trial

Sepsis remains one of the most important causes of morbidity and mortality worldwide. In approximately 30–50% of cases of suspected sepsis, no pathogen is isolated, disabling the clinician to treat the patient...

Authors: Rishi S. Nannan Panday, Eline M. J. Lammers, Nadia Alam and Prabath W. B. Nanayakkara

Response

Authors: Huoyan Liang, Xianfei Ding and Tongwen Sun

High-flow nasal cannula oxygen therapy versus conventional oxygen therapy in patients after planned extubation: a systematic review and meta-analysis

The effect of high-flow nasal cannula (HFNC) therapy in patients after planned extubation remains inconclusive. We aimed to perform a rigorous and comprehensive systematic meta-analysis to robustly quantify th...

Authors: Youfeng Zhu, Haiyan Yin, Rui Zhang, Xiaoling Ye and Jianrui Wei

Time course of fluid responsiveness in sepsis: the fluid challenge revisiting (FCREV) study

Fluid challenge (FC) is one of the most common practices in Intensive Care Unit (ICU). The present study aimed to evaluate whether echocardiographic assessment of the response to FC at the end of the infusion ...

Authors: Claire Roger, Laurent Zieleskiewicz, Christophe Demattei, Karim Lakhal, Gael Piton, Benjamin Louart, Jean-Michel Constantin, Russell Chabanne, Jean-Sébastien Faure, Yazine Mahjoub, Isabelle Desmeulles, Hervé Quintard, Jean-Yves Lefrant and Laurent Muller

Are we really preventing lung collapse with APRV?

Authors: Ryota Sato, Natsumi Hamahata and Ehab G. Daoud

How I manage a difficult intubation

Authors: Jonathan D. Casey, Matthew W. Semler, Kevin High and Wesley H. Self

How I ventilate an obese patient

Authors: Lorenzo Ball and Paolo Pelosi

Patterns of utilization and effects of hospital-specific factors on physical, occupational, and speech therapy for critically ill patients with acute respiratory failure in the USA: results of a 5-year sample

Timely initiation of physical, occupational, and speech therapy in critically ill patients is crucial to reduce morbidity and improve outcomes. Over a 5-year time interval, we sought to determine the utilizati...

Authors: Clare C. Prohaska, Peter D. Sottile, Amy Nordon-Craft, Matt D. Gallagher, Ellen L. Burnham, Brendan J. Clark, Michael Ho, Tyree H. Kiser, R. William Vandivier, Wenhui Liu, Margaret Schenkman and Marc Moss

Should ECMO be used in cardiogenic shock?

Authors: Orhan Gokalp, Koksal Donmez, Hasan Iner, Gamze Gokalp, Yuksel Besir, Nihan Karakas Yesilkaya, Levent Yilik and Ali Gurbuz

The challenge of removal of sepsis markers by continuous hemofiltration

Authors: Patrick M. Honore, David De Bels, Rachid Attou, Sebastien Redant and Kianoush Kashani

Temporal change in characteristics and outcomes of acute kidney injury on renal replacement therapy in intensive care units: analysis of a nationwide administrative database in Japan, 2007–2016

We aimed to examine recent trends in patient characteristics and mortality in patients with acute kidney injury (AKI) receiving renal replacement therapy (RRT), including continuous RRT (CRRT) and intermittent...

Authors: Yoshihisa Miyamoto, Masao Iwagami, Shotaro Aso, Hideo Yasunaga, Hiroki Matsui, Kiyohide Fushimi, Yoshifumi Hamasaki, Masaomi Nangaku and Kent Doi

Near-infrared spectroscopy after out-of-hospital cardiac arrest

Cerebral hypoperfusion may aggravate neurological damage after cardiac arrest. Near-infrared spectroscopy (NIRS) provides information on cerebral oxygenation but its relevance during post-resuscitation care is...

Authors: Pekka Jakkula, Johanna Hästbacka, Matti Reinikainen, Ville Pettilä, Pekka Loisa, Marjaana Tiainen, Erika Wilkman, Stepani Bendel, Thomas Birkelund, Anni Pulkkinen, Minna Bäcklund, Sirkku Heino, Sari Karlsson, Hiski Kopponen and Markus B. Skrifvars

Is systematic fecal carriage screening of extended-spectrum beta-lactamase-producing Enterobacteriaceae still useful in intensive care unit: a systematic review

Extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-E) are disseminating worldwide leading to increased hospital length of stay and mortality in intensive care units (ICU). ESBL-E dissemination wa...

Authors: Renaud Prevel, Alexandre Boyer, Fatima M’Zali, Agnès Lasheras, Jean-Ralph Zahar, Anne-Marie Rogues and Didier Gruson

Nuclear magnetic resonance-based serum metabolomic analysis reveals different disease evolution profiles between septic shock survivors and non-survivors

Septic shock is the most severe phase of sepsis and is associated with high rates of mortality. However, early stage prediction of septic shock outcomes remains difficult. Metabolomic techniques have emerged a...

Authors: Zhicheng Liu, Mohamed N. Triba, Roland Amathieu, Xiangping Lin, Nadia Bouchemal, Edith Hantz, Laurence Le Moyec and Philippe Savarin

Comparative efficacy of vasoactive medications in patients with septic shock: a network meta-analysis of randomized controlled trials

Catecholamines, especially norepinephrine, are the most frequently used vasopressors for treating patients with septic shock. During the recent decades, terlipressin, vasopressin V1A agonist, and even Ca²⁺ sensit...

Authors: Lu Cheng, Jing Yan, Shutang Han, Qiuhua Chen, Mingqi Chen, Hua Jiang and Jun Lu

Letter in response to “Vascular endothelial cadherin shedding is more severe in sepsis patients with severe acute kidney injury”

Authors: Richard W Pierce

Inducible metabolic pathway for citrate metabolism in case of major liver dysfunction: fact or fiction?

Authors: Patrick M. Honore, David De Bels, Sebastien Redant, Rachid Attou, Luc Kugener and Willem Boer

Adding an orange to the banana bag: vitamin C deficiency is common in alcohol use disorders

At least a third of the world’s population consumes alcohol regularly. Patients with alcohol use disorders (AUDs) are frequently hospitalized for both alcohol-related and unrelated medical conditions. It is we...

Authors: Paul E. Marik and Amanda Liggett

Hypothermia after decompressive hemicraniectomy in treatment of malignant middle cerebral artery stroke: comment on the randomized clinical trial

Authors: N. Engrand, M. Mazighi and V. Dinkelacker

Renal function after out-of-hospital cardiac arrest; the influence of temperature management and coronary angiography, a post hoc study of the target temperature management trial

To elucidate the incidence of acute kidney injury (AKI) after out-of-hospital cardiac arrest (OHCA) and to examine the impact of target temperature management (TTM) and early coronary angiography on renal func...

Authors: Malin Rundgren, Susann Ullén, Matt P. G. Morgan, Guy Glover, Julius Cranshaw, Nawaf Al-Subaie, Andrew Walden, Michael Joannidis, Marlies Ostermann, Josef Dankiewicz, Niklas Nielsen and Matthew P. Wise

Pyroglutamic acidosis by glutathione regeneration blockage in critical patients with septic shock

The aim of this study was to evaluate oxidative stress from glutathione depletion in critically ill patients with a septic shock through the abnormal presence of pyroglutamic acid (PyroGlu) in the urine (indir...

Authors: Yenifer Gamarra, Felipe C. Santiago, Jorge Molina-López, José Castaño, Lourdes Herrera-Quintana, Álvaro Domínguez and Elena Planells

The effect of adhesive tape versus endotracheal tube fastener in critically ill adults: the endotracheal tube securement (ETTS) randomized controlled trial

The optimal securement method of endotracheal tubes is unknown but should prevent dislodgement while minimizing complications. The use of an endotracheal tube fastener might reduce complications among critical...

Authors: Janna S. Landsperger, Jesse M. Byram, Bradley D. Lloyd and Todd W. Rice

How I monitor cerebral autoregulation

Authors: Samuel P. Klein, Bart Depreitere and Geert Meyfroidt

Fluid management in patients undergoing cardiac surgery: effects of an acetate- versus lactate-buffered balanced infusion solution on hemodynamic stability (HEMACETAT)

Recent evidence suggests that acetate-buffered infusions result in better hemodynamic stabilization than 0.9% saline in patients undergoing major surgery. The choice of buffer in balanced crystalloid solutions...

Authors: Carmen A. Pfortmueller, Livia Faeh, Martin Müller, Balthasar Eberle, Hansjörg Jenni, Björn Zante, Josef Prazak, Lars Englberger, Jukka Takala and Stephan M. Jakob

Retrospective cohort study of hospital variation in airway management during in-hospital cardiac arrest and the association with patient survival: insights from Get With The Guidelines-Resuscitation

The optimal approach to airway management during in-hospital cardiac arrest is unknown.

Authors: Steven M. Bradley, Yunshu Zhou, Satya Krishna Ramachandran, Milo Engoren, Michael Donnino and Saket Girotra

Does training level affect the accuracy of visual assessment of capillary refill time?

Authors: Koichiro Shinozaki, Lee S. Jacobson, Kota Saeki, Naoki Kobayashi, Steve Weisner, Julianne M. Falotico, Timmy Li, Junhwan Kim, Joshua W. Lampe and Lance B. Becker

Heterogeneity of treatment effect by baseline risk of mortality in critically ill patients: re-analysis of three recent sepsis and ARDS randomised controlled trials

Randomised controlled trials (RCTs) enrolling patients with sepsis or acute respiratory distress syndrome (ARDS) generate heterogeneous trial populations. Non-random variation in the treatment effect of an int...

Authors: Shalini Santhakumaran, Anthony Gordon, A. Toby Prevost, Cecilia O’Kane, Daniel F. McAuley and Manu Shankar-Hari

Quantitative pupillometry for the monitoring of intracranial hypertension in patients with severe traumatic brain injury

Elevated intracranial pressure (ICP) is frequent after traumatic brain injury (TBI) and may cause abnormal pupillary reactivity, which in turn is associated with a worse prognosis. Using automated infrared pup...

Authors: Fritz-Patrick Jahns, John Paul Miroz, Mahmoud Messerer, Roy T. Daniel, Fabio Silvio Taccone, Philippe Eckert and Mauro Oddo

When circulatory death does not come in time in potential organ donors

Authors: Angela Kotsopoulos, Nichon Jansen and Wilson Farid Abdo

Social and economic problems of ICU survivors identified by a structured social welfare consultation

Authors: J. M. McPeake, P. Henderson, G. Darroch, T. J. Iwashyna, P. MacTavish, C. Robinson and T. Quasim

Influenza and associated co-infections in critically ill immunosuppressed patients

It is unclear whether influenza infection and associated co-infection are associated with patient-important outcomes in critically ill immunocompromised patients with acute respiratory failure.

Authors: Ignacio Martin-Loeches, Virginie Lemiale, Pierce Geoghegan, Mary Aisling McMahon, Peter Pickkers, Marcio Soares, Anders Perner, Tine Sylvest Meyhoff, Ramin Brandt Bukan, Jordi Rello, Philippe R. Bauer, Andry van de Louw, Fabio Silvio Taccone, Jorge Salluh, Pleun Hemelaar, Peter Schellongowski…

Procalcitonin is an essential biomarker for hydrocortisone, ascorbic acid, and thiamine (HAT) therapy in patients with sepsis

Authors: Paul E. Marik

The global challenge of Candida auris in the intensive care unit

Authors: Andrea Cortegiani, Giovanni Misseri, Antonino Giarratano, Matteo Bassetti and David Eyre

Renin-angiotensin-aldosterone system blockers after KDIGO stage 3 acute kidney injury: use and impact on 2-year mortality in the AKIKI trial

Authors: Mathilde Scarton, Anne Oppenheimer, Khalil Chaïbi, Didier Dreyfuss and Stéphane Gaudry

Quality and quantity of sample size is crucial in clinical studies to exclude association: antimicrobial exposure and the risk of delirium in critically ill patients

Authors: Rashid Nadeem, Zainab Ameer Obeida, Sahish Kamat and Ahmed Nazir Elsousi

Optimizing ceftolozane-tazobactam dosage in critically ill patients during continuous venovenous hemodiafiltration

Authors: Gerardo Aguilar, Rafael Ferriols, Sara Martínez-Castro, Carlos Ezquer, Ernesto Pastor, José A. Carbonell, Manuel Alós and David Navarro

Angiotensin II in ECMO patients: a word of caution

Authors: Elio Antonucci and Fabio Silvio Taccone

Epidemiology of infective endocarditis in French intensive care units over the 1997–2014 period—from CUB-Réa Network

Few studies focus only on severe forms of infective endocarditis, for which organ failure requires admission to an intensive care unit (ICU). This study aimed to describe demographical, comorbidities, organ fa...

Authors: Jérémie Joffre, Guillaume Dumas, Philippe Aegerter, Vincent Dubée, Naike Bigé, Gabriel Preda, Jean-Luc Baudel, Eric Maury, Bertrand Guidet and Hafid Ait-Oufella

Correction to: Early versus late initiation of renal replacement therapy impacts mortality in patients with acute kidney injury post cardiac surgery: a meta-analysis

After publication of this article [1], it was noticed that the affiliations of Honghong Zhou were incorrect. The sole affiliation should be, “Department of Nephrology, the Second Affiliated Hospital of Nanchan...

Authors: Honghong Zou, Qianwen Hong and Gaosi XU

Biomarkers to guide antibiotic timing and administration in infected patients presenting to the emergency department

Authors: Mari Rosenqvist, Darius Cameron Wilson, Lena Tegnér, Maria Bengtsson-Toni, Marjaneh Peyman, Juan Gonzalez del Castillo, Kordo Saeed and Olle Melander

Composed endotypes to guide antibiotic discontinuation in sepsis

Overuse of empiric antibiotic therapy in the ICU is responsible for promoting the dissemination of multidrug-resistant (MDR) bacteria. Shortened antibiotic treatment duration could contribute to palliating the...

Authors: Jesus F. Bermejo-Martin, David Andaluz-Ojeda, Marta Martin-Fernandez, Cesar Aldecoa and Raquel Almansa

Trial sequential analysis suggested the potential overestimated effect of carbonic anhydrase inhibitor for respiratory failure and metabolic alkalosis

Authors: Meng-Si Luo, Hui-Zi Li, Guan-Jiang Huang and Lun Wu

Response to “Incidence of hypotension according to the discontinuation order of vasopressors: a matter of pharmacokinetics”

Authors: Kyeongman Jeon, Jae-Uk Song and Gee Young Suh

Intelligently learning from data

Authors: Edward Palmer, Roman Klapaukh, Steve Harris and Mervyn Singer

Control of respiratory drive by extracorporeal CO₂ removal in acute exacerbation of COPD breathing on non-invasive NAVA

Veno-venous extracorporeal CO₂ removal (vv-ECCO₂R) and non-invasive neurally adjusted ventilator assist (NIV-NAVA) are two promising techniques which may prevent complications related to prolonged invasive mechan...

Authors: Christian Karagiannidis, Stephan Strassmann, Sarah Schwarz, Michaela Merten, Eddy Fan, Jennifer Beck, Christer Sinderby and Wolfram Windisch

vvECMO can be avoided by a transpulmonary pressure guided open lung concept in patients with severe ARDS

Authors: Philip van der Zee, Dinis Dos Reis Miranda, Han Meeder, Henrik Endeman and Diederik Gommers

Liberal versus conservative oxygen therapy in critically ill patients: using the fragility index to determine robust results

Authors: Maria Vargas and Giuseppe Servillo

TCR activation mimics CD127^lowPD-1^high phenotype and functional alterations of T lymphocytes from septic shock patients

Sepsis is the leading cause of mortality for critically ill patients worldwide. Patients develop T lymphocyte dysfunctions leading to T-cell exhaustion associated with increased risk of death. As interleukin-7...

Authors: Julie Mouillaux, Camille Allam, Morgane Gossez, Thomas Uberti, Benjamin Delwarde, Jack Hayman, Thomas Rimmelé, Julien Textoris, Guillaume Monneret, Estelle Peronnet and Fabienne Venet

Sedation practices and clinical outcomes in mechanically ventilated patients in a prospective multicenter cohort

We sought to study the association between sedation status, medications (benzodiazepines, opioids, and antipsychotics), and clinical outcomes in a resource-limited setting.

Authors: Romina E. Aragón, Alvaro Proaño, Nicole Mongilardi, Aldo de Ferrari, Phabiola Herrera, Rollin Roldan, Enrique Paz, Amador A. Jaymez, Eduardo Chirinos, Jose Portugal, Rocio Quispe, Roy G. Brower and William Checkley

Application of MR-ProADM to predict prevention of hospitalisation, derived from a multi-centre study

Authors: Milo Cullinan, Sara Graziadio and David Ashley Price