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  1. Septic shock is characterized by breakdown of the endothelial glycocalyx and endothelial damage, contributing to fluid extravasation, organ failure and death. Albumin has shown benefit in septic shock patients...

    Authors: Arianna Piotti, Deborah Novelli, Jennifer Marie Theresia Anna Meessen, Daniela Ferlicca, Sara Coppolecchia, Antonella Marino, Giovanni Salati, Monica Savioli, Giacomo Grasselli, Giacomo Bellani, Antonio Pesenti, Serge Masson, Pietro Caironi, Luciano Gattinoni, Marco Gobbi, Claudia Fracasso…

    Citation: Critical Care 2021 25:113

    Content type: Research

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    The Letter to this article has been published in Critical Care 2021 25:232

  2. The availability of handheld, noninvasive sublingual video-microscopes allows for visualization of the microcirculation in critically ill patients. Recent studies demonstrate that reduced numbers of blood-perf...

    Authors: Alexandros Rovas, Jan Sackarnd, Jan Rossaint, Stefanie Kampmeier, Hermann Pavenstädt, Hans Vink and Philipp Kümpers

    Citation: Critical Care 2021 25:112

    Content type: Research

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  3. In patients ventilated with tidal volume (Vt) < 8 mL/kg, pulse pressure variation (PPV) and, likely, the variation of distensibility of the inferior vena cava diameter (IVCDV) are unable to detect preload respons...

    Authors: Temistocle Taccheri, Francesco Gavelli, Jean-Louis Teboul, Rui Shi and Xavier Monnet

    Citation: Critical Care 2021 25:110

    Content type: Research

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  4. Galectin-3 (Gal-3) is a pleiotropic glycan-binding protein shown to be involved in sepsis and acute kidney injury (AKI). However, its role has never been elucidated in sepsis-associated AKI (S-AKI). We aimed t...

    Authors: Haibing Sun, Huiping Jiang, Amity Eliaz, John A. Kellum, Zhiyong Peng and Isaac Eliaz

    Citation: Critical Care 2021 25:109

    Content type: Research

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  5. Intensive care survivors often experience post-intensive care sequelae, which are frequently gathered together under the term “post-intensive care syndrome” (PICS). The consequences of PICS on quality of life,...

    Authors: Anne-Françoise Rousseau, Hallie C. Prescott, Stephen J. Brett, Björn Weiss, Elie Azoulay, Jacques Creteur, Nicola Latronico, Catherine L. Hough, Steffen Weber-Carstens, Jean-Louis Vincent and Jean-Charles Preiser

    Citation: Critical Care 2021 25:108

    Content type: Viewpoint

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  6. Single- (SL) and double-lumen (DL) catheters are used in clinical practice for veno-venous extracorporeal membrane oxygenation (V-V ECMO) therapy. However, information is lacking regarding the effects of the c...

    Authors: Roberto Lorusso, Mirko Belliato, Michael Mazzeffi, Michele Di Mauro, Fabio Silvio Taccone, Orlando Parise, Ayat Albanawi, Veena Nandwani, Paul McCarthy, Zachary Kon, Jay Menaker, Daniel M. Johnson, Sandro Gelsomino and Daniel Herr

    Citation: Critical Care 2021 25:107

    Content type: Research

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  7. Coronavirus disease 2019 (COVID-19) pandemic has caused unprecedented pressure on healthcare system globally. Lack of high-quality evidence on the respiratory management of COVID-19-related acute respiratory f...

    Authors: Prashant Nasa, Elie Azoulay, Ashish K. Khanna, Ravi Jain, Sachin Gupta, Yash Javeri, Deven Juneja, Pradeep Rangappa, Krishnaswamy Sundararajan, Waleed Alhazzani, Massimo Antonelli, Yaseen M. Arabi, Jan Bakker, Laurent J. Brochard, Adam M. Deane, Bin Du…

    Citation: Critical Care 2021 25:106

    Content type: Research

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  8. Severe traumatic brain injury (TBI) is associated with blood–brain barrier (BBB) disruption and a subsequent neuroinflammatory process. We aimed to perform a multiplex screening of brain enriched and inflammat...

    Authors: Caroline Lindblad, Elisa Pin, David Just, Faiez Al Nimer, Peter Nilsson, Bo-Michael Bellander, Mikael Svensson, Fredrik Piehl and Eric Peter Thelin

    Citation: Critical Care 2021 25:103

    Content type: Research

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  9. Fluid overload has been associated with increased morbidity and mortality in critically ill patients. The goal of this study was to assess the efficacy and safety of a diuretic strategy to overcome positive fl...

    Authors: Raphaël Cinotti, Jean-Baptiste Lascarrou, Marie-Ange Azais, Gwenhaël Colin, Jean-Pierre Quenot, Pierre-Joachim Mahé, Antoine Roquilly, Aurélie Gaultier, Karim Asehnoune and Jean Reignier

    Citation: Critical Care 2021 25:98

    Content type: Research

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  10. The approach for veno-arterial extracorporeal membrane oxygenation implantation (VA-ECMO) in patients with cardiogenic shock can be either surgical or percutaneous. Complete angio-guided percutaneous implantat...

    Authors: Anne-Sophie Martin-Tuffreau, François Bagate, Madjid Boukantar, Gabriel Saiydoun, Andrea Mangiameli, Laura Rostain, Gauthier Mouillet, Antonio Fiore, Olivier Langeron, Armand Mekontso-Dessap, Nicolas Mongardon, Thierry Folliguet, Emmanuel Teiger and Romain Gallet

    Citation: Critical Care 2021 25:93

    Content type: Research

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  11. The use of indirect calorimetry (IC) is increasing due to its precision in resting energy expenditure (REE) measurement in critically ill patients. Thus, we aimed to evaluate the clinical outcomes of an IC-gui...

    Authors: Jing-Yi Duan, Wen-He Zheng, Hua Zhou, Yuan Xu and Hui-Bin Huang

    Citation: Critical Care 2021 25:88

    Content type: Research

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  12. Mortality rates for patients with ARDS remain high. We assessed temporal changes in the epidemiology and management of ARDS patients requiring invasive mechanical ventilation in European ICUs. We also investig...

    Authors: Yasser Sakr, Bruno François, Jordi Solé-Violan, Katarzyna Kotfis, Ulrich Jaschinski, Angel Estella, Marc Leone, Stephan M. Jakob, Xavier Wittebole, Luis E. Fontes, Miguel de Melo Gurgel, Thais Midega, Jean-Louis Vincent and V. Marco Ranieri

    Citation: Critical Care 2021 25:87

    Content type: Research

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  13. Questions remain about long-term outcome for COVID-19 patients in general, and differences between men and women in particular given the fact that men seem to suffer a more dramatic course of the disease. We t...

    Authors: Erik Zettersten, Lars Engerström, Max Bell, Gabriella Jäderling, Johan Mårtensson, Linda Block and Emma Larsson

    Citation: Critical Care 2021 25:86

    Content type: Research

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  14. Frailty status among critically ill patients with acute kidney injury (AKI) is not well described despite its importance for prognostication and informed decision-making on life-sustaining therapies. In this s...

    Authors: William Beaubien-Souligny, Alan Yang, Gerald Lebovic, Ron Wald and Sean M. Bagshaw

    Citation: Critical Care 2021 25:84

    Content type: Research

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  15. Prognostication of neurological outcome in patients who remain comatose after cardiac arrest resuscitation is complex. Clinical variables, as well as biomarkers of brain injury, cardiac injury, and systemic in...

    Authors: Peder Andersson, Jesper Johnsson, Ola Björnsson, Tobias Cronberg, Christian Hassager, Henrik Zetterberg, Pascal Stammet, Johan Undén, Jesper Kjaergaard, Hans Friberg, Kaj Blennow, Gisela Lilja, Matt P. Wise, Josef Dankiewicz, Niklas Nielsen and Attila Frigyesi

    Citation: Critical Care 2021 25:83

    Content type: Research

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  16. ICU survivorship includes a diverse burden of disease. Current questionnaires used for collecting information about health-related problems and their relation to quality of life lack detailed questions in seve...

    Authors: Johan Malmgren, Ann-Charlotte Waldenström, Christian Rylander, Elias Johannesson and Stefan Lundin

    Citation: Critical Care 2021 25:82

    Content type: Research

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    The Letter to this article has been published in Critical Care 2021 25:255

  17. There is a paucity of data concerning the optimal ventilator management in patients with COVID-19 pneumonia; particularly, the optimal levels of positive-end expiratory pressure (PEEP) are unknown. We aimed to...

    Authors: Lorenzo Ball, Chiara Robba, Lorenzo Maiello, Jacob Herrmann, Sarah E. Gerard, Yi Xin, Denise Battaglini, Iole Brunetti, Giuseppe Minetti, Sara Seitun, Antonio Vena, Daniele Roberto Giacobbe, Matteo Bassetti, Patricia R. M. Rocco, Maurizio Cereda, Lucio Castellan…

    Citation: Critical Care 2021 25:81

    Content type: Research

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    The Letter to this article has been published in Critical Care 2021 25:163

  18. Respiratory failure due to COVID-19 pneumonia is associated with high mortality and may overwhelm health care systems, due to the surge of patients requiring advanced respiratory support. Shortage of intensive...

    Authors: Andrea Coppadoro, Annalisa Benini, Robert Fruscio, Luisa Verga, Paolo Mazzola, Giuseppe Bellelli, Marco Carbone, Giacomo Mulinacci, Alessandro Soria, Beatrice Noè, Eduardo Beck, Riccardo Di Sciacca, Davide Ippolito, Giuseppe Citerio, Maria Grazia Valsecchi, Andrea Biondi…

    Citation: Critical Care 2021 25:80

    Content type: Research

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  19. To study variation in, and clinical impact of high Therapy Intensity Level (TIL) treatments for elevated intracranial pressure (ICP) in patients with traumatic brain injury (TBI) across European Intensive Care...

    Authors: Jilske A. Huijben, Abhishek Dixit, Nino Stocchetti, Andrew I. R. Maas, Hester F. Lingsma, Mathieu van der Jagt, David Nelson, Giuseppe Citerio, Lindsay Wilson, David K. Menon and Ari Ercole

    Citation: Critical Care 2021 25:78

    Content type: Research

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  20. Capillary leakage is a key contributor to the pathological host response to infections. The underlying mechanisms remain incompletely understood, and the role of microRNAs (MIR) has not been investigated in de...

    Authors: Valerie Etzrodt, Temitayo O. Idowu, Heiko Schenk, Benjamin Seeliger, Antje Prasse, Kristina Thamm, Thorben Pape, Janina Müller-Deile, Matijs van Meurs, Thomas Thum, Ankita Garg, Robert Geffers, Klaus Stahl, Samir M. Parikh, Hermann Haller and Sascha David

    Citation: Critical Care 2021 25:76

    Content type: Research

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  21. Pediatric (PARDS) and neonatal (NARDS) acute respiratory distress syndrome have different age-specific characteristics and definitions. Trials on surfactant for ARDS in children and neonates have been perform...

    Authors: Daniele De Luca, Paola Cogo, Martin C. Kneyber, Paolo Biban, Malcolm Grace Semple, Jesus Perez-Gil, Giorgio Conti, Pierre Tissieres and Peter C. Rimensberger

    Citation: Critical Care 2021 25:75

    Content type: Review

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  22. Biomarkers can be used to detect the presence of endothelial and/or alveolar epithelial injuries in case of ARDS. Angiopoietin-2 (Ang-2), soluble intercellular adhesion molecule-1 (ICAM-1), vascular cell adhes...

    Authors: Savino Spadaro, Alberto Fogagnolo, Gianluca Campo, Ottavio Zucchetti, Marco Verri, Irene Ottaviani, Tanushree Tunstall, Salvatore Grasso, Valentina Scaramuzzo, Francesco Murgolo, Elisabetta Marangoni, Francesco Vieceli Dalla Sega, Francesca Fortini, Rita Pavasini, Paola Rizzo, Roberto Ferrari…

    Citation: Critical Care 2021 25:74

    Content type: Research

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  23. The COVID-19 pandemic is responsible for many hospitalizations in intensive care units (ICU), with widespread use of invasive mechanical ventilation (IMV) which exposes patients to the risk of ventilator-assoc...

    Authors: Gauthier Blonz, Achille Kouatchet, Nicolas Chudeau, Emmanuel Pontis, Julien Lorber, Anthony Lemeur, Lucie Planche, Jean-Baptiste Lascarrou and Gwenhael Colin

    Citation: Critical Care 2021 25:72

    Content type: Research

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  24. The early months of the COVID-19 pandemic were fraught with much uncertainty and some resource constraint. We assessed the change in survival to hospital discharge over time for intensive care unit patients wi...

    Authors: Christopher R. Dale, Rachael W. Starcher, Shu Ching Chang, Ari Robicsek, Guilford Parsons, Jason D. Goldman, Andre Vovan, David Hotchkin and Tyler J. Gluckman

    Citation: Critical Care 2021 25:70

    Content type: Research

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  25. Many studies have compared quality of life of post-intensive care syndrome (PICS) patients with age-matched population-based controls. Many studies on PICS used the 36-item Short Form (SF-36) health survey que...

    Authors: Daisuke Kawakami, Shigeki Fujitani, Takeshi Morimoto, Hisashi Dote, Mumon Takita, Akihiro Takaba, Masaaki Hino, Michitaka Nakamura, Hiromasa Irie, Tomohiro Adachi, Mami Shibata, Jun Kataoka, Akira Korenaga, Tomoya Yamashita, Tomoya Okazaki, Masatoshi Okumura…

    Citation: Critical Care 2021 25:69

    Content type: Research

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  26. Sepsis is typically hallmarked by high plasma (free) cortisol and suppressed cortisol breakdown, while plasma adrenocorticotropic hormone (ACTH) is not increased, referred to as ‘ACTH–cortisol dissociation.’ W...

    Authors: Arno Téblick, Sarah Vander Perre, Lies Pauwels, Sarah Derde, Tim Van Oudenhove, Lies Langouche and Greet Van den Berghe

    Citation: Critical Care 2021 25:65

    Content type: Research

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  27. Acute increases in muscle sonographic echodensity reflect muscle injury. Diaphragm echodensity has not been measured in mechanically ventilated patients. We undertook to develop a technique to characterize cha...

    Authors: Benjamin Coiffard, Stephen Riegler, Michael C. Sklar, Martin Dres, Stefannie Vorona, W. Darlene Reid, Laurent J. Brochard, Niall D. Ferguson and Ewan C. Goligher

    Citation: Critical Care 2021 25:64

    Content type: Research

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  28. The identification of factors associated with Intensive Care Unit (ICU) mortality and derived clinical phenotypes in COVID-19 patients could help for a more tailored approach to clinical decision-making that i...

    Authors: Alejandro Rodríguez, Manuel Ruiz-Botella, Ignacio Martín-Loeches, María Jimenez Herrera, Jordi Solé-Violan, Josep Gómez, María Bodí, Sandra Trefler, Elisabeth Papiol, Emili Díaz, Borja Suberviola, Montserrat Vallverdu, Eric Mayor-Vázquez, Antonio Albaya Moreno, Alfonso Canabal Berlanga, Miguel Sánchez…

    Citation: Critical Care 2021 25:63

    Content type: Research

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