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  1. Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) has been increasingly used over the last decade in patients with refractory cardiogenic shock. ECMO weaning can, however, be challenging and lead to ...

    Authors: Enrique Guilherme, Matthias Jacquet-Lagrèze, Matteo Pozzi, Felix Achana, Xavier Armoiry and Jean-Luc Fellahi

    Citation: Critical Care 2020 24:442

    Content type: Research

    Published on:

    The Correction to this article has been published in Critical Care 2020 24:487

  2. Septic shock is associated with decreased vasopressor responsiveness. Experimental data suggest that central alpha2-agonists like dexmedetomidine (DEX) increase vasopressor responsiveness and reduce catecholam...

    Authors: Luca Cioccari, Nora Luethi, Michael Bailey, Yahya Shehabi, Belinda Howe, Anna S. Messmer, Helena K. Proimos, Leah Peck, Helen Young, Glenn M. Eastwood, Tobias M. Merz, Jukka Takala, Stephan M. Jakob and Rinaldo Bellomo

    Citation: Critical Care 2020 24:441

    Content type: Research

    Published on:

  3. Coronavirus disease 2019 (COVID-19) has become a public health emergency of global concern. We aimed to explore the risk factors of 14-day and 28-day mortality and develop a model for predicting 14-day and 28-...

    Authors: Shuai Zhang, Mengfei Guo, Limin Duan, Feng Wu, Guorong Hu, Zhihui Wang, Qi Huang, Tingting Liao, Juanjuan Xu, Yanling Ma, Zhilei Lv, Wenjing Xiao, Zilin Zhao, Xueyun Tan, Daquan Meng, Shujing Zhang…

    Citation: Critical Care 2020 24:438

    Content type: Research

    Published on:

  4. Improving timeliness of pathogen identification is crucial to allow early adaptation of antibiotic therapy and improve prognosis in patients with pneumonia. We evaluated the relevance of a new syndromic rapid ...

    Authors: Céline Monard, Jonathan Pehlivan, Gabriel Auger, Sophie Alviset, Alexy Tran Dinh, Paul Duquaire, Nabil Gastli, Camille d’Humières, Adel Maamar, André Boibieux, Marion Baldeyrou, Julien Loubinoux, Olivier Dauwalder, Vincent Cattoir, Laurence Armand-Lefèvre and Solen Kernéis

    Citation: Critical Care 2020 24:434

    Content type: Research

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  5. Measurement of central venous pressure (CVP) can be a useful clinical tool. However, the formal utility of CVP measurement in preventing mortality in septic patients has never been proven.

    Authors: Hui Chen, Zhu Zhu, Chenyan Zhao, Yanxia Guo, Dongyu Chen, Yao Wei and Jun Jin

    Citation: Critical Care 2020 24:433

    Content type: Research

    Published on:

  6. Endotracheal suctioning (ES) provokes a cumulative hemodynamic response by activation of sympathetic and parasympathetic circuits in the central nervous system. In this proof-of-concept study, we aimed to anal...

    Authors: Verena Rass, Bogdan-Andrei Ianosi, Anna Lindner, Mario Kofler, Alois J. Schiefecker, Bettina Pfausler, Ronny Beer, Erich Schmutzhard and Raimund Helbok

    Citation: Critical Care 2020 24:432

    Content type: Research

    Published on:

  7. Clostridioides difficile infection (CDI) is a leading cause of nosocomial diarrhea. Patients receiving enteral nutrition (EN) in the intensive care unit (ICU) are potentially at high risk of CDI. In the present s...

    Authors: Daosheng Wang, Danfeng Dong, Chen Wang, Yingchao Cui, Cen Jiang, Qi Ni, Tongxuan Su, Guanzheng Wang, Enqiang Mao and Yibing Peng

    Citation: Critical Care 2020 24:426

    Content type: Research

    Published on:

  8. Dysregulation of the host immune response is a pathognomonic feature of sepsis. Abnormal physiological conditions are understood to shift efficient linear splicing of protein-coding RNA towards non-canonical s...

    Authors: Hina N. Khan, Xanthe Brands, Simona Aufiero, Arie J. Hoogendijk, Augustijn M. Klarenbeek, Tjitske S. R. van Engelen, Bastiaan W. Haak, Lonneke A. van Vught, Janneke Horn, Marcus J. Schultz, Aeilko H. Zwinderman, Tom van der Poll and Brendon P. Scicluna

    Citation: Critical Care 2020 24:423

    Content type: Research

    Published on:

  9. An outbreak of pneumonia caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that started in Wuhan, China, at the end of 2019 has become a global pandemic. Both SARS-CoV-2 and SARS-CoV enter...

    Authors: Wentao Ni, Xiuwen Yang, Deqing Yang, Jing Bao, Ran Li, Yongjiu Xiao, Chang Hou, Haibin Wang, Jie Liu, Donghong Yang, Yu Xu, Zhaolong Cao and Zhancheng Gao

    Citation: Critical Care 2020 24:422

    Content type: Review

    Published on:

  10. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the global spread of coronavirus disease (COVID-19). Our understanding of the impact this virus has on the nervous system is limi...

    Authors: Gaurav Nepal, Jessica Holly Rehrig, Gentle Sunder Shrestha, Yow Ka Shing, Jayant Kumar Yadav, Rajeev Ojha, Gaurab Pokhrel, Zhi Lan Tu and Dong Ya Huang

    Citation: Critical Care 2020 24:421

    Content type: Research

    Published on:

  11. The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) outbreak is spreading worldwide. To date, no specific treatment has convincingly demonstrated its efficacy. Hydroxychloroquine and lopinavir/rit...

    Authors: Marie Lecronier, Alexandra Beurton, Sonia Burrel, Luc Haudebourg, Robin Deleris, Julien Le Marec, Sara Virolle, Safaa Nemlaghi, Côme Bureau, Pierre Mora, Martin De Sarcus, Olivier Clovet, Baptiste Duceau, Paul Henri Grisot, Marie Hélène Pari, Jérémy Arzoine…

    Citation: Critical Care 2020 24:418

    Content type: Research

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  12. Mechanical power (MP) is the energy delivered to the respiratory system over time during mechanical ventilation. Our aim was to compare the currently available methods to calculate MP during volume- and pressu...

    Authors: Davide Chiumello, Miriam Gotti, Mariateresa Guanziroli, Paolo Formenti, Michele Umbrello, Iacopo Pasticci, Giovanni Mistraletti and Mattia Busana

    Citation: Critical Care 2020 24:417

    Content type: Research

    Published on:

  13. Cystatin C is a well-validated marker of glomerular filtration rate in chronic kidney disease. Higher plasma concentrations of cystatin C are associated with worse clinical outcomes in heterogenous populations...

    Authors: Carolyn M. Hendrickson, Yuenting D. Kwong, Annika G. Belzer, Michael G. Shlipak, Michael A. Matthay and Kathleen D. Liu

    Citation: Critical Care 2020 24:416

    Content type: Research

    Published on:

  14. More men than women have died from COVID-19. Genes encoded on X chromosomes, and sex hormones may explain the decreased fatality of COVID-19 in women. The angiotensin-converting enzyme 2 gene is located on X c...

    Authors: Yuchong Li, Mirjana Jerkic, Arthur S. Slutsky and Haibo Zhang

    Citation: Critical Care 2020 24:405

    Content type: Viewpoint

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  15. The need for early antibiotics in the intensive care unit (ICU) is often balanced against the goal of antibiotic stewardship. Long-course antibiotics increase the burden of antimicrobial resistance within colo...

    Authors: Christian Munck, Ravi U. Sheth, Edward Cuaresma, Jessica Weidler, Stephania L. Stump, Philip Zachariah, David H. Chong, Anne-Catrin Uhlemann, Julian A. Abrams, Harris H. Wang and Daniel E. Freedberg

    Citation: Critical Care 2020 24:404

    Content type: Research

    Published on:

  16. Prescribing pharmacologic therapies for critically ill patients requires a careful balancing of risks and benefits. Defining, monitoring, and reporting harms that occur in clinical trials conducted in critical...

    Authors: Ari Moskowitz, Lars W. Andersen, Mathias J. Holmberg, Anne V. Grossestreuer, Katherine M. Berg and Asger Granfeldt

    Citation: Critical Care 2020 24:398

    Content type: Research

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  17. Prone positioning (PP) has shown to improve survival in patients with severe acute respiratory distress syndrome (ARDS). To this point, it is unclear if PP is also beneficial for ARDS patients treated with ven...

    Authors: Jonathan Rilinger, Viviane Zotzmann, Xavier Bemtgen, Carin Schumacher, Paul M. Biever, Daniel Duerschmied, Klaus Kaier, Peter Stachon, Constantin von zur Mühlen, Manfred Zehender, Christoph Bode, Dawid L. Staudacher and Tobias Wengenmayer

    Citation: Critical Care 2020 24:397

    Content type: Research

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  18. The global numbers of confirmed cases and deceased critically ill patients with COVID-19 are increasing. However, the clinical course, and the 60-day mortality and its predictors in critically ill patients hav...

    Authors: Jiqian Xu, Xiaobo Yang, Luyu Yang, Xiaojing Zou, Yaxin Wang, Yongran Wu, Ting Zhou, Yin Yuan, Hong Qi, Shouzhi Fu, Hong Liu, Jia’an Xia, Zhengqin Xu, Yuan Yu, Ruiting Li, Yaqi Ouyang…

    Citation: Critical Care 2020 24:394

    Content type: Research

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  19. Critical care ultrasound (CCUS) is an essential component of intensive care practice. Although existing international guidelines have focused on training principles and determining competency in CCUS, few coun...

    Authors: Adrian Wong, Laura Galarza, Lui Forni, Daniel De Backer, Michael Slama, Bernard Cholley, Paul Mayo, Anthony McLean, Antoine Vieillard-Baron, Daniel Lichtenstein, Giovanni Volpicelli, Robert Arntfield, Ignacio Martin-Loeches, Gizella Melania Istrate and František Duška

    Citation: Critical Care 2020 24:393

    Content type: Review

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  20. Acute hypoxemic respiratory failure (AHRF) and acute respiratory distress syndrome (ARDS) are associated with high in-hospital mortality. However, in cohorts of ARDS patients from the 1990s, patients more comm...

    Authors: Scott W. Ketcham, Yub Raj Sedhai, H. Catherine Miller, Thomas C. Bolig, Amy Ludwig, Ivan Co, Dru Claar, Jakob I. McSparron, Hallie C. Prescott and Michael W. Sjoding

    Citation: Critical Care 2020 24:391

    Content type: Research

    Published on: