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  1. COVID-19 has caused great devastation in the past year. Multi-organ point-of-care ultrasound (PoCUS) including lung ultrasound (LUS) and focused cardiac ultrasound (FoCUS) as a clinical adjunct has played a si...

    Authors: Arif Hussain, Gabriele Via, Lawrence Melniker, Alberto Goffi, Guido Tavazzi, Luca Neri, Tomas Villen, Richard Hoppmann, Francesco Mojoli, Vicki Noble, Laurent Zieleskiewicz, Pablo Blanco, Irene W. Y. Ma, Mahathar Abd. Wahab, Abdulmohsen Alsaawi, Majid Al Salamah…

    Citation: Critical Care 2020 24:702

    Content type: Review

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  2. Bedside lung ultrasound (LUS) has emerged as a useful and non-invasive tool to detect lung involvement and monitor changes in patients with coronavirus disease 2019 (COVID-19). However, the clinical significan...

    Authors: Li Ji, Chunyan Cao, Ying Gao, Wen Zhang, Yuji Xie, Yilian Duan, Shuangshuang Kong, Manjie You, Rong Ma, Lili Jiang, Jie Liu, Zhenxing Sun, Ziming Zhang, Jing Wang, Yali Yang, Qing Lv…

    Citation: Critical Care 2020 24:700

    Content type: Research

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  3. Data on incidence of ventilator-associated pneumonia (VAP) and invasive pulmonary aspergillosis in patients with severe SARS-CoV-2 infection are limited.

    Authors: Keyvan Razazi, Romain Arrestier, Anne Fleur Haudebourg, Brice Benelli, Guillaume Carteaux, Jean‑Winoc Decousser, Slim Fourati, Paul Louis Woerther, Frederic Schlemmer, Anais Charles-Nelson, Francoise Botterel, Nicolas de Prost and Armand Mekontso Dessap

    Citation: Critical Care 2020 24:699

    Content type: Research

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    The Correction to this article has been published in Critical Care 2021 25:118

  4. Corticoid therapy has been recommended in the treatment of critically ill patients with COVID-19, yet its efficacy is currently still under evaluation. We investigated the effect of corticosteroid treatment on...

    Authors: Yiming Li, Qinghe Meng, Xin Rao, Binbin Wang, Xingguo Zhang, Fang Dong, Tao Yu, Zhongyi Li, Huibin Feng, Jinpeng Zhang, Xiangyang Chen, Hunian Li, Yi Cheng, Xiaoyang Hong, Xiang Wang, Yimei Yin…

    Citation: Critical Care 2020 24:698

    Content type: Research

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  5. Efficacy and safety of different hemoglobin thresholds for transfusion of red blood cells (RBCs) in adults with an acute respiratory distress syndrome (ARDS) are unknown. We therefore assessed the effect of tw...

    Authors: O. Hunsicker, L. Materne, V. Bünger, A. Krannich, F. Balzer, C. Spies, R. C. Francis, S. Weber-Carstens, M. Menk and J. A. Graw

    Citation: Critical Care 2020 24:697

    Content type: Research

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  6. In the current SARS-CoV-2 pandemic, there has been worldwide debate on the use of corticosteroids in COVID-19. In the recent RECOVERY trial, evaluating the effect of dexamethasone, a reduced 28-day mortality i...

    Authors: Judith van Paassen, Jeroen S. Vos, Eva M. Hoekstra, Katinka M. I. Neumann, Pauline C. Boot and Sesmu M. Arbous

    Citation: Critical Care 2020 24:696

    Content type: Research

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  7. Little is known on the association between local signs and intravascular catheter infections. This study aimed to evaluate the association between local signs at removal and catheter-related bloodstream infect...

    Authors: Niccolò Buetti, Stéphane Ruckly, Jean-Christophe Lucet, Lila Bouadma, Maité Garrouste-Orgeas, Carole Schwebel, Olivier Mimoz, Bertrand Souweine and Jean-François Timsit

    Citation: Critical Care 2020 24:694

    Content type: Research

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  8. Crystalloids and different component colloids, used for volume resuscitation, are sometimes associated with various adverse effects. Clinical trial findings for such fluid types in different patients’ conditio...

    Authors: Chien-Hua Tseng, Tzu-Tao Chen, Mei-Yi Wu, Ming-Cheng Chan, Ming-Chieh Shih and Yu-Kang Tu

    Citation: Critical Care 2020 24:693

    Content type: Research

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  9. The efficacy and safety of high flow nasal therapy (HFNT) in patients with acute hypercapnic exacerbation of chronic obstructive pulmonary disease (AECOPD) are unclear. Our aim was to evaluate the short-term e...

    Authors: Andrea Cortegiani, Federico Longhini, Fabiana Madotto, Paolo Groff, Raffaele Scala, Claudia Crimi, Annalisa Carlucci, Andrea Bruni, Eugenio Garofalo, Santi Maurizio Raineri, Roberto Tonelli, Vittoria Comellini, Enrico Lupia, Luigi Vetrugno, Enrico Clini, Antonino Giarratano…

    Citation: Critical Care 2020 24:692

    Content type: Research

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  10. COVID-19 can course with respiratory and extrapulmonary disease. SARS-CoV-2 RNA is detected in respiratory samples but also in blood, stool and urine. Severe COVID-19 is characterized by a dysregulated host re...

    Authors: Jesús F. Bermejo-Martin, Milagros González-Rivera, Raquel Almansa, Dariela Micheloud, Ana P. Tedim, Marta Domínguez-Gil, Salvador Resino, Marta Martín-Fernández, Pablo Ryan Murua, Felipe Pérez-García, Luis Tamayo, Raúl Lopez-Izquierdo, Elena Bustamante, César Aldecoa, José Manuel Gómez, Jesús Rico-Feijoo…

    Citation: Critical Care 2020 24:691

    Content type: Research

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  11. A subset of critically ill COVID-19 patients develop a hyperinflammatory state. Anakinra, a recombinant interleukin-1 receptor antagonist, is known to be effective in several hyperinflammatory diseases. We inv...

    Authors: Emma J. Kooistra, Nicole J. B. Waalders, Inge Grondman, Nico A. F. Janssen, Aline H. de Nooijer, Mihai G. Netea, Frank L. van de Veerdonk, Esther Ewalds, Johannes G. van der Hoeven, Matthijs Kox and Peter Pickkers

    Citation: Critical Care 2020 24:688

    Content type: Research

    Published on:

    The Letter to this article has been published in Critical Care 2021 25:131

  12. The short-term and long-term consequences of the most frequent painful procedures performed in the ICU are unclear. This study aimed to identify the risk factors associated with pain-related discomfort perceiv...

    Authors: Pierre Kalfon, Mohamed Boucekine, Philippe Estagnasie, Marie-Agnès Geantot, Audrey Berric, Georges Simon, Bernard Floccard, Thomas Signouret, Mélanie Fromentin, Martine Nyunga, Juliette Audibert, Adel Ben Salah, Bénédicte Mauchien, Achille Sossou, Marion Venot, René Robert…

    Citation: Critical Care 2020 24:685

    Content type: Research

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  13. The benefits of extracorporeal membrane oxygenation (ECMO) in children with sepsis remain controversial. Current guidelines on management of septic shock in children recommend consideration of ECMO as salvage ...

    Authors: Kollengode Ramanathan, Nicholas Yeo, Peta Alexander, Lakshmi Raman, Ryan Barbaro, Chuen Seng Tan, Luregn J. Schlapbach and Graeme MacLaren

    Citation: Critical Care 2020 24:684

    Content type: Research

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  14. The postoperative period is critical for a patient’s recovery, and postoperative hypotension, specifically, is associated with adverse clinical outcomes and significant harm to the patient. However, little is ...

    Authors: Nathan J. Smischney, Andrew D. Shaw, Wolf H. Stapelfeldt, Isabel J. Boero, Qinyu Chen, Mitali Stevens and Ashish K. Khanna

    Citation: Critical Care 2020 24:682

    Content type: Research

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  15. Acute respiratory distress syndrome (ARDS) is heterogeneous and may be amenable to sub-phenotyping to improve enrichment for trials. We aimed to identify subtypes of pediatric ARDS based on whole blood transcr...

    Authors: Nadir Yehya, Brian M. Varisco, Neal J. Thomas, Hector R. Wong, Jason D. Christie and Rui Feng

    Citation: Critical Care 2020 24:681

    Content type: Research

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  16. Early prognostication in patients with acute consciousness impairment is a challenging but essential task. Current prognostic guidelines vary with the underlying etiology. In particular, electroencephalography...

    Authors: Michael Müller, Andrea O. Rossetti, Rebekka Zimmermann, Vincent Alvarez, Stephan Rüegg, Matthias Haenggi, Werner J. Z’Graggen, Kaspar Schindler and Frédéric Zubler

    Citation: Critical Care 2020 24:680

    Content type: Research

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  17. Microaspiration of gastric and oropharyngeal secretions is the main causative mechanism of ventilator-associated pneumonia (VAP). Transesophageal echocardiography (TEE) is a routine investigation tool in inten...

    Authors: François Bagate, Anahita Rouzé, Farid Zerimech, Florence Boissier, Vincent Labbe, Keyvan Razazi, Guillaume Carteaux, Nicolas de Prost, Malika Balduyck, Patrice Maboudou, Saad Nseir and Armand Mekontso Dessap

    Citation: Critical Care 2020 24:679

    Content type: Research

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  18. Patients with coronavirus disease-19-related acute respiratory distress syndrome (C-ARDS) could have a specific physiological phenotype as compared with those affected by ARDS from other causes (NC-ARDS).

    Authors: François Perier, Samuel Tuffet, Tommaso Maraffi, Glasiele Alcala, Marcus Victor, Anne-Fleur Haudebourg, Keyvan Razazi, Nicolas De Prost, Marcelo Amato, Guillaume Carteaux and Armand Mekontso Dessap

    Citation: Critical Care 2020 24:678

    Content type: Research

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  19. There is emerging evidence for enhanced blood coagulation in coronavirus 2019 (COVID-19) patients, with thromboembolic complications contributing to morbidity and mortality. The mechanisms underlying this prot...

    Authors: Jan Matthias Kruse, Abakar Magomedov, Annika Kurreck, Frédéric H. Münch, Roland Koerner, Julian Kamhieh-Milz, Andreas Kahl, Inka Gotthardt, Sophie K. Piper, Kai-Uwe Eckardt, Thomas Dörner and Daniel Zickler

    Citation: Critical Care 2020 24:676

    Content type: Research

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  20. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Vincent Bonny, Vincent Janiak, Savino Spadaro, Andrea Pinna, Alexandre Demoule and Martin Dres

    Citation: Critical Care 2020 24:675

    Content type: Correction

    Published on:

    The original article was published in Critical Care 2020 24:596

  21. There is wide variability between intensivists in the decisions to forgo life-sustaining treatment (DFLST). Advance directives (ADs) allow patients to communicate their end-of-life wishes to physicians. We ass...

    Authors: Margot Smirdec, Mercé Jourdain, Virginie Guastella, Céline Lambert, Jean-Christophe Richard, Laurent Argaud, Samir Jaber, Kada Klouche, Anne Medard, Jean Reignier, Jean-Philippe Rigaud, Jean-Marc Doise, Russell Chabanne, Bertrand Souweine, Jeremy Bourenne, Julie Delmas…

    Citation: Critical Care 2020 24:672

    Content type: Research

    Published on:

  22. To investigate the prevalence and prognostic impact of right heart failure and right ventricular-arterial uncoupling in Corona Virus Infectious Disease 2019 (COVID-19) complicated by an Acute Respiratory Distr...

    Authors: Michele D’Alto, Alberto M. Marra, Sergio Severino, Andrea Salzano, Emanuele Romeo, Rosanna De Rosa, Francesca Maria Stagnaro, Gianpiero Pagnano, Raffaele Verde, Patrizia Murino, Andrea Farro, Giovanni Ciccarelli, Maria Vargas, Giuseppe Fiorentino, Giuseppe Servillo, Ivan Gentile…

    Citation: Critical Care 2020 24:670

    Content type: Research

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  23. Diaphragm dysfunction is highly prevalent in mechanically ventilated patients. Recent work showed that changes in diaphragm shear modulus (ΔSMdi) assessed using ultrasound shear wave elastography (SWE) are str...

    Authors: Quentin Fossé, Thomas Poulard, Marie-Cécile Niérat, Sara Virolle, Elise Morawiec, Jean-Yves Hogrel, Thomas Similowski, Alexandre Demoule, Jean-Luc Gennisson, Damien Bachasson and Martin Dres

    Citation: Critical Care 2020 24:669

    Content type: Research

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  24. Traumatic brain injury (TBI) is a major cause of morbidity and mortality, but there are no clinically proven treatments that specifically target neuronal loss and secondary injury development following TBI. In...

    Authors: Rita Campos-Pires, Haldis Onggradito, Eszter Ujvari, Shughoofa Karimi, Flavia Valeo, Jitka Aldhoun, Christopher J. Edge, Nicholas P. Franks and Robert Dickinson

    Citation: Critical Care 2020 24:667

    Content type: Research

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  25. Multisystem inflammatory syndrome temporally associated with COVID-19 (MIS-C) has been described as a novel and often severe presentation of SARS-CoV-2 infection in children. We aimed to describe the character...

    Authors: Alberto García-Salido, Juan Carlos de Carlos Vicente, Sylvia Belda Hofheinz, Joan Balcells Ramírez, María Slöcker Barrio, Inés Leóz Gordillo, Alexandra Hernández Yuste, Carmina Guitart Pardellans, Maite Cuervas-Mons Tejedor, Beatriz Huidobro Labarga, José Luís Vázquez Martínez, Míriam Gutiérrez Jimeno, Ignacio Oulego-Erróz, Javier Trastoy Quintela, Carmen Medina Monzón, Laura Medina Ramos…

    Citation: Critical Care 2020 24:666

    Content type: Research

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  26. Effective antimicrobial treatment is key to reduce mortality associated with bacterial sepsis in patients on intensive care units (ICUs). Dose adjustments are often necessary to account for pathophysiological ...

    Authors: Dennis Kühn, Carlos Metz, Frederik Seiler, Holger Wehrfritz, Sophie Roth, Mohammad Alqudrah, André Becker, Hendrik Bracht, Stefan Wagenpfeil, Mathias Hoffmann, Robert Bals, Ulrich Hübner, Jürgen Geisel, Philipp M. Lepper and Sören L. Becker

    Citation: Critical Care 2020 24:664

    Content type: Research

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  27. Flow-controlled ventilation is a novel ventilation method which allows to individualize ventilation according to dynamic lung mechanic limits based on direct tracheal pressure measurement at a stable constant ...

    Authors: Patrick Spraider, Judith Martini, Julia Abram, Gabriel Putzer, Bernhard Glodny, Tobias Hell, Tom Barnes and Dietmar Enk

    Citation: Critical Care 2020 24:662

    Content type: Research

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  28. Even brief hypotension is associated with increased morbidity and mortality. We developed a machine learning model to predict the initial hypotension event among intensive care unit (ICU) patients and designed...

    Authors: Joo Heung Yoon, Vincent Jeanselme, Artur Dubrawski, Marilyn Hravnak, Michael R. Pinsky and Gilles Clermont

    Citation: Critical Care 2020 24:661

    Content type: Research

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  29. Acute kidney injury (AKI) affects a large proportion of the critically ill and is associated with worse patient outcomes. Early identification of AKI can lead to earlier initiation of supportive therapy and be...

    Authors: Christopher Bourdeaux, Erina Ghosh, Louis Atallah, Krishnamoorthy Palanisamy, Payaal Patel, Matthew Thomas, Timothy Gould, John Warburton, Jon Rivers and John Hadfield

    Citation: Critical Care 2020 24:656

    Content type: Research

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  30. Nasal high flow delivered at flow rates higher than 60 L/min in patients with acute hypoxemic respiratory failure might be associated with improved physiological effects. However, poor comfort might limit feas...

    Authors: Maria Cristina Basile, Tommaso Mauri, Elena Spinelli, Francesca Dalla Corte, Giacomo Montanari, Ines Marongiu, Savino Spadaro, Alessandro Galazzi, Giacomo Grasselli and Antonio Pesenti

    Citation: Critical Care 2020 24:654

    Content type: Research

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  31. A substantial proportion of critically ill COVID-19 patients develop thromboembolic complications, but it is unclear whether higher doses of thromboprophylaxis are associated with lower mortality rates. The pu...

    Authors: Sandra Jonmarker, Jacob Hollenberg, Martin Dahlberg, Otto Stackelberg, Jacob Litorell, Åsa H. Everhov, Hans Järnbert-Pettersson, Mårten Söderberg, Jonathan Grip, Anna Schandl, Mattias Günther and Maria Cronhjort

    Citation: Critical Care 2020 24:653

    Content type: Research

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  32. Pressure support ventilation (PSV) should allow spontaneous breathing with a “normal” neuro-ventilatory drive. Low neuro-ventilatory drive puts the patient at risk of diaphragmatic atrophy while high neuro-ven...

    Authors: Rosa Di mussi, Savino Spadaro, Carlo Alberto Volta, Nicola Bartolomeo, Paolo Trerotoli, Francesco Staffieri, Luigi Pisani, Rachele Iannuzziello, Lidia Dalfino, Francesco Murgolo and Salvatore Grasso

    Citation: Critical Care 2020 24:652

    Content type: Research

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