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  1. A higher-than-usual resistance to standard sedation regimens in COVID-19 patients suffering from acute respiratory distress syndrome (ARDS) has led to the frequent use of the second-line anaesthetic agent keta...

    Authors: Pedro David Wendel-Garcia, Rolf Erlebach, Daniel Andrea Hofmaenner, Giovanni Camen, Reto Andreas Schuepbach, Christoph Jüngst, Beat Müllhaupt, Jan Bartussek, Philipp Karl Buehler, Rea Andermatt and Sascha David
    Citation: Critical Care 2022 26:148
  2. Extracorporeal membrane oxygenation (ECMO) has been used extensively for coronavirus disease 2019 (COVID-19)-related acute respiratory distress syndrome (ARDS). Reports early in the pandemic suggested that mor...

    Authors: Ryan Ruiyang Ling, Kollengode Ramanathan, Jackie Jia Lin Sim, Suei Nee Wong, Ying Chen, Faizan Amin, Shannon M. Fernando, Bram Rochwerg, Eddy Fan, Ryan P. Barbaro, Graeme MacLaren, Kiran Shekar and Daniel Brodie
    Citation: Critical Care 2022 26:147
  3. A recent randomised controlled trial failed to demonstrate a beneficial effect of recombinant human thrombomodulin (rhTM) on sepsis. However, there is still controversy in the effects of rhTM for sepsis due to...

    Authors: Tadahiro Goto, Daisuke Kudo, Ryo Uchimido, Mineji Hayakawa, Kazuma Yamakawa, Toshikazu Abe, Atsushi Shiraishi and Shigeki Kushimoto
    Citation: Critical Care 2022 26:145
  4. Medical nutrition therapy may be associated with clinical outcomes in critically ill patients with prolonged intensive care unit (ICU) stay. We wanted to assess nutrition practices in European intensive care u...

    Authors: Martin Matejovic, Olivier Huet, Karolien Dams, Gunnar Elke, Clara Vaquerizo Alonso, Akos Csomos, Łukasz J. Krzych, Romano Tetamo, Zudin Puthucheary, Olav Rooyackers, Inga Tjäder, Helmut Kuechenhoff, Wolfgang H. Hartl and Michael Hiesmayr
    Citation: Critical Care 2022 26:143
  5. Critically ill COVID-19 patients may develop acute respiratory distress syndrome and the need for respiratory support, including mechanical ventilation in the intensive care unit. Previous observational studie...

    Authors: Måns Eeg-Olofsson, Nina Pauli, Louise Hafsten, Josephine Jacobsson, Christopher Lundborg, Magnus Brink, Helen Larsson, Ellen Lindell, Karin Löwhagen, Magnus Gisslén and Henrik Bergquist
    Citation: Critical Care 2022 26:142
  6. The role of neuromuscular blocking agents (NMBAs) in coronavirus disease 2019 (COVID-19) acute respiratory distress syndrome (ARDS) is not fully elucidated. Therefore, we aimed to investigate in COVID-19 patie...

    Authors: Gianluigi Li Bassi, Kristen Gibbons, Jacky Y. Suen, Heidi J. Dalton, Nicole White, Amanda Corley, Sally Shrapnel, Samuel Hinton, Simon Forsyth, John G. Laffey, Eddy Fan, Jonathon P. Fanning, Mauro Panigada, Robert Bartlett, Daniel Brodie, Aidan Burrell…
    Citation: Critical Care 2022 26:141
  7. Sarcopenia is defined as age-related loss of muscle mass, strength, and/or function in the context of aging. Mechanical ventilation (MV) is one of the most frequently used critical care technologies in critica...

    Authors: Tingting Jiang, Taiping Lin, Xiaoyu Shu, Quhong Song, Miao Dai, Yanli Zhao, Li Huang, Xiangping Tu and Jirong Yue
    Citation: Critical Care 2022 26:140
  8. Stress hyperglycemia can persist during an intensive care unit (ICU) stay and result in prolonged requirement for insulin (PRI). The impact of PRI on ICU patient outcomes is not known. We evaluated the relatio...

    Authors: François Thouy, Julien Bohé, Bertrand Souweine, Hassane Abidi, Jean-Pierre Quenot, Fabrice Thiollière, Jean Dellamonica, Jean-Charles Preiser, Jean-François Timsit, Vincent Brunot, Amna Klich, Nicholas Sedillot, Xavier Tchenio, Jean-Baptiste Roudaut, Nicolas Mottard, Hervé Hyvernat…
    Citation: Critical Care 2022 26:138
  9. In Japan, emergency medical service (EMS) providers are prohibited from field termination-of-resuscitation (TOR) in out-of-hospital cardiac arrest (OHCA) patients. In 2013, we developed a TOR rule for emergenc...

    Authors: Yoshikazu Goto, Akira Funada, Tetsuo Maeda and Yumiko Goto
    Citation: Critical Care 2022 26:137
  10. Hospital- and community-onset sepsis are significant sepsis subgroups. Japanese data comparing these subgroups are limited. This study aimed to describe the epidemiology of hospital- and community-onset sepsis...

    Authors: Mayuko Tonai, Atsushi Shiraishi, Toshiyuki Karumai, Akira Endo, Hirotada Kobayashi, Kiyohide Fushimi and Yoshiro Hayashi
    Citation: Critical Care 2022 26:136
  11. Blood purification through the removal of plasma solutes by adsorption to beads of charcoal or resins contained in a cartridge (hemoperfusion) has a long and imperfect history. Developments in production and c...

    Authors: Claudio Ronco and Rinaldo Bellomo
    Citation: Critical Care 2022 26:135
  12. Recently, a randomized controlled trial (RCT) demonstrated rapid but individually variable hemodynamic improvement with therapeutic plasma exchange (TPE) in patients with septic shock. Prediction of clinical e...

    Authors: Klaus Stahl, Philipp Wand, Benjamin Seeliger, Pedro David Wendel-Garcia, Julius J. Schmidt, Bernhard M. W. Schmidt, Andrea Sauer, Felix Lehmann, Ulrich Budde, Markus Busch, Olaf Wiesner, Tobias Welte, Hermann Haller, Heiner Wedemeyer, Christian Putensen, Marius M. Hoeper…
    Citation: Critical Care 2022 26:134
  13. Many critically ill children face long-term developmental impairments. The PEPaNIC trial attributed part of the problems at the level of neurocognitive and emotional/behavioral development to early use of pare...

    Authors: Ilse Vanhorebeek, An Jacobs, Liese Mebis, Karolijn Dulfer, Renate Eveleens, Hanna Van Cleemput, Pieter J. Wouters, Ines Verlinden, Koen Joosten, Sascha Verbruggen and Greet Van den Berghe
    Citation: Critical Care 2022 26:133
  14. Authors: Bart G. J. Candel, Wouter Raven, Heleen Lameijer, Wendy A. M. H. Thijssen, Fabian Termorshuizen, Christiaan Boerma, Nicolette F. de Keizer, Evert de Jonge and Bas de Groot
    Citation: Critical Care 2022 26:132

    The original article was published in Critical Care 2022 26:112

  15. The detection of coinfections is important to initiate appropriate antimicrobial therapy. Molecular diagnostic testing identifies pathogens at a greater rate than conventional microbiology. We assessed both ba...

    Authors: Francisco José Molina, Luz Elena Botero, Juan Pablo Isaza, Luz Elena Cano, Lucelly López, Leidy Tamayo and Antoni Torres
    Citation: Critical Care 2022 26:130
  16. The prevalence of extracorporeal cardiopulmonary resuscitation (ECPR) in patients with out-of-hospital cardiac arrest (OHCA) has been increasing rapidly worldwide. However, guidelines or clinical studies do no...

    Authors: Akihiko Inoue, Toru Hifumi, Tetsuya Sakamoto, Hiroshi Okamoto, Jun Kunikata, Hideto Yokoi, Hirotaka Sawano, Yuko Egawa, Shunichi Kato, Kazuhiro Sugiyama, Naofumi Bunya, Takehiko Kasai, Shinichi Ijuin, Shinichi Nakayama, Jun Kanda, Seiya Kanou…
    Citation: Critical Care 2022 26:129
  17. Thrombotic microangiopathy-induced thrombocytopenia-associated multiple organ failure and hyperinflammatory macrophage activation syndrome are important causes of late pediatric sepsis mortality that are often mi...

    Authors: Yidi Qin, Kate F. Kernan, Zhenjiang Fan, Hyun-Jung Park, Soyeon Kim, Scott W. Canna, John A. Kellum, Robert A. Berg, David Wessel, Murray M. Pollack, Kathleen Meert, Mark Hall, Christopher Newth, John C. Lin, Allan Doctor, Tom Shanley…
    Citation: Critical Care 2022 26:128
  18. Prone positioning improves survival in moderate-to-severe acute respiratory distress syndrome (ARDS) unrelated to the novel coronavirus disease (COVID-19). This benefit is probably mediated by a decrease in al...

    Authors: Alessandro Protti, Alessandro Santini, Francesca Pennati, Chiara Chiurazzi, Michele Ferrari, Giacomo E. Iapichino, Luca Carenzo, Francesca Dalla Corte, Ezio Lanza, Nicolò Martinetti, Andrea Aliverti and Maurizio Cecconi
    Citation: Critical Care 2022 26:127
  19. Survival has been considered the cornerstone for clinical outcome evaluation in critically ill patients admitted to intensive care unit (ICU). There is evidence that ICU survivors commonly show impairments in ...

    Authors: Ottavia Pallanch, Alessandro Ortalda, Paolo Pelosi, Nicola Latronico, Chiara Sartini, Gaetano Lombardi, Cristiano Marchetti, Nicolò Maimeri, Alberto Zangrillo and Luca Cabrini
    Citation: Critical Care 2022 26:126
  20. Some academic organizations recommended that physicians intubate patients with COVID-19 with a relatively lower threshold of oxygen usage particularly in the early phase of pandemic. We aimed to elucidate whet...

    Authors: Ryo Yamamoto, Daiki Kaito, Koichiro Homma, Akira Endo, Takashi Tagami, Morio Suzuki, Naoyuki Umetani, Masayuki Yagi, Eisaku Nashiki, Tomohiro Suhara, Hiromasa Nagata, Hiroki Kabata, Koichi Fukunaga, Kazuma Yamakawa, Mineji Hayakawa, Takayuki Ogura…
    Citation: Critical Care 2022 26:124
  21. Current sedatives have different side effects in long-term sedation. The sequential use of midazolam and dexmedetomidine for prolonged sedation may have distinct advantages. We aimed to evaluate the efficacy a...

    Authors: Yongfang Zhou, Jie Yang, Bo Wang, Peng Wang, Zhen Wang, Yunqin Yang, Guopeng Liang, Xiaorong jing, Xiaodong Jin, Zhongwei Zhang, Yiyun Deng, Chenggong Hu, Xuelian Liao, Wanhong Yin, Zhihong Tang, Yongming Tian…
    Citation: Critical Care 2022 26:122
  22. The Clinical Frailty Scale (CFS) is the most commonly used frailty measure in intensive care unit (ICU) patients. The hospital frailty risk score (HFRS) was recently proposed for the quantification of frailty....

    Authors: Ashwin Subramaniam, Ryo Ueno, Ravindranath Tiruvoipati, Velandai Srikanth, Michael Bailey and David Pilcher
    Citation: Critical Care 2022 26:121
  23. To assess the safety and feasibility of imaging of the brain with a point-of-care (POC) magnetic resonance imaging (MRI) system in patients on extracorporeal membrane oxygenation (ECMO). Early detection of acu...

    Authors: Sung-Min Cho, Christopher Wilcox, Steven Keller, Matthew Acton, Hannah Rando, Eric Etchill, Katherine Giuliano, Errol L. Bush, Haris I. Sair, John Pitts, Bo Soo Kim and Glenn Whitman
    Citation: Critical Care 2022 26:119
  24. Whether prone position (PP) improves clinical outcomes in COVID-19 pneumonia treated with noninvasive ventilation (NIV) is unknown. We evaluated the effect of early PP on 28-day NIV failure, intubation and dea...

    Authors: Giovanni Musso, Claudio Taliano, Federica Molinaro, Caterina Fonti, Deliana Veliaj, Davide Torti, Elena Paschetta, Elisabetta Castagna, Giorgio Carbone, Luigi Laudari, Claudio Aseglio, Edoardo Zocca, Sonia Chioni, Laura Ceretto Giannone, Federica Arabia, Cecilia Deiana…
    Citation: Critical Care 2022 26:118
  25. Preclinical models of acute kidney injury (AKI) consistently demonstrate that a uremic milieu enhances renal recovery and decreases kidney fibrosis. Similarly, significant decreases in monocyte/macrophage infi...

    Authors: Lakhmir S. Chawla
    Citation: Critical Care 2022 26:116
  26. Authors: Lu Ke, Jiajia Lin, Gordon S. Doig, Arthur R. H. van Zanten, Yang Wang, Juan Xing, Zhongheng Zhang, Tao Chen, Lixin Zhou, Dongpo Jiang, Qindong Shi, Jiandong Lin, Jun Liu, Aibin Cheng, Yafeng Liang, Peiyang Gao…
    Citation: Critical Care 2022 26:115

    The original article was published in Critical Care 2022 26:46

  27. Late mortality risk in sepsis-survivors persists for years with high readmission rates and low quality of life. The present study seeks to link the clinical sepsis-survivors heterogeneity with distinct biologi...

    Authors: Sabri Soussi, Divya Sharma, Peter Jüni, Gerald Lebovic, Laurent Brochard, John C. Marshall, Patrick R. Lawler, Margaret Herridge, Niall Ferguson, Lorenzo Del Sorbo, Elodie Feliot, Alexandre Mebazaa, Erica Acton, Jason N. Kennedy, Wei Xu, Etienne Gayat…
    Citation: Critical Care 2022 26:114
  28. To assess the usefulness of pre-operative contrast-enhanced transthoracic echocardiography (CE-TTE) and post-operative chest-x-ray (CXR) for evaluating central venous catheter (CVC) tip placements, with trans-...

    Authors: Francesco Corradi, Fabio Guarracino, Gregorio Santori, Claudia Brusasco, Guido Tavazzi, Gabriele Via, Silvia Mongodi, Francesco Mojoli, Raffaello Umberto Dario Biagini, Alessandro Isirdi, Federico Dazzi, Chiara Robba, Luigi Vetrugno and Francesco Forfori
    Citation: Critical Care 2022 26:113
  29. Treatment and the clinical course during Emergency Department (ED) stay before Intensive Care Unit (ICU) admission may affect predicted mortality risk calculated by the Acute Physiology and Chronic Health Eval...

    Authors: Bart G. J. Candel, Wouter Raven, Heleen Lameijer, Wendy A. M. H. Thijssen, Fabian Termorshuizen, Christiaan Boerma, Nicolette F. de Keizer, Evert de Jonge and Bas de Groot
    Citation: Critical Care 2022 26:112

    The Correction to this article has been published in Critical Care 2022 26:132

  30. Volunteerism to provide humanitarian aid occurs in response to disasters, crises, and conflict. Each of those volunteerism triggers engenders personal risk borne by the healthcare volunteer while rendering aid...

    Authors: Heatherlee Bailey and Lewis J. Kaplan
    Citation: Critical Care 2022 26:111
  31. Alternative noninvasive methods capable of excluding intracranial hypertension through use of transcranial Doppler (ICPtcd) in situations where invasive methods cannot be used or are not available would be useful...

    Authors: Frank A. Rasulo, Stefano Calza, Chiara Robba, Fabio Silvio Taccone, Daniele G. Biasucci, Rafael Badenes, Simone Piva, Davide Savo, Giuseppe Citerio, Jamil R. Dibu, Francesco Curto, Martina Merciadri, Paolo Gritti, Paola Fassini, Soojin Park, Massimo Lamperti…
    Citation: Critical Care 2022 26:110
  32. High-flow nasal cannula (HFNC) can improve ventilatory function in patients with acute COPD exacerbation. However, its effect on clinical outcomes remains uncertain.

    Authors: Jingen Xia, Sichao Gu, Wei Lei, Jihua Zhang, Hui Wei, Chao Liu, Han Zhang, Rongli Lu, Liqiong Zhang, Mingyan Jiang, Chao Hu, Zhenshun Cheng, Chaojie Wei, Yusheng Chen, Fengfeng Lu, Min Chen…
    Citation: Critical Care 2022 26:109

    The Correspondence to this article has been published in Critical Care 2022 26:156

  33. We aimed to assess the efficacy of a closed-loop oxygen control in critically ill patients with moderate to severe acute hypoxemic respiratory failure (AHRF) treated with high flow nasal oxygen (HFNO).

    Authors: Oriol Roca, Oriol Caritg, Manel Santafé, Francisco J. Ramos, Andrés Pacheco, Marina García-de-Acilu, Ricard Ferrer, Marcus J. Schultz and Jean-Damien Ricard
    Citation: Critical Care 2022 26:108
  34. Interleukin-17 (IL-17) antagonism in rats reduces the severity and progression of AKI. IL-17-producing circulating T helper-17 (TH17) cells is increased in critically ill patients with AKI indicating that this...

    Authors: Jason A. Collett, Victor Ortiz-Soriano, Xilong Li, Alexander H. Flannery, Robert D. Toto, Orson W. Moe, David P. Basile and Javier A. Neyra
    Citation: Critical Care 2022 26:107
  35. Limitations of life-sustaining interventions in intensive care units (ICUs) exhibit substantial changes over time, and large, contemporary variation across world regions. We sought to determine whether a weigh...

    Authors: Spyros D. Mentzelopoulos, Su Chen, Joseph L. Nates, Jacqueline M. Kruser, Christiane Hartog, Andrej Michalsen, Nikolaos Efstathiou, Gavin M. Joynt, Suzana Lobo, Alexander Avidan and Charles L. Sprung
    Citation: Critical Care 2022 26:106
  36. Gut microbiota is associated with host characteristics such as age, sex, immune condition or frailty and is thought to be a key player in numerous human diseases. Nevertheless, its association with outcome in ...

    Authors: Renaud Prevel, Raphaël Enaud, Arthur Orieux, Adrian Camino, Patrick Berger, Alexandre Boyer, Laurence Delhaes and Didier Gruson
    Citation: Critical Care 2022 26:105
  37. The transcapillary leakage of albumin is increased by inflammation and major surgery, but whether exogenous albumin also disappears faster is unclear.

    Authors: Markus Zdolsek, Patrick Y. Wuethrich, Michaela Gunnström, Joachim H. Zdolsek, Emma Hasselgren, Christian M. Beilstein, Dominique Engel and Robert G. Hahn
    Citation: Critical Care 2022 26:104
  38. Sepsis is a leading cause of morbidity and mortality worldwide and is characterized by vascular leak. Treatment for sepsis, specifically intravenous fluids, may worsen deterioration in the context of vascular ...

    Authors: Jay Chandra, Miguel A. Armengol de la Hoz, Gwendolyn Lee, Alexandria Lee, Patrick Thoral, Paul Elbers, Hyung-Chul Lee, John S. Munger, Leo Anthony Celi and David A. Kaufman
    Citation: Critical Care 2022 26:103
  39. Bereaved ICU family surrogates’ psychological distress, e.g., anxiety, depression, and post-traumatic stress disorder (PTSD), is usually examined independently, despite the well-recognized comorbidity of these...

    Authors: Fur-Hsing Wen, Wen-Chi Chou, Chung-Chi Huang, Tsung-Hui Hu, Ming Chu Chiang, Li-Pang Chuang and Siew Tzuh Tang
    Citation: Critical Care 2022 26:102
  40. To assess the performance of the post-cardiac arrest (CA) prognostication strategy algorithm recommended by the European Resuscitation Council (ERC) and the European Society of Intensive Care Medicine (ESICM) ...

    Authors: Chun Song Youn, Kyu Nam Park, Soo Hyun Kim, Byung Kook Lee, Tobias Cronberg, Sang Hoon Oh, Kyung Woon Jeung, In Soo Cho and Seung Pill Choi
    Citation: Critical Care 2022 26:95
  41. Diaphragm ultrasonography is rapidly evolving in both critical care and research. Nevertheless, methodologically robust guidelines on its methodology and acquiring expertise do not, or only partially, exist. T...

    Authors: Mark E. Haaksma, Jasper M. Smit, Alain Boussuges, Alexandre Demoule, Martin Dres, Giovanni Ferrari, Paolo Formenti, Ewan C. Goligher, Leo Heunks, Endry H. T. Lim, Lidwine B. Mokkink, Eleni Soilemezi, Zhonghua Shi, Michele Umbrello, Luigi Vetrugno, Emmanuel Vivier…
    Citation: Critical Care 2022 26:99