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  1. Socioeconomic variables impact health outcomes but have rarely been evaluated in critical illness. Low- and middle-income countries bear the highest burden of sepsis and also have significant health inequities...

    Authors: Elisa Estenssoro, Cecilia I. Loudet, Vanina S. K. Edul, Javier Osatnik, Fernando G. Ríos, Daniela N. Vásquez, Mario O. Pozo, Bernardo Lattanzio, Fernando Pálizas, Francisco Klein, Damián Piezny, Paolo N. Rubatto Birri, Graciela Tuhay, Anatilde Díaz, Analía Santamaría, Graciela Zakalik…

    Citation: Critical Care 2019 23:250

    Content type: Research

    Published on:

  2. Sepsis remains a complex medical problem and a major challenge in healthcare. Diagnostics and outcome predictions are focused on physiological parameters with less consideration given to patients’ medical back...

    Authors: Zsolt Zador, Alexander Landry, Michael D. Cusimano and Nophar Geifman

    Citation: Critical Care 2019 23:247

    Content type: Research

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  3. In critically ill patients, poor patient-ventilator interaction may worsen outcomes. Although sedatives are often administered to improve comfort and facilitate ventilation, they can be deleterious. Whether op...

    Authors: Candelaria de Haro, Rudys Magrans, Josefina López-Aguilar, Jaume Montanyà, Enrico Lena, Carles Subirà, Sol Fernandez-Gonzalo, Gemma Gomà, Rafael Fernández, Guillermo M. Albaiceta, Yoanna Skrobik, Umberto Lucangelo, Gastón Murias, Ana Ochagavia, Robert M. Kacmarek, Montserrat Rue…

    Citation: Critical Care 2019 23:245

    Content type: Research

    Published on:

  4. Epidemiologic data have shown an increasing incidence and declining mortality rate in sepsis. However, confounding effects due to differences in disease classification might have contributed to these trends.

    Authors: Robert Luhr, Yang Cao, Bo Söderquist and Sara Cajander

    Citation: Critical Care 2019 23:241

    Content type: Research

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  5. ICU-acquired weakness is a debilitating consequence of prolonged critical illness that is associated with poor outcome. Recently, premorbid obesity has been shown to protect against such illness-induced muscle...

    Authors: Chloë Goossens, Ruben Weckx, Sarah Derde, Thomas Dufour, Sarah Vander Perre, Lies Pauwels, Steven E. Thiessen, Paul P. Van Veldhoven, Greet Van den Berghe and Lies Langouche

    Citation: Critical Care 2019 23:236

    Content type: Research

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  6. Necroptosis, a form of programmed cell death mediated by receptor interacting serine/threonine-protein kinase-3 (RIPK3), is implicated in murine models of acute respiratory distress syndrome (ARDS). We hypothe...

    Authors: Michael G. S. Shashaty, John P. Reilly, Hilary E. Faust, Caitlin M. Forker, Caroline A. G. Ittner, Peggy X. Zhang, Meghan J. Hotz, David Fitzgerald, Wei Yang, Brian J. Anderson, Daniel N. Holena, Paul N. Lanken, Jason D. Christie, Nuala J. Meyer and Nilam S. Mangalmurti

    Citation: Critical Care 2019 23:235

    Content type: Research

    Published on:

  7. Perioperative goal-directed therapy (GDT) reduces the risk of renal injury. However, several questions remain unanswered, such as target, kind of patients and surgery, and role of fluids and inotropes. We ther...

    Authors: Mariateresa Giglio, Lidia Dalfino, Filomena Puntillo and Nicola Brienza

    Citation: Critical Care 2019 23:232

    Content type: Research

    Published on:

  8. Sepsis survivors often develop chronic critical illness (CCI) and demonstrate the persistent inflammation, immunosuppression, and catabolism syndrome predisposing them to long-term functional limitations and h...

    Authors: Carlo Custodero, Quran Wu, Gabriela L. Ghita, Stephen D. Anton, Scott C. Brakenridge, Babette A. Brumback, Philip A. Efron, Anna K. Gardner, Christiaan Leeuwenburgh, Lyle L. Moldawer, John W. Petersen, Frederick A. Moore and Robert T. Mankowski

    Citation: Critical Care 2019 23:230

    Content type: Research

    Published on:

    The Letter to this article has been published in Critical Care 2019 23:341

  9. The last decade, there have been many initiatives worldwide to increase the number of organ donors. However, it is not clear which initiatives are most effective. The aim of this study is to provide an overvie...

    Authors: Marloes Witjes, Nichon E. Jansen, Johannes G. van der Hoeven and Wilson F. Abdo

    Citation: Critical Care 2019 23:227

    Content type: Research

    Published on:

  10. The first FDA-approved test to assess risk for acute kidney injury (AKI), [TIMP-2]•[IGFBP7], is clinically available in many parts of the world, including the USA and Europe. We sought to understand how the te...

    Authors: Louis M. Guzzi, Tobias Bergler, Brian Binnall, Daniel T. Engelman, Lui Forni, Michael J. Germain, Eric Gluck, Ivan Göcze, Michael Joannidis, Jay L. Koyner, V. Seenu Reddy, Thomas Rimmelé, Claudio Ronco, Julien Textoris, Alexander Zarbock and John A. Kellum

    Citation: Critical Care 2019 23:225

    Content type: Research

    Published on:

  11. We hypothesized that the absence of P25 and the N20–P25 amplitude in somatosensory evoked potentials (SSEPs) have higher sensitivity than the absence of N20 for poor neurological outcomes, and we evaluated the...

    Authors: Sang Hoon Oh, Kyu Nam Park, Seung Pill Choi, Joo Suk Oh, Han Joon Kim, Chun Song Youn, Soo Hyun Kim, Kiyuk Chang and Seong Hoon Kim

    Citation: Critical Care 2019 23:224

    Content type: Research

    Published on:

  12. During the initial phase of critical illness, the association between the dose of nutrition support and mortality risk may vary among patients in the intensive care unit (ICU) because the prevalence of malnutr...

    Authors: Charles Chin Han Lew, Gabriel Jun Yung Wong, Ka Po Cheung, Robert J. L. Fraser, Ai Ping Chua, Mary Foong Fong Chong and Michelle Miller

    Citation: Critical Care 2019 23:222

    Content type: Research

    Published on:

  13. Intubation is frequently required for patients in the intensive care unit (ICU) but is associated with high morbidity and mortality mainly in emergency procedures and in the presence of severe organ failures. ...

    Authors: Samir Jaber, Audrey De Jong, Paolo Pelosi, Luca Cabrini, Jean Reignier and Jean Baptiste Lascarrou

    Citation: Critical Care 2019 23:221

    Content type: Viewpoint

    Published on:

  14. Limited critical care subspecialty training and experience is available in many low- and middle-income countries, creating barriers to the delivery of evidence-based critical care. We hypothesized that a struc...

    Authors: Pedja Kovacevic, Sasa Dragic, Tijana Kovacevic, Danica Momcicevic, Emir Festic, Rahul Kashyap, Alexander S. Niven, Yue Dong and Ognjen Gajic

    Citation: Critical Care 2019 23:220

    Content type: Research

    Published on:

  15. The objective of this study was to assess the cumulative incidence of invasive candidiasis (IC) in intensive care units (ICUs) in Europe.

    Authors: Matteo Bassetti, Daniele R. Giacobbe, Antonio Vena, Cecilia Trucchi, Filippo Ansaldi, Massimo Antonelli, Vaclava Adamkova, Cristiano Alicino, Maria-Panagiota Almyroudi, Enora Atchade, Anna M. Azzini, Novella Carannante, Alessia Carnelutti, Silvia Corcione, Andrea Cortegiani, George Dimopoulos…

    Citation: Critical Care 2019 23:219

    Content type: Research

    Published on:

  16. Progress toward determining the true worth of ongoing practices or value of recent innovations can be glacially slow when we insist on following the conventional stepwise scientific pathway. Moreover, a widely...

    Authors: John J. Marini, Daniel DeBacker, Luciano Gattinoni, Can Ince, Ignacio Martin-Loeches, Pierre Singer, Mervyn Singer, Martin Westphal and Jean-Louis Vincent

    Citation: Critical Care 2019 23(Suppl 1):197

    Content type: Proceedings

    Published on:

    This article is part of a Supplement: Volume 23 Supplement 1

  17. Patients admitted to the intensive care unit (ICU) often require invasive mechanical ventilation. Ventilator-associated lower respiratory tract infections (VA-LRTI), either ventilator-associated tracheobronchi...

    Authors: Sean Keane and Ignacio Martin-Loeches

    Citation: Critical Care 2019 23(Suppl 1):134

    Content type: Review

    Published on:

    This article is part of a Supplement: Volume 23 Supplement 1

  18. The founding tenet of evidence-based medicine is to combine best evidence with clinical expertise. As David Sackett opined ‘Without clinical expertise, practice risks becoming tyrannised by evidence’. Rigid pr...

    Authors: Mervyn Singer

    Citation: Critical Care 2019 23(Suppl 1):127

    Content type: Review

    Published on:

    This article is part of a Supplement: Volume 23 Supplement 1

  19. In the absence of evidence, therapies are often based on intuition, belief, common sense or gut feeling. Over the years, some treatment strategies may become dogmas that are eventually considered as state-of-t...

    Authors: Martin Westphal

    Citation: Critical Care 2019 23(Suppl 1):125

    Content type: Review

    Published on:

    This article is part of a Supplement: Volume 23 Supplement 1

  20. Until relatively recently, critical illness was considered as a separate entity and the intensive care unit (ICU), often a little cut-off from other areas of the hospital, was in many cases used as a last reso...

    Authors: Jean-Louis Vincent

    Citation: Critical Care 2019 23(Suppl 1):122

    Content type: Review

    Published on:

    This article is part of a Supplement: Volume 23 Supplement 1

  21. Our current understanding of protective measures for avoiding ventilator-induced lung injury (VILI) has evolved from targeting low tidal volumes to lowering plateau and driving pressure. Even when pressures ac...

    Authors: John J. Marini

    Citation: Critical Care 2019 23(Suppl 1):114

    Content type: Review

    Published on:

    This article is part of a Supplement: Volume 23 Supplement 1

  22. Oesophageal pressure (PES) is used for calculation of lung and chest wall mechanics and transpulmonary pressure during mechanical ventilation. Measurements performed with a balloon catheter are suggested as a ...

    Authors: Per Persson, Rebecca Ahlstrand, Magni Gudmundsson, Alex de Leon and Stefan Lundin

    Citation: Critical Care 2019 23:217

    Content type: Research

    Published on:

  23. As more patients are surviving intensive care, mental health concerns in survivors have become a research priority. Among these, post-traumatic stress disorder (PTSD) can have an important impact on the qualit...

    Authors: Cássia Righy, Regis Goulart Rosa, Rodrigo Teixeira Amancio da Silva, Renata Kochhann, Celina Borges Migliavaca, Caroline Cabral Robinson, Stefania Pigatto Teche, Cassiano Teixeira, Fernando Augusto Bozza and Maicon Falavigna

    Citation: Critical Care 2019 23:213

    Content type: Research

    Published on:

  24. Mottling score, a tissue perfusion parameter, is correlated with outcome in septic shock patients. However, its predictive value on mortality according to prognostic covariates such as vasopressor dose and oth...

    Authors: Guillaume Dumas, Jean-Rémi Lavillegrand, Jérémie Joffre, Naïke Bigé, Edmilson Bastos de-Moura, Jean-Luc Baudel, Sylvie Chevret, Bertrand Guidet, Eric Maury, Fabio Amorim and Hafid Ait-Oufella

    Citation: Critical Care 2019 23:211

    Content type: Research

    Published on:

    The Letter to this article has been published in Critical Care 2019 23:268