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  1. Mechanical power is a composite variable for energy transmitted to the respiratory system over time that may better capture risk for ventilator-induced lung injury than individual ventilator management compone...

    Authors: Anoopindar K. Bhalla, Margaret J. Klein, Vicent Modesto I Alapont, Guillaume Emeriaud, Martin C. J. Kneyber, Alberto Medina, Pablo Cruces, Franco Diaz, Muneyuki Takeuchi, Aline B. Maddux, Peter M. Mourani, Cristina Camilo, Benjamin R. White, Nadir Yehya, John Pappachan, Matteo Di Nardo…
    Citation: Critical Care 2022 26:2
  2. SARS-CoV-2 seems to affect the regulation of pulmonary perfusion. Hypoperfusion in areas of well-aerated lung parenchyma results in a ventilation–perfusion mismatch that can be characterized using subtraction ...

    Authors: Mario G. Santamarina, Ignacio Beddings, Felipe Martinez Lomakin, Dominique Boisier Riscal, Mónica Gutiérrez Claveria, Jaime Vidal Marambio, Nicole Retamal Báez, Cristian Pavez Novoa, César Reyes Allende, Paulina Ferreira Perey, Miguel Gutiérrez Torres, Camila Villalobos Mazza, Constanza Vergara Sagredo, Sebastian Ahumada Bermejo, Eduardo Labarca Mellado, Elizabeth Barthel Munchmeyer…
    Citation: Critical Care 2022 26:1
  3. Determining the optimal timing for extubation can be challenging in the intensive care. In this study, we aim to identify predictors for extubation failure in critically ill patients with COVID-19.

    Authors: Lucas M. Fleuren, Tariq A. Dam, Michele Tonutti, Daan P. de Bruin, Robbert C. A. Lalisang, Diederik Gommers, Olaf L. Cremer, Rob J. Bosman, Sander Rigter, Evert-Jan Wils, Tim Frenzel, Dave A. Dongelmans, Remko de Jong, Marco Peters, Marlijn J. A. Kamps, Dharmanand Ramnarain…
    Citation: Critical Care 2021 25:448
  4. Over a third of critical illness survivors suffer from mental health problems following hospitalization. Memories of delusional experiences are a major risk factor. In this project, ICU doulas delivered a uniq...

    Authors: Lioudmila V. Karnatovskaia, Katalin Varga, Alexander S. Niven, Phillip J. Schulte, Midhat Mujic, Ognjen Gajic, Brent A. Bauer, Matthew M. Clark, Roberto P. Benzo and Kemuel L. Philbrick
    Citation: Critical Care 2021 25:446
  5. Therapeutic antibiotic dose monitoring can be particularly challenging in septic patients requiring renal replacement therapy. Our aim was to conduct an exploratory population pharmacokinetic (PK) analysis on ...

    Authors: Marcus Kirwan, Reema Munshi, Hannah O’Keeffe, Conor Judge, Mary Coyle, Evelyn Deasy, Yvelynne P. Kelly, Peter J. Lavin, Maria Donnelly and Deirdre M. D’Arcy
    Citation: Critical Care 2021 25:443
  6. Inspiratory patient effort under assisted mechanical ventilation is an important quantity for assessing patient–ventilator interaction and recognizing over and under assistance. An established clinical standar...

    Authors: Jan Graßhoff, Eike Petersen, Franziska Farquharson, Max Kustermann, Hans-Joachim Kabitz, Philipp Rostalski and Stephan Walterspacher
    Citation: Critical Care 2021 25:441
  7. Oxygen (O2) toxicity remains a concern, particularly to the lung. This is mainly related to excessive production of reactive oxygen species (ROS). Supplemental O2, i.e. inspiratory O2 concentrations (FIO2) > 0.21...

    Authors: Mervyn Singer, Paul J. Young, John G. Laffey, Pierre Asfar, Fabio Silvio Taccone, Markus B. Skrifvars, Christian S. Meyhoff and Peter Radermacher
    Citation: Critical Care 2021 25:440
  8. Critically ill patients require complex care and experience unique needs during and after their stay in the intensive care unit (ICU). Discharging or transferring a patient from the ICU to a hospital ward or b...

    Authors: Kara M. Plotnikoff, Karla D. Krewulak, Laura Hernández, Krista Spence, Nadine Foster, Shelly Longmore, Sharon E. Straus, Daniel J. Niven, Jeanna Parsons Leigh, Henry T. Stelfox and Kirsten M. Fiest
    Citation: Critical Care 2021 25:438
  9. The measurement of circulating substrate concentrations does not provide information about substrate kinetics. It, therefore, remains unclear if a decrease in plasma concentration of albumin, as seen during cr...

    Authors: Keisuke Omiya, Hiroaki Sato, Tamaki Sato, Linda Wykes, Mengyin Hong, Roupen Hatzakorzian, Arnold S. Kristof and Thomas Schricker
    Citation: Critical Care 2021 25:436
  10. Authors: Antoni Torres, Anna Motos, Jordi Riera, Laia Fernández-Barat, Adrián Ceccato, Raquel Pérez-Arnal, Dario García-Gasulla, Oscar Peñuelas, José Angel Lorente, Alejandro Rodriguez, David de Gonzalo-Calvo, Raquel Almansa, Albert Gabarrús, Rosario Menéndez, Jesús F. Bermejo-Martin, Ricard Ferrer…
    Citation: Critical Care 2021 25:435

    The original article was published in Critical Care 2021 25:331

  11. While targeted temperature management (TTM) has been recommended in patients with shockable cardiac arrest (CA) and suggested in patients with non-shockable rhythms, few data exist regarding the impact of the ...

    Authors: Jean-Baptiste Lascarrou, Elie Guichard, Jean Reignier, Amélie Le Gouge, Caroline Pouplet, Stéphanie Martin, Jean-Claude Lacherade and Gwenhael Colin
    Citation: Critical Care 2021 25:434
  12. Community-acquired pneumonia (CAP) is a leading cause of morbidity and mortality worldwide despite correct antibiotic use. Corticosteroids have long been evaluated as a treatment option, but heterogeneous effe...

    Authors: A. Ceccato, A. Russo, E. Barbeta, P. Oscanoa, G. Tiseo, A. Gabarrus, P. Di Giannatale, S. Nogas, C. Cilloniz, F. Menichetti, M. Ferrer, M. Niederman, M. Falcone and A. Torres
    Citation: Critical Care 2021 25:432
  13. We hypothesized that as CARDS may present different pathophysiological features than classic ARDS, the application of high levels of end-expiratory pressure is questionable. Our first aim was to investigate th...

    Authors: Davide Chiumello, Matteo Bonifazi, Tommaso Pozzi, Paolo Formenti, Giuseppe Francesco Sferrazza Papa, Gabriele Zuanetti and Silvia Coppola
    Citation: Critical Care 2021 25:431
  14. Critical illness is hallmarked by neuroendocrine alterations throughout ICU stay. We investigated whether the neuroendocrine axes recover after ICU discharge and whether any residual abnormalities associate wi...

    Authors: Ilse Vanhorebeek, Inge Derese, Jan Gunst, Pieter J. Wouters, Greet Hermans and Greet Van den Berghe
    Citation: Critical Care 2021 25:430
  15. Traumatic brain injury (TBI) and severe blood loss resulting in hemorrhagic shock (HS) represent leading causes of trauma-induced mortality, especially when co-occurring in pre-hospital settings where standard...

    Authors: Andrew R. Mayer, Andrew B. Dodd, Julie G. Rannou-Latella, David D. Stephenson, Rebecca J. Dodd, Josef M. Ling, Carissa J. Mehos, Cidney R. Robertson-Benta, Sharvani Pabbathi Reddy, Rachel E. Kinsler, Meghan S. Vermillion, Andrew P. Gigliotti, Veronik Sicard, Amy L. Lloyd, Erik B. Erhardt, Jessica M. Gill…
    Citation: Critical Care 2021 25:428
  16. Flow Index, a numerical expression of the shape of the inspiratory flow-time waveform recorded during pressure support ventilation, is associated with patient inspiratory effort. The aim of this study was to a...

    Authors: Filippo Albani, Federica Fusina, Gianni Ciabatti, Luigi Pisani, Valeria Lippolis, Maria Elena Franceschetti, Alessia Giovannini, Rossella di Mussi, Francesco Murgolo, Antonio Rosano, Salvatore Grasso and Giuseppe Natalini
    Citation: Critical Care 2021 25:427
  17. The preferential use of the oral/enteral route in critically ill patients over gut rest is uniformly recommended and applied. This article provides practical guidance on enteral nutrition in compliance with re...

    Authors: Jean-Charles Preiser, Yaseen M. Arabi, Mette M. Berger, Michael Casaer, Stephen McClave, Juan C. Montejo-González, Sandra Peake, Annika Reintam Blaser, Greet Van den Berghe, Arthur van Zanten, Jan Wernerman and Paul Wischmeyer
    Citation: Critical Care 2021 25:424
  18. Autoptic pulmonary findings have been described in severe COVID-19 patients, but evidence regarding the correlation between clinical picture and lung histopathologic patterns is still weak.

    Authors: Maddalena Alessandra Wu, Gianluca Lopez, Manuela Nebuloni, Davide Ottolina, Jonathan Montomoli, Luca Carsana, Tommaso Fossali, Antonio Castelli, Roberto Rech, Chiara Cogliati, Emanuele Catena and Riccardo Colombo
    Citation: Critical Care 2021 25:423
  19. Severity scores are commonly used for outcome adjustment and benchmarking of trauma care provided. No specific models performed only with critically ill patients are available. Our objective was to develop a n...

    Authors: Luis Serviá, Juan Antonio Llompart-Pou, Mario Chico-Fernández, Neus Montserrat, Mariona Badia, Jesús Abelardo Barea-Mendoza, María Ángeles Ballesteros-Sanz and Javier Trujillano
    Citation: Critical Care 2021 25:420
  20. The present study was performed to investigate the impacts of type 2 diabetes mellitus (T2DM) on severe community-acquired pneumonia (SCAP) and to develop a novel prediction model for mortality in SCAP patient...

    Authors: Dong Huang, Dingxiu He, Linjing Gong, Wen Wang, Lei Yang, Zhongwei Zhang, Yujun Shi and Zongan Liang
    Citation: Critical Care 2021 25:419
  21. Data in the literature about HSV reactivation in COVID-19 patients are scarce, and the association between HSV-1 reactivation and mortality remains to be determined. Our objectives were to evaluate the impact of

    Authors: Antoine Meyer, Niccolò Buetti, Nadhira Houhou-Fidouh, Juliette Patrier, Moustafa Abdel-Nabey, Pierre Jaquet, Simona Presente, Tiphaine Girard, Faiza Sayagh, Stephane Ruckly, Paul-Henri Wicky, Etienne de Montmollin, Lila Bouadma, Romain Sonneville, Diane Descamps and Jean-Francois Timsit
    Citation: Critical Care 2021 25:417
  22. Several clinical guidelines recommend monitoring blood lactate levels and central venous oxygen saturation for hemodynamic management of patients with sepsis. We hypothesized that carbon dioxide production (VCO2)...

    Authors: Ichiro Hirayama, Toshifumi Asada, Miyuki Yamamoto, Naoki Hayase, Takahiro Hiruma and Kent Doi
    Citation: Critical Care 2021 25:416
  23. Although the combination of rehabilitation and nutrition may be important for the prevention of intensive care unit (ICU)-acquired weakness, a protocolized intervention of this combination has not yet been rep...

    Authors: Hidehiko Nakano, Hiromu Naraba, Hideki Hashimoto, Masaki Mochizuki, Yuji Takahashi, Tomohiro Sonoo, Yasuhiro Ogawa, Yujiro Matsuishi, Nobutake Shimojo, Yoshiaki Inoue and Kensuke Nakamura
    Citation: Critical Care 2021 25:415
  24. Although non-invasive respiratory management strategies have been implemented to avoid intubation, patients with de novo acute hypoxaemic respiratory failure (AHRF) are high risk of treatment failure. In the p...

    Authors: Masaaki Sakuraya, Hiromu Okano, Tomoyuki Masuyama, Shunsuke Kimata and Satoshi Hokari
    Citation: Critical Care 2021 25:414
  25. Sepsis is often associated with multiple organ failure; however, changes in brain volume with sepsis are not well understood. We assessed brain atrophy in the acute phase of sepsis using brain computed tomogra...

    Authors: Ryuta Nakae, Tetsuro Sekine, Takashi Tagami, Yasuo Murai, Eigo Kodani, Geoffrey Warnock, Hidetaka Sato, Akio Morita, Hiroyuki Yokota and Shoji Yokobori
    Citation: Critical Care 2021 25:411
  26. There is limited information about the long-term outcome of patients suffering from acute respiratory distress syndrome (ARDS) supported with veno-venous extracorporeal membrane oxygenation (VV ECMO). Most stu...

    Authors: Jonathan Rilinger, Klara Krötzsch, Xavier Bemtgen, Markus Jäckel, Viviane Zotzmann, Corinna N. Lang, Klaus Kaier, Daniel Duerschmied, Alexander Supady, Christoph Bode, Dawid L. Staudacher and Tobias Wengenmayer
    Citation: Critical Care 2021 25:410
  27. The International Liaison Committee on Resuscitation recommends that dispatchers provide instructions to perform compression-only cardiopulmonary resuscitation (CPR) to callers responding to adults with out-of...

    Authors: Yoshikazu Goto, Akira Funada, Tetsuo Maeda and Yumiko Goto
    Citation: Critical Care 2021 25:408
  28. The use of ultrasonography in the intensive care unit (ICU) is steadily increasing but is usually restricted to examinations of single organs or organ systems. In this study, we combine the ultrasound approach...

    Authors: Stefan Schmidt, Jana-Katharina Dieks, Michael Quintel and Onnen Moerer
    Citation: Critical Care 2021 25:405
  29. Identifying new effective treatments for the acute respiratory distress syndrome (ARDS), including COVID-19 ARDS, remains a challenge. The field of ARDS investigation is moving increasingly toward innovative a...

    Authors: Katherine D. Wick, Daniel F. McAuley, Joseph E. Levitt, Jeremy R. Beitler, Djillali Annane, Elisabeth D. Riviello, Carolyn S. Calfee and Michael A. Matthay
    Citation: Critical Care 2021 25:404
  30. Evidence about the impact of the pandemic of COVID-19 on the incidence rates of blood cultures contaminations and bloodstream infections in intensive care units (ICUs) remains scant. The objective of this stud...

    Authors: Lauro Damonti, Andreas Kronenberg, Jonas Marschall, Philipp Jent, Rami Sommerstein, Marlieke E. A. De Kraker, Stephan Harbarth, Michael Gasser and Niccolò Buetti
    Citation: Critical Care 2021 25:403