Articles

Description of an alternative method for optimal and comfortable two-handed face mask ventilation: the transverse mandibular technique

Authors: Francois Lemay and Jeremy Cooper

Low-resolution pressure reactivity index and its derived optimal cerebral perfusion pressure in adult traumatic brain injury: a CENTER-TBI study

After traumatic brain injury (TBI), brain tissue can be further damaged when cerebral autoregulation is impaired. Managing cerebral perfusion pressure (CPP) according to computed “optimal CPP” values based on ...

Authors: Lennart Riemann, Erta Beqiri, Peter Smielewski, Marek Czosnyka, Nino Stocchetti, Oliver Sakowitz, Klaus Zweckberger, Andreas Unterberg and Alexander Younsi

Universal mobile protection system for aerosol-generating medical interventions in COVID-19 patients

Authors: Florian Straube, Clemens Wendtner and Ellen Hoffmann

COVID-19 patients exhibit less pronounced immune suppression compared with bacterial septic shock patients

Authors: Matthijs Kox, Tim Frenzel, Jeroen Schouten, Frank L. van de Veerdonk, Hans J. P. M. Koenen and Peter Pickkers

Essential ICU drug shortages for COVID-19: what can frontline clinicians do?

Authors: Wen Ting Siow, Simeon H. Tang, Rohit Vijay Agrawal, Addy Y. H. Tan and Kay Choong See

Two consecutive myocardial tissue insults for inpatients with COVID-19

Authors: Minghua Su, Jieru Peng, Mengjun Wu, Wuquan Deng, Yousheng Yang and Yong G. Peng

Prone ventilation of critically ill adults with COVID-19: how to perform CPR in cardiac arrest?

Authors: Wioletta Mędrzycka-Dąbrowska, Katarzyna Lewandowska, Daniel Ślęzak and Sebastian Dąbrowski

Clinical analysis of sinus bradycardia in patients with severe COVID-19 pneumonia

Authors: Lijuan Hu, Linjing Gong, Zhilong Jiang, Qibing Wang, Yunzeng Zou and Lei Zhu

Prone positioning combined with high-flow nasal or conventional oxygen therapy in severe Covid-19 patients

Authors: Cyrielle Despres, Yannick Brunin, Francis Berthier, Sebastien Pili-Floury and Guillaume Besch

The association of low serum albumin level with severe COVID-19: a systematic review and meta-analysis

Authors: Muhammad Aziz, Rawish Fatima, Wade Lee-Smith and Ragheb Assaly

Nutritional therapy in patients with sepsis: is less really more?

Authors: Marie-Sophie Louise Yvonne de Koning, Florianne Johanna Louise van Zanten and Arthur Raymond Hubert van Zanten

Do critically ill patients with AKI benefit from furosemide? Further real-word evidence from a large multi-center database

Authors: Shaowei Gao, Lu Yang and Zhongxing Wang

Transfer of skills for difficult intubation after videolaryngoscopy training: a randomized simulation study

Authors: Adrian Kee, Reyor Ko, Rolando Capistrano, Melvin Dajac, Juvel Taculod and Kay Choong See

Never a rose without a prick: pseudohyperglycemia when administering high-dose intravenous vitamin C

Authors: Yongli Zhang and Wei Huang

Early awake prone position combined with high-flow nasal oxygen therapy in severe COVID-19: a case series

Authors: Qiancheng Xu, Tao Wang, Xuemei Qin, Yanli Jie, Lei Zha and Weihua Lu

Towards a fasting-mimicking diet for critically ill patients: the pilot randomized crossover ICU-FM-1 study

In two recent randomized controlled trials, withholding parenteral nutrition early in critical illness improved outcome as compared to early up-to-calculated-target nutrition, which may be explained by benefic...

Authors: Lisa Van Dyck, Ilse Vanhorebeek, Alexander Wilmer, An Schrijvers, Inge Derese, Liese Mebis, Pieter J. Wouters, Greet Van den Berghe, Jan Gunst and Michaël P. Casaer

Effect of flow and cannula size on generated pressure during nasal high flow

Authors: Maximilian Pinkham and Stanislav Tatkov

Current definition of acute kidney injury actually identifies a heterogenous group of patients with elevated serum creatinine and reduced urine output

Authors: Yanxiao Chen

Effect of mechanical power on intensive care mortality in ARDS patients

In ARDS patients, mechanical ventilation should minimize ventilator-induced lung injury. The mechanical power which is the energy per unit time released to the respiratory system according to the applied tidal...

Authors: Silvia Coppola, Alessio Caccioppola, Sara Froio, Paolo Formenti, Valentina De Giorgis, Valentina Galanti, Dario Consonni and Davide Chiumello

Duration of SARS-CoV-2 viral RNA in asymptomatic carriers

Authors: Xiquan Yan, Xiaotong Han, Yong Fan, Zhixiong Fang, Da Long and Yimin Zhu

Hemophagocytic lymphohistiocytosis in critically ill patients: diagnostic reliability of HLH-2004 criteria and HScore

Hemophagocytic lymphohistiocytosis (HLH) is a rare though often fatal hyperinflammatory syndrome mimicking sepsis in the critically ill. Diagnosis relies on the HLH-2004 criteria and HScore, both of which have...

Authors: Cornelia Knaak, Peter Nyvlt, Friederike S. Schuster, Claudia Spies, Patrick Heeren, Thomas Schenk, Felix Balzer, Paul La Rosée, Gritta Janka, Frank M. Brunkhorst, Didier Keh and Gunnar Lachmann

A systematic review of biomarkers multivariately associated with acute respiratory distress syndrome development and mortality

Heterogeneity of acute respiratory distress syndrome (ARDS) could be reduced by identification of biomarker-based phenotypes. The set of ARDS biomarkers to prospectively define these phenotypes remains to be e...

Authors: Philip van der Zee, Wim Rietdijk, Peter Somhorst, Henrik Endeman and Diederik Gommers

Letter to the editor: The role of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers in developing a COVID-19 comorbidity-based host risk score

Authors: George D. Vavougios

Adjuvant corticosteroid therapy for critically ill patients with COVID-19

Authors: Xiaofan Lu, Taige Chen, Yang Wang, Jun Wang and Fangrong Yan

Interpreting trials on renal replacement therapy initiation: beware of methodologic issues

Authors: Stéphane Gaudry, Paul M. Palevsky and Didier Dreyfuss

Mortality in sepsis and septic shock in Europe, North America and Australia between 2009 and 2019— results from a systematic review and meta-analysis

Sepsis and septic shock remain drivers for mortality in critically ill patients. The heterogeneity of the syndrome hinders the generation of reproducible numbers on mortality risks. Consequently, mortality rat...

Authors: Michael Bauer, Herwig Gerlach, Tobias Vogelmann, Franziska Preissing, Julia Stiefel and Daniel Adam

Crucial role of temporary airborne infection isolation rooms in an intensive care unit: containing the COVID-19 outbreak in South Korea

Authors: Shin Yup Lee, Sun Ha Choi, Ji Eun Park, Soyoon Hwang and Ki Tae Kwon

Logistic and organizational aspects of a dedicated intensive care unit for COVID-19 patients

Authors: Maria Vargas, Giuseppe De Marco, Stefania De Simone and Giuseppe Servillo

Cardiovascular phenotypes in ventilated patients with COVID-19 acute respiratory distress syndrome

Authors: Bruno Evrard, Marine Goudelin, Noelie Montmagnon, Anne-Laure Fedou, Thomas Lafon and Philippe Vignon

Bedside ultrasound measurement of optic nerve sheath diameter in patients with sepsis: a prospective observational study

Authors: Ziyue Yang, Cuihong Qin, Shuguang Zhang, Shaohua Liu and Tongwen Sun

With the current COVID pandemic: should we use single-use flexible bronchoscopes instead of conventional bronchoscopes?

Authors: Patrick M. Honore, Aude Mugisha, Luc Kugener, Sebastien Redant, Rachid Attou, Andrea Gallerani and David De Bels

Unconventional approaches to mechanical ventilation—step-by-step through the COVID-19 crisis

Authors: Christopher Lotz, Quirin Notz, Peter Kranke, Markus Kredel and Patrick Meybohm

Prognostic value of venous blood analysis at the start of CPR in non-traumatic out-of-hospital cardiac arrest: association with ROSC and the neurological outcome: do not forget the no-flow influence!

Authors: Romain Jouffroy and Benoît Vivien

Severe diffuse alveolar hemorrhage related to autoimmune disease: a multicenter study

Diffuse alveolar hemorrhage (DAH) occurs during the course of autoimmune disease and may be life threatening. The objective was to assess characteristics and prognosis factors of DAH who required intensive car...

Authors: Adrien Mirouse, Antoine Parrot, Vincent Audigier, Alexandre Demoule, Julien Mayaux, Guillaume Géri, Eric Mariotte, Nicolas Bréchot, Nicolas de Prost, Mathieu Vautier, Mathilde Neuville, Naïke Bigé, Etienne de Montmollin, Patrice Cacoub, Matthieu Resche-Rigon, Jacques Cadranel…

Advanced respiratory monitoring in COVID-19 patients: use less PEEP!

Authors: Lisanne Roesthuis, Maarten van den Berg and Hans van der Hoeven

COVID-19: room for treating T cell exhaustion?

Authors: Giovanni Riva, Vincenzo Nasillo, Enrico Tagliafico, Tommaso Trenti and Mario Luppi

COVID-19 mortality and ICU admission: the Italian experience

Authors: Paolo Immovilli, Nicola Morelli, Elio Antonucci, Guido Radaelli, Mario Barbera and Donata Guidetti

Angiotensin II infusion in COVID-19-associated vasodilatory shock: a case series

Authors: Alberto Zangrillo, Giovanni Landoni, Luigi Beretta, Federica Morselli, Ary Serpa Neto and Rinaldo Bellomo

Therapeutic plasma exchange as a routine therapy in septic shock and as an experimental treatment for COVID-19: we are not sure

Authors: Patrick M. Honore, Aude Mugisha, Luc Kugener, Sebastien Redant, Rachid Attou, Andrea Gallerani and David De Bels

Prolonged prone position ventilation for SARS-CoV-2 patients is feasible and effective

Authors: Andrea Carsetti, Agnese Damia Paciarini, Benedetto Marini, Simona Pantanetti, Erica Adrario and Abele Donati

Gastrointestinal dysfunction in the critically ill: a systematic scoping review and research agenda proposed by the Section of Metabolism, Endocrinology and Nutrition of the European Society of Intensive Care Medicine

Gastrointestinal (GI) dysfunction is frequent in the critically ill but can be overlooked as a result of the lack of standardization of the diagnostic and therapeutic approaches. We aimed to develop a research...

Authors: Annika Reintam Blaser, Jean-Charles Preiser, Sonja Fruhwald, Alexander Wilmer, Jan Wernerman, Carina Benstoem, Michael P. Casaer, Joel Starkopf, Arthur van Zanten, Olav Rooyackers, Stephan M. Jakob, Cecilia I. Loudet, Danielle E. Bear, Gunnar Elke, Matthias Kott, Ingmar Lautenschläger…

Trauma complications and in-hospital mortality: failure-to-rescue

Reducing medical errors and minimizing complications have become the focus of quality improvement in medicine. Failure-to-rescue (FTR) is defined as death after a surgical complication, which is an institution...

Authors: Toshikazu Abe, Akira Komori, Atsushi Shiraishi, Takehiro Sugiyama, Hiroki Iriyama, Takako Kainoh and Daizoh Saitoh

Safe doubling of ventilator capacity: a last resort proposal for last resorts

Authors: J. Geoffrey Chase, Yeong Shiong Chiew, Bernard Lambermont, Philippe Morimont, Geoffrey M. Shaw and Thomas Desaive

Age and sex differences in soluble ACE2 may give insights for COVID-19

Authors: Per Swärd, Andreas Edsfeldt, Anton Reepalu, Lars Jehpsson, Björn E. Rosengren and Magnus K. Karlsson

Neurally adjusted ventilatory assist versus pressure support ventilation: a randomized controlled feasibility trial performed in patients at risk of prolonged mechanical ventilation

The clinical effectiveness of neurally adjusted ventilatory assist (NAVA) has yet to be demonstrated, and preliminary studies are required. The study aim was to assess the feasibility of a randomized controlle...

Authors: Daniel J. Hadfield, Louise Rose, Fiona Reid, Victoria Cornelius, Nicholas Hart, Clare Finney, Bethany Penhaligon, Jasmine Molai, Clair Harris, Sian Saha, Harriet Noble, Emma Clarey, Leah Thompson, John Smith, Lucy Johnson, Phillip A. Hopkins…

Patients with COVID-19 in 19 ICUs in Wuhan, China: a cross-sectional study

A COVID-19 outbreak started in Wuhan, China, last December and now has become a global pandemic. The clinical information in caring of critically ill patients with COVID-19 needs to be shared timely, especiall...

Authors: Yuan Yu, Dan Xu, Shouzhi Fu, Jun Zhang, Xiaobo Yang, Liang Xu, Jiqian Xu, Yongran Wu, Chaolin Huang, Yaqi Ouyang, Luyu Yang, Minghao Fang, Hongwen Xiao, Jing Ma, Wei Zhu, Song Hu…

Microcirculatory perfusion disturbances following cardiopulmonary bypass: a systematic review

Microcirculatory perfusion disturbances are associated with increased morbidity and mortality in patients undergoing cardiac surgery with cardiopulmonary bypass (CPB). Technological advancements made it possib...

Authors: Matthijs M. den Os, Charissa E. van den Brom, Anoek L. I. van Leeuwen and Nicole A. M. Dekker

The use of a neuromuscular blocking agent could significantly decrease mortality in moderate-to-severe ARDS patients: is moderate ARDS the best indication for neuromuscular blocking agents

Authors: Patrick M. Honore, Aude Mugisha, Luc Kugener, Sebastien Redant, Rachid Attou, Andrea Gallerani and David De Bels

A longitudinal cohort of stress cardiomyopathy assessed with speckle-tracking echocardiography after moderate to severe traumatic brain injury

Authors: Raphaël Cinotti, Thierry Le Tourneau, Kalyane Bach-Ngohou, Maxime Le Courtois du Manoir, Bertrand Rozec and Karim Asehnoune

Simultaneous ventilation of two simulated ARDS patients in COVID-19 pandemic

Authors: Danny Epstein, Yoav Hoffman, George Dahoud, Aeyal Raz and Asaf Miller