Articles
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Citation: Critical Care 2022 26:5
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Mechanical power in pediatric acute respiratory distress syndrome: a PARDIE study
Mechanical power is a composite variable for energy transmitted to the respiratory system over time that may better capture risk for ventilator-induced lung injury than individual ventilator management compone...
Citation: Critical Care 2022 26:2 -
Sildenafil for treating patients with COVID-19 and perfusion mismatch: a pilot randomized trial
SARS-CoV-2 seems to affect the regulation of pulmonary perfusion. Hypoperfusion in areas of well-aerated lung parenchyma results in a ventilation–perfusion mismatch that can be characterized using subtraction ...
Citation: Critical Care 2022 26:1 -
Awake prone positioning on diaphragmatic function: Really bad or maybe good?
Citation: Critical Care 2021 25:449 -
Predictors for extubation failure in COVID-19 patients using a machine learning approach
Determining the optimal timing for extubation can be challenging in the intensive care. In this study, we aim to identify predictors for extubation failure in critically ill patients with COVID-19.
Citation: Critical Care 2021 25:448 -
Demystifying machine learning for mortality prediction
Citation: Critical Care 2021 25:447 -
A pilot study of trained ICU doulas providing early psychological support to critically ill patients
Over a third of critical illness survivors suffer from mental health problems following hospitalization. Memories of delusional experiences are a major risk factor. In this project, ICU doulas delivered a uniq...
Citation: Critical Care 2021 25:446 -
Ventilator-associated pneumonia in critically-ill patients with COVID-19 in a setting of selective decontamination of the digestive tract
Citation: Critical Care 2021 25:445 -
Anti-influenza T cells in bronchoalveolar microenvironment of critically severe COVID-19 patients
Citation: Critical Care 2021 25:444 -
Exploring population pharmacokinetic models in patients treated with vancomycin during continuous venovenous haemodiafiltration (CVVHDF)
Therapeutic antibiotic dose monitoring can be particularly challenging in septic patients requiring renal replacement therapy. Our aim was to conduct an exploratory population pharmacokinetic (PK) analysis on ...
Citation: Critical Care 2021 25:443 -
Effect of chest wall loading during supine and prone position in a critically ill covid-19 patient: a new strategy for ARDS?
Citation: Critical Care 2021 25:442 -
Surface EMG-based quantification of inspiratory effort: a quantitative comparison with Pes
Inspiratory patient effort under assisted mechanical ventilation is an important quantity for assessing patient–ventilator interaction and recognizing over and under assistance. An established clinical standar...
Citation: Critical Care 2021 25:441 -
Dangers of hyperoxia
Oxygen (O2) toxicity remains a concern, particularly to the lung. This is mainly related to excessive production of reactive oxygen species (ROS). Supplemental O2, i.e. inspiratory O2 concentrations (FIO2) > 0.21...
Citation: Critical Care 2021 25:440 -
How to monitor thiopental administration in the intensive care unit for refectory status epilepticus or intracranial hypertension?
Citation: Critical Care 2021 25:439 -
Patient discharge from intensive care: an updated scoping review to identify tools and practices to inform high-quality care
Critically ill patients require complex care and experience unique needs during and after their stay in the intensive care unit (ICU). Discharging or transferring a patient from the ICU to a hospital ward or b...
Citation: Critical Care 2021 25:438 -
Hyperglycemia and insulin resistance in COVID-19 versus non-COVID critical illness: Are they really different?
Citation: Critical Care 2021 25:437 -
Albumin and fibrinogen kinetics in sepsis: a prospective observational study
The measurement of circulating substrate concentrations does not provide information about substrate kinetics. It, therefore, remains unclear if a decrease in plasma concentration of albumin, as seen during cr...
Citation: Critical Care 2021 25:436 -
Correction to: The evolution of the ventilatory ratio is a prognostic factor in mechanically ventilated COVID-19 ARDS patients
Citation: Critical Care 2021 25:435 -
Impact of rewarming rate on interleukin-6 levels in patients with shockable cardiac arrest receiving targeted temperature management at 33 °C: the ISOCRATE pilot randomized controlled trial
While targeted temperature management (TTM) has been recommended in patients with shockable cardiac arrest (CA) and suggested in patients with non-shockable rhythms, few data exist regarding the impact of the ...
Citation: Critical Care 2021 25:434 -
Anisodamine microcirulatory effects in septic shock: be aware of cardiac side effects
Citation: Critical Care 2021 25:433 -
Real-world corticosteroid use in severe pneumonia: a propensity-score-matched study
Community-acquired pneumonia (CAP) is a leading cause of morbidity and mortality worldwide despite correct antibiotic use. Corticosteroids have long been evaluated as a treatment option, but heterogeneous effe...
Citation: Critical Care 2021 25:432 -
Positive end-expiratory pressure in COVID-19 acute respiratory distress syndrome: the heterogeneous effects
We hypothesized that as CARDS may present different pathophysiological features than classic ARDS, the application of high levels of end-expiratory pressure is questionable. Our first aim was to investigate th...
Citation: Critical Care 2021 25:431 -
Persisting neuroendocrine abnormalities and their association with physical impairment 5 years after critical illness
Critical illness is hallmarked by neuroendocrine alterations throughout ICU stay. We investigated whether the neuroendocrine axes recover after ICU discharge and whether any residual abnormalities associate wi...
Citation: Critical Care 2021 25:430 -
Orthodeoxia and its implications on awake-proning in COVID-19 pneumonia
Citation: Critical Care 2021 25:429 -
17α-Ethinyl estradiol-3-sulfate increases survival and hemodynamic functioning in a large animal model of combined traumatic brain injury and hemorrhagic shock: a randomized control trial
Traumatic brain injury (TBI) and severe blood loss resulting in hemorrhagic shock (HS) represent leading causes of trauma-induced mortality, especially when co-occurring in pre-hospital settings where standard...
Citation: Critical Care 2021 25:428 -
Flow Index accurately identifies breaths with low or high inspiratory effort during pressure support ventilation
Flow Index, a numerical expression of the shape of the inspiratory flow-time waveform recorded during pressure support ventilation, is associated with patient inspiratory effort. The aim of this study was to a...
Citation: Critical Care 2021 25:427 -
Collaborative intelligence for intensive care units
Citation: Critical Care 2021 25:426 -
Is endocan correlated to ARDS severity or an epiphenomenon of thrombo-embolic disease in COVID
Citation: Critical Care 2021 25:425 -
A guide to enteral nutrition in intensive care units: 10 expert tips for the daily practice
The preferential use of the oral/enteral route in critically ill patients over gut rest is uniformly recommended and applied. This article provides practical guidance on enteral nutrition in compliance with re...
Citation: Critical Care 2021 25:424 -
Lung histopathologic clusters in severe COVID-19: a link between clinical picture and tissue damage
Autoptic pulmonary findings have been described in severe COVID-19 patients, but evidence regarding the correlation between clinical picture and lung histopathologic patterns is still weak.
Citation: Critical Care 2021 25:423 -
Early versus late proning in non-intubated COVID-19 pneumonia
Citation: Critical Care 2021 25:422 -
Benefits and risks of noninvasive oxygenation strategy in COVID-19: a multicenter, prospective cohort study (COVID-ICU) in 137 hospitals
To evaluate the respective impact of standard oxygen, high-flow nasal cannula (HFNC) and noninvasive ventilation (NIV) on oxygenation failure rate and mortality in COVID-19 patients admitted to intensive care ...
Citation: Critical Care 2021 25:421 -
Development of a new score for early mortality prediction in trauma ICU patients: RETRASCORE
Severity scores are commonly used for outcome adjustment and benchmarking of trauma care provided. No specific models performed only with critically ill patients are available. Our objective was to develop a n...
Citation: Critical Care 2021 25:420 -
Clinical characteristics and risk factors associated with mortality in patients with severe community-acquired pneumonia and type 2 diabetes mellitus
The present study was performed to investigate the impacts of type 2 diabetes mellitus (T2DM) on severe community-acquired pneumonia (SCAP) and to develop a novel prediction model for mortality in SCAP patient...
Citation: Critical Care 2021 25:419 -
Pneumocystis jirovecii pneumonia in COVID-19: an overlooked clinical entity—Response to “Pneumocystis pneumonia risk among viral acute respiratory distress syndrome related or not to COVID 19”
Citation: Critical Care 2021 25:418 -
HSV-1 reactivation is associated with an increased risk of mortality and pneumonia in critically ill COVID-19 patients
Data in the literature about HSV reactivation in COVID-19 patients are scarce, and the association between HSV-1 reactivation and mortality remains to be determined. Our objectives were to evaluate the impact of
Citation: Critical Care 2021 25:417 -
Changes in carbon dioxide production and oxygen uptake evaluated using indirect calorimetry in mechanically ventilated patients with sepsis
Several clinical guidelines recommend monitoring blood lactate levels and central venous oxygen saturation for hemodynamic management of patients with sepsis. We hypothesized that carbon dioxide production (VCO2)...
Citation: Critical Care 2021 25:416 -
Novel protocol combining physical and nutrition therapies, Intensive Goal-directed REhabilitation with Electrical muscle stimulation and Nutrition (IGREEN) care bundle
Although the combination of rehabilitation and nutrition may be important for the prevention of intensive care unit (ICU)-acquired weakness, a protocolized intervention of this combination has not yet been rep...
Citation: Critical Care 2021 25:415 -
Efficacy of non-invasive and invasive respiratory management strategies in adult patients with acute hypoxaemic respiratory failure: a systematic review and network meta-analysis
Although non-invasive respiratory management strategies have been implemented to avoid intubation, patients with de novo acute hypoxaemic respiratory failure (AHRF) are high risk of treatment failure. In the p...
Citation: Critical Care 2021 25:414 -
Complete countrywide mortality in COVID patients receiving ECMO in Germany throughout the first three waves of the pandemic
Citation: Critical Care 2021 25:413 -
Effects of intermittent hemodialysis on plasmatic levels of endocan
Citation: Critical Care 2021 25:412 -
Rapidly progressive brain atrophy in septic ICU patients: a retrospective descriptive study using semiautomatic CT volumetry
Sepsis is often associated with multiple organ failure; however, changes in brain volume with sepsis are not well understood. We assessed brain atrophy in the acute phase of sepsis using brain computed tomogra...
Citation: Critical Care 2021 25:411 -
Long-term survival and health-related quality of life in patients with severe acute respiratory distress syndrome and veno-venous extracorporeal membrane oxygenation support
There is limited information about the long-term outcome of patients suffering from acute respiratory distress syndrome (ARDS) supported with veno-venous extracorporeal membrane oxygenation (VV ECMO). Most stu...
Citation: Critical Care 2021 25:410 -
Randomised trials of temperature management in cardiac arrest: Are we observing the Zeno’s paradox of the Tortoise and Achilles?
Citation: Critical Care 2021 25:409 -
Dispatcher instructions for bystander cardiopulmonary resuscitation and neurologically intact survival after bystander-witnessed out-of-hospital cardiac arrests: a nationwide, population-based observational study
The International Liaison Committee on Resuscitation recommends that dispatchers provide instructions to perform compression-only cardiopulmonary resuscitation (CPR) to callers responding to adults with out-of...
Citation: Critical Care 2021 25:408 -
Role of MR-proADM in the risk stratification of COVID-19 patients assessed at the triage of the Emergency Department
Citation: Critical Care 2021 25:407 -
Indirect calorimetry is the gold standard to assess REE in ICU patients: some limitations to consider
Citation: Critical Care 2021 25:406 -
Development and evaluation of the focused assessment of sonographic pathologies in the intensive care unit (FASP-ICU) protocol
The use of ultrasonography in the intensive care unit (ICU) is steadily increasing but is usually restricted to examinations of single organs or organ systems. In this study, we combine the ultrasound approach...
Citation: Critical Care 2021 25:405 -
Promises and challenges of personalized medicine to guide ARDS therapy
Identifying new effective treatments for the acute respiratory distress syndrome (ARDS), including COVID-19 ARDS, remains a challenge. The field of ARDS investigation is moving increasingly toward innovative a...
Citation: Critical Care 2021 25:404 -
The effect of the COVID-19 pandemic on the epidemiology of positive blood cultures in Swiss intensive care units: a nationwide surveillance study
Evidence about the impact of the pandemic of COVID-19 on the incidence rates of blood cultures contaminations and bloodstream infections in intensive care units (ICUs) remains scant. The objective of this stud...
Citation: Critical Care 2021 25:403
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- ISSN: 1364-8535 (electronic)