Cytomegalovirus (CMV) reactivation in previously immunocompetent critically ill patients is associated with increased mortality, which has been hypothesized to result from virus-induced immunomodulation. There...
Authors: Kirsten van de Groep, Stefan Nierkens, Olaf L. Cremer, Linda M. Peelen, Peter M. C. Klein Klouwenberg, Marcus J. Schultz, C. Erik Hack, Tom van der Poll, Marc J. M. Bonten and David S. Y. Ong
Organ failure, including acute kidney injury (AKI), is the third leading cause of death after bleeding and brain injury in trauma patients. We sought to assess the prevalence, the risk factors and the impact o...
Authors: Anatole Harrois, Benjamin Soyer, Tobias Gauss, Sophie Hamada, Mathieu Raux and Jacques Duranteau
Recently, the use of nebulized antibiotics in the intensive care unit, in particular amikacin, has been the subject of much discussion, owing to unconvincing results from the latest randomized clinical trials....
Authors: Antoni Torres, Anna Motos, Denise Battaglini and Gianluigi Li Bassi
Critical illness polyneuromyopathy (CIPNM) is a major cause of weakness in intensive care unit (ICU) patients, but current diagnostic tests are limited. We evaluated the generalizability and validity of single...
Authors: Daniel A. Kelmenson, Dianna Quan and Marc Moss
Tigecycline is a vital antibiotic treatment option for infections caused by multiresistant bacteria in the intensive care unit (ICU). Acute kidney injury (AKI) is a common complication in the ICU requiring con...
Authors: A. Broeker, S. G. Wicha, C. Dorn, A. Kratzer, M. Schleibinger, F. Kees, A. Heininger, M. G. Kees and H. Häberle
Prior retrospective cross-sectional work has associated antimicrobials with a non-specific phrase: encephalopathy without seizures. The purpose of this study is to determine whether different classes of antimi...
Authors: Jessica J. Grahl, Joanna L. Stollings, Shayan Rakhit, Anna K. Person, Li Wang, Jennifer L. Thompson, Pratik P. Pandharipande, E. Wesley Ely and Mayur B. Patel
Dimethylarginine dimethylaminohydrolase 2 (DDAH2) regulates the synthesis of nitric oxide (NO) through the metabolism of the endogenous inhibitor of nitric oxide synthase, asymmetric dimethylarginine (ADMA). P...
Authors: Simon Lambden, James Tomlinson, Sophie Piper, Anthony C. Gordon and James Leiper
The management of complaints in the setting of intensive care may provide opportunities to understand patient and family experiences and needs. However, there are limited reports on the structured application ...
Authors: Jih-Shuin Jerng, Szu-Fen Huang, Hsin-Yu Yu, Yi-Chun Chan, Huang-Ju Liang, Huey-Wen Liang and Jui-Sheng Sun
In most countries, patients receiving mechanical ventilation (MV) are treated in intensive care units (ICUs). However, in some countries, including Japan, many patients on MV are not treated in ICUs. There are...
Acute respiratory failure related to diffuse alveolar hemorrhage (DAH) is a typical presentation of small-vessel vasculitis that requires prompt multidisciplinary management. The primary treatment is based on ...
Authors: Guillaume Geri, Benjamin Terrier, Farhad Heshmati, Hanafi Moussaoui, Julien Massot, Jean-Paul Mira, Luc Mouthon and Frédéric Pène
Sepsis-associated brain dysfunction (SABD) is associated with high morbidity and mortality. The pathophysiology of SABD is multifactorial. One hypothesis is that impaired cerebral autoregulation (CAR) may resu...
Authors: Ilaria Alice Crippa, Carles Subirà, Jean-Louis Vincent, Rafael Fernandez Fernandez, Silvia Cano Hernandez, Federica Zama Cavicchi, Jacques Creteur and Fabio Silvio Taccone
The study objective was to assess the influence of neutropenia on outcome of critically ill cancer patients by meta-analysis of individual data. Secondary objectives were to assess the influence of neutropenia...
Authors: Quentin Georges, Elie Azoulay, Djamel Mokart, Marcio Soares, Kyeongman Jeon, Sandra Oeyen, Chin Kook Rhee, Pascale Gruber, Marlies Ostermann, Quentin A. Hill, Pieter Depuydt, Christelle Ferra, Anne-Claire Toffart, Peter Schellongowski, Alice Müller, Virginie Lemiale…
Maximal left ventricular (LV) pressure rise (LV dP/dtmax), a classical marker of LV systolic function, requires LV catheterization, thus surrogate arterial pressure waveform measures have been proposed. We compar...
Authors: Manuel Ignacio Monge Garcia, Zhongping Jian, Jos J. Settels, Charles Hunley, Maurizio Cecconi, Feras Hatib and Michael R. Pinsky
Survivors of intensive care are known to be at increased risk of developing longer-term psychopathology issues. We present a large UK multicentre study assessing the anxiety, depression and post-traumatic stre...
Authors: Robert Hatch, Duncan Young, Vicki Barber, John Griffiths, David A. Harrison and Peter Watkinson
We evaluated whether Alberta Stroke Program Early Computed Tomography Score (ASPECTS) with some modifications could be used to predict neurological outcomes in patients after extracorporeal cardiopulmonary res...
Authors: Jeong-Am Ryu, Young Hwan Lee, Chi Ryang Chung, Yang Hyun Cho, Kiick Sung, Kyeongman Jeon, Gee Young Suh, Taek Kyu Park, Joo Myung Lee, Minjung Kathy Chae, Jeong-Ho Hong, Sei Hee Lee, Hyoung Soo Kim and Jeong Hoon Yang
Sepsis is a leading cause of death and long-term disability in developed countries. A comprehensive report on the incidence, clinical characteristics, and evolving management of sepsis is important. Thus, this...
Infected pancreatic necrosis, which occurs in about 40% of patients admitted for acute necrotizing pancreatitis, requires combined antibiotic therapy and local drainage. Since 2010, drainage by open surgical n...
Authors: Lucie Darrivere, Nathanael Lapidus, Nikias Colignon, Najim Chafai, Ulriikka Chaput, Franck Verdonk, François Paye and Thomas Lescot
Following a fatal intensive care unit (ICU) outbreak of carbapenem-resistant Acinetobacter baumanii (CRAB) in 2015, an aggressive infection control intervention was instituted. We outline the intervention and lon...
Authors: Eli Ben-Chetrit, Yonit Wiener-Well, Emil Lesho, Puah Kopuit, Chaya Broyer, Liora Bier, Marc V. Assous, Shmuel Benenson, Matan J. Cohen, Patrick T. McGann, Erik Snesrud and Phillip D. Levin
Patients in refractory status epilepticus (RSE) may require treatment with continuous intravenous anesthetic drugs (cIVADs) for seizure control. The use of cIVADs, however, was recently associated with poor ou...
Authors: Dominik Madžar, Caroline Reindl, Antje Giede-Jeppe, Tobias Bobinger, Maximilian I. Sprügel, Ruben U. Knappe, Hajo M. Hamer and Hagen B. Huttner
Iron deficiency is difficult to diagnose in critically ill patients, but may be frequent and may impair recovery. Measurement of hepcidin could help in the diagnosis of iron deficiency. We aim to assess if iro...
The interaction between hyperaldosteronism and immune dysfunction has been reported and glucocorticoid co-secretion is frequently found in primary aldosteronism (PA). The aforementioned conditions raise the po...
Septic shock is the most severe complication of sepsis and this syndrome is associated with high mortality. Treatment of septic shock remains largely supportive of hemodynamics and tissue perfusion. Early chan...
Reports of increasing incidence rates of delirium in critically ill children are reason for concern. We evaluated the measurement properties of the pediatric delirium component (PD-scale) of the Sophia Observa...
Authors: Erwin Ista, Babette van Beusekom, Joost van Rosmalen, Martin C. J. Kneyber, Joris Lemson, Arno Brouwers, Gwen C. Dieleman, Bram Dierckx, Matthijs de Hoog, Dick Tibboel and Monique van Dijk
We sought to determine the effects of alternative resuscitation strategies on microcirculatory perfusion and examine any association between microcirculatory perfusion and mortality in sepsis.
Authors: Michael J. Massey, Peter C. Hou, Michael Filbin, Henry Wang, Long Ngo, David T. Huang, William C. Aird, Victor Novack, Stephen Trzeciak, Donald M. Yealy, John A. Kellum, Derek C. Angus and Nathan I. Shapiro
Despite modern intensive care with standardized strategies against acute respiratory distress syndrome (ARDS), Pneumocystis pneumonia (PcP) remains a life-threatening disease with a high mortality rate. Here, we ...
Authors: Julius J. Schmidt, Catherina Lueck, Stefan Ziesing, Matthias Stoll, Hermann Haller, Jens Gottlieb, Matthias Eder, Tobias Welte, Marius M. Hoeper, André Scherag and Sascha David
We aimed to investigate the extent of the agreement on practices around brain death and postmortem organ donation.
Authors: Ernest van Veen, Mathieu van der Jagt, Maryse C. Cnossen, Andrew I. R. Maas, Inez D. de Beaufort, David K. Menon, Giuseppe Citerio, Nino Stocchetti, Wim J. R. Rietdijk, Jeroen T. J. M. van Dijck and Erwin J. O. Kompanje
Acute kidney injury (AKI) is associated with high morbidity and mortality in surgical patients. Nonrecovery from AKI may increase mortality and early risk stratification seems key to improving clinical outcome...
Authors: Hui-Miao Jia, Yue Zheng, Li-Feng Huang, Xin Xin, Wen-Liang Ma, Yi-Jia Jiang, Xi Zheng, Shu-Yan Guo and Wen-Xiong Li
High tidal volume ventilation of healthy lungs or exacerbation of existing acute lung injury (ALI) by more moderate mechanical ventilation (MTV) produces ventilator-induced lung injury. It is less clear whethe...
Authors: Xibing Ding, Yao Tong, Shuqing Jin, Zhixia Chen, Tunliang Li, Timothy R. Billiar, Bruce R. Pitt, Quan Li and Li-Ming Zhang
Aerosolized antibiotics have been proposed as a novel and promising treatment option for the treatment of ventilator-associated pneumonia (VAP). However, the optimum aerosolized antibiotics for VAP remain unce...
Authors: Feng Xu, Lu-Lu He, Luan-Qing Che, Wen Li, Song-Min Ying, Zhi-Hua Chen and Hua-Hao Shen
Glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP) are incretin hormones. By lowering blood glucose in a glucose-dependent manner, incretin-based therapies represent a novel and...
Authors: Abraham H Hulst, Mark P Plummer, Markus W Hollmann, J Hans DeVries, Benedikt Preckel, Adam M Deane and Jeroen Hermanides
Whether goal-directed fluid therapy based on dynamic predictors of fluid responsiveness (GDFTdyn) alone improves clinical outcomes in comparison with standard fluid therapy among patients undergoing surgery re...
Available evidence from randomized controlled trials including adult critically ill patients tends to show that percutaneous dilatational tracheostomy (PDT) techniques are performed faster and reduce stoma inf...
Authors: Maria Vargas, Pasquale Buonanno, Lina Giorgiano, Giovanna Sorriento, Carmine Iacovazzo and Giuseppe Servillo
Selective decontamination of the digestive tract (SDD) has been with us since the early days of our specialty, and in some ways it marks our progression and maturation. How we have dealt with SDD to date range...
