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Socioeconomic variables impact health outcomes but have rarely been evaluated in critical illness. Low- and middle-income countries bear the highest burden of sepsis and also have significant health inequities...
Citation: Critical Care 2019 23:250
Sepsis remains a complex medical problem and a major challenge in healthcare. Diagnostics and outcome predictions are focused on physiological parameters with less consideration given to patients’ medical back...
Citation: Critical Care 2019 23:247
Citation: Critical Care 2019 23(Suppl 3):237
This article is part of a Supplement: Volume 23 Supplement 3
Citation: Critical Care 2019 23:246
The original article was published in Critical Care 2019 23:107
In critically ill patients, poor patient-ventilator interaction may worsen outcomes. Although sedatives are often administered to improve comfort and facilitate ventilation, they can be deleterious. Whether op...
Citation: Critical Care 2019 23:245
Citation: Critical Care 2019 23:244
The original article was published in Critical Care 2018 22:284
Citation: Critical Care 2019 23:243
The Letter to this article has been published in Critical Care 2019 23:342
The Letter to this article has been published in Critical Care 2019 23:287
Citation: Critical Care 2019 23:242
Epidemiologic data have shown an increasing incidence and declining mortality rate in sepsis. However, confounding effects due to differences in disease classification might have contributed to these trends.
Citation: Critical Care 2019 23:241
Citation: Critical Care 2019 23:240
The original article was published in Critical Care 2017 21:17
Citation: Critical Care 2019 23:239
The original article was published in Critical Care 2018 22:227
Citation: Critical Care 2019 23:238
ICU-acquired weakness is a debilitating consequence of prolonged critical illness that is associated with poor outcome. Recently, premorbid obesity has been shown to protect against such illness-induced muscle...
Citation: Critical Care 2019 23:236
Necroptosis, a form of programmed cell death mediated by receptor interacting serine/threonine-protein kinase-3 (RIPK3), is implicated in murine models of acute respiratory distress syndrome (ARDS). We hypothe...
Citation: Critical Care 2019 23:235
Brain injury (BI) induces a state of immunodepression leading to pneumonia. We investigated the invariant natural killer T (iNKT) cell compartment.
Citation: Critical Care 2019 23:234
Citation: Critical Care 2019 23:233
The original article was published in Critical Care 2019 23:128
Perioperative goal-directed therapy (GDT) reduces the risk of renal injury. However, several questions remain unanswered, such as target, kind of patients and surgery, and role of fluids and inotropes. We ther...
Citation: Critical Care 2019 23:232
Citation: Critical Care 2019 23:231
The original article was published in Critical Care 2018 22:347
Sepsis survivors often develop chronic critical illness (CCI) and demonstrate the persistent inflammation, immunosuppression, and catabolism syndrome predisposing them to long-term functional limitations and h...
Citation: Critical Care 2019 23:230
The Letter to this article has been published in Critical Care 2019 23:341
Citation: Critical Care 2019 23:229
Citation: Critical Care 2019 23:228
The Letter to this article has been published in Critical Care 2019 23:354
The original article was published in Critical Care 2014 18:654
The last decade, there have been many initiatives worldwide to increase the number of organ donors. However, it is not clear which initiatives are most effective. The aim of this study is to provide an overvie...
Citation: Critical Care 2019 23:227
Citation: Critical Care 2019 23:226
The original article was published in Critical Care 2016 20:267
The first FDA-approved test to assess risk for acute kidney injury (AKI), [TIMP-2]•[IGFBP7], is clinically available in many parts of the world, including the USA and Europe. We sought to understand how the te...
Citation: Critical Care 2019 23:225
We hypothesized that the absence of P25 and the N20–P25 amplitude in somatosensory evoked potentials (SSEPs) have higher sensitivity than the absence of N20 for poor neurological outcomes, and we evaluated the...
Citation: Critical Care 2019 23:224
Citation: Critical Care 2019 23:223
The original article was published in Critical Care 2017 21:162
During the initial phase of critical illness, the association between the dose of nutrition support and mortality risk may vary among patients in the intensive care unit (ICU) because the prevalence of malnutr...
Citation: Critical Care 2019 23:222
Intubation is frequently required for patients in the intensive care unit (ICU) but is associated with high morbidity and mortality mainly in emergency procedures and in the presence of severe organ failures. ...
Citation: Critical Care 2019 23:221
Limited critical care subspecialty training and experience is available in many low- and middle-income countries, creating barriers to the delivery of evidence-based critical care. We hypothesized that a struc...
Citation: Critical Care 2019 23:220
The objective of this study was to assess the cumulative incidence of invasive candidiasis (IC) in intensive care units (ICUs) in Europe.
Citation: Critical Care 2019 23:219
Citation: Critical Care 2019 23(Suppl 1):203
This article is part of a Supplement: Volume 23 Supplement 1
The Letter to this article has been published in Critical Care 2019 23:275
Progress toward determining the true worth of ongoing practices or value of recent innovations can be glacially slow when we insist on following the conventional stepwise scientific pathway. Moreover, a widely...
Citation: Critical Care 2019 23(Suppl 1):197
This article is part of a Supplement: Volume 23 Supplement 1
Catecholamines are used to increase cardiac output and blood pressure, aiming ultimately at restoring/improving tissue perfusion. While intuitive in its concept, this approach nevertheless implies to be effect...
Citation: Critical Care 2019 23(Suppl 1):149
This article is part of a Supplement: Volume 23 Supplement 1
Citation: Critical Care 2019 23(Suppl 1):146
This article is part of a Supplement: Volume 23 Supplement 1
Critically ill patients require adequate nutritional support to meet energy requirements both during and after intensive care unit (ICU) stay to protect against severe catabolism and prevent significant decond...
Citation: Critical Care 2019 23(Suppl 1):139
This article is part of a Supplement: Volume 23 Supplement 1
Patients admitted to the intensive care unit (ICU) often require invasive mechanical ventilation. Ventilator-associated lower respiratory tract infections (VA-LRTI), either ventilator-associated tracheobronchi...
Citation: Critical Care 2019 23(Suppl 1):134
This article is part of a Supplement: Volume 23 Supplement 1
The founding tenet of evidence-based medicine is to combine best evidence with clinical expertise. As David Sackett opined ‘Without clinical expertise, practice risks becoming tyrannised by evidence’. Rigid pr...
Citation: Critical Care 2019 23(Suppl 1):127
This article is part of a Supplement: Volume 23 Supplement 1
This paper discusses the physiological and technological concepts that might form the future of critical care medicine. Initially, we discuss the need for a personalized approach and introduce the concept of p...
Citation: Critical Care 2019 23(Suppl 1):126
This article is part of a Supplement: Volume 23 Supplement 1
In the absence of evidence, therapies are often based on intuition, belief, common sense or gut feeling. Over the years, some treatment strategies may become dogmas that are eventually considered as state-of-t...
Citation: Critical Care 2019 23(Suppl 1):125
This article is part of a Supplement: Volume 23 Supplement 1
Until relatively recently, critical illness was considered as a separate entity and the intensive care unit (ICU), often a little cut-off from other areas of the hospital, was in many cases used as a last reso...
Citation: Critical Care 2019 23(Suppl 1):122
This article is part of a Supplement: Volume 23 Supplement 1
Our current understanding of protective measures for avoiding ventilator-induced lung injury (VILI) has evolved from targeting low tidal volumes to lowering plateau and driving pressure. Even when pressures ac...
Citation: Critical Care 2019 23(Suppl 1):114
This article is part of a Supplement: Volume 23 Supplement 1
Citation: Critical Care 2019 23:218
The original article was published in Critical Care 2019 23:89
Oesophageal pressure (PES) is used for calculation of lung and chest wall mechanics and transpulmonary pressure during mechanical ventilation. Measurements performed with a balloon catheter are suggested as a ...
Citation: Critical Care 2019 23:217
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Citation: Critical Care 2019 23:215
The original article was published in Critical Care 2018 22:128
Annual seasonal influenza epidemics of variable severity result in significant morbidity and mortality in the United States (U.S.) and worldwide. In temperate climate countries, including the U.S., influenza a...
Citation: Critical Care 2019 23:214
As more patients are surviving intensive care, mental health concerns in survivors have become a research priority. Among these, post-traumatic stress disorder (PTSD) can have an important impact on the qualit...
Citation: Critical Care 2019 23:213
Aetiology and outcomes of sepsis in sub-Saharan Africa (sSA) are poorly described; we performed a systematic review and meta-analysis to summarise the available data.
Citation: Critical Care 2019 23:212
Mottling score, a tissue perfusion parameter, is correlated with outcome in septic shock patients. However, its predictive value on mortality according to prognostic covariates such as vasopressor dose and oth...
Citation: Critical Care 2019 23:211
The Letter to this article has been published in Critical Care 2019 23:268
Citation: Critical Care 2019 23:210
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