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  4. Proenkephalin A 119-159 (PENK) is freely filtered in the glomerulus with plasma levels correlating with glomerular filtration rate. Therefore, PENK has been proposed as an early indicator of acute kidney injur...

    Authors: Li-Chun Lin, Min-Hsiang Chuan, Jung-Hua Liu, Hung-Wei Liao, Leong L. Ng, Martin Magnusson, Amra Jujic, Heng-Chih Pan, Vin-Cent Wu and Lui G. Forni
    Citation: Critical Care 2023 27:481
    Content type: Research Published on:

  6. Previous research indicated outcomes among refractory out-of-hospital cardiac arrest (OHCA) patients with initial shockable rhythm were different in Singapore and Osaka, Japan, possibly due to the differences ...

    Authors: Yohei Okada, Nur Shahidah, Yih Yng Ng, Michael Y. C. Chia, Han Nee Gan, Benjamin S. H. Leong, Desmond R. Mao, Wei Ming Ng, Nausheen Edwin, Takeyuki Kiguchi, Norihiro Nishioka, Tetsuhisa Kitamura, Taku Iwami and Marcus Eng Hock Ong
    Citation: Critical Care 2023 27:479
    Content type: Brief Report Published on:

  9. Observational studies have indicated a potential association between autoimmune diseases and the occurrence of sepsis, with an increased risk of mortality among affected patients. However, whether a causal rel...

    Authors: Hui Li, Xiaojun Pan, Sheng Zhang, Xuan Shen, Wan Li, Weifeng Shang, Zhenliang Wen, Sisi Huang, Limin Chen, Xu Zhang, Dechang Chen and Jiao Liu
    Citation: Critical Care 2023 27:476
    Content type: Research Published on:

  10. The multiple roles of iron in the body have been known for decades, particularly its involvement in iron overload diseases such as hemochromatosis. More recently, compelling evidence has emerged regarding the ...

    Authors: Coralie Grange, François Lux, Thomas Brichart, Laurent David, Aymeric Couturier, David E. Leaf, Bernard Allaouchiche and Olivier Tillement
    Citation: Critical Care 2023 27:475
    Content type: Review Published on:

  12. Acute circulatory failure leads to tissue hypoperfusion. Capillary refill time (CRT) has been widely studied, but its predictive value remains debated. We conducted a meta-analysis to assess the ability of CRT...

    Authors: Matthias Jacquet-Lagrèze, Aymeric Pernollet, Eduardo Kattan, Hafid Ait-Oufella, Delphine Chesnel, Martin Ruste, Rémi Schweizer, Bernard Allaouchiche, Glenn Hernandez and Jean-Luc Fellahi
    Citation: Critical Care 2023 27:473
    Content type: Review Published on:

  13. To evaluate the potential association between early dysnatremia and 6-month functional outcome after cardiac arrest.

    Authors: Jean Baptiste Lascarrou, Cyrielle Ermel, Alain Cariou, Timo Laitio, Hans Kirkegaard, Eldar Søreide, Anders M. Grejs, Matti Reinikainen, Gwenhael Colin, Fabio Silvio Taccone, Amélie Le Gouge and Markus B. Skrifvars
    Citation: Critical Care 2023 27:472
    Content type: Research Published on:

  15. Intra-abdominal candidiasis (IAC) is difficult to predict in critically ill patients with intra-abdominal infection, leading to the overuse of antifungal treatments. Serum and peritoneal 1.3-beta-d-glucan (sBDG a...

    Authors: Emmanuel Novy, Jérémie Rivière, Maxime Nguyen, Gaëlle Arfeuille, Guillaume Louis, Bélaïd Bouhemad, Julien Pottecher, Stéphane Hecketsweiler, Adeline Germain, François-Xavier Laithier, Marie-Reine Losser, Anne Debourgogne, Yohann Bernard, Hélène Rousseau, Cédric Baumann, Amandine Luc…
    Citation: Critical Care 2023 27:470
    Content type: Research Published on:

  17. Despite the extensive volume of research published on checklists in the intensive care unit (ICU), no review has been published on the broader role of checklists within the intensive care unit, their implement...

    Authors: Ethan J. Erikson, Daniel A. Edelman, Fiona M. Brewster, Stuart D. Marshall, Maryann C. Turner, Vineet V. Sarode and David J. Brewster
    Citation: Critical Care 2023 27:468
    Content type: Review Published on:

  18. Bacteria are the main pathogens that cause sepsis. The pathogenic mechanisms of sepsis caused by gram-negative and gram-positive bacteria are completely different, and their prognostic differences in sepsis re...

    Authors: Aling Tang, Yi Shi, Qingqing Dong, Sihui Wang, Yao Ge, Chenyan Wang, Zhimin Gong, Weizhen Zhang and Wei Chen
    Citation: Critical Care 2023 27:467
    Content type: Research Published on:

  19. Monitoring respiratory effort in ventilated patients is important to balance lung and diaphragm protection. Esophageal manometry remains the gold standard for monitoring respiratory effort but is invasive and ...

    Authors: Yukie Ito, Matías G. Herrera, Justin C. Hotz, Miyako Kyogoku, Christopher J. L. Newth, Anoopindar K. Bhalla, Muneyuki Takeuchi and Robinder G. Khemani
    Citation: Critical Care 2023 27:466
    Content type: Research Published on:

  20. It is unclear how often survival benefits observed in single-center randomized controlled trials (sRCTs) involving critically ill patients are confirmed by subsequent multicenter randomized controlled trials (...

    Authors: Yuki Kotani, Stefano Turi, Alessandro Ortalda, Martina Baiardo Redaelli, Cristiano Marchetti, Giovanni Landoni and Rinaldo Bellomo
    Citation: Critical Care 2023 27:465
    Content type: Research Published on:

  22. Acute kidney injury (AKI) occurs commonly in pediatric septic shock and increases morbidity and mortality. Early identification of high-risk patients can facilitate targeted intervention to improve outcomes. W...

    Authors: Natalja L. Stanski, Rajit K. Basu, Natalie Z. Cvijanovich, Julie C. Fitzgerald, Michael T. Bigham, Parag N. Jain, Adam J. Schwarz, Riad Lutfi, Neal J. Thomas, Torrey Baines, Bereketeab Haileselassie, Scott L. Weiss, Mihir R. Atreya, Andrew J. Lautz, Basilia Zingarelli, Stephen W. Standage…
    Citation: Critical Care 2023 27:463
    Content type: Research Published on:

  23. Prone position has been shown to improve oxygenation and survival in patients with early acute respiratory distress syndrome (ARDS). These beneficial effects are partly mediated by improved ventilation/perfusi...

    Authors: Xueyan Yuan, Zhanqi Zhao, Yali Chao, Dongyu Chen, Hui Chen, Rui Zhang, Songqiao Liu, Jianfeng Xie, Yi Yang, Haibo Qiu, Leo Heunks and Ling Liu
    Citation: Critical Care 2023 27:462
    Content type: Research Published on:

    The Matters Arising to this article has been published in Critical Care 2024 28:129

  24. ICU survival is improving. However, many patients leave ICU with ongoing cognitive, physical, and/or psychological impairments and reduced quality of life. Many of the reasons for these ongoing problems are un...

    Authors: Oystein Tronstad, Dylan Flaws, Sue Patterson, Robert Holdsworth, Veronica Garcia-Hansen, Francisca Rodriguez Leonard, Ruth Ong, Stephanie Yerkovich and John F. Fraser
    Citation: Critical Care 2023 27:461
    Content type: Research Published on:

  25. Recent clinical and research efforts in cardiogenic shock (CS) have largely focussed on the restoration of the low cardiac output state that is the conditio sine qua non of the clinical syndrome. This approach ha...

    Authors: Marie Buckel, Patrick Maclean, Julian C. Knight, Patrick R. Lawler and Alastair G. Proudfoot
    Citation: Critical Care 2023 27:460
    Content type: Review Published on:

  26. Burn inhalation injury (BII) is a major cause of burn-related mortality and morbidity. Despite published practice guidelines, no consensus exists for the best strategies regarding diagnosis and management of B...

    Authors: Helena Milton-Jones, Sabri Soussi, Roger Davies, Emmanuel Charbonney, Walton N. Charles, Heather Cleland, Ken Dunn, Dashiell Gantner, Julian Giles, Marc Jeschke, Nicole Lee, Matthieu Legrand, Joanne Lloyd, Ignacio Martin-Loeches, Olivier Pantet, Mark Samaan…
    Citation: Critical Care 2023 27:459
    Content type: Research Published on:

  27. Extracellular histones have been associated with severity and outcome in sepsis. The aim of the present study was to assess the effects of sodium-β-O-Methyl cellobioside sulfate (mCBS), a histone-neutralizing ...

    Authors: Bruno Garcia, Fuhong Su, Laurence Dewachter, Yong Wang, Ning Li, Myriam Remmelink, Marie Van Eycken, Amina Khaldi, Raphaël Favory, Antoine Herpain, Anthony Moreau, Alexander Moiroux-Sahraoui, Francesca Manicone, Filippo Annoni, Lin Shi, Jean-Louis Vincent…
    Citation: Critical Care 2023 27:458
    Content type: Research Published on:

  28. In the acute distress respiratory syndrome (ARDS), specific lung regions can be exposed to excessive strain due to heterogeneous disease, gravity-dependent lung collapse and injurious mechanical ventilation. C...

    Authors: Roberto Brito, Caio C. A. Morais, Marioli T. Lazo, Dannette V. Guiñez, Abraham I. J. Gajardo, Daniel H. Arellano, Marcelo B. P. Amato and Rodrigo A. Cornejo
    Citation: Critical Care 2023 27:457
    Content type: Brief Report Published on:

  30. Cardiac complications due to non-traumatic subarachnoid hemorrhage (SAH) are usually described using classical echocardiographic evaluation. Strain imaging appears to have better sensitivity than standard echo...

    Authors: Hugues de Courson, Grégoire Chadefaux, Alexandre Loiseau, Delphine Georges and Matthieu Biais
    Citation: Critical Care 2023 27:455
    Content type: Brief Report Published on:

    The Matters Arising to this article has been published in Critical Care 2024 28:103

    The Matters Arising to this article has been published in Critical Care 2024 28:21

  31. Authors: Bruno Caldeira Antônio, Maiara Sulzbach Denardin, Henrique Alexsander Ferreira Neves and Eduardo Messias Hirano Padrao
    Citation: Critical Care 2023 27:454
    Content type: Matters Arising Published on:

    The original article was published in Critical Care 2023 27:422

  32. The renin–angiotensin system (RAS) plays a crucial role in regulating blood pressure and the cardio-renal system. The classical RAS, mainly mediated by angiotensin I, angiotensin-converting enzyme, and angiote...

    Authors: Bruno Garcia, Alexander Zarbock, Rinaldo Bellomo and Matthieu Legrand
    Citation: Critical Care 2023 27:453
    Content type: Review Published on:

  35. CONCISE is an internationally agreed minimum set of outcomes for use in nutritional and metabolic clinical research in critically ill adults. Clinicians and researchers need to be aware of the clinimetric prop...

    Authors: T. W. Davies, E. Kelly, R. J. J. van Gassel, M. C. G. van de Poll, J. Gunst, M. P. Casaer, K. B. Christopher, J. C. Preiser, A. Hill, K. Gundogan, A. Reintam-Blaser, A.-F. Rousseau, C. Hodgson, D. M. Needham, S. J. Schaller, T. McClelland…
    Citation: Critical Care 2023 27:450
    Content type: Research Published on:

  36. Intra-abdominal candidiasis (IAC) is one of the most common of invasive candidiasis observed in critically ill patients. It is associated with high mortality, with up to 50% of deaths attributable to delays in...

    Authors: Emmanuel Novy, Claire Roger, Jason A. Roberts and Menino Osbert Cotta
    Citation: Critical Care 2023 27:449
    Content type: Review Published on:

  37. Traumatic spinal cord injury (SCI) leads to profound neurologic sequelae, and the provision of life-supporting treatment serves great importance among this patient population. The decision for withdrawal of li...

    Authors: Husain Shakil, Armaan K. Malhotra, Rachael H. Jaffe, Christopher W. Smith, Erin M. Harrington, Alick P. Wang, Eva Y. Yuan, Yingshi He, Karim Ladha, Duminda N. Wijeysundera, Avery B. Nathens, Jefferson R. Wilson and Christopher D. Witiw
    Citation: Critical Care 2023 27:448
    Content type: Research Published on:

  38. Midline shift and mass lesions may occur with traumatic brain injury (TBI) and are associated with higher mortality and morbidity. The shape of intracranial pressure (ICP) pulse waveform reflects the state of ...

    Authors: Agnieszka Kazimierska, Agnieszka Uryga, Cyprian Mataczyński, Marek Czosnyka, Erhard W. Lang and Magdalena Kasprowicz
    Citation: Critical Care 2023 27:447
    Content type: Research Published on:

  39. Sepsis is a medical emergency with potentially life-threatening consequences. Patients play a crucial role in preventing and recognizing sepsis at an early stage. The understanding of risk groups’ sepsis knowl...

    Authors: Sebastian Born, Carolin Fleischmann-Struzek, Wiltrud Abels, Silke Piedmont, Edmund Neugebauer, Konrad Reinhart, Evjenia Toubekis, Odette Wegwarth and Daniel Schwarzkopf
    Citation: Critical Care 2023 27:446
    Content type: Research Published on:

  42. Sepsis survivors commonly experience functional impairment, which may limit return to work. We investigated return to work (RTW) of patients hospitalized with sepsis and the associations with patient and clini...

    Authors: Nina Vibeche Skei, Karoline Moe, Tom Ivar Lund Nilsen, Lene Aasdahl, Hallie C. Prescott, Jan Kristian Damås and Lise Tuset Gustad
    Citation: Critical Care 2023 27:443
    Content type: Research Published on:

  43. Extracorporeal cardiopulmonary resuscitation (ECPR) has been proposed as a rescue therapy for patients with refractory cardiac arrest. This study aimed to evaluate the association between ECPR and clinical out...

    Authors: Yohei Okada, Sho Komukai, Taro Irisawa, Tomoki Yamada, Kazuhisa Yoshiya, Changhwi Park, Tetsuro Nishimura, Takuya Ishibe, Hitoshi Kobata, Takeyuki Kiguchi, Masafumi Kishimoto, Sung-Ho Kim, Yusuke Ito, Taku Sogabe, Takaya Morooka, Haruko Sakamoto…
    Citation: Critical Care 2023 27:442
    Content type: Research Published on:

  44. Although the stretch that generates ventilator-induced lung injury (VILI) occurs within the peripheral tissue that encloses the alveolar space, airway pressures and volumes monitor the gas within the interior cor...

    Authors: John J. Marini, Lauren T. Thornton, Patricia R. M. Rocco and Philip S. Crooke
    Citation: Critical Care 2023 27:441
    Content type: Perspective Published on:

  45. The mortality benefit of VV-ECMO in ARDS has been extensively studied, but the impact on long-term functional outcomes of survivors is poorly defined. We aimed to assess the association between ECMO and functi...

    Authors: Mackenzie Snyder, Binta Y. Njie, Ilana Grabenstein, Sara Viola, Hatoon Abbas, Waqas Bhatti, Ryan Lee, Rosalie Traficante, Siu Yan Amy Yeung, Jonathan H. Chow, Ali Tabatabai, Bradley S. Taylor, Siamak Dahi, Thomas Scalea, Joseph Rabin, Alison Grazioli…
    Citation: Critical Care 2023 27:440
    Content type: Research Published on:

  46. Severe weakness associated with critical illness (CIW) is common. This narrative review summarizes the latest scientific insights and proposes a guide for clinicians to optimize the diagnosis and management of...

    Authors: Nicola Latronico, Frank A. Rasulo, Matthias Eikermann and Simone Piva
    Citation: Critical Care 2023 27:439
    Content type: Review Published on:

    The Publisher Correction to this article has been published in Critical Care 2023 27:469

  47. Individuals who survive sepsis are at high risk of chronic sequelae, resulting in significant health-economic costs. Several studies have focused on aspects of healthcare pathways of sepsis survivors but compr...

    Authors: Fanny Pandolfi, Christian Brun-Buisson, Didier Guillemot and Laurence Watier
    Citation: Critical Care 2023 27:438
    Content type: Research Published on:

  50. While venoarterial extracorporeal membrane oxygenation (V-A ECMO) provides lifesaving support for cardiopulmonary failure, complications may increase mortality, with few studies focusing on ischemic/hemorrhagi...

    Authors: Jaeho Hwang, Andrew Kalra, Benjamin L. Shou, Glenn Whitman, Christopher Wilcox, Daniel Brodie, Akram M. Zaaqoq, Roberto Lorusso, Ken Uchino and Sung-Min Cho
    Citation: Critical Care 2023 27:433
    Content type: Research Published on:
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  • ISSN: 1364-8535 (electronic)

Critical Care

ISSN: 1364-8535