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  1. After traumatic brain injury (TBI), brain tissue can be further damaged when cerebral autoregulation is impaired. Managing cerebral perfusion pressure (CPP) according to computed “optimal CPP” values based on ...

    Authors: Lennart Riemann, Erta Beqiri, Peter Smielewski, Marek Czosnyka, Nino Stocchetti, Oliver Sakowitz, Klaus Zweckberger, Andreas Unterberg and Alexander Younsi

    Citation: Critical Care 2020 24:266

    Content type: Research

    Published on:

  2. In two recent randomized controlled trials, withholding parenteral nutrition early in critical illness improved outcome as compared to early up-to-calculated-target nutrition, which may be explained by benefic...

    Authors: Lisa Van Dyck, Ilse Vanhorebeek, Alexander Wilmer, An Schrijvers, Inge Derese, Liese Mebis, Pieter J. Wouters, Greet Van den Berghe, Jan Gunst and Michaël P. Casaer

    Citation: Critical Care 2020 24:249

    Content type: Research

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  3. In ARDS patients, mechanical ventilation should minimize ventilator-induced lung injury. The mechanical power which is the energy per unit time released to the respiratory system according to the applied tidal...

    Authors: Silvia Coppola, Alessio Caccioppola, Sara Froio, Paolo Formenti, Valentina De Giorgis, Valentina Galanti, Dario Consonni and Davide Chiumello

    Citation: Critical Care 2020 24:246

    Content type: Research

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  4. Hemophagocytic lymphohistiocytosis (HLH) is a rare though often fatal hyperinflammatory syndrome mimicking sepsis in the critically ill. Diagnosis relies on the HLH-2004 criteria and HScore, both of which have...

    Authors: Cornelia Knaak, Peter Nyvlt, Friederike S. Schuster, Claudia Spies, Patrick Heeren, Thomas Schenk, Felix Balzer, Paul La Rosée, Gritta Janka, Frank M. Brunkhorst, Didier Keh and Gunnar Lachmann

    Citation: Critical Care 2020 24:244

    Content type: Research

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  5. Heterogeneity of acute respiratory distress syndrome (ARDS) could be reduced by identification of biomarker-based phenotypes. The set of ARDS biomarkers to prospectively define these phenotypes remains to be e...

    Authors: Philip van der Zee, Wim Rietdijk, Peter Somhorst, Henrik Endeman and Diederik Gommers

    Citation: Critical Care 2020 24:243

    Content type: Research

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  6. Sepsis and septic shock remain drivers for mortality in critically ill patients. The heterogeneity of the syndrome hinders the generation of reproducible numbers on mortality risks. Consequently, mortality rat...

    Authors: Michael Bauer, Herwig Gerlach, Tobias Vogelmann, Franziska Preissing, Julia Stiefel and Daniel Adam

    Citation: Critical Care 2020 24:239

    Content type: Research

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  7. Diffuse alveolar hemorrhage (DAH) occurs during the course of autoimmune disease and may be life threatening. The objective was to assess characteristics and prognosis factors of DAH who required intensive car...

    Authors: Adrien Mirouse, Antoine Parrot, Vincent Audigier, Alexandre Demoule, Julien Mayaux, Guillaume Géri, Eric Mariotte, Nicolas Bréchot, Nicolas de Prost, Mathieu Vautier, Mathilde Neuville, Naïke Bigé, Etienne de Montmollin, Patrice Cacoub, Matthieu Resche-Rigon, Jacques Cadranel…

    Citation: Critical Care 2020 24:231

    Content type: Research

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  8. Gastrointestinal (GI) dysfunction is frequent in the critically ill but can be overlooked as a result of the lack of standardization of the diagnostic and therapeutic approaches. We aimed to develop a research...

    Authors: Annika Reintam Blaser, Jean-Charles Preiser, Sonja Fruhwald, Alexander Wilmer, Jan Wernerman, Carina Benstoem, Michael P. Casaer, Joel Starkopf, Arthur van Zanten, Olav Rooyackers, Stephan M. Jakob, Cecilia I. Loudet, Danielle E. Bear, Gunnar Elke, Matthias Kott, Ingmar Lautenschläger…

    Citation: Critical Care 2020 24:224

    Content type: Research

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  9. Reducing medical errors and minimizing complications have become the focus of quality improvement in medicine. Failure-to-rescue (FTR) is defined as death after a surgical complication, which is an institution...

    Authors: Toshikazu Abe, Akira Komori, Atsushi Shiraishi, Takehiro Sugiyama, Hiroki Iriyama, Takako Kainoh and Daizoh Saitoh

    Citation: Critical Care 2020 24:223

    Content type: Research

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  10. The clinical effectiveness of neurally adjusted ventilatory assist (NAVA) has yet to be demonstrated, and preliminary studies are required. The study aim was to assess the feasibility of a randomized controlle...

    Authors: Daniel J. Hadfield, Louise Rose, Fiona Reid, Victoria Cornelius, Nicholas Hart, Clare Finney, Bethany Penhaligon, Jasmine Molai, Clair Harris, Sian Saha, Harriet Noble, Emma Clarey, Leah Thompson, John Smith, Lucy Johnson, Phillip A. Hopkins…

    Citation: Critical Care 2020 24:220

    Content type: Research

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  11. A COVID-19 outbreak started in Wuhan, China, last December and now has become a global pandemic. The clinical information in caring of critically ill patients with COVID-19 needs to be shared timely, especiall...

    Authors: Yuan Yu, Dan Xu, Shouzhi Fu, Jun Zhang, Xiaobo Yang, Liang Xu, Jiqian Xu, Yongran Wu, Chaolin Huang, Yaqi Ouyang, Luyu Yang, Minghao Fang, Hongwen Xiao, Jing Ma, Wei Zhu, Song Hu…

    Citation: Critical Care 2020 24:219

    Content type: Research

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  12. Microcirculatory perfusion disturbances are associated with increased morbidity and mortality in patients undergoing cardiac surgery with cardiopulmonary bypass (CPB). Technological advancements made it possib...

    Authors: Matthijs M. den Os, Charissa E. van den Brom, Anoek L. I. van Leeuwen and Nicole A. M. Dekker

    Citation: Critical Care 2020 24:218

    Content type: Research

    Published on: