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  1. Content type: Research

    Low cardiac output syndrome (LCOS) is a severe condition which can occur after cardiac surgery, especially among patients with pre-existing left ventricular dysfunction. Dobutamine, its first-line treatment, i...

    Authors: Lee S. Nguyen, Pierre Squara, Julien Amour, Daniel Carbognani, Kamel Bouabdallah, Stéphane Thierry, Caroline Apert-Verneuil, Aurélie Moyne and Bernard Cholley

    Citation: Critical Care 2018 22:193

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  2. Content type: Research

    To better understand the epidemiology and patterns of tracheostomy practice for patients with acute respiratory distress syndrome (ARDS), we investigated the current usage of tracheostomy in patients with ARDS...

    Authors: Toshikazu Abe, Fabiana Madotto, Tài Pham, Isao Nagata, Masatoshi Uchida, Nanako Tamiya, Kiyoyasu Kurahashi, Giacomo Bellani and John G. Laffey

    Citation: Critical Care 2018 22:195

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  3. Content type: Research

    Tuberculous meningitis (TBM) is a devastating infection in tuberculosis endemic areas with limited access to intensive care. Functional outcomes of severe adult TBM patients admitted to the ICU in nonendemic a...

    Authors: Marie Cantier, Adeline Morisot, Emmanuel Guérot, Bruno Megarbane, Keyvan Razazi, Damien Contou, Eric Mariotte, Emmanuel Canet, Etienne De Montmollin, Vincent Dubée, Eric Boulet, Stéphane Gaudry, Guillaume Voiriot, Julien Mayaux, Frédéric Pène, Mathilde Neuville…

    Citation: Critical Care 2018 22:210

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  4. Content type: Review

    The clinical utility of serum procalcitonin levels in guiding antibiotic treatment decisions in patients with sepsis remains unclear. This patient-level meta-analysis based on 11 randomized trials investigates...

    Authors: Yannick Wirz, Marc A. Meier, Lila Bouadma, Charles E. Luyt, Michel Wolff, Jean Chastre, Florence Tubach, Stefan Schroeder, Vandack Nobre, Djillali Annane, Konrad Reinhart, Pierre Damas, Maarten Nijsten, Arezoo Shajiei, Dylan W. deLange, Rodrigo O. Deliberato…

    Citation: Critical Care 2018 22:191

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  5. Content type: Research

    Sepsis-induced myocardial dysfunction is associated with poor outcomes, but traditional measurements of systolic function such as left ventricular ejection fraction (LVEF) do not directly correlate with progno...

    Authors: F. Sanfilippo, C. Corredor, N. Fletcher, L. Tritapepe, F. L. Lorini, A. Arcadipane, A. Vieillard-Baron and M. Cecconi

    Citation: Critical Care 2018 22:183

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  6. Content type: Research

    Arterial hyperoxia may induce vasoconstriction and reduce cardiac output, which is particularly undesirable in patients who already have compromised perfusion of vital organs. Due to the inaccessibility of vit...

    Authors: Bob Smit, Yvo M. Smulders, Etto C. Eringa, Heleen M. Oudemans - van Straaten, Armand R. J. Girbes, Kimberley E. Wever, Carlijn R. Hooijmans and Angelique M. E. Spoelstra - de Man

    Citation: Critical Care 2018 22:189

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  7. Content type: Research

    Acute kidney injury (AKI) is a common complication of critical illness and is associated with worse outcomes. However, the influence of deterioration or improvement in renal function on clinical outcomes is un...

    Authors: Esther Peters, Massimo Antonelli, Xavier Wittebole, Rahul Nanchal, Bruno François, Yasser Sakr, Jean-Louis Vincent and Peter Pickkers

    Citation: Critical Care 2018 22:188

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  8. Content type: Research

    Indirect calorimetry (IC) measurement is considered the gold standard for the assessment of resting energy expenditure (REE). It is based on the measurement of oxygen and carbon dioxide consumption (VO2 and VCO2,...

    Authors: I. Kagan, O. Zusman, I. Bendavid, M. Theilla, J. Cohen and P. Singer

    Citation: Critical Care 2018 22:186

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  9. Content type: Research

    Pore-forming proteins released from bacteria or formed as result of complement activation are known to produce severe cell damage. Inhibition of purinergic P2X receptors markedly reduces damage inflicted by cy...

    Authors: Steen K. Fagerberg, Parth Patel, Lars W. Andersen, Xiaowen Lui, Michael W. Donnino and Helle A. Praetorius

    Citation: Critical Care 2018 22:181

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  10. Content type: Research

    Electroencephalography (EEG) is a well-established tool for assessing brain function that is available at the bedside in the intensive care unit (ICU). This review aims to discuss the relevance of electroencep...

    Authors: Eric Azabou, Vincent Navarro, Nathalie Kubis, Martine Gavaret, Nicholas Heming, Alain Cariou, Djillali Annane, Fréderic Lofaso, Lionel Naccache and Tarek Sharshar

    Citation: Critical Care 2018 22:184

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  11. Content type: Research

    The physiological effects of high-flow nasal cannula O2 therapy (HFNC) have been evaluated mainly in patients with hypoxemic respiratory failure. In this study, we compared the effects of HFNC and conventional lo...

    Authors: Rosa Di mussi, Savino Spadaro, Tania Stripoli, Carlo Alberto Volta, Paolo Trerotoli, Paola Pierucci, Francesco Staffieri, Francesco Bruno, Luigi Camporota and Salvatore Grasso

    Citation: Critical Care 2018 22:180

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  12. Content type: Review

    There is considerable physiological and clinical evidence of harm and increased risk of death associated with dysglycemia in critical care. However, glycemic control (GC) currently leads to increased hypoglyce...

    Authors: J. Geoffrey Chase, Thomas Desaive, Julien Bohe, Miriam Cnop, Christophe De Block, Jan Gunst, Roman Hovorka, Pierre Kalfon, James Krinsley, Eric Renard and Jean-Charles Preiser

    Citation: Critical Care 2018 22:182

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  13. Content type: Research

    Decompressive laparotomy has been advised as potential treatment for abdominal compartment syndrome (ACS) when medical management fails; yet, the effect on parameters of organ function differs markedly in the ...

    Authors: Lana Van Damme and Jan J. De Waele

    Citation: Critical Care 2018 22:179

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  14. Content type: Research

    Recent studies have suggested that excessive formation of neutrophil extracellular traps (NETs) plays a critical role in the pathogenesis of sepsis. Although elevation of the plasma level of cell-free DNA (cf-...

    Authors: Yuki Maruchi, Masanobu Tsuda, Hisatake Mori, Nobuyoshi Takenaka, Takayoshi Gocho, Muhammad A. Huq and Naoshi Takeyama

    Citation: Critical Care 2018 22:176

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    The Letter to this article has been published in Critical Care 2018 22:294

  15. Content type: Research

    Bloodstream infections of abdominal origin are usually associated with poor prognosis. We assessed the clinical and microbiological characteristics of critically ill patients admitted to the intensive care uni...

    Authors: Adel Alqarni, Elie Kantor, Nathalie Grall, Sebastien Tanaka, Nathalie Zappella, Mathieu Godement, Lara Ribeiro-Parenti, Alexy Tran-Dinh and Philippe Montravers

    Citation: Critical Care 2018 22:175

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  16. Content type: Research

    In the early stage of severe burn, patients often exhibit a high level of inflammatory mediators in blood and are likely to develop sepsis. High-volume haemofiltration (HVHF) can eliminate these inflammatory m...

    Authors: Bo You, Yu Long Zhang, Gao Xing Luo, Yong Ming Dang, Bei Jiang, Guang Tao Huang, Xin Zhu Liu, Zi Chen Yang, Yu Chen, Jing Chen, Zhi Qiang Yuan, Su Peng Yin and Yi Zhi Peng

    Citation: Critical Care 2018 22:173

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    The Letter to this article has been published in Critical Care 2018 22:290

  17. Content type: Review

    Vasoplegia is the syndrome of pathological low systemic vascular resistance, the dominant clinical feature of which is reduced blood pressure in the presence of a normal or raised cardiac output. The vasoplegi...

    Authors: Simon Lambden, Ben C. Creagh-Brown, Julie Hunt, Charlotte Summers and Lui G. Forni

    Citation: Critical Care 2018 22:174

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  18. Content type: Research

    Following emergency department (ED) assessment, patients with infection may be directly admitted to the intensive care unit (ICU) or alternatively admitted to hospital wards or sent home. Those admitted to the...

    Authors: Shannon M. Fernando, Bram Rochwerg, Peter M. Reardon, Kednapa Thavorn, Andrew J. E. Seely, Jeffrey J. Perry, Douglas P. Barnaby, Peter Tanuseputro and Kwadwo Kyeremanteng

    Citation: Critical Care 2018 22:172

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  19. Content type: Research

    The risk of ventilator-associated pneumonia (VAP) is reduced when postpyloric enteral nutrition (EN) is administered compared to when gastric EN is administered in specific populations. In the present study, w...

    Authors: Youfeng Zhu, Haiyan Yin, Rui Zhang, Xiaoling Ye and Jianrui Wei

    Citation: Critical Care 2018 22:170

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  20. Content type: Research

    Basic science data suggest that acute kidney injury (AKI) induced by ischemia-reperfusion injury (IRI) is an inflammatory process involving the adaptive immune response. Little is known about the T-cell contri...

    Authors: Ivan Göcze, Katharina Ehehalt, Florian Zeman, Paloma Riquelme, Karin Pfister, Bernhard M. Graf, Thomas Bein, Edward K. Geissler, Piotr Kasprzak, Hans J. Schlitt, John A. Kellum, James A. Hutchinson, Elke Eggenhofer and Philipp Renner

    Citation: Critical Care 2018 22:168

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  21. Content type: Research

    Whether a restrictive strategy for red blood cell (RBC) transfusion is applied to patients with aneurysmal subarachnoid hemorrhage (aSAH) is unclear. To inform the design and conduct of a future clinical trial...

    Authors: Shane W. English, Michaël Chassé, Alexis F. Turgeon, François Lauzier, Donald Griesdale, Allan Garland, Dean Fergusson, Ryan Zarychanski, Carl van Walraven, Kaitlyn Montroy, Jennifer Ziegler, Raphael Dupont-Chouinard, Raphaëlle Carignan, Andy Dhaliwal, Ranjeeta Mallick, John Sinclair…

    Citation: Critical Care 2018 22:169

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  22. Content type: Research

    Early appropriate antibiotic treatment is essential in sepsis. We aimed to evaluate the impact of a multifaceted educational intervention to improve antibiotic treatment. We hypothesized that the intervention ...

    Authors: Ricard Ferrer, María Luisa Martínez, Gemma Gomà, David Suárez, Luis Álvarez-Rocha, María Victoria de la Torre, Gumersindo González, Rafael Zaragoza, Marcio Borges, Jesús Blanco, Eduardo Palencia Herrejón and Antonio Artigas

    Citation: Critical Care 2018 22:167

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  23. Content type: Research

    Cardiorespiratory arrest can result in a spectrum of hypoxic ischemic brain injury leading to global hypoperfusion and brain death (BD). Because up to 40% of patients with BD are viable organ donors, avoiding ...

    Authors: Miriam E. Peckham, Jeffrey S. Anderson, Ulrich A. Rassner, Lubdha M. Shah, Peter J. Hinckley, Adam de Havenon, Seong-Eun Kim and J. Scott McNally

    Citation: Critical Care 2018 22:165

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  24. Content type: Research

    There is increasing interest in the timely administration of concentrated sources of fibrinogen to patients with major traumatic bleeding. Following evaluation of early cryoprecipitate in the CRYOSTAT 1 trial,...

    Authors: Nicola Curry, Claire Foley, Henna Wong, Ana Mora, Elinor Curnow, Agne Zarankaite, Renate Hodge, Valerie Hopkins, Alison Deary, James Ray, Phil Moss, Matthew J. Reed, Suzanne Kellett, Ross Davenport and Simon Stanworth

    Citation: Critical Care 2018 22:164

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  25. Content type: Research

    Post-resuscitation hemodynamic instability following out-of-hospital cardiac arrest (OHCA) may occur from myocardial dysfunction underlying cardiogenic shock and/or inflammation-mediated distributive shock. Di...

    Authors: Ryan J. Anderson, Sayuri P. Jinadasa, Leeyen Hsu, Tiffany Bita Ghafouri, Sanjeev Tyagi, Jisha Joshua, Ariel Mueller, Daniel Talmor, Rebecca E. Sell and Jeremy R. Beitler

    Citation: Critical Care 2018 22:162

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  26. Content type: Research

    Renal perfusion status remains poorly studied at the bedside during septic shock. We sought to measure cortical renal perfusion in patients with septic shock during their first 3 days of care using renal contr...

    Authors: Anatole Harrois, Nicolas Grillot, Samy Figueiredo and Jacques Duranteau

    Citation: Critical Care 2018 22:161

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  27. Content type: Viewpoint

    Extracorporeal membrane oxygenation (ECMO) is used in critically ill patients with severe pulmonary and/or cardiac failure. Blood is drained from the venous system and pumped through a membrane oxygenator wher...

    Authors: B. Frenckner, M. Broman and M. Broomé

    Citation: Critical Care 2018 22:163

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  28. Content type: Review

    Identifying predictors of health-related quality of life (HRQL) following burns is essential for optimization of rehabilitation for burn survivors. This study aimed to systematically review predictors of HRQL ...

    Authors: Inge Spronk, Catherine M. Legemate, Jan Dokter, Nancy E. E. van Loey, Margriet E. van Baar and Suzanne Polinder

    Citation: Critical Care 2018 22:160

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  29. Content type: Research

    The aim of this study was to describe data on epidemiology, ventilatory management, and outcome of acute respiratory distress syndrome (ARDS) in immunocompromised patients.

    Authors: Andrea Cortegiani, Fabiana Madotto, Cesare Gregoretti, Giacomo Bellani, John G. Laffey, Tai Pham, Frank Van Haren, Antonino Giarratano, Massimo Antonelli, Antonio Pesenti and Giacomo Grasselli

    Citation: Critical Care 2018 22:157

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  30. Content type: Research

    Optimal energy and protein provision through enteral nutrition is essential for critically ill patients. However, in clinical practice, the intake achieved is often far below the recommended targets. Because n...

    Authors: Arthur R. H. van Zanten, Laurent Petit, Jan De Waele, Hans Kieft, Janneke de Wilde, Peter van Horssen, Marianne Klebach and Zandrie Hofman

    Citation: Critical Care 2018 22:156

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    The Letter to this article has been published in Critical Care 2018 22:230

  31. Content type: Research

    The aim of this study was to investigate the influence of mild therapeutic hypothermia (MTH) on the incidence of and recovery from acute kidney injury (AKI).

    Authors: Julia Hasslacher, Fabian Barbieri, Ulrich Harler, Hanno Ulmer, Lui G. Forni, Romuald Bellmann and Michael Joannidis

    Citation: Critical Care 2018 22:154

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  32. Content type: Review

    The incidence of seizures in intensive care units ranges from 3.3% to 34%. It is therefore often necessary to initiate or continue anticonvulsant drugs in this setting. When a new anticonvulsant is initiated, ...

    Authors: Salia Farrokh, Pouya Tahsili-Fahadan, Eva K. Ritzl, John J. Lewin III and Marek A. Mirski

    Citation: Critical Care 2018 22:153

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  33. Content type: Research

    In major abdominal surgery albumin is shifted from the circulation, presumably leaking into the interstitial space, contributing to a 30–40% decrease in plasma albumin concentration. During and after liver tra...

    Authors: Mariam Amouzandeh, Greg Nowak, Anna Januszkiewicz, Jan Wernerman, Olav Rooyackers and Åke Norberg

    Citation: Critical Care 2018 22:152

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