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  1. The profile of changes in airway driving pressure (dPaw) induced by positive-end expiratory pressure (PEEP) might aid for individualized protective ventilation. Our aim was to describe the dPaw versus PEEP curves...

    Authors: Mônica Rodrigues da Cruz, Luciana Moisés Camilo, Tiago Batista da Costa Xavier, Gabriel Casulari da Motta Ribeiro, Denise Machado Medeiros, Luís Felipe da Fonseca Reis, Bruno Leonardo da Silva Guimarães, André Miguel Japiassú and Alysson Roncally Silva Carvalho
    Citation: Critical Care 2023 27:118
  2. The CytoSorb hemoadsorption device has been demonstrated to be capable of clearing inflammatory cytokines, but has not yet been shown to attenuate plasma cytokine concentrations. We investigated the effects of...

    Authors: Aron Jansen, Nicole J. B. Waalders, Dirk P. T. van Lier, Matthijs Kox and Peter Pickkers
    Citation: Critical Care 2023 27:117
  3. Immune-mediated thrombotic thrombocytopenic purpura (iTTP) is a rare disease characterized by arteriolar and capillary microthrombosis precipitating organ failure. However, the contribution of endothelial dysf...

    Authors: Jérémie Joffre, Lisa Raia, Tomas Urbina, Vincent Bonny, Paul Gabarre, Louai Missri, Jean-Luc Baudel, Paul Coppo, Bertrand Guidet, Eric Maury and Hafid Ait-Oufella
    Citation: Critical Care 2023 27:116
  4. Lung protective ventilation (LPV) comprising low tidal volume (VT) and high positive end-expiratory pressure (PEEP) may compromise cerebral perfusion in acute brain injury (ABI). In patients with ABI, we inves...

    Authors: Erta Beqiri, Peter Smielewski, Claude Guérin, Marek Czosnyka, Chiara Robba, Lars Bjertnæs and Shirin K. Frisvold
    Citation: Critical Care 2023 27:115
  5. Although subcutaneous edema is a common symptom of critically ill patients, it is still underreported due to the lack of a systematic method for evaluating it. The present study aims to describe the occurrence...

    Authors: Weiqing Zhang, Yanting Gu, Yujin Zhao, Jun Lian, Qian Zeng, Xiaoting Wang, Jun Wu and Qiuying Gu
    Citation: Critical Care 2023 27:114
  6. To determine the clinical feasibility of novel serum biomarkers in out-of-hospital cardiac arrest (OHCA) patients treated with target temperature management (TTM).

    Authors: Hwan Song, Hyo Jin Bang, Yeonho You, Jung Soo Park, Changshin Kang, Hyo Joon Kim, Kyu Nam Park, Sang Hoon Oh and Chun Song Youn
    Citation: Critical Care 2023 27:113

    The Correspondence to this article has been published in Critical Care 2023 27:187

  7. The use of glucocorticoids has given contradictory results for treating acute respiratory distress syndrome (ARDS). The use of intravenous Interferon beta (IFN β) for the treatment of ARDS was recently tested ...

    Authors: Juho Jalkanen, Sofia Khan, Kati Elima, Teppo Huttunen, Ning Wang, Maija Hollmén, Laura L. Elo and Sirpa Jalkanen
    Citation: Critical Care 2023 27:112
  8. The current ARDS guidelines highly recommend lung protective ventilation which include plateau pressure (Pplat < 30 cm H2O), positive end expiratory pressure (PEEP > 5 cm H2O) and tidal volume (Vt of 6 ml/kg) of ...

    Authors: K. Hoppe, E. Khan, P. Meybohm and T. Riese
    Citation: Critical Care 2023 27:111
  9. Methylene blue (MB) has been tested as a rescue therapy for patients with refractory septic shock. However, there is a lack of evidence on MB as an adjuvant therapy, its’ optimal timing, dosing and safety prof...

    Authors: Miguel Ibarra-Estrada, Eduardo Kattan, Pavel Aguilera-González, Laura Sandoval-Plascencia, Uriel Rico-Jauregui, Carlos A. Gómez-Partida, Iris X. Ortiz-Macías, José A. López-Pulgarín, Quetzalcóatl Chávez-Peña, Julio C. Mijangos-Méndez, Guadalupe Aguirre-Avalos and Glenn Hernández
    Citation: Critical Care 2023 27:110
  10. Despite antiviral therapy (ART), 800,000 deaths still occur yearly and globally due to HIV infection. In parallel with the good virological control and the aging of this population, multiple comorbidities [HIV...

    Authors: Antoine Gaillet, Elie Azoulay, Etienne de Montmollin, Maité Garrouste-Orgeas, Yves Cohen, Claire Dupuis, Carole Schwebel, Jean Reignier, Shidasp Siami, Laurent Argaud, Christophe Adrie, Bruno Mourvillier, Stéphane Ruckly, Jean-Marie Forel and Jean-Francois Timsit
    Citation: Critical Care 2023 27:108
  11. Alterations in the renin–angiotensin system have been implicated in the pathophysiology of septic shock. In particular, angiotensin 1–7 (Ang-(1–7)), an anti-inflammatory heptapeptide, has been hypothesized to ...

    Authors: Bruno Garcia, Fuhong Su, Francesca Manicone, Laurence Dewachter, Raphaël Favory, Amina Khaldi, Alexander Moiroux-Sahroui, Anthony Moreau, Antoine Herpain, Jean-Louis Vincent, Jacques Creteur, Fabio Silvio Taccone and Filippo Annoni
    Citation: Critical Care 2023 27:106
  12. Epinephrine is provided during cardiopulmonary resuscitation (CPR) to increase systemic vascular resistance and generate higher diastolic blood pressure (DBP) to improve coronary perfusion and attain return of...

    Authors: Ryan W. Morgan, Robert A. Berg, Ron W. Reeder, Todd C. Carpenter, Deborah Franzon, Aisha H. Frazier, Kathryn Graham, Kathleen L. Meert, Vinay M. Nadkarni, Maryam Y. Naim, Bradley Tilford, Heather A. Wolfe, Andrew R. Yates and Robert M. Sutton
    Citation: Critical Care 2023 27:105
  13. To summarize knowledge and identify gaps in evidence regarding treatment of right ventricular dysfunction (RVD) in acute respiratory distress syndrome (ARDS).

    Authors: Simran Ganeriwal, Gabriele Alves dos Anjos, Mary Schleicher, Maxwell A. Hockstein, Adriano R. Tonelli, Abhijit Duggal and Matthew T. Siuba
    Citation: Critical Care 2023 27:104

    The Correspondence to this article has been published in Critical Care 2023 27:133

  14. Limitations of life-sustaining therapies (LST) practices are frequent and vary among intensive care units (ICUs). However, scarce data were available during the COVID-19 pandemic when ICUs were under intense p...

    Authors: Mikhael Giabicani, Christophe Le Terrier, Antoine Poncet, Bertrand Guidet, Jean-Philippe Rigaud, Jean-Pierre Quenot, Marie-France Mamzer, Jérôme Pugin, Emmanuel Weiss and Simon Bourcier
    Citation: Critical Care 2023 27:103

    The Comment to this article has been published in Critical Care 2023 27:195

  15. Sepsis involves the dynamic interplay between a pathogen, the host response, the failure of organ systems, medical interventions and a myriad of other factors. This together results in a complex, dynamic and d...

    Authors: Alex R. Schuurman, Peter M. A. Sloot, W. Joost Wiersinga and Tom van der Poll
    Citation: Critical Care 2023 27:102
  16. Prolonged Intermittent Renal Replacement Therapy (PIRRT) is the term used to define ‘hybrid’ forms of renal replacement therapy. PIRRT can be provided using an intermittent hemodialysis machine or a continuous...

    Authors: Edward G. Clark and Anitha Vijayan
    Citation: Critical Care 2023 27:88

    The Correspondence to this article has been published in Critical Care 2023 27:165

    The Correspondence to this article has been published in Critical Care 2023 27:159

  17. There is inconclusive evidence regarding the effectiveness of extracorporeal cardiopulmonary resuscitation (ECPR) for out-of-hospital cardiac arrest (OHCA) patients. We aimed to evaluate the association betwee...

    Authors: Yeongho Choi, Jeong Ho Park, Joo Jeong, Yu Jin Kim, Kyoung Jun Song and Sang Do Shin
    Citation: Critical Care 2023 27:87
  18. Hyperoxemia may aggravate reperfusion brain injury after cardiac arrest. The aim of this study was to study the associations between different levels of hyperoxemia in the reperfusion period after cardiac arre...

    Authors: Akil Awad, Per Nordberg, Martin Jonsson, Robin Hofmann, Mattias Ringh, Jacob Hollenberg, Jens Olson and Eva Joelsson-Alm
    Citation: Critical Care 2023 27:86
  19. Management of bleeding trauma patients is still a difficult challenge. Massive transfusion (MT) requires resources to ensure the safety and timely delivery of blood products. Early prediction of MT need may be...

    Authors: Andrea Carsetti, Riccardo Antolini, Erika Casarotta, Elisa Damiani, Francesco Gasparri, Benedetto Marini, Erica Adrario and Abele Donati
    Citation: Critical Care 2023 27:85
  20. Sepsis is a leading cause of preventable death around the world. Population-based estimation of sepsis incidence is lacking in China. In this study, we aimed to estimate the population-based incidence and geog...

    Authors: Li Weng, Yang Xu, Peng Yin, Yi Wang, Yan Chen, Wei Liu, Shan Li, Jin-min Peng, Run Dong, Xiao-yun Hu, Wei Jiang, Chun-yao Wang, Pei Gao, Mai-geng Zhou and Bin Du
    Citation: Critical Care 2023 27:84
  21. This study assessed the mobility levels among critically ill patients and the association of early mobility with incident proximal lower-limb deep-vein thrombosis and 90-day mortality.

    Authors: Hasan M. Al-Dorzi, Samah AlQahtani, Abdulaziz Al-Dawood, Fahad M. Al-Hameed, Karen E. A. Burns, Sangeeta Mehta, Jesna Jose, Sami J. Alsolamy, Sheryl Ann I. Abdukahil, Lara Y. Afesh, Mohammed S. Alshahrani, Yasser Mandourah, Ghaleb A. Almekhlafi, Mohammed Almaani, Ali Al Bshabshe, Simon Finfer…
    Citation: Critical Care 2023 27:83
  22. Insufficient antimicrobial exposure has been associated with worse clinical outcomes. Reportedly, flucloxacillin target attainment in critically ill patients was heterogeneous considering the study population sel...

    Authors: Sjoerd D. Meenks, Nieko Punt, Jos L. M. L. le Noble, Norbert A. Foudraine, Kees Neef and Paddy K. C. Janssen
    Citation: Critical Care 2023 27:82
  23. The Chain of Survival highlights the effectiveness of early recognition of cardiac arrest and call for help, early cardiopulmonary resuscitation and early defibrillation. Most patients, however, remain in card...

    Authors: Gavin D. Perkins and Keith Couper
    Citation: Critical Care 2023 27:81
  24. Severe trauma represents a major global public health burden and the management of post-traumatic bleeding continues to challenge healthcare systems around the world. Post-traumatic bleeding and associated tra...

    Authors: Rolf Rossaint, Arash Afshari, Bertil Bouillon, Vladimir Cerny, Diana Cimpoesu, Nicola Curry, Jacques Duranteau, Daniela Filipescu, Oliver Grottke, Lars Grønlykke, Anatole Harrois, Beverley J. Hunt, Alexander Kaserer, Radko Komadina, Mikkel Herold Madsen, Marc Maegele…
    Citation: Critical Care 2023 27:80
  25. Community-acquired pneumonia (CAP) is the primary cause of death for children under five years of age globally. Hence, it is essential to investigate new early biomarkers and potential mechanisms involved in d...

    Authors: Yi Wang, Xiaolan Huang, Fang Li, Xinbei Jia, Nan Jia, Jin Fu, Shuang Liu, Jin Zhang, Haiyan Ge, Siyuan Huang, Yi Hui, Chunrong Sun, Fei Xiao, Xiaodai Cui, Laurence Don Wai Luu, Dong Qu…
    Citation: Critical Care 2023 27:79
  26. During high-flow nasal cannula (HFNC) therapy, flow plays a crucial role in the physiological effects. However, there is no consensus on the initial flow settings and subsequent titration. Thus, we aimed to sy...

    Authors: Jie Li, Fai A. Albuainain, Wei Tan, J. Brady Scott, Oriol Roca and Tommaso Mauri
    Citation: Critical Care 2023 27:78
  27. Both high mobility group box-1 (HMGB1) and histones are major damage-associated molecular patterns (DAPMs) that mediate lethal systemic inflammation, activation of the complement and coagulation system, endoth...

    Authors: Yupei Li, Yu Chen, Tinghang Yang, Kaixi Chang, Ningyue Deng, Weifeng Zhao and Baihai Su
    Citation: Critical Care 2023 27:77
  28. So far, the few prospective studies on near-death experience (NDE) were carried out only in intensive care unit (ICU) patients with homogeneous aetiologies, such as cardiac arrest or trauma survivors. The aims...

    Authors: Anne-Françoise Rousseau, Laurence Dams, Quentin Massart, Laila Choquer, Héléna Cassol, Steven Laureys, Benoit Misset, Nadia Dardenne, Olivia Gosseries and Charlotte Martial
    Citation: Critical Care 2023 27:76

    The Correspondence to this article has been published in Critical Care 2023 27:185

  29. This paper discusses the use of Artificial Intelligence Chatbot in scientific writing. ChatGPT is a type of chatbot, developed by OpenAI, that uses the Generative Pre-trained Transformer (GPT) language model t...

    Authors: Michele Salvagno, Fabio Silvio Taccone and Alberto Giovanni Gerli
    Citation: Critical Care 2023 27:75

    The Correction to this article has been published in Critical Care 2023 27:99

    The Correspondence to this article has been published in Critical Care 2023 27:180

    The Comment to this article has been published in Critical Care 2023 27:148

    The Correspondence to this article has been published in Critical Care 2023 27:120

  30. Previous studies have reported high prognostic accuracy of circulating neurofilament light (NfL) at 24–72 h after out-of-hospital cardiac arrest (OHCA), but performance at earlier time points and after in-hosp...

    Authors: Helena Levin, Anna Lybeck, Attila Frigyesi, Isabelle Arctaedius, Bergthóra Thorgeirsdóttir, Martin Annborn, Marion Moseby-Knappe, Niklas Nielsen, Tobias Cronberg, Nicholas J. Ashton, Henrik Zetterberg, Kaj Blennow, Hans Friberg and Niklas Mattsson-Carlgren
    Citation: Critical Care 2023 27:74
  31. This study aimed to assess the effect of different blood pressure levels on global cerebral metabolism in comatose patients resuscitated from out-of-hospital cardiac arrest (OHCA).

    Authors: Simon Mølstrøm, Troels Halfeld Nielsen, Carl-Henrik Nordstrøm, Axel Forsse, Søren Møller, Søren Venø, Dmitry Mamaev, Tomas Tencer, Ásta Theódórsdóttir, Thomas Krøigård, Jacob Møller, Christian Hassager, Jesper Kjærgaard, Henrik Schmidt and Palle Toft
    Citation: Critical Care 2023 27:73
  32. Gut microbiota alterations have been reported in hospitalized COVID-19 patients, with reduced alpha diversity and altered microbiota composition related to respiratory failure. However, data regarding gut micr...

    Authors: Marius Trøseid, Jan Cato Holter, Kristian Holm, Beate Vestad, Taisiia Sazonova, Beathe K. Granerud, Anne Ma Dyrhol-Riise, Aleksander R. Holten, Kristian Tonby, Anders Benjamin Kildal, Lars Heggelund, Anders Tveita, Simen Bøe, Karl Erik Müller, Synne Jenum, Johannes R. Hov…
    Citation: Critical Care 2023 27:69