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  1. Content type: Research

    Sepsis is a leading cause of death and long-term disability in developed countries. A comprehensive report on the incidence, clinical characteristics, and evolving management of sepsis is important. Thus, this...

    Authors: Toshikazu Abe, Hiroshi Ogura, Atsushi Shiraishi, Shigeki Kushimoto, Daizoh Saitoh, Seitaro Fujishima, Toshihiko Mayumi, Yasukazu Shiino, Taka-aki Nakada, Takehiko Tarui, Toru Hifumi, Yasuhiro Otomo, Kohji Okamoto, Yutaka Umemura, Joji Kotani, Yuichiro Sakamoto…

    Citation: Critical Care 2018 22:322

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  2. Content type: Research

    Following a fatal intensive care unit (ICU) outbreak of carbapenem-resistant Acinetobacter baumanii (CRAB) in 2015, an aggressive infection control intervention was instituted. We outline the intervention and lon...

    Authors: Eli Ben-Chetrit, Yonit Wiener-Well, Emil Lesho, Puah Kopuit, Chaya Broyer, Liora Bier, Marc V. Assous, Shmuel Benenson, Matan J. Cohen, Patrick T. McGann, Erik Snesrud and Phillip D. Levin

    Citation: Critical Care 2018 22:319

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  3. Content type: Research

    Patients in refractory status epilepticus (RSE) may require treatment with continuous intravenous anesthetic drugs (cIVADs) for seizure control. The use of cIVADs, however, was recently associated with poor ou...

    Authors: Dominik Madžar, Caroline Reindl, Antje Giede-Jeppe, Tobias Bobinger, Maximilian I. Sprügel, Ruben U. Knappe, Hajo M. Hamer and Hagen B. Huttner

    Citation: Critical Care 2018 22:317

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  4. Content type: Research

    Sepsis is an important cause of neonatal morbidity and mortality; therefore, the early diagnosis of neonatal sepsis is essential.

    Authors: Lin Ruan, Guan-Yu Chen, Zhen Liu, Yun Zhao, Guang-Yu Xu, Shu-Fang Li, Chun-Ni Li, Lin-Shan Chen and Zheng Tao

    Citation: Critical Care 2018 22:316

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  5. Content type: Research

    Iron deficiency is difficult to diagnose in critically ill patients, but may be frequent and may impair recovery. Measurement of hepcidin could help in the diagnosis of iron deficiency. We aim to assess if iro...

    Authors: Sigismond Lasocki, Thibaud Lefebvre, Claire Mayeur, Hervé Puy, Alexandre Mebazaa and Etienne Gayat

    Citation: Critical Care 2018 22:314

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  6. Content type: Research

    The interaction between hyperaldosteronism and immune dysfunction has been reported and glucocorticoid co-secretion is frequently found in primary aldosteronism (PA). The aforementioned conditions raise the po...

    Authors: Chieh-Kai Chan, Ya-Hui Hu, Likwang Chen, Chin-Chen Chang, Yu-Feng Lin, Tai-Shuan Lai, Kuo-How Huang, Yen-Hung Lin, Vin-Cent Wu and Kwan-Dun Wu

    Citation: Critical Care 2018 22:313

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  7. Content type: Research

    Septic shock is the most severe complication of sepsis and this syndrome is associated with high mortality. Treatment of septic shock remains largely supportive of hemodynamics and tissue perfusion. Early chan...

    Authors: Matteo Barcella, Bernardo Bollen Pinto, Daniele Braga, Francesca D’Avila, Federico Tagliaferri, Marie-Angelique Cazalis, Guillaume Monneret, Antoine Herpain, Karim Bendjelid and Cristina Barlassina

    Citation: Critical Care 2018 22:312

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  8. Content type: Research

    Reports of increasing incidence rates of delirium in critically ill children are reason for concern. We evaluated the measurement properties of the pediatric delirium component (PD-scale) of the Sophia Observa...

    Authors: Erwin Ista, Babette van Beusekom, Joost van Rosmalen, Martin C. J. Kneyber, Joris Lemson, Arno Brouwers, Gwen C. Dieleman, Bram Dierckx, Matthijs de Hoog, Dick Tibboel and Monique van Dijk

    Citation: Critical Care 2018 22:309

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  9. Content type: Research

    We sought to determine the effects of alternative resuscitation strategies on microcirculatory perfusion and examine any association between microcirculatory perfusion and mortality in sepsis.

    Authors: Michael J. Massey, Peter C. Hou, Michael Filbin, Henry Wang, Long Ngo, David T. Huang, William C. Aird, Victor Novack, Stephen Trzeciak, Donald M. Yealy, John A. Kellum, Derek C. Angus and Nathan I. Shapiro

    Citation: Critical Care 2018 22:308

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  10. Content type: Research

    Despite modern intensive care with standardized strategies against acute respiratory distress syndrome (ARDS), Pneumocystis pneumonia (PcP) remains a life-threatening disease with a high mortality rate. Here, we ...

    Authors: Julius J. Schmidt, Catherina Lueck, Stefan Ziesing, Matthias Stoll, Hermann Haller, Jens Gottlieb, Matthias Eder, Tobias Welte, Marius M. Hoeper, André Scherag and Sascha David

    Citation: Critical Care 2018 22:307

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  11. Content type: Research

    We aimed to investigate the extent of the agreement on practices around brain death and postmortem organ donation.

    Authors: Ernest van Veen, Mathieu van der Jagt, Maryse C. Cnossen, Andrew I. R. Maas, Inez D. de Beaufort, David K. Menon, Giuseppe Citerio, Nino Stocchetti, Wim J. R. Rietdijk, Jeroen T. J. M. van Dijck and Erwin J. O. Kompanje

    Citation: Critical Care 2018 22:306

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  12. Content type: Research

    Acute kidney injury (AKI) is associated with high morbidity and mortality in surgical patients. Nonrecovery from AKI may increase mortality and early risk stratification seems key to improving clinical outcome...

    Authors: Hui-Miao Jia, Yue Zheng, Li-Feng Huang, Xin Xin, Wen-Liang Ma, Yi-Jia Jiang, Xi Zheng, Shu-Yan Guo and Wen-Xiong Li

    Citation: Critical Care 2018 22:305

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  13. Content type: Research

    High tidal volume ventilation of healthy lungs or exacerbation of existing acute lung injury (ALI) by more moderate mechanical ventilation (MTV) produces ventilator-induced lung injury. It is less clear whethe...

    Authors: Xibing Ding, Yao Tong, Shuqing Jin, Zhixia Chen, Tunliang Li, Timothy R. Billiar, Bruce R. Pitt, Quan Li and Li-Ming Zhang

    Citation: Critical Care 2018 22:302

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  14. Content type: Review

    Aerosolized antibiotics have been proposed as a novel and promising treatment option for the treatment of ventilator-associated pneumonia (VAP). However, the optimum aerosolized antibiotics for VAP remain unce...

    Authors: Feng Xu, Lu-Lu He, Luan-Qing Che, Wen Li, Song-Min Ying, Zhi-Hua Chen and Hua-Hao Shen

    Citation: Critical Care 2018 22:301

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    The Editorial to this article has been published in Critical Care 2018 22:333

  15. Content type: Research

    Glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP) are incretin hormones. By lowering blood glucose in a glucose-dependent manner, incretin-based therapies represent a novel and...

    Authors: Abraham H Hulst, Mark P Plummer, Markus W Hollmann, J Hans DeVries, Benedikt Preckel, Adam M Deane and Jeroen Hermanides

    Citation: Critical Care 2018 22:299

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  16. Content type: Research

    Whether goal-directed fluid therapy based on dynamic predictors of fluid responsiveness (GDFTdyn) alone improves clinical outcomes in comparison with standard fluid therapy among patients undergoing surgery re...

    Authors: Qi-Wen Deng, Wen-Cheng Tan, Bing-Cheng Zhao, Shi-Hong Wen, Jian-Tong Shen and Miao Xu

    Citation: Critical Care 2018 22:298

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  17. Content type: Letter

    Available evidence from randomized controlled trials including adult critically ill patients tends to show that percutaneous dilatational tracheostomy (PDT) techniques are performed faster and reduce stoma inf...

    Authors: Maria Vargas, Pasquale Buonanno, Lina Giorgiano, Giovanna Sorriento, Carmine Iacovazzo and Giuseppe Servillo

    Citation: Critical Care 2018 22:297

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  18. Content type: Editorial

    Selective decontamination of the digestive tract (SDD) has been with us since the early days of our specialty, and in some ways it marks our progression and maturation. How we have dealt with SDD to date range...

    Authors: Brian H. Cuthbertson

    Citation: Critical Care 2018 22:296

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    The original article was published in Critical Care 2018 22:243

  19. Content type: Research

    Procalcitonin (PCT) testing can help in safely reducing antibiotic treatment duration in intensive care patients with sepsis. However, the cost-effectiveness of such PCT guidance is not yet known.

    Authors: Michelle M. A. Kip, Jos A. van Oers, Arezoo Shajiei, Albertus Beishuizen, A. M. Sofie Berghuis, Armand R. Girbes, Evelien de Jong, Dylan W. de Lange, Maarten W. N. Nijsten, Maarten J. IJzerman, Hendrik Koffijberg and Ron Kusters

    Citation: Critical Care 2018 22:293

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  20. Content type: Research

    Community-acquired pneumonia (CAP) remains a major cause of death worldwide. Mechanisms underlying the detrimental outcome despite adequate antibiotic therapy and comorbidity management are still not fully und...

    Authors: Sarah Berger, Cengiz Goekeri, Shishir K. Gupta, Julio Vera, Kristina Dietert, Ulrike Behrendt, Jasmin Lienau, Sandra-Maria Wienhold, Achim D. Gruber, Norbert Suttorp, Martin Witzenrath and Geraldine Nouailles

    Citation: Critical Care 2018 22:287

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  21. Content type: Research

    Acute respiratory failure occurs frequently in hospitalized patients and often starts before ICU admission. A risk stratification tool to predict mortality and risk for mechanical ventilation (MV) may allow fo...

    Authors: Mikhail A Dziadzko, Paul J Novotny, Jeff Sloan, Ognjen Gajic, Vitaly Herasevich, Parsa Mirhaji, Yiyuan Wu and Michelle Ng Gong

    Citation: Critical Care 2018 22:286

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  22. Content type: Research

    Given the pathophysiological key role of the host response to an infection rather than the infection per se, an ideal therapeutic strategy would also target this response. This study was designed to demonstrat...

    Authors: Hannah Knaup, Klaus Stahl, Bernhard M. W. Schmidt, Temitayo O. Idowu, Markus Busch, Olaf Wiesner, Tobias Welte, Hermann Haller, Jan T. Kielstein, Marius M. Hoeper and Sascha David

    Citation: Critical Care 2018 22:285

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    The Editorial to this article has been published in Critical Care 2018 22:357

  23. Content type: Research

    Intensive care unit (ICU) outcome prediction models, such as Acute Physiology And Chronic Health Evaluation (APACHE), were designed in general critical care populations and their use in obstetric populations i...

    Authors: Beth A. Payne, Helen Ryan, Jeffrey Bone, Laura A. Magee, Alice B. Aarvold, J. Mark Ansermino, Zulfiqar A. Bhutta, Mary Bowen, J. Guilherme Cecatti, Cynthia Chazotte, Tim Crozier, Anne-Cornélie J. M. de Pont, Oktay Demirkiran, Tao Duan, Marlot Kallen, Wessel Ganzevoort…

    Citation: Critical Care 2018 22:278

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  24. Content type: Research

    Whether perioperative hyperchloremia can induce postoperative acute kidney injury (AKI) is controversial. We investigated the association between perioperative hyperchloremia and postoperative AKI in patients ...

    Authors: Tak Kyu Oh, In-Ae Song, Se Joong Kim, Sung Yoon Lim, Sang-Hwan Do, Jung-Won Hwang, Jinhee Kim and Young-Tae Jeon

    Citation: Critical Care 2018 22:277

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    The Letter to this article has been published in Critical Care 2019 23:10

  25. Content type: Viewpoint

    Critical illness results in millions of deaths each year. Care for those with critical illness is often neglected due to a lack of prioritisation, co-ordination, and coverage of timely identification and basic...

    Authors: Carl Otto Schell, Martin Gerdin Wärnberg, Anna Hvarfner, Andreas Höög, Ulrika Baker, Markus Castegren and Tim Baker

    Citation: Critical Care 2018 22:284

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  26. Content type: Review

    The combination of thiamine, ascorbic acid, and hydrocortisone has recently emerged as a potential adjunctive therapy to antibiotics, infectious source control, and supportive care for patients with sepsis and...

    Authors: Ari Moskowitz, Lars W. Andersen, David T. Huang, Katherine M. Berg, Anne V. Grossestreuer, Paul E. Marik, Robert L. Sherwin, Peter C. Hou, Lance B. Becker, Michael N. Cocchi, Pratik Doshi, Jonathan Gong, Ayan Sen and Michael W. Donnino

    Citation: Critical Care 2018 22:283

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  27. Content type: Research

    Antibiotic exposure alters the microbiota, which can impact the inflammatory immune responses. Critically ill patients frequently receive antibiotic treatment and are often subjected to mechanical ventilation,...

    Authors: Sandra-Maria Wienhold, Mario Macrì, Geraldine Nouailles, Kristina Dietert, Corinne Gurtner, Achim D Gruber, Markus M Heimesaat, Jasmin Lienau, Fabian Schumacher, Burkhard Kleuser, Bastian Opitz, Norbert Suttorp, Martin Witzenrath and Holger C Müller-Redetzky

    Citation: Critical Care 2018 22:282

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  28. Content type: Research

    Metabolic alkalosis is common in patients with respiratory failure and may delay weaning in mechanically ventilated patients. Carbonic anhydrase inhibitors block renal bicarbonate reabsorption, and thus revers...

    Authors: Bassem Y Tanios, Maryam O Omran, Carlos Noujeim, Tamara Lotfi, Samir S Mallat, Pierre K Bou-Khalil, Elie A Akl and Houssam S Itani

    Citation: Critical Care 2018 22:275

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  29. Content type: Research

    Sepsis is a life-threatening medical emergency requiring early diagnosis and urgent treatment. Knowledge is crucial, especially in major risk groups such as the elderly. We therefore assessed sophisticated kno...

    Authors: Sarah Eitze, Carolin Fleischmann-Struzek, Cornelia Betsch and Konrad Reinhart

    Citation: Critical Care 2018 22:273

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  30. Content type: Research

    Pathogenic enteric bacteria aspirated from the oropharynx are the main cause of ventilator-associated pneumonia (VAP). Using chlorhexidine (CHX) orally or selective decontamination has been shown to reduce VAP...

    Authors: Bengt Klarin, Anne Adolfsson, Anders Torstensson and Anders Larsson

    Citation: Critical Care 2018 22:272

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  31. Content type: Research

    Extracorporeal membrane oxygenation (ECMO) is a cardiorespiratory support technique for patients with circulatory or pulmonary failure. Frequently, large-volume fluid resuscitation is needed to ensure sufficie...

    Authors: Hyoungnae Kim, Jin Hyuk Paek, Joo Han Song, Hajeong Lee, Jong Hyun Jhee, Seohyun Park, Hae-Ryong Yun, Youn Kyung Kee, Seung Hyeok Han, Tae-Hyun Yoo, Shin-Wook Kang, Sejoong Kim and Jung Tak Park

    Citation: Critical Care 2018 22:270

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  32. Content type: Research

    Sepsis and related multiple organ dysfunction result in high morbidity and mortality. Angiotensin (Ang)-(1–7), a biologically active peptide, has various opposing effects of Ang II. Because the effect of Ang-(...

    Authors: Hsin-Jung Tsai, Mei-Hui Liao, Chih-Chin Shih, Shuk-Man Ka, Cheng-Ming Tsao and Chin-Chen Wu

    Citation: Critical Care 2018 22:269

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  33. Content type: Research

    Diabetes mellitus is a common co-existing disease in the critically ill. Diabetes mellitus may reduce the risk of acute respiratory distress syndrome (ARDS), but data from previous studies are conflicting. The...

    Authors: Andrew J. Boyle, Fabiana Madotto, John G. Laffey, Giacomo Bellani, Tài Pham, Antonio Pesenti, B. Taylor Thompson, Cecilia M. O’Kane, Adam M. Deane and Daniel F. McAuley

    Citation: Critical Care 2018 22:268

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