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  1. Extracorporeal carbon dioxide removal (ECCO2R) uses an extracorporeal circuit to directly remove carbon dioxide from the blood either in lieu of mechanical ventilation or in combination with it. While the potenti...

    Authors: Sascha Gross-Hardt, Felix Hesselmann, Jutta Arens, Ulrich Steinseifer, Leen Vercaemst, Wolfram Windisch, Daniel Brodie and Christian Karagiannidis

    Citation: Critical Care 2019 23:348

    Content type: Research

    Published on:

  2. Although tranexamic acid is widely used in patients with haemoptysis, whether it improves mortality has not been well investigated. The aim of this study was to evaluate the effect of tranexamic acid on in-hos...

    Authors: Takahiro Kinoshita, Hiroyuki Ohbe, Hiroki Matsui, Kiyohide Fushimi, Hiroshi Ogura and Hideo Yasunaga

    Citation: Critical Care 2019 23:347

    Content type: Research

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  3. Excessive respiratory muscle effort during mechanical ventilation may cause patient self-inflicted lung injury and load-induced diaphragm myotrauma, but there are no non-invasive methods to reliably detect ele...

    Authors: Michele Bertoni, Irene Telias, Martin Urner, Michael Long, Lorenzo Del Sorbo, Eddy Fan, Christer Sinderby, Jennifer Beck, Ling Liu, Haibo Qiu, Jenna Wong, Arthur S. Slutsky, Niall D. Ferguson, Laurent J. Brochard and Ewan C. Goligher

    Citation: Critical Care 2019 23:346

    Content type: Research

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  4. Adaptive mechanical ventilation automatically adjusts respiratory rate (RR) and tidal volume (VT) to deliver the clinically desired minute ventilation, selecting RR and VT based on Otis’ equation on least work of...

    Authors: Tobias Becher, Anna Adelmeier, Inéz Frerichs, Norbert Weiler and Dirk Schädler

    Citation: Critical Care 2019 23:338

    Content type: Research

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  5. Few viruses have shaped the course of human history more than influenza viruses. A century since the 1918–1919 Spanish influenza pandemic—the largest and deadliest influenza pandemic in recorded history—we hav...

    Authors: Taylor Kain and Robert Fowler

    Citation: Critical Care 2019 23:337

    Content type: Review

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  6. The performance of blood biomarkers (mid-regional proadrenomedullin (MR-proADM), procalcitonin (PCT), C-reactive protein (CRP), and lactate) and clinical scores (Sequential Organ Failure Assessment (SOFA), Nat...

    Authors: Juan Gonzalez del Castillo, Darius Cameron Wilson, Carlota Clemente-Callejo, Francisco Román, Ignasi Bardés-Robles, Inmaculada Jiménez, Eva Orviz, Macarena Dastis-Arias, Begoña Espinosa, Fernando Tornero-Romero, Jordi Giol-Amich, Veronica González and Ferran Llopis-Roca

    Citation: Critical Care 2019 23:335

    Content type: Research

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  7. The concept of personalized cardiopulmonary resuscitation (CPR) requires a parameter that reflects its hemodynamic efficiency. While intra-arrest ultrasound is increasingly implemented into the advanced life s...

    Authors: Roman Skulec, Petr Vojtisek and Vladimir Cerny

    Citation: Critical Care 2019 23:334

    Content type: Research

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  8. The interactive effect of cumulative input and output on achieving optimal fluid balance has not been well elucidated in patients with acute kidney injury (AKI) requiring continuous renal replacement therapy (...

    Authors: Jong Hyun Jhee, Hye Ah Lee, Seonmi Kim, Youn Kyung Kee, Ji Eun Lee, Shina Lee, Seung-Jung Kim, Duk-Hee Kang, Kyu Bok Choi, Hyung Jung Oh and Dong-Ryeol Ryu

    Citation: Critical Care 2019 23:329

    Content type: Research

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  9. In the publication of this article [1], there was an error in a contributors Family Name. This has now been updated in the original article.

    Authors: Luca Cabrini, Giovanni Landoni, Martina Baiardo Redaelli, Omar Saleh, Carmine D. Votta, Evgeny Fominskiy, Alessandro Putzu, Cézar Daniel Snak de Souza, Massimo Antonelli, Rinaldo Bellomo, Paolo Pelosi and Alberto Zangrillo

    Citation: Critical Care 2019 23:325

    Content type: Correction

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    The original article was published in Critical Care 2018 22:6

  10. Antibiotic-associated diarrhea (AAD) is a risk factor for exacerbating the outcome of critically ill patients. Dysbiosis induced by the exposure to antibiotics reveals the potential therapeutic role of fecal m...

    Authors: Min Dai, Yafei Liu, Wei Chen, Heena Buch, Yi Shan, Liuhui Chang, Yong Bai, Chen Shen, Xiaoyin Zhang, Yufeng Huo, Dian Huang, Zhou Yang, Zhihang Hu, Xuwei He, Junyu Pan, Lili Hu…

    Citation: Critical Care 2019 23:324

    Content type: Research

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  11. Most deaths of comatose survivors of out-of-hospital sudden cardiac arrest result from withdrawal of life-sustaining treatment (WLST) decisions based on poor neurological prognostication and the family’s inten...

    Authors: Hiroshi Endoh, Natuo Kamimura, Hiroyuki Honda and Masakazu Nitta

    Citation: Critical Care 2019 23:323

    Content type: Research

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  12. Weaning-induced cardiac pulmonary edema (WiPO) is one of the main mechanisms of weaning failure during mechanical ventilation. We hypothesized that weaning-induced cardiac ischemia (WiCI) may contribute to wea...

    Authors: Alexandre Bedet, Françoise Tomberli, Gwenael Prat, Pierre Bailly, Achille Kouatchet, Sater Mortaza, Emmanuel Vivier, Sylvene Rosselli, Larissa Lipskaia, Guillaume Carteaux, Keyvan Razazi and Armand Mekontso Dessap

    Citation: Critical Care 2019 23:321

    Content type: Research

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  13. Venoarterial extracorporeal membrane oxygenation (VA-ECMO) can be a rescue therapy for patients in cardiogenic shock or in refractory cardiac arrest. After cannulation, vasoplegia and cardiac depression are fr...

    Authors: Viviane Zotzmann, Jonathan Rilinger, Corinna N. Lang, Klaus Kaier, Christoph Benk, Daniel Duerschmied, Paul M. Biever, Christoph Bode, Tobias Wengenmayer and Dawid L. Staudacher

    Citation: Critical Care 2019 23:320

    Content type: Research

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    A Letter has been published.

  14. Patients with acute hypoxemic respiratory failure are at risk for life-threatening complications during endotracheal intubation. Preoxygenation might help reduce the risk of hypoxemia and intubation-related co...

    Authors: Ka Man Fong, Shek Yin Au and George Wing Yiu Ng

    Citation: Critical Care 2019 23:319

    Content type: Research

    Published on:

  15. Metabolic alterations in the critically ill have been studied for more than a century, but the heterogeneity of the critically ill patient population, the varying duration and severity of the acute phase of il...

    Authors: Jan Wernerman, Kenneth B. Christopher, Djillali Annane, Michael P. Casaer, Craig M. Coopersmith, Adam M. Deane, Elisabeth De Waele, Gunnar Elke, Carole Ichai, Constantine J. Karvellas, Stephen A. McClave, Heleen M. Oudemans-van Straaten, Olav Rooyackers, Renee D. Stapleton, Jukka Takala, Arthur R. H. van Zanten…

    Citation: Critical Care 2019 23:318

    Content type: Review

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  16. Innovative treatment modalities have not yet shown a clinical benefit in patients with septic shock. To reduce severe cytokinaemia, CytoSorb as an add-on to continuous renal replacement therapy (CRRT) showed p...

    Authors: Willem Pieter Brouwer, Servet Duran, Martijn Kuijper and Can Ince

    Citation: Critical Care 2019 23:317

    Content type: Research

    Published on:

    The Letter to this article has been published in Critical Care 2020 24:13

  17. Though echocardiographic evaluation assesses the right ventricular systolic function, which of the existing parameters best reflects the right ventricular ejection fraction (RVEF) in the critically ill patient...

    Authors: Romain Barthélémy, Xavier Roy, Tujia Javanainen, Alexandre Mebazaa and Benjamin Glenn Chousterman

    Citation: Critical Care 2019 23:312

    Content type: Research

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  18. In patients with septic shock, the skin is often chosen for the evaluation of peripheral perfusion and oxygenation. Changes in skin microcirculatory vessel oxygen saturation and relative hemoglobin concentrati...

    Authors: Sigita Kazune, Anastasija Caica, Karina Volceka, Olegs Suba, Uldis Rubins and Andris Grabovskis

    Citation: Critical Care 2019 23:311

    Content type: Research

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    The Letter to this article has been published in Critical Care 2019 23:359

  19. Over the last decade, multiple large randomized controlled trials have studied alternative transfusion strategies in critically ill patients, demonstrating the safety of restrictive transfusion strategies. Due...

    Authors: Sanne de Bruin, Thomas W. L. Scheeren, Jan Bakker, Robin van Bruggen and Alexander P. J. Vlaar

    Citation: Critical Care 2019 23:309

    Content type: Research

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  20. Neuromuscular electrical stimulation (NMES) has been investigated as a preventative measure for intensive care unit-acquired weakness. Trial results remain contradictory and therefore inconclusive. As it has b...

    Authors: Julius J. Grunow, Moritz Goll, Niklas M. Carbon, Max E. Liebl, Steffen Weber-Carstens and Tobias Wollersheim

    Citation: Critical Care 2019 23:308

    Content type: Research

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  21. Enterococcus species are associated with an increased morbidity in intraabdominal infections (IAI). However, their impact on mortality remains uncertain. Moreover, the influence on outcome of the appropriate or i...

    Authors: Anne-Cécile Morvan, Baptiste Hengy, Maïté Garrouste-Orgeas, Stéphane Ruckly, Jean-Marie Forel, Laurent Argaud, Thomas Rimmelé, Jean-Pierre Bedos, Elie Azoulay, Claire Dupuis, Bruno Mourvillier, Carole Schwebel and Jean-François Timsit

    Citation: Critical Care 2019 23:307

    Content type: Research

    Published on:

  22. Acute respiratory failure is the leading reason for intensive care unit (ICU) admission in immunocompromised patients, and the need for invasive mechanical ventilation has become a major clinical endpoint in r...

    Authors: Guillaume Dumas, Alexandre Demoule, Djamel Mokart, Virginie Lemiale, Saad Nseir, Laurent Argaud, Frédéric Pène, Loay Kontar, Fabrice Bruneel, Kada Klouche, François Barbier, Jean Reignier, Annabelle Stoclin, Guillaume Louis, Jean-Michel Constantin, Florent Wallet…

    Citation: Critical Care 2019 23:306

    Content type: Research

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  23. Most people exposed to a new flu virus do not notice any symptoms. A small minority develops critical illness. Some of this extremely broad variation in susceptibility is explained by the size of the initial i...

    Authors: Sara Clohisey and John Kenneth Baillie

    Citation: Critical Care 2019 23:303

    Content type: Review

    Published on:

  24. Part of the pathophysiology in septic shock is a progressive activation of the endothelium and platelets leading to widespread microvascular injury with capillary leakage, microthrombi and consumption coagulop...

    Authors: Rasmus Ehrenfried Berthelsen, Sisse Rye Ostrowski, Morten Heiberg Bestle and Per Ingemar Johansson

    Citation: Critical Care 2019 23:301

    Content type: Research

    Published on: