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  1. Authors: Rosanna Vaschetto, Alessandro Pecere, Gavin D. Perkins, Dipesh Mistry, Gianmaria Cammarota, Federico Longhini, Miguel Ferrer, Renata Pletsch-Assunção, Michele Carron, Francesca Moretto, Haibo Qiu, Francesco Della Corte, Francesco Barone-Adesi and Paolo Navalesi

    Citation: Critical Care 2021 25:272

    Content type: Correction

    Published on:

    The original article was published in Critical Care 2021 25:189

  2. Acute respiratory failure (ARF) can progress to acute respiratory distress syndrome and death. Biomarkers may allow for risk stratification and prognostic enrichment in ARF. Thrombomodulin (TM) is a transmembr...

    Authors: Ana Carolina Costa Monteiro, Heidi Flori, Mary K. Dahmer, Myung Shin Sim, Michael W. Quasney, Martha A. Q. Curley, Michael A. Matthay and Anil Sapru

    Citation: Critical Care 2021 25:271

    Content type: Research

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  3. Noninvasive respiratory support (NIRS) has been diffusely employed outside the intensive care unit (ICU) to face the high request of ventilatory support due to the massive influx of patients with acute respira...

    Authors: Gianmaria Cammarota, Teresa Esposito, Danila Azzolina, Roberto Cosentini, Francesco Menzella, Stefano Aliberti, Andrea Coppadoro, Giacomo Bellani, Giuseppe Foti, Giacomo Grasselli, Maurizio Cecconi, Antonio Pesenti, Michele Vitacca, Tom Lawton, V. Marco Ranieri, Sandro Luigi Di Domenico…

    Citation: Critical Care 2021 25:268

    Content type: Research

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  4. Hyperchloremia and chloride load have been associated with worse clinical outcomes in critically ill patients. We sought to evaluate the electrolyte profile and clinical outcomes associated with a unit-wide tr...

    Authors: Matthew F. Barhight, Delphine Nelson, Thomas Moran, Jessica Christiano and L. Nelson Sanchez-Pinto

    Citation: Critical Care 2021 25:266

    Content type: Research

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  5. Perioperative cardiac arrest is a rare complication with an incidence of around 1 in 1400 cases, but it carries a high burden of mortality reaching up to 70% at 30 days. Despite its specificities, guidelines f...

    Authors: Athanasios Chalkias, Nicolas Mongardon, Vladimir Boboshko, Vladimir Cerny, Anne-Laure Constant, Quentin De Roux, Gabriele Finco, Francesca Fumagalli, Eleana Gkamprela, Stéphane Legriel, Vladimir Lomivorotov, Aurora Magliocca, Panagiotis Makaronis, Ioannis Mamais, Iliana Mani, Theodoros Mavridis…

    Citation: Critical Care 2021 25:265

    Content type: Review

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  6. Pathophysiological features of coronavirus disease 2019-associated acute respiratory distress syndrome (COVID-19 ARDS) were indicated to be somewhat different from those described in nonCOVID-19 ARDS, because ...

    Authors: Annalisa Boscolo, Nicolò Sella, Giulia Lorenzoni, Tommaso Pettenuzzo, Laura Pasin, Chiara Pretto, Martina Tocco, Enrico Tamburini, Alessandro De Cassai, Paolo Rosi, Enrico Polati, Katia Donadello, Leonardo Gottin, Silvia De Rosa, Fabio Baratto, Fabio Toffoletto…

    Citation: Critical Care 2021 25:263

    Content type: Research

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  7. High-level antibiotic consumption plays a critical role in the selection and spread of extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-E) in the ICU. Implementation of a stewardship program in...

    Authors: Christophe Le Terrier, Marco Vinetti, Paul Bonjean, Régine Richard, Bruno Jarrige, Bertrand Pons, Benjamin Madeux, Pascale Piednoir, Fanny Ardisson, Elain Elie, Frédéric Martino, Marc Valette, Edouard Ollier, Sébastien Breurec, Michel Carles and Guillaume Thiéry

    Citation: Critical Care 2021 25:261

    Content type: Research

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  8. The optimal protein dose in critical illness is unknown. We aim to conduct a systematic review of randomized controlled trials (RCTs) to compare the effect of higher versus lower protein delivery (with similar...

    Authors: Zheng-Yii Lee, Cindy Sing Ling Yap, M. Shahnaz Hasan, Julia Patrick Engkasan, Mohd Yusof Barakatun-Nisak, Andrew G. Day, Jayshil J. Patel and Daren K. Heyland

    Citation: Critical Care 2021 25:260

    Content type: Research

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  9. New-onset atrial fibrillation (NOAF) in patients treated on an intensive care unit (ICU) is common and associated with significant morbidity and mortality. We undertook a systematic scoping review to summarise...

    Authors: Laura Drikite, Jonathan P. Bedford, Liam O’Bryan, Tatjana Petrinic, Kim Rajappan, James Doidge, David A. Harrison, Kathryn M. Rowan, Paul R. Mouncey, Duncan Young, Peter J. Watkinson and Mark Corbett

    Citation: Critical Care 2021 25:257

    Content type: Review

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  10. During 50 years of extracorporeal life support (ECLS), this highly invasive technology has left a considerable imprint on modern medicine, and it still confronts researchers, clinicians and policymakers with m...

    Authors: Alexandra Schou, Jesper Mølgaard, Lars Willy Andersen, Søren Holm and Marc Sørensen

    Citation: Critical Care 2021 25:256

    Content type: Review

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  11. Drowning is a cause of significant global mortality. The mechanism of injury involves inhalation of water, lung injury and hypoxia. This systematic review addressed the following question: In drowning patients...

    Authors: Ogilvie Thom, Kym Roberts, Susan Devine, Peter A. Leggat and Richard C. Franklin

    Citation: Critical Care 2021 25:253

    Content type: Research

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  12. Muscle weakness is a complication of critical illness which hampers recovery. In critically ill mice, supplementation with the ketone body 3-hydroxybutyrate has been shown to improve muscle force and to normal...

    Authors: Chloë Goossens, Ruben Weckx, Sarah Derde, Sarah Vander Perre, Inge Derese, Paul P. Van Veldhoven, Bart Ghesquière, Greet Van den Berghe and Lies Langouche

    Citation: Critical Care 2021 25:252

    Content type: Research

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    The Letter to this article has been published in Critical Care 2021 25:296

  13. Meropenem dosing for septic critically patients is difficult due to pathophysiological changes associated with sepsis as well as supportive symptomatic therapies. A prospective single-center study assessed whe...

    Authors: Renata Černá Pařízková, Jiřina Martínková, Eduard Havel, Petr Šafránek, Milan Kaška, David Astapenko, Jan Bezouška, Jaroslav Chládek and Vladimír Černý

    Citation: Critical Care 2021 25:251

    Content type: Research

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  14. A personalized mechanical ventilation approach for patients with adult respiratory distress syndrome (ARDS) based on lung physiology and morphology, ARDS etiology, lung imaging, and biological phenotypes may i...

    Authors: Paolo Pelosi, Lorenzo Ball, Carmen S. V. Barbas, Rinaldo Bellomo, Karen E. A. Burns, Sharon Einav, Luciano Gattinoni, John G. Laffey, John J. Marini, Sheila N. Myatra, Marcus J. Schultz, Jean Louis Teboul and Patricia R. M. Rocco

    Citation: Critical Care 2021 25:250

    Content type: Review

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  15. Differences in physiology of ARDS have been described between COVID-19 and non-COVID-19 patients. This study aimed to compare initial values and longitudinal changes in respiratory system compliance (CRS), oxygen...

    Authors: François Beloncle, Antoine Studer, Valérie Seegers, Jean-Christophe Richard, Christophe Desprez, Nicolas Fage, Hamid Merdji, Bertrand Pavlovsky, Julie Helms, Sibylle Cunat, Satar Mortaza, Julien Demiselle, Laurent Brochard, Alain Mercat and Ferhat Meziani

    Citation: Critical Care 2021 25:248

    Content type: Research

    Published on:

    The Letter to this article has been published in Critical Care 2021 25:366

  16. We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) to assess the association of higher positive end-expiratory pressure (PEEP), as opposed to lower PEEP, with hospital mo...

    Authors: Tommaso Pettenuzzo, Annalisa Boscolo, Alessandro De Cassai, Nicolò Sella, Francesco Zarantonello, Paolo Persona, Laura Pasin, Giovanni Landoni and Paolo Navalesi

    Citation: Critical Care 2021 25:247

    Content type: Research

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  17. While recommended by international societal guidelines in the paediatric population, the use of venoarterial extracorporeal membrane oxygenation (VA ECMO) as mechanical circulatory support for refractory septi...

    Authors: Ryan Ruiyang Ling, Kollengode Ramanathan, Wynne Hsing Poon, Chuen Seng Tan, Nicolas Brechot, Daniel Brodie, Alain Combes and Graeme MacLaren

    Citation: Critical Care 2021 25:246

    Content type: Research

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  18. Septic shock comprises a heterogeneous population, and individualized resuscitation strategy is of vital importance. The study aimed to identify subclasses of septic shock with non-supervised learning algorith...

    Authors: Penglin Ma, Jingtao Liu, Feng Shen, Xuelian Liao, Ming Xiu, Heling Zhao, Mingyan Zhao, Jing Xie, Peng Wang, Man Huang, Tong Li, Meili Duan, Kejian Qian, Yue Peng, Feihu Zhou, Xin Xin…

    Citation: Critical Care 2021 25:243

    Content type: Research

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  19. Bloodstream infections (BSIs) are frequent on veno-arterial extracorporeal membrane oxygenation (V-A ECMO). Performing routine blood cultures (BCs) may identify early paucisymptomatic BSIs. We investigated the...

    Authors: Quentin de Roux, Marie Renaudier, Wulfran Bougouin, Johanna Boccara, Vincent Fihman, Raphaël Lepeule, Chamsedine Cherait, Antonio Fiore, François Hemery, Jean-Winoc Decousser, Olivier Langeron and Nicolas Mongardon

    Citation: Critical Care 2021 25:241

    Content type: Research

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  20. A plasma glutamine concentration outside the normal range at Intensive Care Unit (ICU) admission has been reported to be associated with an increased mortality rate. Whereas hypoglutaminemia has been frequentl...

    Authors: Marie Smedberg, Johan Helleberg, Åke Norberg, Inga Tjäder, Olav Rooyackers and Jan Wernerman

    Citation: Critical Care 2021 25:240

    Content type: Research

    Published on:

    The Letter to this article has been published in Critical Care 2021 25:342

  21. Current practices regarding tracheostomy in patients treated with extracorporeal membrane oxygenation (ECMO) for acute respiratory distress syndrome are unknown. Our objectives were to assess the prevalence an...

    Authors: Matthieu Schmidt, Christoph Fisser, Gennaro Martucci, Darryl Abrams, Thomas Frapard, Konstantin Popugaev, Antonio Arcadipane, Bianca Bromberger, Giovanni Lino, Alexis Serra, Sacha Rozencwajg, Matthias Lubnow, Sergey Petrikov, Thomas Mueller, Alain Combes, Tài Pham…

    Citation: Critical Care 2021 25:238

    Content type: Research

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  22. Infectious diseases may affect brain function and cause encephalopathy even when the pathogen does not directly infect the central nervous system, known as infectious disease-associated encephalopathy. The sys...

    Authors: Maria C. Barbosa-Silva, Maiara N. Lima, Denise Battaglini, Chiara Robba, Paolo Pelosi, Patricia R. M. Rocco and Tatiana Maron-Gutierrez

    Citation: Critical Care 2021 25:236

    Content type: Review

    Published on:

  23. The coronavirus disease 2019 (COVID-19) has induced a worldwide epidemiological event with a high infectivity and mortality. However, the predicting biomarkers and their potential mechanism in the progression ...

    Authors: Runzhi Huang, Tong Meng, Qiongfang Zha, Kebin Cheng, Xin Zhou, Junhua Zheng, Dingyu Zhang and Ruilin Liu

    Citation: Critical Care 2021 25:234

    Content type: Research

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  24. The Clinical Frailty Scale (CFS) is frequently used to measure frailty in critically ill adults. There is wide variation in the approach to analysing the relationship between the CFS score and mortality after ...

    Authors: Jakub Fronczek, Kamil Polok, Dylan W. de Lange, Christian Jung, Michael Beil, Andrew Rhodes, Jesper Fjølner, Jacek Górka, Finn H. Andersen, Antonio Artigas, Maurizio Cecconi, Steffen Christensen, Michael Joannidis, Susannah Leaver, Brian Marsh, Alessandro Morandi…

    Citation: Critical Care 2021 25:231

    Content type: Research

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  25. Individualized positive end-expiratory pressure (PEEP) by electrical impedance tomography (EIT) has potential interest in the optimization of ventilation distribution in acute respiratory distress syndrome (AR...

    Authors: Huaiwu He, Yi Chi, Yingying Yang, Siyi Yuan, Yun Long, Pengyu Zhao, Inéz Frerichs, Feng Fu, Knut Möller and Zhanqi Zhao

    Citation: Critical Care 2021 25:230

    Content type: Research

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  26. There is no universally accepted method to assess the pressure-generating capacity of inspiratory muscles in children on mechanical ventilation (MV), and no study describing its evolution over time in this pop...

    Authors: Benjamin Crulli, Atsushi Kawaguchi, Jean-Paul Praud, Basil J. Petrof, Karen Harrington and Guillaume Emeriaud

    Citation: Critical Care 2021 25:229

    Content type: Research

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  27. Early sepsis diagnosis has emerged as one of the main challenges in the emergency room. Measurement of sepsis biomarkers is largely used in current practice to improve the diagnosis accuracy. Monocyte distribu...

    Authors: Pierre Hausfater, Neus Robert Boter, Cristian Morales Indiano, Marta Cancella de Abreu, Adria Mendoza Marin, Julie Pernet, Dolores Quesada, Iris Castro, Diana Careaga, Michel Arock, Liliana Tejidor and Laetitia Velly

    Citation: Critical Care 2021 25:227

    Content type: Research

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  28. Rapid response systems aim to achieve a timely response to the deteriorating patient; however, the existing literature varies on whether timing of escalation directly affects patient outcomes. Prior studies ha...

    Authors: Stephen F. Whebell, Emma J. Prower, Joe Zhang, Megan Pontin, David Grant, Andrew T. Jones and Guy W. Glover

    Citation: Critical Care 2021 25:226

    Content type: Research

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  29. Previous studies reporting the causes of death in patients with severe COVID-19 have provided conflicting results. The objective of this study was to describe the causes and timing of death in patients with se...

    Authors: Charles de Roquetaillade, Swann Bredin, Jean-Baptiste Lascarrou, Thibaud Soumagne, Mariana Cojocaru, Benjamin Glenn Chousterman, Maxime Leclerc, Albin Gouhier, Gaël Piton, Frédéric Pène, Annabelle Stoclin and Jean-François Llitjos

    Citation: Critical Care 2021 25:224

    Content type: Research

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  30. Thiamine is a precursor of the essential coenzyme thiamine pyrophosphate required for glucose metabolism; it improves the immune system function and has shown to reduce the risk of several diseases. The role o...

    Authors: Khalid Al Sulaiman, Ohoud Aljuhani, Maram Al Dossari, Asma Alshahrani, Aisha Alharbi, Rahmah Algarni, Majed Al Jeraisy, Shmeylan Al Harbi, Abdulmalik Al Katheri, Fahad Al Eidan, Abdulkareem M. Al Bekairy, Nouf Al Qahtani, Mashael Al Muqrin, Ramesh Vishwakarma and Ghassan Al Ghamdi

    Citation: Critical Care 2021 25:223

    Content type: Research

    Published on: