Survivors of an acute critical illness with continuing organ dysfunction and uncontrolled inflammatory responses are prone to become chronically critically ill. As mental sequelae, a post-traumatic stress diso...
Authors: Gloria-Beatrice Wintermann, Katja Petrowski, Kerstin Weidner, Bernhard Strauß and Jenny Rosendahl
Although light sedation levels are associated with several beneficial outcomes for critically ill patients on mechanical ventilation, the majority of patients are still deeply sedated. Organizational factors m...
Authors: Antonio Paulo Nassar Jr, Fernando G. Zampieri, Jorge I. Salluh, Fernando A. Bozza, Flávia Ribeiro Machado, Helio Penna Guimarães, Lucas P. Damiani and Alexandre Biasi Cavalcanti
Assessment of fluid responsiveness is problematic in intensive care unit (ICU) patients, in particular for those undergoing modes of partial support, such as pressure support ventilation (PSV). We propose a ne...
Authors: Antonio Messina, Davide Colombo, Federico Lorenzo Barra, Gianmaria Cammarota, Giacomo De Mattei, Federico Longhini, Stefano Romagnoli, Francesco DellaCorte, Daniel De Backer, Maurizio Cecconi and Paolo Navalesi
Exposure to hyperoxemia and hypoxemia is common in out-of-hospital cardiac arrest (OHCA) patients following return of spontaneous circulation (ROSC), but its effects on neurological outcome are uncertain, and ...
Authors: Florian Ebner, Susann Ullén, Anders Åneman, Tobias Cronberg, Niklas Mattsson, Hans Friberg, Christian Hassager, Jesper Kjærgaard, Michael Kuiper, Paolo Pelosi, Johan Undén, Matt P. Wise, Jørn Wetterslev and Niklas Nielsen
Hyperglycemia during the acute phase after burn is associated with increased morbidity and mortality. There is little knowledge regarding the effect of pre-existing hyperglycemia in the form of diabetes on the...
Authors: Reinhard Dolp, Sarah Rehou, Ruxandra Pinto, Rachel Trister and Marc G. Jeschke
The potential benefit of extracorporeal cardiopulmonary resuscitation (ECPR) compared to conventional CPR (CCPR) for patients with refractory cardiac arrest (CA) remains unclear.
Authors: Daniel Patricio, Lorenzo Peluso, Alexandre Brasseur, Olivier Lheureux, Mirko Belliato, Jean-Louis Vincent, Jacques Creteur and Fabio Silvio Taccone
Published data revealed that host genetic variants have a substantial influence on sepsis susceptibility. However, the results have been inconsistent. We aimed to systematically review the published studies an...
Authors: Hongxiang Lu, Dalin Wen, Xu Wang, Lebin Gan, Juan Du, Jianhui Sun, Ling Zeng, Jianxin Jiang and Anqiang Zhang
Acute kidney injury (AKI) is a frequent complication of hospitalization and is associated with an increased risk of chronic kidney disease (CKD), end-stage renal disease (ESRD), and mortality. While AKI is a k...
Authors: Gijs Fortrie, Hilde R. H. de Geus and Michiel G. H. Betjes
Regional citrate anticoagulation (RCA) is a widely used strategy for continuous renal replacement therapy (CRRT). Most of the current guidelines recommend liver failure as one of the contraindications for citr...
Authors: Wei Zhang, Ming Bai, Yan Yu, Lu Li, Lijuan Zhao, Shiren Sun and Xiangmei Chen
The concept of net ultrafiltration (UFNET) mentioned in the paper by Murugan et al. in a recent issue of Critical Care does not equate to the real UFNET in patients with renal replacement therapy initiation. Furt...
A passive leg raising (PLR) test is positive if the cardiac index (CI) increased by > 10%, but it requires a direct measurement of CI. On the oxygen saturation plethysmographic signal, the perfusion index (PI)...
Authors: Alexandra Beurton, Jean-Louis Teboul, Francesco Gavelli, Filipe Andre Gonzalez, Valentina Girotto, Laura Galarza, Nadia Anguel, Christian Richard and Xavier Monnet
Vascular endothelial cadherin (VE-cadherin) is a membrane protein that is the major component of adherens junctions between endothelial cells. It is crucial for regulating vascular integrity, endothelial perme...
Authors: Wen-Kuang Yu, J. Brennan McNeil, Nancy E. Wickersham, Ciara M. Shaver, Julie A. Bastarache and Lorraine B. Ware
The glycocalyx is a gel-like layer covering the luminal surface of vascular endothelial cells. It is comprised of membrane-attached proteoglycans, glycosaminoglycan chains, glycoproteins, and adherent plasma p...
Authors: Ryo Uchimido, Eric P. Schmidt and Nathan I. Shapiro
No evidence exists to date on which to base the selection of outcome measures for assessing nutritional interventions in critically ill patients. We conducted a systematic literature review to describe the out...
Authors: Garry Taverny, Thomas Lescot, Emmanuel Pardo, Frederique Thonon, Manar Maarouf and Corinne Alberti
Prediction scoring systems for coronary artery bypass grafting (CABG) patients on venoarterial extracorporeal membrane oxygenation (VA-ECMO) have not yet been reported. This study was designed to develop a pre...
Authors: Liangshan Wang, Feng Yang, Xiaomeng Wang, Haixiu Xie, Eddy Fan, Mark Ogino, Daniel Brodie, Hong Wang and Xiaotong Hou
The effect of loop diuretic use in critically ill patients on vasopressor support or in shock is unclear. This study aimed to explore the relationship between loop diuretic use and hospital mortality in critic...
ICU patients must be kept conscious, calm, and cooperative even during the critical phases of illness. Enteral administration of sedative drugs might avoid over sedation, and would be as adequate as intravenou...
Authors: Giovanni Mistraletti, Michele Umbrello, Silvia Salini, Paolo Cadringher, Paolo Formenti, Davide Chiumello, Cristina Villa, Riccarda Russo, Silvia Francesconi, Federico Valdambrini, Giacomo Bellani, Alessandra Palo, Francesca Riccardi, Enrica Ferretti, Maurilio Festa, Anna Maria Gado…
Prolonged weaning is a major issue in intensive care patients and tracheostomy is one of the last resort options. Optimized patient-ventilator interaction is essential to weaning. The purpose of this study was...
Authors: Olivier Lamouret, Laure Crognier, Fanny Vardon Bounes, Jean-Marie Conil, Caroline Dilasser, Thibaut Raimondi, Stephanie Ruiz, Antoine Rouget, Clément Delmas, Thierry Seguin, Vincent Minville and Bernard Georges
Although the utilization of extracorporeal membrane oxygenation (ECMO) is increasing and its technology is evolving, only a few epidemiologic reports have described the uses and outcomes of ECMO. The aim of th...
Authors: Moon Seong Baek, Sang-Min Lee, Chi Ryang Chung, Woo Hyun Cho, Young-Jae Cho, Sunghoon Park, So-My Koo, Jae-Seung Jung, Seung Yong Park, Youjin Chang, Byung Ju Kang, Jung-Hyun Kim, Jin Young Oh, So Hee Park, Jung-Wan Yoo, Yun Su Sim…
Cell-free plasma mitochondrial DNA (mtDNA) levels are associated with endothelial dysfunction and differential outcomes in critical illness. A substantial alteration in metabolic homeostasis is commonly observ...
Authors: Pär I. Johansson, Kiichi Nakahira, Angela J. Rogers, Michael J. McGeachie, Rebecca M. Baron, Laura E. Fredenburgh, John Harrington, Augustine M. K. Choi and Kenneth B. Christopher
The histopathology of sepsis-associated acute kidney injury (AKI) in critically ill patients remains an understudied area. Previous studies have identified that acute tubular necrosis (ATN) is not the only dri...
Authors: Adnan Aslan, Marius C. van den Heuvel, Coen A. Stegeman, Eliane R. Popa, Annemarie M. Leliveld, Grietje Molema, Jan G. Zijlstra, Jill Moser and Matijs van Meurs
Neutrophils release neutrophil extracellular traps (NETs) in response to invading pathogens. Although NETs play an important role in host defense against microbial pathogens, they have also been shown to play ...
Authors: Carmen Mikacenic, Richard Moore, Victoria Dmyterko, T. Eoin West, William A. Altemeier, W. Conrad Liles and Christian Lood
Adrenomedullin (ADM) regulates vascular tone and endothelial permeability during sepsis. Levels of circulating biologically active ADM (bio-ADM) show an inverse relationship with blood pressure and a direct re...
Authors: Alexandre Mebazaa, Christopher Geven, Alexa Hollinger, Xavier Wittebole, Benjamin Glen Chousterman, Alice Blet, Etienne Gayat, Oliver Hartmann, Paul Scigalla, Joachim Struck, Andreas Bergmann, Massimo Antonelli, Albertus Beishuizen, Jean-Michel Constantin, Charles Damoisel, Nicolas Deye…
Lung diseases such as acute respiratory distress syndrome (ARDS) have a high incidence worldwide. The current drug therapies for ARDS have supportive effects, making them inefficient. New methods such as strom...
Authors: Mohammad Reza Mokhber Dezfouli, Massoumeh Jabbari Fakhr, Sirous Sadeghian Chaleshtori, Mohammad Mehdi Dehghan, Alireza Vajhi and Roshanak Mokhtari
The association between isolated admission heart rate (HR) and prognosis has been discussed, but not that between gross HR change and neurological outcome in patients with severe traumatic brain injury (TBI). ...
While influenza-like-illness (ILI) surveillance is well-organized at primary care level in Europe, few data are available on more severe cases. With retrospective data from intensive care units (ICU) we aim to...
Authors: Liselotte van Asten, Angie Luna Pinzon, Dylan W. de Lange, Evert de Jonge, Frederika Dijkstra, Sierk Marbus, Gé A. Donker, Wim van der Hoek and Nicolette F. de Keizer
Sepsis is a heterogeneous disease and identification of its subclasses may facilitate and optimize clinical management. This study aimed to identify subclasses of sepsis and its responses to different amounts ...
Authors: Zhongheng Zhang, Gensheng Zhang, Hemant Goyal, Lei Mo and Yucai Hong
