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  1. Enterococcus species are associated with an increased morbidity in intraabdominal infections (IAI). However, their impact on mortality remains uncertain. Moreover, the influence on outcome of the appropriate or i...

    Authors: Anne-Cécile Morvan, Baptiste Hengy, Maïté Garrouste-Orgeas, Stéphane Ruckly, Jean-Marie Forel, Laurent Argaud, Thomas Rimmelé, Jean-Pierre Bedos, Elie Azoulay, Claire Dupuis, Bruno Mourvillier, Carole Schwebel and Jean-François Timsit

    Citation: Critical Care 2019 23:307

    Content type: Research

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  2. Acute respiratory failure is the leading reason for intensive care unit (ICU) admission in immunocompromised patients, and the need for invasive mechanical ventilation has become a major clinical endpoint in r...

    Authors: Guillaume Dumas, Alexandre Demoule, Djamel Mokart, Virginie Lemiale, Saad Nseir, Laurent Argaud, Frédéric Pène, Loay Kontar, Fabrice Bruneel, Kada Klouche, François Barbier, Jean Reignier, Annabelle Stoclin, Guillaume Louis, Jean-Michel Constantin, Florent Wallet…

    Citation: Critical Care 2019 23:306

    Content type: Research

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  3. Most people exposed to a new flu virus do not notice any symptoms. A small minority develops critical illness. Some of this extremely broad variation in susceptibility is explained by the size of the initial i...

    Authors: Sara Clohisey and John Kenneth Baillie

    Citation: Critical Care 2019 23:303

    Content type: Review

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  4. Part of the pathophysiology in septic shock is a progressive activation of the endothelium and platelets leading to widespread microvascular injury with capillary leakage, microthrombi and consumption coagulop...

    Authors: Rasmus Ehrenfried Berthelsen, Sisse Rye Ostrowski, Morten Heiberg Bestle and Per Ingemar Johansson

    Citation: Critical Care 2019 23:301

    Content type: Research

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  5. Our pilot study suggested that noninvasive ventilation (NIV) reduced the need for intubation compared with conventional administration of oxygen on patients with “early” stage of mild acute respiratory distres...

    Authors: Hangyong He, Bing Sun, Lirong Liang, Yanming Li, He Wang, Luqing Wei, Guofeng Li, Shuliang Guo, Jun Duan, Yuping Li, Ying Zhou, Yusheng Chen, Hongru Li, Jingping Yang, Xiyuan Xu, Liqiang Song…

    Citation: Critical Care 2019 23:300

    Content type: Research

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    The Letter to this article has been published in Critical Care 2019 23:358

  6. The effect of premorbid β-blocker exposure on clinical outcomes in patients with sepsis is not well characterized. We aimed to examine the association between premorbid β-blocker exposure and mortality in sepsis.

    Authors: Kaiquan Tan, Martin Harazim, Benjamin Tang, Anthony Mclean and Marek Nalos

    Citation: Critical Care 2019 23:298

    Content type: Research

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  7. It remains unclear whether sepsis-related cardiovascular complications have an adverse impact on survival independent of pre-existing comorbidities. To investigate the survival impact of post-sepsis cardiovasc...

    Authors: Meng-Huan Wu, Po-Yang Tsou, Yu-Hsun Wang, Meng-tse Gabriel Lee, Christin Chih Ting Chao, Wan-Chien Lee, Si-Huei Lee, Jiun-Ruey Hu, Jiunn-Yih Wu, Shy-Shin Chang and Chien-Chang Lee

    Citation: Critical Care 2019 23:293

    Content type: Research

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  8. Red blood cell (RBC) transfusion is a common treatment for hospitalized patients. However, the effects of RBC transfusion on microvascular function remain controversial.

    Authors: Geoffroy Hariri, Simon Bourcier, Zora Marjanovic, Jérémie Joffre, Jérémie Lemarié, Jean-Rémi Lavillegrand, Dominique Charue, Thomas Duflot, Naïke Bigé, Jean-Luc Baudel, Eric Maury, Mohamad Mohty, Bertrand Guidet, Jeremy Bellien, Olivier Blanc-Brude and Hafid Ait-Oufella

    Citation: Critical Care 2019 23:292

    Content type: Research

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  9. Though the prevalence of dementia among hospitalized patients is increasing, there is limited population data in Europe about the use of life-support measures such as invasive mechanical ventilation in these p...

    Authors: Carmen Bouza, Gonzalo Martínez-Alés and Teresa López-Cuadrado

    Citation: Critical Care 2019 23:291

    Content type: Research

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  10. Sepsis is a serious syndrome that is caused by an unbalanced host inflammatory response to an infection. The cytokine network plays a pivotal role in the orchestration of inflammatory response during sepsis. I...

    Authors: Hongmei Tu, Xiaofei Lai, Jiaxi Li, Lili Huang, Yi Liu and Ju Cao

    Citation: Critical Care 2019 23:290

    Content type: Research

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    The Letter to this article has been published in Critical Care 2019 23:397

  11. This pilot study was designed to develop a fully automatic and quantitative scoring system of B-lines (QLUSS: quantitative lung ultrasound score) involving the pleural line and to compare it with previously de...

    Authors: Claudia Brusasco, Gregorio Santori, Elisa Bruzzo, Rosella Trò, Chiara Robba, Guido Tavazzi, Fabio Guarracino, Francesco Forfori, Patrizia Boccacci and Francesco Corradi

    Citation: Critical Care 2019 23:288

    Content type: Research

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  12. Patients with hematologic malignancies who are admitted to hospital are at increased risk of deterioration and death. Rapid response systems (RRSs) respond to hospitalized patients who clinically deteriorate. ...

    Authors: Benjamin Gershkovich, Shannon M. Fernando, Brent Herritt, Lana A. Castellucci, Bram Rochwerg, Laveena Munshi, Sangeeta Mehta, Andrew J. E. Seely, Daniel I. McIsaac, Alexandre Tran, Peter M. Reardon, Peter Tanuseputro and Kwadwo Kyeremanteng

    Citation: Critical Care 2019 23:286

    Content type: Research

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  13. Although targeted temperature management (TTM) is recommended in comatose survivors after cardiac arrest (CA), the optimal method to deliver TTM remains unknown. We performed a meta-analysis to evaluate the ef...

    Authors: Lorenzo Calabró, Wulfran Bougouin, Alain Cariou, Chiara De Fazio, Markus Skrifvars, Eldar Soreide, Jacques Creteur, Hans Kirkegaard, Stéphane Legriel, Jean-Baptiste Lascarrou, Bruno Megarbane, Nicolas Deye and Fabio Silvio Taccone

    Citation: Critical Care 2019 23:285

    Content type: Research

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  14. Intensive care units (ICUs) face financial, bed management, and staffing constraints. Detailed data covering all aspects of patients’ journeys into and through intensive care are now collected and stored in el...

    Authors: Duncan Shillan, Jonathan A. C. Sterne, Alan Champneys and Ben Gibbison

    Citation: Critical Care 2019 23:284

    Content type: Research

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  15. Altered coagulation and alveolar injury are the hallmarks of acute respiratory distress syndrome (ARDS). However, whether the biomarkers that reflect pathophysiology differ depending on the etiology of ARDS ha...

    Authors: Kansuke Koyama, Shinshu Katayama, Ken Tonai, Jun Shima, Toshitaka Koinuma and Shin Nunomiya

    Citation: Critical Care 2019 23:283

    Content type: Research

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  16. Early diagnosis of acute kidney injury (AKI) is a major challenge in the intensive care unit (ICU). The AKIpredictor is a set of machine-learning-based prediction models for AKI using routinely collected patie...

    Authors: Marine Flechet, Stefano Falini, Claudia Bonetti, Fabian Güiza, Miet Schetz, Greet Van den Berghe and Geert Meyfroidt

    Citation: Critical Care 2019 23:282

    Content type: Research

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  17. A peripheral perfusion-targeted resuscitation during early septic shock has shown encouraging results. Capillary refill time, which has a prognostic value, was used. Adding accuracy and predictability on capil...

    Authors: Matthias Jacquet-Lagrèze, Nourredine Bouhamri, Philippe Portran, Rémi Schweizer, Florent Baudin, Marc Lilot, William Fornier and Jean-Luc Fellahi

    Citation: Critical Care 2019 23:281

    Content type: Research

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  18. Thrombomodulin plays a vital role in maintaining intravascular patency due to its anticoagulant, antiinflammatory, and cytoprotective properties. However, under pathological conditions such as sepsis and syste...

    Authors: Takashi Ito, Jecko Thachil, Hidesaku Asakura, Jerrold H. Levy and Toshiaki Iba

    Citation: Critical Care 2019 23:280

    Content type: Review

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  19. The rapid development in big data analytics and the data-rich environment of intensive care units together provide unprecedented opportunities for medical breakthroughs in the field of critical care. We develo...

    Authors: Soo Yeon Kim, Saehoon Kim, Joongbum Cho, Young Suh Kim, In Suk Sol, Youngchul Sung, Inhyeok Cho, Minseop Park, Haerin Jang, Yoon Hee Kim, Kyung Won Kim and Myung Hyun Sohn

    Citation: Critical Care 2019 23:279

    Content type: Research

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  20. As many as 90% of patients develop anemia by their third day in an intensive care unit (ICU). We evaluated the efficacy of interventions to reduce phlebotomy-related blood loss on the volume of blood lost, hem...

    Authors: Nedra S. Whitehead, Laurina O. Williams, Sreelatha Meleth, Sara M. Kennedy, Nneka Ubaka-Blackmoore, Sharon M. Geaghan, James H. Nichols, Patrick Carroll, Michael T. McEvoy, Julie Gayken, Dennis J. Ernst, Christine Litwin, Paul Epner, Jennifer Taylor and Mark L. Graber

    Citation: Critical Care 2019 23:278

    Content type: Research

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  21. Posttraumatic stress disorder (PTSD) symptoms are common in acute respiratory distress syndrome (ARDS) survivors. Brief screening instruments are needed for clinical and research purposes. We evaluated interna...

    Authors: Megan M. Hosey, Jeannie-Marie S. Leoutsakos, Ximin Li, Victor D. Dinglas, O. Joseph Bienvenu, Ann M. Parker, Ramona O. Hopkins, Dale M. Needham and Karin J. Neufeld

    Citation: Critical Care 2019 23:276

    Content type: Research

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    The Letter to this article has been published in Critical Care 2019 23:313

  22. Invasive fungal infections (IFI) are difficult to diagnose, especially in critically ill patients. As the mannose receptor (MR) is shed from macrophage cell surfaces after exposure to fungi, we investigate whe...

    Authors: Greet De Vlieger, Ilse Vanhorebeek, Pieter J. Wouters, Inge Derese, Michael P. Casaer, Yves Debaveye, Greet Hermans, Philippe Meersseman, Holger J. Møller, Greet Van den Berghe and Catherine Ingels

    Citation: Critical Care 2019 23:270

    Content type: Research

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  23. Data that indicate vitamin A status in critically ill children with sepsis are sparse. The association between serum vitamin A levels and the clinical outcomes of sepsis has not been well assessed. The aim of ...

    Authors: Xuepeng Zhang, Kaiying Yang, Linwen Chen, Xuelian Liao, Liping Deng, Siyuan Chen and Yi Ji

    Citation: Critical Care 2019 23:267

    Content type: Research

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  24. Veno-arterial extracorporeal membrane oxygenation (V-A ECMO) is an increasingly adopted life-saving mechanical circulatory support for a number of potentially reversible or treatable cardiac diseases. It is al...

    Authors: Eleonora Bonicolini, Gennaro Martucci, Jorik Simons, Giuseppe M. Raffa, Cristina Spina, Valeria Lo Coco, Antonio Arcadipane, Michele Pilato and Roberto Lorusso

    Citation: Critical Care 2019 23:266

    Content type: Review

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  25. Bedside functional hemodynamic assessment has gained in popularity in the last years to overcome the limitations of static or dynamic indexes in predicting fluid responsiveness. The aim of this systematic revi...

    Authors: Antonio Messina, Antonio Dell’Anna, Marta Baggiani, Flavia Torrini, Gian Marco Maresca, Victoria Bennett, Laura Saderi, Giovanni Sotgiu, Massimo Antonelli and Maurizio Cecconi

    Citation: Critical Care 2019 23:264

    Content type: Research

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  26. We assessed the effect of liberal versus restrictive red blood cell transfusion strategy on survival outcome in sepsis or septic shock by systematically reviewing the literature and synthesizing evidence from ...

    Authors: Yohei Hirano, Yukari Miyoshi, Yutaka Kondo, Ken Okamoto and Hiroshi Tanaka

    Citation: Critical Care 2019 23:262

    Content type: Research

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  27. For every day a person is dependent on mechanical ventilation, respiratory and cardiac complications increase, quality of life decreases and costs increase by > $USD 1500. Interventions that improve respirator...

    Authors: Euan J. McCaughey, Annemijn H. Jonkman, Claire L. Boswell-Ruys, Rachel A. McBain, Elizabeth A. Bye, Anna L. Hudson, David W. Collins, Leo M. A. Heunks, Angus J. McLachlan, Simon C. Gandevia and Jane E. Butler

    Citation: Critical Care 2019 23:261

    Content type: Research

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  28. The endothelial glycocalyx (eGC) covers the luminal surface of the vascular endothelium and plays an important protective role in systemic inflammatory states and particularly in sepsis. Its breakdown leads to...

    Authors: Alexandros Rovas, Laura Mareen Seidel, Hans Vink, Timo Pohlkötter, Hermann Pavenstädt, Christian Ertmer, Michael Hessler and Philipp Kümpers

    Citation: Critical Care 2019 23:260

    Content type: Research

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  29. Intravenous fluids, an essential component of sepsis resuscitation, may paradoxically worsen outcomes by exacerbating endothelial injury. Preclinical models suggest that fluid resuscitation degrades the endoth...

    Authors: Joseph A. Hippensteel, Ryo Uchimido, Patrick D. Tyler, Ryan C. Burke, Xiaorui Han, Fuming Zhang, Sarah A. McMurtry, James F. Colbert, Christopher J. Lindsell, Derek C. Angus, John A. Kellum, Donald M. Yealy, Robert J. Linhardt, Nathan I. Shapiro and Eric P. Schmidt

    Citation: Critical Care 2019 23:259

    Content type: Research

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  30. Diagnosis of significant coronary artery disease (CAD) and acute coronary artery occlusion in ICU can be difficult, and an inappropriate intervention is potentially harmful. Myocardial contrast perfusion echo ...

    Authors: Sam Orde, Michel Slama, Faraz Pathan, Stephen Huang and Anthony Mclean

    Citation: Critical Care 2019 23:257

    Content type: Research

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