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  1. High serum levels of certain aromatic microbial metabolites (AMM) are associated with severity and mortality in critically ill patients. Omics-based studies suggest gut dysbiosis and reduced microbiome diversi...

    Authors: Ekaterina Chernevskaya, Natalia Beloborodova, Natalia Klimenko, Alisa Pautova, Dmitrii Shilkin, Vitaliy Gusarov and Alexander Tyakht

    Citation: Critical Care 2020 24:312

    Content type: Research

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  2. Early and rapid identification of Pseudomonas aeruginosa (P. aeruginosa) in patients with suspected ventilator-associated pneumonia (VAP) provides theoretical clinical advantages in therapeutic optimization strat...

    Authors: Juxiang Wang, Huimin Chen, Xiaomin Lin, Chengyi Ji and Bin Chen

    Citation: Critical Care 2020 24:306

    Content type: Research

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  3. Emergency department overcrowding negatively impacts critically ill patients and could lead to the occurrence of cardiac arrest. However, the association between emergency department crowding and the occurrenc...

    Authors: June-sung Kim, Hyun-Jin Bae, Chang Hwan Sohn, Sung-Eun Cho, Jeongeun Hwang, Won Young Kim, Namkug Kim and Dong-Woo Seo

    Citation: Critical Care 2020 24:305

    Content type: Research

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  4. Group A streptococci (GAS) are known to cause serious invasive infections, but little is known about outcomes when patients with these infections are admitted to intensive care. We wanted to describe criticall...

    Authors: Viveka Björck, Lisa I. Påhlman, Mikael Bodelsson, Ann-Cathrine Petersson and Thomas Kander

    Citation: Critical Care 2020 24:302

    Content type: Research

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  5. The spread of coronavirus disease 2019 (COVID-19) continues to grow exponentially in most countries, posing an unprecedented burden on the healthcare sector and the world economy. Previous respiratory virus ou...

    Authors: Hwa Jin Cho, Silver Heinsar, In Seok Jeong, Kiran Shekar, Gianluigi Li Bassi, Jae Seung Jung, Jacky Y. Suen and John F. Fraser

    Citation: Critical Care 2020 24:301

    Content type: Review

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  6. SARS-CoV-2 has caused a global pandemic unprecedented in size, spread, severity, and mortality. The influx of patients with severe or life-threatening disease means that in some cases, the available medical re...

    Authors: Élie Azoulay, Sadek Beloucif, Bertrand Guidet, Dominique Pateron, Benoît Vivien and Matthieu Le Dorze

    Citation: Critical Care 2020 24:293

    Content type: Viewpoint

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  7. Those involved in the airway management of COVID-19 patients are particularly at risk. Here, we describe a practical, stepwise protocol for safe in-hospital airway management in patients with suspected or conf...

    Authors: Elise H. Sullivan, Lauren E. Gibson, Lorenzo Berra, Marvin G. Chang and Edward A. Bittner

    Citation: Critical Care 2020 24:292

    Content type: Review

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  8. Venoarterial extracorporeal membrane oxygenation (VA-ECMO) is increasingly used in patients with critical cardiopulmonary failure. To investigate the association between hospital VA-ECMO procedure volume and o...

    Authors: Peter Moritz Becher, Alina Goßling, Benedikt Schrage, Raphael Twerenbold, Nina Fluschnik, Moritz Seiffert, Alexander M. Bernhardt, Hermann Reichenspurner, Stefan Blankenberg and Dirk Westermann

    Citation: Critical Care 2020 24:291

    Content type: Research

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  9. Sepsis biomarkers can have important diagnostic, therapeutic, and prognostic functions. In a previous review, we identified 3370 references reporting on 178 different biomarkers related to sepsis. In the prese...

    Authors: Charalampos Pierrakos, Dimitrios Velissaris, Max Bisdorff, John C. Marshall and Jean-Louis Vincent

    Citation: Critical Care 2020 24:287

    Content type: Research

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  10. Sepsis guidelines are widely used in high-income countries and intravenous fluids are an important supportive treatment modality. However, fluids have been harmful in intervention trials in low-income countrie...

    Authors: Benjamin Silberberg, Stephen Aston, Selda Boztepe, Shevin Jacob and Jamie Rylance

    Citation: Critical Care 2020 24:286

    Content type: Research

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  11. We dissected total power into its primary components to resolve its relative contributions to tissue damage (VILI). We hypothesized that driving power or elastic (dynamic) power offers more precise VILI risk i...

    Authors: Patricia R. M. Rocco, Pedro L. Silva, Cynthia S. Samary, Muhammad K. Hayat Syed and John J. Marini

    Citation: Critical Care 2020 24:284

    Content type: Research

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  12. The rational use of antibiotics is one of the main strategies to limit the development of bacterial resistance. We therefore sought to evaluate the effectiveness of a C-reactive protein-based protocol in reduc...

    Authors: Isabela Borges, Rafael Carneiro, Rafael Bergo, Larissa Martins, Enrico Colosimo, Carolina Oliveira, Saulo Saturnino, Marcus Vinícius Andrade, Cecilia Ravetti and Vandack Nobre

    Citation: Critical Care 2020 24:281

    Content type: Research

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  13. The urine biomarkers tissue inhibitor of metalloproteinases-2 (TIMP-2) and insulin-like growth factor-binding protein 7 (IGFBP7) have been validated for predicting and stratifying AKI. In this study, we analyz...

    Authors: Dimitri Titeca-Beauport, Delphine Daubin, Ly Van Vong, Guillaume Belliard, Cédric Bruel, Sami Alaya, Karim Chaoui, Maud Andrieu, Isabelle Rouquette-Vincenti, Frederic Godde, Michel Pascal, Momar Diouf, Christophe Vinsonneau, Kada Klouche and Julien Maizel

    Citation: Critical Care 2020 24:280

    Content type: Research

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  14. Fluid overload is associated with morbidity and mortality in patients receiving renal replacement therapy (RRT). We aimed to explore whether fluid overload at initiation of RRT was independently associated wit...

    Authors: Anna Hall, Siobhan Crichton, Alison Dixon, Ilia Skorniakov, John A. Kellum and Marlies Ostermann

    Citation: Critical Care 2020 24:279

    Content type: Research

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  15. The gut microbiome regulates a number of homeostatic mechanisms in the healthy host including immune function and gut barrier protection. Loss of normal gut microbial structure and function has been associated...

    Authors: Max W. Adelman, Michael H. Woodworth, Charles Langelier, Lindsay M. Busch, Jordan A. Kempker, Colleen S. Kraft and Greg S. Martin

    Citation: Critical Care 2020 24:278

    Content type: Review

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  16. The intestinal microbiota plays a crucial role in human health, which could affect host immunity and the susceptibility to infectious diseases. However, the role of intestinal microbiota in the immunopathology...

    Authors: Mengmeng Li, Congya Li, Xianan Wu, Tangtian Chen, Lei Ren, Banglao Xu and Ju Cao

    Citation: Critical Care 2020 24:268

    Content type: Research

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