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  1. Spontaneous pneumomediastinum (SP) has been described early during the COVID-19 pandemic in large series of patients with severe pneumonia, but most patients were receiving invasive mechanical ventilation (IMV...

    Authors: Alexandre Elabbadi, Tomas Urbina, Enora Berti, Damien Contou, Gaëtan Plantefève, Quintana Soulier, Audrey Milon, Guillaume Carteaux, Guillaume Voiriot, Muriel Fartoukh and Aude Gibelin
    Citation: Critical Care 2022 26:350

    The Correspondence to this article has been published in Critical Care 2023 27:38

  2. Several biomarkers have been proposed to predict the occurrence of acute kidney injury (AKI); however, their efficacy varies between different trials. The aim of this study was to compare the predictive perfor...

    Authors: Heng-Chih Pan, Shao-Yu Yang, Terry Ting-Yu Chiou, Chih-Chung Shiao, Che-Hsiung Wu, Chun-Te Huang, Tsai-Jung Wang, Jui-Yi Chen, Hung-Wei Liao, Sheng-Yin Chen, Tao-Min Huang, Ya-Fei Yang, Hugo You-Hsien Lin, Ming-Jen Chan, Chiao-Yin Sun, Yih-Ting Chen…
    Citation: Critical Care 2022 26:349
  3. Non-invasive ventilation (NIV) with bi-level positive pressure ventilation is a first-line intervention for selected patients with acute hypercapnic respiratory failure. Compared to conventional oxygen therapy...

    Authors: N. Ovtcharenko, E. Ho, W. Alhazzani, A. Cortegiani, B. Ergan, R. Scala, G. Sotgiu, D. Chaudhuri, S. Oczkowski and K. Lewis
    Citation: Critical Care 2022 26:348
  4. The intensive care unit (ICU) is an emotionally taxing environment. Patients and family members are at an increased risk of long-term physical and psychological consequences of critical illness, known collecti...

    Authors: Sarah Petrecca, Adrian Goin, David Hornstein, Milanka Stevanovic and Adamo Anthony Donovan
    Citation: Critical Care 2022 26:346
  5. The delayed diagnosis of acute kidney injury (AKI) episodes and the lack of specificity of current single AKI biomarkers hamper its management. Urinary peptidome analysis may help to identify early molecular c...

    Authors: Alexis Piedrafita, Justyna Siwy, Julie Klein, Amal Akkari, Ana Amaya-garrido, Alexandre Mebazaa, Anna Belen Sanz, Benjamin Breuil, Laura Montero Herrero, Bertrand Marcheix, François Depret, Lucie Fernandez, Elsa Tardif, Vincent Minville, Melinda Alves, Jochen Metzger…
    Citation: Critical Care 2022 26:344

    The Publisher Correction to this article has been published in Critical Care 2022 26:406

  6. Steroid profiles in combination with a corticotropin stimulation test provide information about steroidogenesis and its functional reserves in critically ill patients.

    Authors: Josef Briegel, Patrick Möhnle, Didier Keh, Johanna M. Lindner, Anna C. Vetter, Holger Bogatsch, Dorothea Lange, Sandra Frank, Ludwig C. Hinske, Djillali Annane and Michael Vogeser
    Citation: Critical Care 2022 26:343
  7. Authors: Patrick M. Honore, Sebastien Redant, Pharan Djimafo, Sydney Blackman, Ibrahim Bousbiat, Emily Perriens, Thierry Preseau, Bogdan Vasile Cismas, Keitiane Kaefer, Leonel Barreto Gutierrez, Sami Anane, Andrea Gallerani and Rachid Attou
    Citation: Critical Care 2022 26:342

    The original article was published in Critical Care 2022 26:100

  8. Sepsis is a severe systemic inflammatory response to infections that is accompanied by organ dysfunction and has a high mortality rate in adult intensive care units. Most genetic studies have identified gene v...

    Authors: Tamara Hernandez-Beeftink, Beatriz Guillen-Guio, Jose M. Lorenzo-Salazar, Almudena Corrales, Eva Suarez-Pajes, Rui Feng, Luis A. Rubio-Rodríguez, Megan L. Paynton, Raquel Cruz, M. Isabel García-Laorden, Miryam Prieto-González, Aurelio Rodríguez-Pérez, Demetrio Carriedo, Jesús Blanco, Alfonso Ambrós, Elena González-Higueras…
    Citation: Critical Care 2022 26:341
  9. Previously identified phenotypes of acute respiratory distress syndrome (ARDS) have been limited by a disregard for temporal dynamics. We aimed to identify longitudinal phenotypes in ARDS to test the prognosti...

    Authors: Hui Chen, Qian Yu, Jianfeng Xie, Songqiao Liu, Chun Pan, Ling Liu, Yingzi Huang, Fengmei Guo, Haibo Qiu and Yi Yang
    Citation: Critical Care 2022 26:340
  10. Chronic obstructive pulmonary disease (COPD) is one of most common comorbidities in acute respiratory distress syndrome (ARDS). There are few specific studies on the appropriate ventilation strategy for patien...

    Authors: Xuesong Liu, Xiao Liu, Jue Meng, Dongdong Liu, Yongbo Huang, Ling Sang, Yonghao Xu, Zhiheng Xu, Weiqun He, Sibei Chen, Rong Zhang, Xiaoqing Liu and Yimin Li
    Citation: Critical Care 2022 26:339
  11. We conducted a proof of concept study where Anapnoguard endotracheal tubes and its control unit were used in 15 patients with COVID-19 acute respiratory distress syndrome. Anapnoguard system provides suction, ...

    Authors: Eloisa Sofia Tanzarella, Gianmarco Lombardi, Silvia Baroni, Francesca Sarlo, Salvatore Lucio Cutuli, Simone Carelli, Melania Cesarano, Veronica Gennenzi, Gabriele Pintaudi, Joel Vargas, Antonio Maria Dell’Anna, Domenico Luca Grieco, Andrea Urbani, Massimo Antonelli and Gennaro De Pascale
    Citation: Critical Care 2022 26:338
  12. Sepsis is a life-threatening complication of the body’s response to infection. The financial, medical, and psychological costs of sepsis to individuals and to the healthcare system are high. Most sepsis cases ...

    Authors: Jeanna Parsons Leigh, Rebecca Brundin-Mather, Stephana Julia Moss, Angie Nickel, Ariana Parolini, Deirdre Walsh, Blair L. Bigham, Alix J. E. Carter, Alison Fox-Robichaud and Kirsten M. Fiest
    Citation: Critical Care 2022 26:337
  13. Bereaved ICU family surrogates are at risk of comorbid prolonged grief disorder (PGD), posttraumatic stress disorder (PTSD), and depression. Knowledge about temporal relationships between PGD, PTSD, and depres...

    Authors: Fur-Hsing Wen, Holly G. Prigerson, Wen-Chi Chou, Chung-Chi Huang, Tsung-Hui Hu, Ming Chu Chiang, Li-Pang Chuang and Siew Tzuh Tang
    Citation: Critical Care 2022 26:336
  14. Early public-access defibrillation (PAD) effectively improves the outcomes of out-of-hospital cardiac arrests (OHCA), but several strategies implemented to prevent the spread of coronavirus disease 2019 (COVID...

    Authors: Tasuku Matsuyama, Kosuke Kiyohara, Tetsuhisa Kitamura, Chika Nishiyama, Takeyuki Kiguchi and Taku Iwami
    Citation: Critical Care 2022 26:335
  15. Renal replacement therapy (RRT) remains the key rescue therapy for critically ill patients with severe acute kidney injury (AKI). However, there are currently no tools available to predict successful liberatio...

    Authors: Thilo von Groote, Felix Albert, Melanie Meersch, Raphael Koch, Christian Porschen, Oliver Hartmann, Deborah Bergmann, Peter Pickkers and Alexander Zarbock
    Citation: Critical Care 2022 26:333
  16. Survival rates in refractory out-of-hospital cardiac arrest (OHCA) remain low with conventional advanced cardiac life support (ACLS). Extracorporeal life support (ECLS) implantation during ongoing resuscitatio...

    Authors: Daniel Rob, Jana Smalcova, Ondrej Smid, Ales Kral, Tomas Kovarnik, David Zemanek, Petra Kavalkova, Michal Huptych, Arnost Komarek, Ondrej Franek, Stepan Havranek, Ales Linhart and Jan Belohlavek
    Citation: Critical Care 2022 26:330
  17. Steroids have been shown to reduce inflammation, hypoxic pulmonary vasoconstriction (HPV) and lung edema. Based on evidence from clinical trials, steroids are widely used in severe COVID-19. However, the effec...

    Authors: Gaetano Perchiazzi, Aleksandra Larina, Tomas Hansen, Robert Frithiof, Michael Hultström, Miklos Lipcsey and Mariangela Pellegrini
    Citation: Critical Care 2022 26:328
  18. Virtual reality (VR) and augmented reality (AR) are aspiring, new technologies with increasing use in critical care medicine. While VR fully immerses the user into a virtual three-dimensional space, AR adds ov...

    Authors: Raphael Romano Bruno, Georg Wolff, Bernhard Wernly, Maryna Masyuk, Kerstin Piayda, Susannah Leaver, Ralf Erkens, Daniel Oehler, Shazia Afzal, Houtan Heidari, Malte Kelm and Christian Jung
    Citation: Critical Care 2022 26:326
  19. The enteral route is commonly utilised to support the nutritional requirements of critically ill patients. However, there is paucity of data guiding clinicians regarding the appropriate method of delivering th...

    Authors: Aaron J. Heffernan, C. Talekar, M. Henain, L. Purcell, M. Palmer and H. White
    Citation: Critical Care 2022 26:325
  20. Rapid fluid administration may decrease hemoglobin concentration (Hb) by a diluting effect, which could limit the increase in oxygen delivery (DO2) expected with a positive response to fluid challenge in critical...

    Authors: Armin A. Quispe-Cornejo, Ana L. Alves da Cunha, Hassane Njimi, Wasineenart Mongkolpun, Ana L. Valle-Martins, Mónica Arébalo-López, Jacques Creteur and Jean-Louis Vincent
    Citation: Critical Care 2022 26:324
  21. Optimal oxygen targets in patients resuscitated after cardiac arrest are uncertain. The primary aim of this study was to describe the values of partial pressure of oxygen values (PaO2) and the episodes of hypoxem...

    Authors: Chiara Robba, Rafael Badenes, Denise Battaglini, Lorenzo Ball, Filippo Sanfilippo, Iole Brunetti, Janus Christian Jakobsen, Gisela Lilja, Hans Friberg, Pedro David Wendel-Garcia, Paul J. Young, Glenn Eastwood, Michelle S. Chew, Johan Unden, Matthew Thomas, Michael Joannidis…
    Citation: Critical Care 2022 26:323
  22. We have previously shown that iatrogenic dehydration is associated with a shift to organic osmolyte production in the general ICU population. The aim of the present investigation was to determine the validity ...

    Authors: Michael Hultström, Miklos Lipcsey, Dave R. Morrison, Tomoko Nakanishi, Guillaume Butler-Laporte, Yiheng Chen, Satoshi Yoshiji, Vincenzo Forgetta, Yossi Farjoun, Ewa Wallin, Ing-Marie Larsson, Anders Larsson, Adriana Marton, Jens Marc Titze, Sandra Nihlén, J. Brent Richards…
    Citation: Critical Care 2022 26:322
  23. Cell stress promotes degradation of mitochondria which release danger-associated molecular patterns that are catabolized to N-formylmethionine. We hypothesized that in critically ill adults, the response to N-for...

    Authors: Martin Ingi Sigurdsson, Hirotada Kobayashi, Karin Amrein, Kiichi Nakahira, Angela J. Rogers, Mayra Pinilla-Vera, Rebecca M. Baron, Laura E. Fredenburgh, Jessica A. Lasky-Su and Kenneth B. Christopher
    Citation: Critical Care 2022 26:321
  24. Evidence supports therapeutic drug monitoring of polymyxin B, but clinical data for establishing an area under the concentration–time curve across 24 h at steady state (AUCss,24 h) threshold are still limited. Th...

    Authors: Jing Yang, Shaohua Liu, Jingli Lu, Tongwen Sun, Peile Wang and Xiaojian Zhang
    Citation: Critical Care 2022 26:320

    The Correspondence to this article has been published in Critical Care 2023 27:41

  25. The study aimed to describe the epidemiology and outcomes of hospital-acquired bloodstream infections (HABSIs) between COVID-19 and non-COVID-19 critically ill patients.

    Authors: Niccolò Buetti, Alexis Tabah, Ambre Loiodice, Stéphane Ruckly, Abdullah Tarik Aslan, Giorgia Montrucchio, Andrea Cortegiani, Nese Saltoglu, Bircan Kayaaslan, Firdevs Aksoy, Akova Murat, Özlem Akdoğan, Kemal Tolga Saracoglu, Cem Erdogan, Marc Leone, Ricard Ferrer…
    Citation: Critical Care 2022 26:319
  26. Early data suggest use of a mixed lipid emulsion (LE) with a soybean oil reduction strategy in parenteral nutrition (PN) may improve clinical outcomes. Duke University Hospital made a full switch to a Soybean ...

    Authors: Krista L. Haines, Tetsu Ohnuma, Charles Trujillo, Obanor Osamudiamen, Vijay Krishnamoorthy, Karthik Raghunathan and Paul E. Wischmeyer
    Citation: Critical Care 2022 26:317
  27. Mechanical ventilation increases the risk of lung injury (VILI). Some authors propose that the way to reduce VILI is to find the threshold of driving pressure below which VILI is minimized. In this study, we p...

    Authors: Álvaro Mingote, Ramsés Marrero García, Martín Santos González, Raquel Castejón, Clara Salas Antón, Juan Antonio Vargas Nuñez and Javier García-Fernández
    Citation: Critical Care 2022 26:316
  28. Monitoring with electrical impedance tomography (EIT) during a decremental PEEP trial has been used to identify the PEEP that yields the optimal balance of pulmonary overdistension and collapse. This method is...

    Authors: Douglas Slobod, Marco Leali, Elena Spinelli, Domenico Luca Grieco, Savino Spadaro and Tommaso Mauri
    Citation: Critical Care 2022 26:314

    The Correspondence to this article has been published in Critical Care 2022 26:381

    The Correspondence to this article has been published in Critical Care 2022 26:370

  29. Although rarely addressed in the literature, a key question in the care of critically pregnant women with severe acute respiratory distress syndrome (ARDS), especially at the time of extracorporeal membrane ox...

    Authors: Sarah Aissi James, Christophe Guervilly, Mathieu Lesouhaitier, Alexandre Coppens, Clément Haddadi, Guillaume Lebreton, Jacky Nizard, Nicolas Brechot, Benjamin Assouline, Ouriel Saura, David Levy, Lucie Lefèvre, Pétra Barhoum, Juliette Chommeloux, Guillaume Hékimian, Charles-Edouard Luyt…
    Citation: Critical Care 2022 26:312
  30. The sublingual microcirculation presumably exhibits disease-specific changes in function and morphology. Algorithm-based quantification of functional microcirculatory hemodynamic variables in handheld vital mi...

    Authors: Matthias Peter Hilty, Emanuele Favaron, Pedro David Wendel Garcia, Yavuz Ahiska, Zuhre Uz, Sakir Akin, Moritz Flick, Sesmu Arbous, Daniel A. Hofmaenner, Bernd Saugel, Henrik Endeman, Reto Andreas Schuepbach and Can Ince
    Citation: Critical Care 2022 26:311
  31. Shortage of nurses on the ICU is not a new phenomenon, but has been exacerbated by the COVID-19 pandemic. The underlying reasons are relatively well-recognized, and include excessive workload, moral distress, ...

    Authors: Jean-Louis Vincent, Carole Boulanger, Margo M. C. van Mol, Laura Hawryluck and Elie Azoulay
    Citation: Critical Care 2022 26:310
  32. The 40-year-old experience with glucocorticosteroids (GCs) in the context of severe infections is complex and troublesome. Recently, however, a clear indication for GCs in severe COVID-19 has been established....

    Authors: Martin S. Winkler, Marcin F. Osuchowski, Didier Payen, Antoni Torres, Steffen Dickel and Tomasz Skirecki
    Citation: Critical Care 2022 26:308
  33. Impact of in-ICU transfusion on long-term outcomes remains unknown. The purpose of this study was to assess in critical-care survivors the association between in-ICU red blood cells transfusion and 1-year mort...

    Authors: Alice Blet, Joel B. McNeil, Julie Josse, Bernard Cholley, Raphaël Cinotti, Gad Cotter, Agnès Dauvergne, Beth Davison, Kévin Duarte, Jacques Duranteau, Marie-Céline Fournier, Etienne Gayat, Samir Jaber, Sigismond Lasocki, Thomas Merkling, Katell Peoc’h…
    Citation: Critical Care 2022 26:307

    The Correspondence to this article has been published in Critical Care 2022 26:374

  34. We aimed to optimize prediction of long-term all-cause mortality of intensive care unit (ICU) patients, using quantitative register-based comorbidity information assessed from hospital discharge diagnoses prio...

    Authors: Anna Aronsson Dannewitz, Bodil Svennblad, Karl Michaëlsson, Miklos Lipcsey and Rolf Gedeborg
    Citation: Critical Care 2022 26:306
  35. Fluid overload and venous congestion are associated with morbi-mortality in the ICU (intensive care unit). Administration of diuretics to correct the fluid balance is common, although there is no strong relati...

    Authors: Pierre-Grégoire Guinot, Pierre-Alain Bahr, Stefan Andrei, Bogdan A. Popescu, Vincenza Caruso, Paul-Michel Mertes, Vivien Berthoud, Maxime Nguyen and Belaid Bouhemad
    Citation: Critical Care 2022 26:305
  36. The incidence of sepsis can be estimated between 250 and 500 cases/100.000 people per year and is responsible for up to 6% of total hospital admissions. Identified as one of the most relevant global health pro...

    Authors: Carolina Lorencio Cárdenas, Juan Carlos Yébenes, Emili Vela, Montserrat Clèries, Josep Mª Sirvent, Cristina Fuster-Bertolín, Clara Reina, Alejandro Rodríguez, Juan Carlos Ruiz-Rodríguez, Josep Trenado and Elisabeth Esteban Torné
    Citation: Critical Care 2022 26:302
  37. The composition of the digestive microbiota may be associated with outcome and infections in patients admitted to the intensive care unit (ICU). The dominance by opportunistic pathogens (such as Enterococcus) has...

    Authors: Juliette Patrier, Khanh Villageois-Tran, Piotr Szychowiak, Stéphane Ruckly, Rémi Gschwind, Paul-Henri Wicky, Signara Gueye, Laurence Armand-Lefevre, Mehdi Marzouk, Romain Sonneville, Lila Bouadma, Marie Petitjean, Fariza Lamara, Etienne de Montmollin, Jean-Francois Timsit and Etienne Ruppé
    Citation: Critical Care 2022 26:300