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  1. Endothelial dysfunction and injury is a major pathophysiologic feature of sepsis. Sepsis is also the most frequent cause of acute kidney injury (AKI) in critically ill patients. Though most studies of AKI in s...

    Authors: Wen-Kuang Yu, J. Brennan McNeil, Nancy E. Wickersham, Ciara M. Shaver, Julie A. Bastarache and Lorraine B. Ware

    Citation: Critical Care 2021 25:48

    Content type: Research

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  2. Metabolic acidosis is a major complication of critical illness. However, its current epidemiology and its treatment with sodium bicarbonate given to correct metabolic acidosis in the ICU are poorly understood.

    Authors: Tomoko Fujii, Andrew A. Udy, Alistair Nichol, Rinaldo Bellomo, Adam M. Deane, Khaled El-Khawas, Naorungroj Thummaporn, Ary Serpa Neto, Hannah Bergin, Robert Short-Burchell, Chin-Ming Chen, Kuang-Hua Cheng, Kuo-Chen Cheng, Clemente Chia, Feng-Fan Chiang, Nai-Kuan Chou…

    Citation: Critical Care 2021 25:45

    Content type: Research

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  3. Ventilator-associated pneumonia (VAP) is the most common hospital-acquired infection (HAI) in intensive care units (ICUs). Ventilator-associated event (VAE), a more objective definition, has replaced tradition...

    Authors: Qiao He, Wen Wang, Shichao Zhu, Mingqi Wang, Yan Kang, Rui Zhang, Kang Zou, Zhiyong Zong and Xin Sun

    Citation: Critical Care 2021 25:44

    Content type: Research

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  4. Appropriate perioperative fluid management is of pivotal importance to reduce postoperative complications, which impact on early and long-term patient outcome. The so-called perioperative goal-directed therapy...

    Authors: Antonio Messina, Chiara Robba, Lorenzo Calabrò, Daniel Zambelli, Francesca Iannuzzi, Edoardo Molinari, Silvia Scarano, Denise Battaglini, Marta Baggiani, Giacomo De Mattei, Laura Saderi, Giovanni Sotgiu, Paolo Pelosi and Maurizio Cecconi

    Citation: Critical Care 2021 25:43

    Content type: Research

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  5. Sleep amongst intensive care patients is reduced and highly fragmented which may adversely impact on recovery. The current challenge for Intensive Care clinicians is identifying feasible and accurate assessmen...

    Authors: L. J. Delaney, E. Litton, K. L. Melehan, H.-C. C. Huang, V. Lopez and F. Van Haren

    Citation: Critical Care 2021 25:42

    Content type: Research

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  6. Rhabdomyolysis is frequently occurring in critically ill patients, resulting in a high risk of acute kidney injury (AKI) and potentially permanent kidney damage due to increased myoglobin levels. The extracorp...

    Authors: Christina Scharf, Uwe Liebchen, Michael Paal, Michael Irlbeck, Michael Zoller and Ines Schroeder

    Citation: Critical Care 2021 25:41

    Content type: Research

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  7. The current coronavirus pandemic has impacted heavily on ICUs worldwide. Although many hospitals and healthcare systems had plans in place to manage multiple casualties as a result of major natural disasters o...

    Authors: Jean-Louis Vincent, Julia Wendon, Greg S. Martin, Nicole P. Juffermans, Jacques Creteur and Maurizio Cecconi

    Citation: Critical Care 2021 25:40

    Content type: Viewpoint

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  8. The EMiC2 membrane is a medium cut-off haemofilter (45 kiloDalton). Little is known regarding its efficacy in eliminating medium-sized cytokines in sepsis. This study aimed to explore the effects of continuous...

    Authors: Nuttha Lumlertgul, Anna Hall, Luigi Camporota, Siobhan Crichton and Marlies Ostermann

    Citation: Critical Care 2021 25:39

    Content type: Research

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  9. Extracorporeal life support (ECLS) has become an integral part of modern intensive therapy. The choice of support mode depends largely on the indication. Patients with respiratory failure are predominantly tre...

    Authors: Benjamin Friedrichson, Haitham Mutlak, Kai Zacharowski and Florian Piekarski

    Citation: Critical Care 2021 25:38

    Content type: Research

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    The Letter to this article has been published in Critical Care 2021 25:123

  10. Sepsis is a life-threatening condition accompanied by organ dysfunction subsequent to a dysregulated host response to infection. Up to 60% of patients with sepsis develop acute kidney injury (AKI), which is as...

    Authors: Elisabeth C. van der Slikke, Bastiaan S. Star, Matijs van Meurs, Robert H. Henning, Jill Moser and Hjalmar R. Bouma

    Citation: Critical Care 2021 25:36

    Content type: Research

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  11. Rapid response teams are intended to improve early diagnosis and intervention in ward patients who develop acute respiratory or circulatory failure. A management protocol including the use of a handheld ultras...

    Authors: Laurent Zieleskiewicz, Alexandre Lopez, Sami Hraiech, Karine Baumstarck, Bruno Pastene, Mathieu Di Bisceglie, Benjamin Coiffard, Gary Duclos, Alain Boussuges, Xavier Bobbia, Sharon Einav, Laurent Papazian and Marc Leone

    Citation: Critical Care 2021 25:34

    Content type: Research

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  12. A recent study found serum neurofilament light chain (NfL) levels to be strongly associated with poor neurological outcome in patients after cardiac arrest. Our aim was to confirm these findings in an independ...

    Authors: Sabina Hunziker, Adrian Quinto, Maja Ramin-Wright, Christoph Becker, Katharina Beck, Alessia Vincent, Kai Tisljar, Giulio Disanto, Pascal Benkert, David Leppert, Hans Pargger, Stephan Marsch, Raoul Sutter, Nils Peters and Jens Kuhle

    Citation: Critical Care 2021 25:32

    Content type: Research

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  13. The properties of semi-elemental enteral nutrition might theoretically improve gastrointestinal tolerance in brain-injured patients, known to suffer gastroparesis. The purpose of this study was to compare the ...

    Authors: Laurent Carteron, Emmanuel Samain, Hadrien Winiszewski, Gilles Blasco, Anne-Sophie Balon, Camille Gilli, Gael Piton, Gilles Capellier, Sebastien Pili-Floury and Guillaume Besch

    Citation: Critical Care 2021 25:31

    Content type: Research

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  14. A prediction model of mortality for patients with acute poisoning has to consider both poisoning-related characteristics and patients’ physiological conditions; moreover, it must be applicable to patients of a...

    Authors: Kap Su Han, Su Jin Kim, Eui Jung Lee, Joong Ho Shin, Ji Sung Lee and Sung Woo Lee

    Citation: Critical Care 2021 25:29

    Content type: Research

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  15. The objective of this study was to describe the prevalence, incidence, prognostic factors, and outcomes of venous thromboembolism in critically ill patients receiving contemporary thrombosis prophylaxis.

    Authors: Ruben J. Eck, Lisa Hulshof, Renske Wiersema, Chris H. L. Thio, Bart Hiemstra, Niels C. Gritters van den Oever, Reinold O. B. Gans, Iwan C. C. van der Horst, Karina Meijer and Frederik Keus

    Citation: Critical Care 2021 25:27

    Content type: Research

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  16. In patients intubated for mechanical ventilation, prolonged diaphragm inactivity could lead to weakness and poor outcome. Time to resume a minimal diaphragm activity may be related to sedation practice and pat...

    Authors: Michael Chaim Sklar, Fabiana Madotto, Annemijn Jonkman, Michela Rauseo, Ibrahim Soliman, L. Felipe Damiani, Irene Telias, Sebastian Dubo, Lu Chen, Nuttapol Rittayamai, Guang-Qiang Chen, Ewan C. Goligher, Martin Dres, Remi Coudroy, Tai Pham, Ricard M. Artigas…

    Citation: Critical Care 2021 25:26

    Content type: Research

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  17. Pandemic COVID-19 caused by the coronavirus SARS-CoV-2 has a high incidence of patients with severe acute respiratory syndrome (SARS). Many of these patients require admission to an intensive care unit (ICU) f...

    Authors: Mailis Maes, Ellen Higginson, Joana Pereira-Dias, Martin D. Curran, Surendra Parmar, Fahad Khokhar, Delphine Cuchet-Lourenço, Janine Lux, Sapna Sharma-Hajela, Benjamin Ravenhill, Islam Hamed, Laura Heales, Razeen Mahroof, Amelia Soderholm, Sally Forrest, Sushmita Sridhar…

    Citation: Critical Care 2021 25:25

    Content type: Research

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    The Correction to this article has been published in Critical Care 2021 25:130

  18. Community-acquired pneumonia (CAP), especially pneumococcal CAP (P-CAP), is associated with a heavy burden of illness as evidenced by high rates of intensive care unit (ICU) admission, mortality, and costs. Al...

    Authors: Claire Dupuis, Ayman Sabra, Juliette Patrier, Gwendoline Chaize, Amine Saighi, Céline Féger, Alexandre Vainchtock, Jacques Gaillat and Jean-François Timsit

    Citation: Critical Care 2021 25:24

    Content type: Research

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  19. Biomarkers of disease severity might help individualizing the management of patients with the acute respiratory distress syndrome (ARDS). Whether the alveolar compartmentalization of biomarkers has a clinical ...

    Authors: Inès Bendib, Asma Beldi-Ferchiou, Frédéric Schlemmer, Mathieu Surenaud, Bernard Maitre, Anne Plonquet, Guillaume Carteaux, Keyvan Razazi, Veronique Godot, Sophie Hüe, Armand Mekontso Dessap and Nicolas de Prost

    Citation: Critical Care 2021 25:23

    Content type: Research

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    The Letter to this article has been published in Critical Care 2021 25:120

  20. Providing optimal care to patients with acute respiratory illness while preventing hospital transmission of COVID-19 is of paramount importance during the pandemic; the challenge lies in achieving both goals s...

    Authors: David Leasa, Paul Cameron, Kimia Honarmand, Tina Mele and Karen J. Bosma

    Citation: Critical Care 2021 25:22

    Content type: Review

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  21. Several studies have shown that heart rate control with selective beta-1 blockers in septic shock is safe. In these trials, esmolol was administered 24 h after onset of septic shock in patients who remained ta...

    Authors: Bruno Levy, Caroline Fritz, Caroline Piona, Kevin Duarte, Andrea Morelli, Philippe Guerci, Antoine Kimmoun and Nicolas Girerd

    Citation: Critical Care 2021 25:21

    Content type: Research

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  22. Sepsis has a high mortality rate, but no specific drug has been proven effective, prompting the development of new drugs. Immunologically, sepsis can involve hyperinflammation, immune paralysis, or both, which...

    Authors: Jung Wook Hwang, Min Ji Lee, Tae Nyoung Chung, Han A. Reum Lee, Jung Ho Lee, Seo Yoon Choi, Ye Jin Park, Chul Hee Kim, Isom Jin, Seong Hoon Kim, Hyo-Bum Kwak, Jun-Won Heo, Kwangmin Na, Sangchun Choi, Yong-Soo Choi and Kyuseok Kim

    Citation: Critical Care 2021 25:20

    Content type: Research

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  23. Intradialytic hypotension (IDH) is a frequent complication of intermittent hemodialysis (IHD), occurring from 15 to 50% of ambulatory sessions, and is more frequent among hospitalized patients with hypoalbumin...

    Authors: Etienne Macedo, Bethany Karl, Euyhyun Lee and Ravindra L. Mehta

    Citation: Critical Care 2021 25:18

    Content type: Research

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  24. Supplementation of vitamin C in septic patients remains controversial despite eight large clinical trials published only in 2020. We aimed to evaluate the evidence on potential effects of vitamin C treatment o...

    Authors: Sean S. Scholz, Rainer Borgstedt, Nicole Ebeling, Leoni C. Menzel, Gerrit Jansen and Sebastian Rehberg

    Citation: Critical Care 2021 25:17

    Content type: Research

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  25. This systematic review and meta-analysis aimed to determine the effectiveness of systematic early mobilization in improving muscle strength and physical function in mechanically ventilated intensive care unit ...

    Authors: Dominik Menges, Bianca Seiler, Yuki Tomonaga, Matthias Schwenkglenks, Milo A. Puhan and Henock G. Yebyo

    Citation: Critical Care 2021 25:16

    Content type: Research

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  26. Acute kidney injury (AKI) is a common serious complication in critically ill patients. AKI occurs in up to 50% patients in intensive care unit (ICU), with poor clinical prognosis. Renal replacement therapy (RR...

    Authors: Xiaoming Li, Chao Liu, Zhi Mao, Qinglin Li and Feihu Zhou

    Citation: Critical Care 2021 25:15

    Content type: Research

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  27. Mechanical power (MP) refers to the energy delivered by a ventilator to the respiratory system per unit of time. MP referenced to predicted body weight (PBW) or respiratory system compliance have better predic...

    Authors: Li-Chung Chiu, Shih-Wei Lin, Li-Pang Chuang, Hsin-Hsien Li, Pi-Hua Liu, Feng-Chun Tsai, Chih-Hao Chang, Chen-Yiu Hung, Chung-Shu Lee, Shaw-Woei Leu, Han-Chung Hu, Chung-Chi Huang, Huang-Pin Wu and Kuo-Chin Kao

    Citation: Critical Care 2021 25:13

    Content type: Research

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  28. Sepsis is a major health issue in preterm infants. Biomarkers are used to diagnose and monitor patients with sepsis, but C-reactive protein (CRP) is proven not predictive at onset of late onset neonatal sepsis...

    Authors: Şerife Kurul, Sinno H. P. Simons, Christian R. B. Ramakers, Yolanda B. De Rijke, René F. Kornelisse, Irwin K. M. Reiss and H. Rob Taal

    Citation: Critical Care 2021 25:12

    Content type: Research

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  29. Over 138,000 patients are discharged to hospital wards from intensive care units (ICUs) in England, Wales and Northern Ireland annually. More than 8000 die before leaving hospital. In hospital-wide populations...

    Authors: Sarah Vollam, Owen Gustafson, J. Duncan Young, Benjamin Attwood, Liza Keating and Peter Watkinson

    Citation: Critical Care 2021 25:10

    Content type: Research

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  30. Venoarterial extracorporeal membrane oxygenation (VA-ECMO) provides heart mechanical support in critically ill patients with cardiogenic shock. Despite important progresses in the management of patients under ...

    Authors: Aurélien Frerou, Mathieu Lesouhaitier, Murielle Gregoire, Fabrice Uhel, Arnaud Gacouin, Florian Reizine, Caroline Moreau, Aurélie Loirat, Adel Maamar, Nicolas Nesseler, Amedeo Anselmi, Erwan Flecher, Jean-Philippe Verhoye, Yves Le Tulzo, Michel Cogné, Mikael Roussel…

    Citation: Critical Care 2021 25:9

    Content type: Research

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  31. Burnout has gained increasing attention worldwide; however, there is a lack of relevant research in China. This study investigated the prevalence and factors associated with burnout in physicians of the intens...

    Authors: Jing Wang, Bo Hu, Zhiyong Peng, Huimin Song, Shuhan Cai, Xin Rao, Lu Li and Jianguo Li

    Citation: Critical Care 2021 25:8

    Content type: Research

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  32. Acute kidney injury (AKI) is a common yet possibly fatal complication among critically ill patients in intensive care units (ICU). Although renal replacement therapy (RRT) is an important supportive management...

    Authors: Heng-Chih Pan, Ying-Ying Chen, I-Jung Tsai, Chih-Chung Shiao, Tao-Min Huang, Chieh-Kai Chan, Hung-Wei Liao, Tai-Shuan Lai, Yvonne Chueh, Vin-Cent Wu and Yung-Ming Chen

    Citation: Critical Care 2021 25:5

    Content type: Research

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  33. Extracorporeal membrane oxygenation (ECMO) support in acute respiratory failure may be lifesaving, but bleeding and thromboembolic complications are common. The optimal anticoagulation strategy balancing these...

    Authors: Benjamin Seeliger, Michael Döbler, Robert Friedrich, Klaus Stahl, Christian Kühn, Johann Bauersachs, Folkert Steinhagen, Stefan F. Ehrentraut, Jens-Christian Schewe, Christian Putensen, Tobias Welte, Marius M. Hoeper, Andreas Tiede, Sascha David and Christian Bode

    Citation: Critical Care 2021 24:701

    Content type: Research

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    The Letter to this article has been published in Critical Care 2021 25:124

  34. Patients with COVID-19 (COVID) may develop acute respiratory distress syndrome with or without sepsis, coagulopathy and visceral damage. While chest CT scans are routinely performed in the initial assessment o...

    Authors: Pelagia Cuvelier, Hélène Roux, Anne Couëdel-Courteille, Jacques Dutrieux, Cécile Naudin, Bénédicte Charmeteau de Muylder, Rémi Cheynier, Pierre Squara and Stefano Marullo

    Citation: Critical Care 2021 25:4

    Content type: Research

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  35. Critically ill patients with coronavirus disease 19 (COVID-19) have a high fatality rate likely due to a dysregulated immune response. Corticosteroids could attenuate this inappropriate response, although ther...

    Authors: Pablo Monedero, Alfredo Gea, Pedro Castro, Angel M. Candela-Toha, María L. Hernández-Sanz, Egoitz Arruti, Jesús Villar and Carlos Ferrando

    Citation: Critical Care 2021 25:2

    Content type: Research

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