Articles

Obituary: Professor Claude Martin

Authors: Marc Leone and Jean-Louis Vincent

Low-flow assessment of current ECMO/ECCO₂R rotary blood pumps and the potential effect on hemocompatibility

Extracorporeal carbon dioxide removal (ECCO₂R) uses an extracorporeal circuit to directly remove carbon dioxide from the blood either in lieu of mechanical ventilation or in combination with it. While the potenti...

Authors: Sascha Gross-Hardt, Felix Hesselmann, Jutta Arens, Ulrich Steinseifer, Leen Vercaemst, Wolfram Windisch, Daniel Brodie and Christian Karagiannidis

Effect of tranexamic acid on mortality in patients with haemoptysis: a nationwide study

Although tranexamic acid is widely used in patients with haemoptysis, whether it improves mortality has not been well investigated. The aim of this study was to evaluate the effect of tranexamic acid on in-hos...

Authors: Takahiro Kinoshita, Hiroyuki Ohbe, Hiroki Matsui, Kiyohide Fushimi, Hiroshi Ogura and Hideo Yasunaga

A novel non-invasive method to detect excessively high respiratory effort and dynamic transpulmonary driving pressure during mechanical ventilation

Excessive respiratory muscle effort during mechanical ventilation may cause patient self-inflicted lung injury and load-induced diaphragm myotrauma, but there are no non-invasive methods to reliably detect ele...

Authors: Michele Bertoni, Irene Telias, Martin Urner, Michael Long, Lorenzo Del Sorbo, Eddy Fan, Christer Sinderby, Jennifer Beck, Ling Liu, Haibo Qiu, Jenna Wong, Arthur S. Slutsky, Niall D. Ferguson, Laurent J. Brochard and Ewan C. Goligher

Caution should be taken when using electronic health record database

Authors: Lina Wang and Xiaoming Wu

High-flow nasal cannula oxygen therapy versus conventional oxygen therapy in patients after planned extubation

Authors: Meng-Si Luo, Guan-Jiang Huang and Lun Wu

Hemoadsorption efficacy for uncomplicated high-risk cardiac surgery

Authors: Sébastien Redant, Matthieu Legrand, Yael Langman, Alejandra Garcia Aguilar, François Angoulvant, Keitiane Kaefer, David De Bels, Rachid Attou, Kianoush Kashani and Patrick M. Honore

Intracranial hypertension and deep sedation

Authors: Guillermo Bugedo and César Santis

NT-proBNP levels might predict outcomes in severe sepsis, but renal function cannot be ignored

Authors: Jiarong Ye, Qianrong Liang and Xiaotu Xi

The place of dexmedetomidine light sedation in patients with acute brain injury

Authors: Simone Carelli, Gennaro De Pascale, Nicoletta Filetici, Maria Grazia Bocci, Gian Marco Maresca, Salvatore Lucio Cutuli, Cecilia Maria Pizzo, Giuseppe Bello, Luca Montini, Anselmo Caricato, Giorgio Conti and Massimo Antonelli

What should be the best dialysis catheter lock in critically ill patients?

Authors: Patrick M. Honore, Leonel Barreto Gutierrez, Sebastien Redant, Keitiane Kaefer, Andrea Gallerani and David De Bels

Adaptive mechanical ventilation with automated minimization of mechanical power—a pilot randomized cross-over study

Adaptive mechanical ventilation automatically adjusts respiratory rate (RR) and tidal volume (V_T) to deliver the clinically desired minute ventilation, selecting RR and V_T based on Otis’ equation on least work of...

Authors: Tobias Becher, Anna Adelmeier, Inéz Frerichs, Norbert Weiler and Dirk Schädler

Preparing intensive care for the next pandemic influenza

Few viruses have shaped the course of human history more than influenza viruses. A century since the 1918–1919 Spanish influenza pandemic—the largest and deadliest influenza pandemic in recorded history—we hav...

Authors: Taylor Kain and Robert Fowler

Comment upon “Time to epinephrine treatment is associated with the risk of mortality in children who achieve sustained ROSC after traumatic out-of-hospital cardiac arrest”

Authors: Benjamin Post, Dominic Peter Douglas Nielsen and Anil Visram

Biomarkers and clinical scores to identify patient populations at risk of delayed antibiotic administration or intensive care admission

The performance of blood biomarkers (mid-regional proadrenomedullin (MR-proADM), procalcitonin (PCT), C-reactive protein (CRP), and lactate) and clinical scores (Sequential Organ Failure Assessment (SOFA), Nat...

Authors: Juan Gonzalez del Castillo, Darius Cameron Wilson, Carlota Clemente-Callejo, Francisco Román, Ignasi Bardés-Robles, Inmaculada Jiménez, Eva Orviz, Macarena Dastis-Arias, Begoña Espinosa, Fernando Tornero-Romero, Jordi Giol-Amich, Veronica González and Ferran Llopis-Roca

Correlation between end-tidal carbon dioxide and the degree of compression of heart cavities measured by transthoracic echocardiography during cardiopulmonary resuscitation for out-of-hospital cardiac arrest

The concept of personalized cardiopulmonary resuscitation (CPR) requires a parameter that reflects its hemodynamic efficiency. While intra-arrest ultrasound is increasingly implemented into the advanced life s...

Authors: Roman Skulec, Petr Vojtisek and Vladimir Cerny

Prognostic performance of age-adapted SOFA and qSOFA in septic children

Authors: Xuepeng Zhang, Xiying Gui, Kaiying Yang, Siyuan Chen and Yi Ji

Positive cultures and clinical outcomes in septic patients: be aware of the influence from patient selection and the in-hospital confounders

Authors: Romain Jouffroy and Benoît Vivien

How levosimendan can improve renal function?

Authors: Patrick M. Honore, Leonel Barreto Gutierrez, Sebastien Redant, Keitiane Kaefer, Andrea Gallerani and David De Bels

Clinical significance of lymphocytopenia in patients hospitalized with pneumonia caused by influenza virus

Authors: Valeria Bellelli, Gabriella d’Ettorre, Luigi Celani, Cristian Borrazzo, Giancarlo Ceccarelli and Mario Venditti

The interactive effects of input and output on managing fluid balance in patients with acute kidney injury requiring continuous renal replacement therapy

The interactive effect of cumulative input and output on achieving optimal fluid balance has not been well elucidated in patients with acute kidney injury (AKI) requiring continuous renal replacement therapy (...

Authors: Jong Hyun Jhee, Hye Ah Lee, Seonmi Kim, Youn Kyung Kee, Ji Eun Lee, Shina Lee, Seung-Jung Kim, Duk-Hee Kang, Kyu Bok Choi, Hyung Jung Oh and Dong-Ryeol Ryu

Obesity inducing acute respiratory distress syndrome: we should choose the right population!

Authors: Patrick M. Honore, Leonel Barreto Gutierrez, Sebastien Redant, Keitiane Kaefer, Andrea Gallerani and David De Bels

SSEP retains its value as predictor of poor outcome following cardiac arrest in the era of therapeutic hypothermia

To re-evaluate the role of median nerve somatosensory evoked potentials (SSEPs) and bilateral loss of the N20 cortical wave as a predictor of unfavorable outcome in comatose patients following cardiac arrest (...

Authors: Ted L. Rothstein

How I optimize power to avoid VILI

Authors: John J. Marini

Correction to: Tracheal intubation in critically ill patients: a comprehensive systematic review of randomized trials

In the publication of this article [1], there was an error in a contributors Family Name. This has now been updated in the original article.

Authors: Luca Cabrini, Giovanni Landoni, Martina Baiardo Redaelli, Omar Saleh, Carmine D. Votta, Evgeny Fominskiy, Alessandro Putzu, Cézar Daniel Snak de Souza, Massimo Antonelli, Rinaldo Bellomo, Paolo Pelosi and Alberto Zangrillo

Rescue fecal microbiota transplantation for antibiotic-associated diarrhea in critically ill patients

Antibiotic-associated diarrhea (AAD) is a risk factor for exacerbating the outcome of critically ill patients. Dysbiosis induced by the exposure to antibiotics reveals the potential therapeutic role of fecal m...

Authors: Min Dai, Yafei Liu, Wei Chen, Heena Buch, Yi Shan, Liuhui Chang, Yong Bai, Chen Shen, Xiaoyin Zhang, Yufeng Huo, Dian Huang, Zhou Yang, Zhihang Hu, Xuwei He, Junyu Pan, Lili Hu…

Early prognostication of neurological outcome by heart rate variability in adult patients with out-of-hospital sudden cardiac arrest

Most deaths of comatose survivors of out-of-hospital sudden cardiac arrest result from withdrawal of life-sustaining treatment (WLST) decisions based on poor neurological prognostication and the family’s inten...

Authors: Hiroshi Endoh, Natuo Kamimura, Hiroyuki Honda and Masakazu Nitta

Correction to: Procalcitonin levels in candidemia versus bacteremia: a systematic review

The author wish to note there are three imprecisions in the article [1].

Authors: Andrea Cortegiani, Giovanni Misseri, Mariachiara Ippolito, Matteo Bassetti, Antonino Giarratano, Ignacio Martin-Loeches and Sharon Einav

Myocardial ischemia during ventilator weaning: a prospective multicenter cohort study

Weaning-induced cardiac pulmonary edema (WiPO) is one of the main mechanisms of weaning failure during mechanical ventilation. We hypothesized that weaning-induced cardiac ischemia (WiCI) may contribute to wea...

Authors: Alexandre Bedet, Françoise Tomberli, Gwenael Prat, Pierre Bailly, Achille Kouatchet, Sater Mortaza, Emmanuel Vivier, Sylvene Rosselli, Larissa Lipskaia, Guillaume Carteaux, Keyvan Razazi and Armand Mekontso Dessap

Epinephrine, inodilator, or no inotrope in venoarterial extracorporeal membrane oxygenation implantation: a single-center experience

Venoarterial extracorporeal membrane oxygenation (VA-ECMO) can be a rescue therapy for patients in cardiogenic shock or in refractory cardiac arrest. After cannulation, vasoplegia and cardiac depression are fr...

Authors: Viviane Zotzmann, Jonathan Rilinger, Corinna N. Lang, Klaus Kaier, Christoph Benk, Daniel Duerschmied, Paul M. Biever, Christoph Bode, Tobias Wengenmayer and Dawid L. Staudacher

Preoxygenation before intubation in adult patients with acute hypoxemic respiratory failure: a network meta-analysis of randomized trials

Patients with acute hypoxemic respiratory failure are at risk for life-threatening complications during endotracheal intubation. Preoxygenation might help reduce the risk of hypoxemia and intubation-related co...

Authors: Ka Man Fong, Shek Yin Au and George Wing Yiu Ng

Metabolic support in the critically ill: a consensus of 19

Metabolic alterations in the critically ill have been studied for more than a century, but the heterogeneity of the critically ill patient population, the varying duration and severity of the acute phase of il...

Authors: Jan Wernerman, Kenneth B. Christopher, Djillali Annane, Michael P. Casaer, Craig M. Coopersmith, Adam M. Deane, Elisabeth De Waele, Gunnar Elke, Carole Ichai, Constantine J. Karvellas, Stephen A. McClave, Heleen M. Oudemans-van Straaten, Olav Rooyackers, Renee D. Stapleton, Jukka Takala, Arthur R. H. van Zanten…

Hemoadsorption with CytoSorb shows a decreased observed versus expected 28-day all-cause mortality in ICU patients with septic shock: a propensity-score-weighted retrospective study

Innovative treatment modalities have not yet shown a clinical benefit in patients with septic shock. To reduce severe cytokinaemia, CytoSorb as an add-on to continuous renal replacement therapy (CRRT) showed p...

Authors: Willem Pieter Brouwer, Servet Duran, Martijn Kuijper and Can Ince

How I wean patients from veno-venous extra-corporeal membrane oxygenation

Authors: Francesco Vasques, Federica Romitti, Luciano Gattinoni and Luigi Camporota

Letter by Neugebauer et al. regarding article “Hypothermia after decompressive hemicraniectomy in treatment of malignant middle cerebral artery stroke: comment on the randomized clinical trial”

Authors: Hermann Neugebauer, Hauke Schneider and Rainer Kollmar

Candida bloodstream infection under veno-arterial ECMO therapy

Authors: Quentin de Roux, Françoise Botterel, Raphaël Lepeule, Fabio Silvio Taccone, Olivier Langeron and Nicolas Mongardon

What is the best core measure after critical illness when the IES-R is no longer accessible for new researchers?

Authors: Reba Umberger

Comparison of echocardiographic indices of right ventricular systolic function and ejection fraction obtained with continuous thermodilution in critically ill patients

Though echocardiographic evaluation assesses the right ventricular systolic function, which of the existing parameters best reflects the right ventricular ejection fraction (RVEF) in the critically ill patient...

Authors: Romain Barthélémy, Xavier Roy, Tujia Javanainen, Alexandre Mebazaa and Benjamin Glenn Chousterman

Relationship of mottling score, skin microcirculatory perfusion indices and biomarkers of endothelial dysfunction in patients with septic shock: an observational study

In patients with septic shock, the skin is often chosen for the evaluation of peripheral perfusion and oxygenation. Changes in skin microcirculatory vessel oxygen saturation and relative hemoglobin concentrati...

Authors: Sigita Kazune, Anastasija Caica, Karina Volceka, Olegs Suba, Uldis Rubins and Andris Grabovskis

SEA-mulation: training for technical treatment related to emergency situations in maritime environment

Authors: Brice Loddé, Gael-Emgan Querellou, Alexandre Morel and Erwan L’Her

Transfusion practice in the non-bleeding critically ill: an international online survey—the TRACE survey

Over the last decade, multiple large randomized controlled trials have studied alternative transfusion strategies in critically ill patients, demonstrating the safety of restrictive transfusion strategies. Due...

Authors: Sanne de Bruin, Thomas W. L. Scheeren, Jan Bakker, Robin van Bruggen and Alexander P. J. Vlaar

Differential contractile response of critically ill patients to neuromuscular electrical stimulation

Neuromuscular electrical stimulation (NMES) has been investigated as a preventative measure for intensive care unit-acquired weakness. Trial results remain contradictory and therefore inconclusive. As it has b...

Authors: Julius J. Grunow, Moritz Goll, Niklas M. Carbon, Max E. Liebl, Steffen Weber-Carstens and Tobias Wollersheim

Impact of species and antibiotic therapy of enterococcal peritonitis on 30-day mortality in critical care—an analysis of the OUTCOMEREA database

Enterococcus species are associated with an increased morbidity in intraabdominal infections (IAI). However, their impact on mortality remains uncertain. Moreover, the influence on outcome of the appropriate or i...

Authors: Anne-Cécile Morvan, Baptiste Hengy, Maïté Garrouste-Orgeas, Stéphane Ruckly, Jean-Marie Forel, Laurent Argaud, Thomas Rimmelé, Jean-Pierre Bedos, Elie Azoulay, Claire Dupuis, Bruno Mourvillier, Carole Schwebel and Jean-François Timsit

Center effect in intubation risk in critically ill immunocompromised patients with acute hypoxemic respiratory failure

Acute respiratory failure is the leading reason for intensive care unit (ICU) admission in immunocompromised patients, and the need for invasive mechanical ventilation has become a major clinical endpoint in r...

Authors: Guillaume Dumas, Alexandre Demoule, Djamel Mokart, Virginie Lemiale, Saad Nseir, Laurent Argaud, Frédéric Pène, Loay Kontar, Fabrice Bruneel, Kada Klouche, François Barbier, Jean Reignier, Annabelle Stoclin, Guillaume Louis, Jean-Michel Constantin, Florent Wallet…

Neuromuscular blocking agents for acute respiratory distress syndrome: how did we get conflicting results?

Authors: Heather Torbic, Sudhir Krishnan and Abhijit Duggal

Sevoflurane and nephrogenic diabetes insipidus on the rise: copeptin to the rescue?

Authors: Patrick M. Honore, David De Bels, Leonel Barreto Gutierrez, Sebastien Redant, Andrea Gallerani and Willem Boer

Host susceptibility to severe influenza A virus infection

Most people exposed to a new flu virus do not notice any symptoms. A small minority develops critical illness. Some of this extremely broad variation in susceptibility is explained by the size of the initial i...

Authors: Sara Clohisey and John Kenneth Baillie

Recombinant human soluble thrombomodulin in patients with sepsis-associated coagulopathy (SCARLET): an updated meta-analysis

Authors: Kazuma Yamakawa, Jerrold H. Levy and Toshiaki Iba

Co-administration of iloprost and eptifibatide in septic shock (CO-ILEPSS)—a randomised, controlled, double-blind investigator-initiated trial investigating safety and efficacy

Part of the pathophysiology in septic shock is a progressive activation of the endothelium and platelets leading to widespread microvascular injury with capillary leakage, microthrombi and consumption coagulop...

Authors: Rasmus Ehrenfried Berthelsen, Sisse Rye Ostrowski, Morten Heiberg Bestle and Per Ingemar Johansson

Time-based capnography detects ineffective triggering in mechanically ventilated children

Authors: Robert G. T. Blokpoel, Alette A. Koopman, Jefta van Dijk, Frans H. C. de Jongh, Johannes G. M. Burgerhof and Martin C. J. Kneyber