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  1. The impact of corticosteroid therapy on outcomes of patients with coronavirus disease 2019 (COVID-19) is highly controversial. We aimed to compare the risk of death between COVID-19-related ARDS patients with ...

    Authors: Chaomin Wu, Dongni Hou, Chunling Du, Yanping Cai, Junhua Zheng, Jie Xu, Xiaoyan Chen, Cuicui Chen, Xianglin Hu, Yuye Zhang, Juan Song, Lu Wang, Yen-cheng Chao, Yun Feng, Weining Xiong, Dechang Chen…

    Citation: Critical Care 2020 24:643

    Content type: Research

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  2. Clinical practice guidelines recommend performing a cuff leak test in mechanically ventilated adults who meet extubation criteria to screen those at high risk for post-extubation stridor. Previous systematic r...

    Authors: Akira Kuriyama, Jeffrey L. Jackson and Jun Kamei

    Citation: Critical Care 2020 24:640

    Content type: Research

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  3. Patients surviving critical illness develop muscle weakness and impairments in physical function; however, the relationship between early skeletal muscle alterations and physical function at hospital discharge...

    Authors: Kirby P. Mayer, Melissa L. Thompson Bastin, Ashley A. Montgomery-Yates, Amy M. Pastva, Esther E. Dupont-Versteegden, Selina M. Parry and Peter E. Morris

    Citation: Critical Care 2020 24:637

    Content type: Research

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  4. Biomarkers can be of help to understand critical illness and to identify and stratify sepsis. Adrenomedullin is a vasoactive hormone, with reported prognostic and potentially therapeutic value in sepsis. The p...

    Authors: Oscar H. M. Lundberg, Maria Lengquist, Martin Spångfors, Martin Annborn, Deborah Bergmann, Janin Schulte, Helena Levin, Olle Melander, Attila Frigyesi and Hans Friberg

    Citation: Critical Care 2020 24:636

    Content type: Research

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  5. Omega-3 (ω-3) fatty acid (FA)-containing parenteral nutrition (PN) is associated with significant improvements in patient outcomes compared with standard PN regimens without ω-3 FA lipid emulsions. Here, we ev...

    Authors: Lorenzo Pradelli, Stanislaw Klek, Konstantin Mayer, Abdul Jabbar Omar Alsaleh, Martin D. Rosenthal, Axel R. Heller and Maurizio Muscaritoli

    Citation: Critical Care 2020 24:634

    Content type: Research

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  6. Survivors of critical illness have significant psychopathological comorbidity. The treatments offered by primary health care professionals to affected patients are unstudied.

    Authors: Robert Hatch, Duncan Young, Vicki S. Barber, John Griffiths, David A. Harrison and Peter J. Watkinson

    Citation: Critical Care 2020 24:633

    Content type: Research

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  7. COVID-19-related ARDS has unique features when compared with ARDS from other origins, suggesting a distinctive inflammatory pathogenesis. Data regarding the host response within the lung are sparse. The object...

    Authors: Mathieu Blot, Marine Jacquier, Ludwig-Serge Aho Glele, Guillaume Beltramo, Maxime Nguyen, Philippe Bonniaud, Sebastien Prin, Pascal Andreu, Belaid Bouhemad, Jean-Baptiste Bour, Christine Binquet, Lionel Piroth, Jean-Paul Pais de Barros, David Masson, Jean-Pierre Quenot and Pierre-Emmanuel Charles

    Citation: Critical Care 2020 24:632

    Content type: Research

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  8. Incidence of right ventricular (RV) failure in septic shock patients is not well known, and tricuspid annular plane systolic excursion (TAPSE) could be of limited value. We report the incidence of RV failure i...

    Authors: Antoine Vieillard-Baron, Amélie Prigent, Xavier Repessé, Marine Goudelin, Gwenaël Prat, Bruno Evrard, Cyril Charron, Philippe Vignon and Guillaume Geri

    Citation: Critical Care 2020 24:630

    Content type: Research

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  9. Neurologic injury is one of the most frequent causes of death in patients undergoing extracorporeal membrane oxygenation (ECMO). As neurological examination is often unreliable in sedated patients, additional ...

    Authors: Lorenzo Peluso, Serena Rechichi, Federico Franchi, Selene Pozzebon, Sabino Scolletta, Alexandre Brasseur, Benjamin Legros, Jean-Louis Vincent, Jacques Creteur, Nicolas Gaspard and Fabio Silvio Taccone

    Citation: Critical Care 2020 24:629

    Content type: Research

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  10. Expiratory muscle weakness leads to difficult ventilator weaning. Maintaining their activity with functional electrical stimulation (FES) may improve outcome. We studied feasibility of breath-synchronized expi...

    Authors: Annemijn H. Jonkman, Tim Frenzel, Euan J. McCaughey, Angus J. McLachlan, Claire L. Boswell-Ruys, David W. Collins, Simon C. Gandevia, Armand R. J. Girbes, Oscar Hoiting, Matthijs Kox, Eline Oppersma, Marco Peters, Peter Pickkers, Lisanne H. Roesthuis, Jeroen Schouten, Zhong-Hua Shi…

    Citation: Critical Care 2020 24:628

    Content type: Research

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  11. Post-discharge deaths are common in patients hospitalized for sepsis, but the drivers of post-discharge deaths are unclear. The objective of this study was to test the hypothesis that hospitals with high risk-...

    Authors: Nicholas M. Mohr, Alexis M. Zebrowski, David F. Gaieski, David G. Buckler and Brendan G. Carr

    Citation: Critical Care 2020 24:626

    Content type: Research

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  12. The physiological behavior of lungs affected by the acute respiratory distress syndrome (ARDS) differs between inspiration and expiration and presents heterogeneous gravity-dependent distribution. This phenome...

    Authors: Gaetano Scaramuzzo, Elena Spinelli, Savino Spadaro, Alessandro Santini, Donatella Tortolani, Francesca Dalla Corte, Antonio Pesenti, Carlo Alberto Volta, Giacomo Grasselli and Tommaso Mauri

    Citation: Critical Care 2020 24:622

    Content type: Research

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  13. Endotracheal intubation (EI) is a potentially lifesaving but high-risk procedure in critically ill patients. While the ACGME mandates that trainees in pulmonary and critical care medicine (PCCM) achieve compet...

    Authors: Wade Brown, Lekshmi Santhosh, Anna K. Brady, Joshua L. Denson, Abesh Niroula, Meredith E. Pugh, Wesley H. Self, Aaron M. Joffe, P. O’Neal Maynord and W. Graham Carlos

    Citation: Critical Care 2020 24:621

    Content type: Viewpoint

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  14. Cardiovascular instability is common in critically ill children. There is a scarcity of published high-quality studies to develop meaningful evidence-based hemodynamic monitoring guidelines and hence, with the...

    Authors: Yogen Singh, Javier Urbano Villaescusa, Eduardo M. da Cruz, Shane M. Tibby, Gabriella Bottari, Rohit Saxena, Marga Guillén, Jesus Lopez Herce, Matteo Di Nardo, Corrado Cecchetti, Joe Brierley, Willem de Boode and Joris Lemson

    Citation: Critical Care 2020 24:620

    Content type: Research

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  15. Subtraction CT angiography (sCTA) is a technique used to evaluate pulmonary perfusion based on iodine distribution maps. The aim of this study is to assess lung perfusion changes with sCTA seen in patients wit...

    Authors: Mario G. Santamarina, Dominique Boisier Riscal, Ignacio Beddings, Roberto Contreras, Martiniano Baque, Mariano Volpacchio and Felipe Martinez Lomakin

    Citation: Critical Care 2020 24:619

    Content type: Research

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  16. ICU patients undergoing invasive mechanical ventilation experience cognitive decline associated with their critical illness and its management. The early detection of different cognitive phenotypes might revea...

    Authors: Sol Fernández-Gonzalo, Guillem Navarra-Ventura, Neus Bacardit, Gemma Gomà Fernández, Candelaria de Haro, Carles Subirà, Josefina López-Aguilar, Rudys Magrans, Leonardo Sarlabous, Jose Aquino Esperanza, Mercè Jodar, Montse Rué, Ana Ochagavía, Diego J. Palao, Rafael Fernández and Lluís Blanch

    Citation: Critical Care 2020 24:618

    Content type: Research

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  17. Natural killer (NK) cells play a major role in immune tolerance after sepsis, and the programmed cell death 1 (PD-1) and programmed cell death ligand 1 (PD-L1) system mediates evasion of host immunity. The cor...

    Authors: Wenqiang Jiang, Xusheng Li, Miaoyun Wen, Xiaoyu Liu, Kangrong Wang, Qiaosheng Wang, Ya Li, Maohua Zhou, Mengting Liu, Bei Hu and Hongke Zeng

    Citation: Critical Care 2020 24:617

    Content type: Research

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  18. Changes in Doppler flow patterns of hepatic veins (HV), portal vein (PV) and intra-renal veins (RV) reflect right atrial pressure and venous congestion; the feasibility of obtaining these assessments and the c...

    Authors: Rory Spiegel, William Teeter, Scott Sullivan, Keegan Tupchong, Nabeel Mohammed, Mark Sutherland, Evan Leibner, Philippe Rola, Samuel M. Galvagno Jr. and Sarah B. Murthi

    Citation: Critical Care 2020 24:615

    Content type: Research

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  19. Sepsis is characterized by a dysregulated immune response to infection leading to life-threatening organ dysfunction. Sepsis-induced liver injury is recognized as a powerful independent predictor of mortality ...

    Authors: Jian Sun, Jingxiao Zhang, Xiangfeng Wang, Fuxi Ji, Claudio Ronco, Jiakun Tian and Yongjie Yin

    Citation: Critical Care 2020 24:614

    Content type: Review

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  20. Data on SARS-CoV-2 load in lower respiratory tract (LRT) are scarce. Our objectives were to describe the viral shedding and the viral load in LRT and to determine their association with mortality in critically...

    Authors: Niccolò Buetti, Paul-Henri Wicky, Quentin Le Hingrat, Stéphane Ruckly, Timothy Mazzuchelli, Ambre Loiodice, Pierpaolo Trimboli, Valentina Forni Ogna, Etienne de Montmollin, Enos Bernasconi, Benoit Visseaux and Jean-François Timsit

    Citation: Critical Care 2020 24:610

    Content type: Research

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  21. Gut dysbiosis due to the adverse effects of antibiotics affects outcomes of lung infection. Previous murine models relied on significant depletion of both gut and lung microbiota, rendering the analysis of imm...

    Authors: Rodrigue Dessein, Marvin Bauduin, Teddy Grandjean, Rémi Le Guern, Martin Figeac, Delphine Beury, Karine Faure, Christelle Faveeuw, Benoit Guery, Philippe Gosset and Eric Kipnis

    Citation: Critical Care 2020 24:611

    Content type: Research

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  22. Clinical frailty among older adults admitted to intensive care has been proposed as an important determinant of patient outcomes. Among this group of patients, an acute episode of delirium is also common, but ...

    Authors: David Sanchez, Kathleen Brennan, Masar Al Sayfe, Sharon-Ann Shunker, Tony Bogdanoski, Sonja Hedges, Yu Chin Hou, Joan Lynch, Leanne Hunt, Evan Alexandrou, Manoj Saxena, Simon Abel, Ramanathan Lakshmanan, Deepak Bhonagiri, Michael J. Parr, Anders Aneman…

    Citation: Critical Care 2020 24:609

    Content type: Research

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  23. Authors: Patrick M. Honore, Leonel Barreto Gutierrez, Luc Kugener, Sebastien Redant, Rachid Attou, Andrea Gallerani and David De Bels

    Citation: Critical Care 2020 24:606

    Content type: Letter

    Published on:

    The original article was published in Critical Care 2020 24:387

  24. Systemic inflammation in COVID-19 often leads to multiple organ failure, including acute kidney injury (AKI). Renal replacement therapy (RRT) in combination with sequential extracorporeal blood purification th...

    Authors: Gianluca Villa, Stefano Romagnoli, Silvia De Rosa, Massimiliano Greco, Marco Resta, Diego Pomarè Montin, Federico Prato, Francesco Patera, Fiorenza Ferrari, Giuseppe Rotondo and Claudio Ronco

    Citation: Critical Care 2020 24:605

    Content type: Research

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  25. Hyperoxemia has been associated with increased mortality in critically ill patients, but little is known about its effect in trauma patients. The objective of this study was to assess the association between e...

    Authors: Josefine S. Baekgaard, Paer-Selim Abback, Marouane Boubaya, Jean-Denis Moyer, Delphine Garrigue, Mathieu Raux, Benoit Champigneulle, Guillaume Dubreuil, Julien Pottecher, Philippe Laitselart, Fleur Laloum, Coralie Bloch-Queyrat, Frédéric Adnet and Catherine Paugam-Burtz

    Citation: Critical Care 2020 24:604

    Content type: Research

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  26. Recurrent delivery of tidal mechanical energy (ME) inflicts ventilator-induced lung injury (VILI) when stress and strain exceed the limits of tissue tolerance. Mechanical power (MP) is the mathematical descrip...

    Authors: Martin C. J. Kneyber, Stavroula Ilia, Alette A. Koopman, Patrick van Schelven, Jefta van Dijk, Johannes G. M. Burgerhof, Dick G. Markhorst and Robert G. T. Blokpoel

    Citation: Critical Care 2020 24:601

    Content type: Research

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  27. Awake prone positioning (awake-PP) in non-intubated coronavirus disease 2019 (COVID-19) patients could avoid endotracheal intubation, reduce the use of critical care resources, and improve survival. We aimed t...

    Authors: Carlos Ferrando, Ricard Mellado-Artigas, Alfredo Gea, Egoitz Arruti, César Aldecoa, Ramón Adalia, Fernando Ramasco, Pablo Monedero, Emilio Maseda, Gonzalo Tamayo, María L. Hernández-Sanz, Jordi Mercadal, Ascensión Martín-Grande, Robert M. Kacmarek, Jesús Villar and Fernando Suárez-Sipmann

    Citation: Critical Care 2020 24:597

    Content type: Research

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  28. Although the prevention of extracorporeal membrane oxygenation (ECMO) catheter-related infection is crucial, scientific evidence regarding best practices are still lacking.

    Authors: Hye Ju Yeo, Dohyung Kim, Mihyang Ha, Hyung Gon Je, Jeong Soo Kim and Woo Hyun Cho

    Citation: Critical Care 2020 24:595

    Content type: Research

    Published on: