Articles
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Citation: Critical Care 2023 27(Suppl 1):119
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Positive end-expiratory pressure induced changes in airway driving pressure in mechanically ventilated COVID-19 Acute Respiratory Distress Syndrome patients
The profile of changes in airway driving pressure (dPaw) induced by positive-end expiratory pressure (PEEP) might aid for individualized protective ventilation. Our aim was to describe the dPaw versus PEEP curves...
Citation: Critical Care 2023 27:118 -
CytoSorb hemoperfusion markedly attenuates circulating cytokine concentrations during systemic inflammation in humans in vivo
The CytoSorb hemoadsorption device has been demonstrated to be capable of clearing inflammatory cytokines, but has not yet been shown to attenuate plasma cytokine concentrations. We investigated the effects of...
Citation: Critical Care 2023 27:117 -
Reversible skin microvascular hyporeactivity in patients with immune-mediated thrombocytopenic thrombotic purpura
Immune-mediated thrombotic thrombocytopenic purpura (iTTP) is a rare disease characterized by arteriolar and capillary microthrombosis precipitating organ failure. However, the contribution of endothelial dysf...
Citation: Critical Care 2023 27:116 -
Hemodynamic Implications of Prone Positioning in Patients with ARDS
This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2023. Other selected articles can be found online at
Citation: Critical Care 2023 27:98 -
Host Response Biomarkers for Sepsis in the Emergency Room
This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2023. Other selected articles can be found online at
Citation: Critical Care 2023 27:97 -
Quality improvement in the determination of death by neurologic criteria around the world
This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2023. Other selected articles can be found online at
Citation: Critical Care 2023 27:96 -
Setting and Monitoring of Mechanical Ventilation During Venovenous ECMO
This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2023. Other selected articles can be found online at
Citation: Critical Care 2023 27:95 -
A structured diagnostic algorithm for patients with ARDS
This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2023. Other selected articles can be found online at
Citation: Critical Care 2023 27:94 -
Interrogating the sepsis host immune response using cytomics
This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2023. Other selected articles can be found online at
Citation: Critical Care 2023 27:93 -
Update on the management of acute respiratory failure using non-invasive ventilation and pulse oximetry
This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2023. Other selected articles can be found online at
Citation: Critical Care 2023 27:92 -
Managing the Physiologically Difficult Airway in Critically Ill Adults
This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2023. Other selected articles can be found online at
Citation: Critical Care 2023 27:91 -
Metagenomic Sequencing in the ICU for Precision Diagnosis of Critical Infectious Illnesses
This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2023. Other selected articles can be found online at
Citation: Critical Care 2023 27:90 -
The Role of Transcriptomics in Redefining Critical Illness
This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2023. Other selected articles can be found online at
Citation: Critical Care 2023 27:89 -
Neurological and respiratory effects of lung protective ventilation in acute brain injury patients without lung injury: brain vent, a single centre randomized interventional study
Lung protective ventilation (LPV) comprising low tidal volume (VT) and high positive end-expiratory pressure (PEEP) may compromise cerebral perfusion in acute brain injury (ABI). In patients with ABI, we inves...
Citation: Critical Care 2023 27:115 -
Focused liquid ultrasonography in dropsy protocol for quantitative assessment of subcutaneous edema
Although subcutaneous edema is a common symptom of critically ill patients, it is still underreported due to the lack of a systematic method for evaluating it. The present study aims to describe the occurrence...
Citation: Critical Care 2023 27:114 -
Novel serum biomarkers for predicting neurological outcomes in postcardiac arrest patients treated with targeted temperature management
To determine the clinical feasibility of novel serum biomarkers in out-of-hospital cardiac arrest (OHCA) patients treated with target temperature management (TTM).
Citation: Critical Care 2023 27:113 -
Polymorphism in interferon alpha/beta receptor contributes to glucocorticoid response and outcome of ARDS and COVID-19
The use of glucocorticoids has given contradictory results for treating acute respiratory distress syndrome (ARDS). The use of intravenous Interferon beta (IFN β) for the treatment of ARDS was recently tested ...
Citation: Critical Care 2023 27:112 -
Mechanical power of ventilation and driving pressure: two undervalued parameters for pre extracorporeal membrane oxygenation ventilation and during daily management?
The current ARDS guidelines highly recommend lung protective ventilation which include plateau pressure (Pplat < 30 cm H2O), positive end expiratory pressure (PEEP > 5 cm H2O) and tidal volume (Vt of 6 ml/kg) of ...
Citation: Critical Care 2023 27:111 -
Early adjunctive methylene blue in patients with septic shock: a randomized controlled trial
Methylene blue (MB) has been tested as a rescue therapy for patients with refractory septic shock. However, there is a lack of evidence on MB as an adjuvant therapy, its’ optimal timing, dosing and safety prof...
Citation: Critical Care 2023 27:110 -
The outcome of IV vitamin C therapy in patients with sepsis or septic shock: a meta-analysis of randomized controlled trials
To update a meta-analysis of randomized controlled trials (RCTs) and further explore the outcome of IV vitamin C (IVVC) administration in sepsis or septic shock patients.
Citation: Critical Care 2023 27:109 -
Outcomes in critically Ill HIV-infected patients between 1997 and 2020: analysis of the OUTCOMEREA multicenter cohort
Despite antiviral therapy (ART), 800,000 deaths still occur yearly and globally due to HIV infection. In parallel with the good virological control and the aging of this population, multiple comorbidities [HIV...
Citation: Critical Care 2023 27:108 -
Only the new beginning of VAP quality control
Citation: Critical Care 2023 27:107 -
Angiotensin 1–7 in an experimental septic shock model
Alterations in the renin–angiotensin system have been implicated in the pathophysiology of septic shock. In particular, angiotensin 1–7 (Ang-(1–7)), an anti-inflammatory heptapeptide, has been hypothesized to ...
Citation: Critical Care 2023 27:106 -
The physiologic response to epinephrine and pediatric cardiopulmonary resuscitation outcomes
Epinephrine is provided during cardiopulmonary resuscitation (CPR) to increase systemic vascular resistance and generate higher diastolic blood pressure (DBP) to improve coronary perfusion and attain return of...
Citation: Critical Care 2023 27:105 -
Right ventricle-specific therapies in acute respiratory distress syndrome: a scoping review
To summarize knowledge and identify gaps in evidence regarding treatment of right ventricular dysfunction (RVD) in acute respiratory distress syndrome (ARDS).
Citation: Critical Care 2023 27:104 -
Limitation of life-sustaining therapies in critically ill patients with COVID-19: a descriptive epidemiological investigation from the COVID-ICU study
Limitations of life-sustaining therapies (LST) practices are frequent and vary among intensive care units (ICUs). However, scarce data were available during the COVID-19 pandemic when ICUs were under intense p...
Citation: Critical Care 2023 27:103 -
Embracing complexity in sepsis
Sepsis involves the dynamic interplay between a pathogen, the host response, the failure of organ systems, medical interventions and a myriad of other factors. This together results in a complex, dynamic and d...
Citation: Critical Care 2023 27:102 -
The clinical frailty scale, but not the FRAIL checklist is associated with mortality in old critically ill patients with COVID-19
Citation: Critical Care 2023 27:101 -
“Reply on: statistics on steroids—how recognizing competing risks gets us closer to the truth about COVID-19-associated VAP”
Citation: Critical Care 2023 27:100 -
Correction to: Can artificial intelligence help for scientific writing?
Citation: Critical Care 2023 27:99 -
How I prescribe prolonged intermittent renal replacement therapy
Prolonged Intermittent Renal Replacement Therapy (PIRRT) is the term used to define ‘hybrid’ forms of renal replacement therapy. PIRRT can be provided using an intermittent hemodialysis machine or a continuous...
Citation: Critical Care 2023 27:88 -
Extracorporeal cardiopulmonary resuscitation for adult out-of-hospital cardiac arrest patients: time-dependent propensity score-sequential matching analysis from a nationwide population-based registry
There is inconclusive evidence regarding the effectiveness of extracorporeal cardiopulmonary resuscitation (ECPR) for out-of-hospital cardiac arrest (OHCA) patients. We aimed to evaluate the association betwee...
Citation: Critical Care 2023 27:87 -
Hyperoxemia after reperfusion in cardiac arrest patients: a potential dose–response association with 30-day survival
Hyperoxemia may aggravate reperfusion brain injury after cardiac arrest. The aim of this study was to study the associations between different levels of hyperoxemia in the reperfusion period after cardiac arre...
Citation: Critical Care 2023 27:86 -
Shock index as predictor of massive transfusion and mortality in patients with trauma: a systematic review and meta-analysis
Management of bleeding trauma patients is still a difficult challenge. Massive transfusion (MT) requires resources to ensure the safety and timely delivery of blood products. Early prediction of MT need may be...
Citation: Critical Care 2023 27:85 -
National incidence and mortality of hospitalized sepsis in China
Sepsis is a leading cause of preventable death around the world. Population-based estimation of sepsis incidence is lacking in China. In this study, we aimed to estimate the population-based incidence and geog...
Citation: Critical Care 2023 27:84 -
Association of early mobility with the incidence of deep-vein thrombosis and mortality among critically ill patients: a post hoc analysis of PREVENT trial
This study assessed the mobility levels among critically ill patients and the association of early mobility with incident proximal lower-limb deep-vein thrombosis and 90-day mortality.
Citation: Critical Care 2023 27:83 -
Target attainment and population pharmacokinetics of flucloxacillin in critically ill patients: a multicenter study
Insufficient antimicrobial exposure has been associated with worse clinical outcomes. Reportedly, flucloxacillin target attainment in critically ill patients was heterogeneous considering the study population sel...
Citation: Critical Care 2023 27:82 -
Improving vasopressor use in cardiac arrest
The Chain of Survival highlights the effectiveness of early recognition of cardiac arrest and call for help, early cardiopulmonary resuscitation and early defibrillation. Most patients, however, remain in card...
Citation: Critical Care 2023 27:81 -
The European guideline on management of major bleeding and coagulopathy following trauma: sixth edition
Severe trauma represents a major global public health burden and the management of post-traumatic bleeding continues to challenge healthcare systems around the world. Post-traumatic bleeding and associated tra...
Citation: Critical Care 2023 27:80 -
Serum-integrated omics reveal the host response landscape for severe pediatric community-acquired pneumonia
Community-acquired pneumonia (CAP) is the primary cause of death for children under five years of age globally. Hence, it is essential to investigate new early biomarkers and potential mechanisms involved in d...
Citation: Critical Care 2023 27:79 -
The effects of flow settings during high-flow nasal cannula support for adult subjects: a systematic review
During high-flow nasal cannula (HFNC) therapy, flow plays a crucial role in the physiological effects. However, there is no consensus on the initial flow settings and subsequent titration. Thus, we aimed to sy...
Citation: Critical Care 2023 27:78 -
Targeting circulating high mobility group box-1 and histones by extracorporeal blood purification as an immunomodulation strategy against critical illnesses
Both high mobility group box-1 (HMGB1) and histones are major damage-associated molecular patterns (DAPMs) that mediate lethal systemic inflammation, activation of the complement and coagulation system, endoth...
Citation: Critical Care 2023 27:77 -
Incidence of near-death experiences in patients surviving a prolonged critical illness and their long-term impact: a prospective observational study
So far, the few prospective studies on near-death experience (NDE) were carried out only in intensive care unit (ICU) patients with homogeneous aetiologies, such as cardiac arrest or trauma survivors. The aims...
Citation: Critical Care 2023 27:76 -
Can artificial intelligence help for scientific writing?
This paper discusses the use of Artificial Intelligence Chatbot in scientific writing. ChatGPT is a type of chatbot, developed by OpenAI, that uses the Generative Pre-trained Transformer (GPT) language model t...
Citation: Critical Care 2023 27:75 -
Plasma neurofilament light is a predictor of neurological outcome 12 h after cardiac arrest
Previous studies have reported high prognostic accuracy of circulating neurofilament light (NfL) at 24–72 h after out-of-hospital cardiac arrest (OHCA), but performance at earlier time points and after in-hosp...
Citation: Critical Care 2023 27:74 -
A randomized, double-blind trial comparing the effect of two blood pressure targets on global brain metabolism after out-of-hospital cardiac arrest
This study aimed to assess the effect of different blood pressure levels on global cerebral metabolism in comatose patients resuscitated from out-of-hospital cardiac arrest (OHCA).
Citation: Critical Care 2023 27:73 -
Antifungal management in ICU: careful follow-up of voriconazole prescription needed!
Citation: Critical Care 2023 27:71 -
No evidence for relevant impact of renal replacement therapy on clinical effect of erythromycin in critically ill patients with sepsis
Citation: Critical Care 2023 27:70 -
Gut microbiota composition during hospitalization is associated with 60-day mortality after severe COVID-19
Gut microbiota alterations have been reported in hospitalized COVID-19 patients, with reduced alpha diversity and altered microbiota composition related to respiratory failure. However, data regarding gut micr...
Citation: Critical Care 2023 27:69
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- ISSN: 1364-8535 (electronic)