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  1. In patients with vasodilatory shock, plasma concentrations of angiotensin I (ANG I) and II (ANG II) and their ratio may reflect differences in the response to severe vasodilation, provide novel insights into i...

    Authors: Rinaldo Bellomo, Richard G. Wunderink, Harold Szerlip, Shane W. English, Laurence W. Busse, Adam M. Deane, Ashish K. Khanna, Michael T. McCurdy, Marlies Ostermann, Paul J. Young, Damian R. Handisides, Lakhmir S. Chawla, George F. Tidmarsh and Timothy E. Albertson

    Citation: Critical Care 2020 24:43

    Content type: Research

    Published on:

  2. Previous scoring models such as the Acute Physiologic Assessment and Chronic Health Evaluation II (APACHE II) and the Sequential Organ Failure Assessment (SOFA) scoring systems do not adequately predict mortal...

    Authors: Min Woo Kang, Jayoun Kim, Dong Ki Kim, Kook-Hwan Oh, Kwon Wook Joo, Yon Su Kim and Seung Seok Han

    Citation: Critical Care 2020 24:42

    Content type: Research

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  3. In the publication of this article [1], there is an error in the Abstract. This has now been included in this correction article.

    Authors: Megan M. Hosey, Jeannie-Marie S. Leoutsakos, Ximin Li, Victor D. Dinglas, O. Joseph Bienvenu, Ann M. Parker, Ramona O. Hopkins, Dale M. Needham and Karin J. Neufeld

    Citation: Critical Care 2020 24:37

    Content type: Correction

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    The original article was published in Critical Care 2019 23:276

  4. Vasoplegic syndrome is a common occurrence following cardiothoracic surgery and is characterized as a high-output shock state with poor systemic vascular resistance. The pathophysiology is complex and includes...

    Authors: Laurence W. Busse, Nicholas Barker and Christopher Petersen

    Citation: Critical Care 2020 24:36

    Content type: Review

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    The Letter to this article has been published in Critical Care 2020 24:138

  5. Nutrition therapy during critical illness has been a focus of recent research, with a rapid increase in publications accompanied by two updated international clinical guidelines. However, the translation of ev...

    Authors: Kate J. Lambell, Oana A. Tatucu-Babet, Lee-anne Chapple, Dashiell Gantner and Emma J. Ridley

    Citation: Critical Care 2020 24:35

    Content type: Review

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  6. Muscle weakness following critical illness is the consequence of loss of muscle mass and alteration of muscle quality. It is associated with long-term disability. Ultrasonography is a reliable tool to quantify...

    Authors: Aurelien Flatres, Yassir Aarab, Stephanie Nougaret, Fanny Garnier, Romaric Larcher, Mathieu Amalric, Kada Klouche, Pascal Etienne, Gilles Subra, Samir Jaber, Nicolas Molinari, Stefan Matecki and Boris Jung

    Citation: Critical Care 2020 24:34

    Content type: Research

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    The Correction to this article has been published in Critical Care 2020 24:79

  7. Post-traumatic cerebral infarction (PTCI) is common after traumatic brain injury (TBI). It is unclear what the occurrence of a PTCI is, how it impacts the long-term outcome, and whether it adds incremental pro...

    Authors: Nicola Latronico, Simone Piva, Nazzareno Fagoni, Lorenzo Pinelli, Michele Frigerio, Davide Tintori, Maurizio Berardino, Andrea Bottazzi, Livio Carnevale, Tiziana Casalicchio, Carlo Alberto Castioni, Simona Cavallo, Davide Cerasti, Giuseppe Citerio, Marco Fontanella, Serena Galiberti…

    Citation: Critical Care 2020 24:33

    Content type: Research

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  8. Both overfeeding and underfeeding of intensive care unit (ICU) patients are associated with worse outcomes. A reliable estimation of the energy expenditure (EE) of ICU patients may help to avoid these phenomen...

    Authors: W. A. C. Koekkoek, Y. A. Menger, F. J. L. van Zanten, D. van Dijk and A. R. H. van Zanten

    Citation: Critical Care 2020 24:32

    Content type: Research

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  9. High-frequency oscillatory ventilation (HFOV) use was associated with greater mortality in adult acute respiratory distress syndrome (ARDS). Nevertheless, HFOV is still frequently used as rescue therapy in pae...

    Authors: Judith Ju-Ming Wong, Siqi Liu, Hongxing Dang, Nattachai Anantasit, Phuc Huu Phan, Suwannee Phumeetham, Suyun Qian, Jacqueline Soo May Ong, Chin Seng Gan, Yek Kee Chor, Rujipat Samransamruajkit, Tsee Foong Loh, Mengling Feng and Jan Hau Lee

    Citation: Critical Care 2020 24:31

    Content type: Research

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    The Letter to this article has been published in Critical Care 2020 24:116

  10. Bloodstream infections (BSIs) by Klebsiella pneumoniae carbapenemase (KPC)-producing Klebsiella pneumoniae (Kp) are associated with high mortality. The aim of this study is to assess the relationship between time...

    Authors: Marco Falcone, Matteo Bassetti, Giusy Tiseo, Cesira Giordano, Elia Nencini, Alessandro Russo, Elena Graziano, Enrico Tagliaferri, Alessandro Leonildi, Simona Barnini, Alessio Farcomeni and Francesco Menichetti

    Citation: Critical Care 2020 24:29

    Content type: Research

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  11. Previous studies suggest that prone positioning (PP) can increase PaO2/FiO2 and reduce mortality in moderate to severe acute respiratory distress syndrome (ARDS). The aim of our study was to determine whether the...

    Authors: Lin Ding, Li Wang, Wanhong Ma and Hangyong He

    Citation: Critical Care 2020 24:28

    Content type: Research

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    The Letter to this article has been published in Critical Care 2020 24:114

  12. This study conducted a meta-analysis to assess the effectiveness, stability, and safety of mild therapeutic hypothermia (TH) induced by endovascular cooling (EC) and surface cooling (SC) and its effect on ICU,...

    Authors: Xueli Liao, Ziyu Zhou, Manhong Zhou, Hui Tang, Menglong Feng, Bujin Kou, Ni Zhu, Futuan Liao and Liaozhang Wu

    Citation: Critical Care 2020 24:27

    Content type: Research

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  13. There remains significant controversy regarding the optimal approach to fluid resuscitation for patients in shock. The magnitude of care variability in shock resuscitation, the confounding effects of disease s...

    Authors: Jason N. Mansoori, Walter Linde-Zwirble, Peter C. Hou, Edward P. Havranek and Ivor S. Douglas

    Citation: Critical Care 2020 24:25

    Content type: Research

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  14. Fluid boluses are administered to septic shock patients with the purpose of increasing cardiac output as a means to restore tissue perfusion. Unfortunately, fluid therapy has a narrow therapeutic index, and th...

    Authors: Eduardo Kattan, Gustavo A. Ospina-Tascón, Jean-Louis Teboul, Ricardo Castro, Maurizio Cecconi, Giorgio Ferri, Jan Bakker and Glenn Hernández

    Citation: Critical Care 2020 24:23

    Content type: Research

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  15. During extracorporeal membrane oxygenation (ECMO), a delicate balance is required to titrate systemic anticoagulation to prevent thrombotic complications within the circuit and prevent bleeding in the patient....

    Authors: Meghan M. Chlebowski, Sirine Baltagi, Mel Carlson, Jerrold H. Levy and Philip C. Spinella

    Citation: Critical Care 2020 24:19

    Content type: Review

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  16. Hemoglobin (Hb) transfusion thresholds are established in intensive care units. A restrictive transfusion threshold (Hb 70–75 g/l) is recommended in septic patients, and a liberal transfusion threshold (Hb 90 ...

    Authors: Jonas Scheuzger, Anna Zehnder, Vera Meier, Desirée Yeginsoy, Julian Flükiger and Martin Siegemund

    Citation: Critical Care 2020 24:18

    Content type: Research

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  17. Limited data exist regarding ventilation in patients with class III obesity [body mass index (BMI) > 40 kg/m2] and acute respiratory distress syndrome (ARDS). The aim of the present study was to determine whether...

    Authors: Gaetano Florio, Matteo Ferrari, Edward A. Bittner, Roberta De Santis Santiago, Massimiliano Pirrone, Jacopo Fumagalli, Maddalena Teggia Droghi, Cristina Mietto, Riccardo Pinciroli, Sheri Berg, Aranya Bagchi, Kenneth Shelton, Alexander Kuo, Yvonne Lai, Abraham Sonny, Peggy Lai…

    Citation: Critical Care 2020 24:4

    Content type: Research

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  18. New-onset atrial fibrillation (NOAF) is commonly encountered in critically ill adults. Evidence evaluating the association between NOAF and patient-important outcomes in this population is conflicting. Further...

    Authors: Shannon M. Fernando, Rebecca Mathew, Benjamin Hibbert, Bram Rochwerg, Laveena Munshi, Allan J. Walkey, Morten Hylander Møller, Trevor Simard, Pietro Di Santo, F. Daniel Ramirez, Peter Tanuseputro and Kwadwo Kyeremanteng

    Citation: Critical Care 2020 24:15

    Content type: Research

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    The Letter to this article has been published in Critical Care 2020 24:40

  19. In critically ill patients, auscultation might be challenging as dorsal lung fields are difficult to reach in supine-positioned patients, and the environment is often noisy. In recent years, clinicians have st...

    Authors: Eline G. M. Cox, Geert Koster, Aidan Baron, Thomas Kaufmann, Ruben J. Eck, T. Corien Veenstra, Bart Hiemstra, Adrian Wong, Thomas C. Kwee, Jaap E. Tulleken, Frederik Keus, Renske Wiersema and Iwan C. C. van der Horst

    Citation: Critical Care 2020 24:14

    Content type: Research

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  20. Herpes simplex virus (HSV) replication can be detected in the respiratory secretions of a high proportion of ventilated intensive care unit (ICU) patients. However, the clinical significance remains poorly def...

    Authors: Lukas Schuierer, Michael Gebhard, Hans-Georg Ruf, Ulrich Jaschinski, Thomas M. Berghaus, Michael Wittmann, Georg Braun, Dirk H. Busch and Reinhard Hoffmann

    Citation: Critical Care 2020 24:12

    Content type: Research

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    The Letter to this article has been published in Critical Care 2020 24:140

  21. The brainstem conveys sensory and motor inputs between the spinal cord and the brain, and contains nuclei of the cranial nerves. It controls the sleep-wake cycle and vital functions via the ascending reticular...

    Authors: Sarah Benghanem, Aurélien Mazeraud, Eric Azabou, Vibol Chhor, Cassia Righy Shinotsuka, Jan Claassen, Benjamin Rohaut and Tarek Sharshar

    Citation: Critical Care 2020 24:5

    Content type: Review

    Published on:

  22. In the publication of this article [1], there was an error in the cited reference 23 [2] within the Family Name. This has now been updated in the original article.

    Authors: Kaiquan Tan, Martin Harazim, Benjamin Tang, Anthony Mclean and Marek Nalos

    Citation: Critical Care 2020 24:3

    Content type: Correction

    Published on:

    The original article was published in Critical Care 2019 23:298

  23. Acute kidney injury (AKI) is a common complication in burn patients admitted to the intensive care unit (ICU) associated with increased morbidity and mortality. Our primary aim was to review incidence, risk fa...

    Authors: Torgeir Folkestad, Kjetil Gundro Brurberg, Kine Marie Nordhuus, Christine Kooy Tveiten, Anne Berit Guttormsen, Ingrid Os and Sigrid Beitland

    Citation: Critical Care 2020 24:2

    Content type: Research

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  24. Acute kidney injury (AKI) is an important complication encountered during the course of diabetic ketoacidosis (DKA). Plasma-Lyte with lower chloride concentration than saline has been shown to be associated wi...

    Authors: Vijai Williams, Muralidharan Jayashree, Karthi Nallasamy, Devi Dayal and Amit Rawat

    Citation: Critical Care 2020 24:1

    Content type: Research

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  25. Peroxisome proliferator-activated receptor gamma (PPARγ) is a major regulator in sepsis. Our previous study identified the enhancer polymorphism rs10865710C/G to be associated with susceptibility to sepsis in ...

    Authors: Hongxiang Lu, Dalin Wen, Jianhui Sun, Ling Zeng, Juan Du, Dingyuan Du, Lianyang Zhang, Jin Deng, Jianxin Jiang and Anqiang Zhang

    Citation: Critical Care 2019 23:430

    Content type: Research

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  26. The surviving sepsis campaign recommends consideration for extracorporeal membrane oxygenation (ECMO) in refractory septic shock. We aimed to define the benefit threshold of ECMO in pediatric septic shock.

    Authors: Luregn J. Schlapbach, Roberto Chiletti, Lahn Straney, Marino Festa, Daniel Alexander, Warwick Butt and Graeme MacLaren

    Citation: Critical Care 2019 23:429

    Content type: Research

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    The Letter to this article has been published in Critical Care 2020 24:88

  27. The administration of levosimendan prophylactically to patients undergoing cardiac surgery remains a controversial practice, and few studies have specifically assessed the value of this approach in pediatric p...

    Authors: Anbiao Wang, Chaomei Cui, Yiou Fan, Jie Zi, Jie Zhang, Guanglai Wang, Fang Wang, Jun Wang and Qi Tan

    Citation: Critical Care 2019 23:428

    Content type: Research

    Published on:

    The Letter to this article has been published in Critical Care 2020 24:113

  28. Spreading depolarizations (SD) are characterized by breakdown of transmembrane ion gradients and excitotoxicity. Experimentally, N-methyl-d-aspartate receptor (NMDAR) antagonists block a majority of SDs. In many ...

    Authors: Edgar Santos, Arturo Olivares-Rivera, Sebastian Major, Renán Sánchez-Porras, Lorenz Uhlmann, Kevin Kunzmann, Roland Zerelles, Modar Kentar, Vasilis Kola, Adrian Hernández Aguilera, Mildred Gutierrez Herrera, Coline L. Lemale, Johannes Woitzik, Jed A. Hartings, Oliver W. Sakowitz, Andreas W. Unterberg…

    Citation: Critical Care 2019 23:427

    Content type: Research

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  29. Systemic blood flow in patients on extracorporeal assist devices is frequently not or only minimally pulsatile. Loss of pulsatile brain perfusion, however, has been implicated in neurological complications. Fu...

    Authors: Cecilia Maria Veraar, Harald Rinösl, Karina Kühn, Keso Skhirtladze-Dworschak, Alessia Felli, Mohamed Mouhieddine, Johannes Menger, Ekaterina Pataraia, Hendrik Jan Ankersmit and Martin Dworschak

    Citation: Critical Care 2019 23:426

    Content type: Research

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  30. In patients with acute respiratory distress syndrome (ARDS), low tidal volume ventilation has been associated with reduced mortality. Driving pressure (tidal volume normalized to respiratory system compliance)...

    Authors: Michael J. Lanspa, Ithan D. Peltan, Jason R. Jacobs, Jeffrey S. Sorensen, Lori Carpenter, Jeffrey P. Ferraro, Samuel M. Brown, Jay G. Berry, Raj Srivastava and Colin K. Grissom

    Citation: Critical Care 2019 23:424

    Content type: Research

    Published on: