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  1. Advances in critical care medicine have led to a growing number of critical illness survivors. A considerable part of them suffers from long-term sequelae, also known as post-intensive care syndrome. Among the...

    Authors: Monique Boede, Jochen S. Gensichen, James C. Jackson, Fiene Eißler, Thomas Lehmann, Sven Schulz, Juliana J. Petersen, Florian P. Wolf, Tobias Dreischulte and Konrad F. R. Schmidt

    Citation: Critical Care 2021 25:161

    Content type: Research

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  2. During venovenous extracorporeal membrane oxygenation (vvECMO), direct thrombin inhibitors are considered by some potentially advantageous over unfractionated heparin (UFH). We tested the hypothesis that Argat...

    Authors: Christoph Fisser, Maren Winkler, Maximilian V. Malfertheiner, Alois Philipp, Maik Foltan, Dirk Lunz, Florian Zeman, Lars S. Maier, Matthias Lubnow and Thomas Müller

    Citation: Critical Care 2021 25:160

    Content type: Research

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  3. COVID-19 has resulted in high mortality worldwide. Information regarding cardiac markers for precise risk-stratification is limited. We aim to discover sensitive and reliable early-warning biomarkers for optim...

    Authors: Pengping Li, Wei Wu, Tingting Zhang, Ziyu Wang, Jie Li, Mengyan Zhu, Yuan Liang, Wenhua You, Kening Li, Rong Ding, Bin Huang, Lingxiang Wu, Weiwei Duan, Yi Han, Xuesong Li, Xin Tang…

    Citation: Critical Care 2021 25:158

    Content type: Research

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  4. Around one third of intensive care unit (ICU) patients will develop severe neuromuscular alterations, known as intensive care unit-acquired weakness (ICUAW), during their stay. The diagnosis of ICUAW is diffic...

    Authors: Djahid Kennouche, Eric Luneau, Thomas Lapole, Jérome Morel, Guillaume Y. Millet and Julien Gondin

    Citation: Critical Care 2021 25:157

    Content type: Review

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    The Letter to this article has been published in Critical Care 2021 25:233

  5. Disrupted vital-sign circadian rhythms in the intensive care unit (ICU) are associated with complications such as immune system disruption, delirium and increased patient mortality. However, the prevalence and...

    Authors: Shaun Davidson, Mauricio Villarroel, Mirae Harford, Eoin Finnegan, João Jorge, Duncan Young, Peter Watkinson and Lionel Tarassenko

    Citation: Critical Care 2021 25:156

    Content type: Research

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  6. Critical illness from SARS-CoV-2 infection (COVID-19) is associated with a high burden of pulmonary embolism (PE) and thromboembolic events despite standard thromboprophylaxis. Available guidance is discordant...

    Authors: Andrea Lavinio, Ari Ercole, Denise Battaglini, Sandra Magnoni, Rafael Badenes, Fabio Silvio Taccone, Raimund Helbok, William Thomas, Paolo Pelosi and Chiara Robba

    Citation: Critical Care 2021 25:155

    Content type: Research

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  7. Acute respiratory distress syndrome remains a heterogeneous syndrome for clinicians and researchers difficulting successful tailoring of interventions and trials. To this moment, phenotyping of this syndrome h...

    Authors: Pedro D. Wendel Garcia, Alessio Caccioppola, Silvia Coppola, Tommaso Pozzi, Arianna Ciabattoni, Stefano Cenci and Davide Chiumello

    Citation: Critical Care 2021 25:154

    Content type: Research

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    The Letter to this article has been published in Critical Care 2021 25:195

  8. We reviewed similarities and differences of ventilator associated pneumonia in Sars-Cov2 infection and with other ARDS. The differences in epidemiology and outcome will be detailed. Possible explanations of di...

    Authors: Paul-Henri Wicky, Michael S. Niedermann and Jean-François Timsit

    Citation: Critical Care 2021 25:153

    Content type: Editorial

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  9. The early recognition and management of sepsis improves outcomes. Biomarkers may help in identifying earlier sub-clinical signs of sepsis. We explored the potential of serial measurements of C-reactive protein...

    Authors: Jérôme Pugin, Thomas Daix, Jean-Luc Pagani, Davide Morri, Angelo Giacomucci, Pierre-François Dequin, Christophe Guitton, Yok-Ai Que, Gianluca Zani, David Brealey, Alain Lepape, Ben Creagh-Brown, Duncan Wyncoll, Daniela Silengo, Irina Irincheeva, Laurie Girard…

    Citation: Critical Care 2021 25:151

    Content type: Research

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  10. The COVID-19 pandemic has led highly developed healthcare systems to the brink of collapse due to the large numbers of patients being admitted into hospitals. One of the potential prognostic indicators in pati...

    Authors: Christian Jung, Hans Flaatten, Jesper Fjølner, Raphael Romano Bruno, Bernhard Wernly, Antonio Artigas, Bernardo Bollen Pinto, Joerg C. Schefold, Georg Wolff, Malte Kelm, Michael Beil, Sigal Sviri, Peter Vernon van Heerden, Wojciech Szczeklik, Miroslaw Czuczwar, Muhammed Elhadi…

    Citation: Critical Care 2021 25:149

    Content type: Research

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  11. Analyses of blood biomarkers involved in the host response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral infection can reveal distinct biological pathways and inform development and tes...

    Authors: Pavan K. Bhatraju, Eric D. Morrell, Leila Zelnick, Neha A. Sathe, Xin-Ya Chai, Sana S. Sakr, Sharon K. Sahi, Anthony Sader, Dawn M. Lum, Ted Liu, Neall Koetje, Ashley Garay, Elizabeth Barnes, Jonathan Lawson, Gail Cromer, Mary K. Bray…

    Citation: Critical Care 2021 25:148

    Content type: Research

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  12. There is a large gender gap in critical care medicine with women underrepresented, particularly in positions of leadership. Yet gender diversity better reflects the current critical care community and has mult...

    Authors: Jean-Louis Vincent, Nicole P. Juffermans, Karen E. A. Burns, V. Marco Ranieri, Chryssa Pourzitaki and Francesca Rubulotta

    Citation: Critical Care 2021 25:147

    Content type: Viewpoint

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    The Letter to this article has been published in Critical Care 2021 25:216

  13. It is unclear whether vasopressors can be safely administered through a peripheral intravenous (PIV). Systematic review and meta-analysis methodology was used to examine the incidence of local anatomic adverse...

    Authors: Victoria S. Owen, Brianna K. Rosgen, Stephana J. Cherak, Andre Ferland, Henry T. Stelfox, Kirsten M. Fiest and Daniel J. Niven

    Citation: Critical Care 2021 25:146

    Content type: Research

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  14. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Mathieu Blot, Marine Jacquier, Ludwig-Serge Aho Glele, Guillaume Beltramo, Maxime Nguyen, Philippe Bonniaud, Sebastien Prin, Pascal Andreu, Belaid Bouhemad, Jean-Baptiste Bour, Christine Binquet, Lionel Piroth, Jean-Paul Pais de Barros, David Masson, Jean-Pierre Quenot and Pierre-Emmanuel Charles

    Citation: Critical Care 2021 25:143

    Content type: Correction

    Published on:

    The original article was published in Critical Care 2020 24:632

  15. Pain assessment in brain-injured patients in the intensive care unit (ICU) is challenging and existing scales may not be representative of behavioral reactions expressed by this specific group. This study aime...

    Authors: Céline Gélinas, Mélanie Bérubé, Kathleen A. Puntillo, Madalina Boitor, Melissa Richard-Lalonde, Francis Bernard, Virginie Williams, Aaron M. Joffe, Craig Steiner, Rebekah Marsh, Louise Rose, Craig M. Dale, Darina M. Tsoller, Manon Choinière and David L. Streiner

    Citation: Critical Care 2021 25:142

    Content type: Research

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  16. Intensive care unit (ICU) physicians have extended the minimum alveolar concentration (MAC) to deliver and monitor long-term volatile sedation in critically ill patients. There is limited evidence of MAC’s rel...

    Authors: Adrian-Iustin Georgevici, Theodoros Kyprianou, Jennifer Herzog-Niescery, Livia Procopiuc, Sivakkanan Loganathan, Thomas Peter Weber and Martin Bellgardt

    Citation: Critical Care 2021 25:141

    Content type: Research

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  17. Since the onset of the pandemic, only few studies focused on longitudinal immune monitoring in critically ill COVID-19 patients with acute respiratory distress syndrome (ARDS) whereas their hospital stay may l...

    Authors: Fabienne Venet, Martin Cour, Thomas Rimmelé, Sebastien Viel, Hodane Yonis, Remy Coudereau, Camille Amaz, Paul Abraham, Céline Monard, Jean-Sebastien Casalegno, Karen Brengel-Pesce, Anne-Claire Lukaszewicz, Laurent Argaud and Guillaume Monneret

    Citation: Critical Care 2021 25:140

    Content type: Research

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  18. High-flow nasal cannula oxygenation (HFNC) and noninvasive positive-pressure ventilation (NPPV) possibly decrease tracheal reintubation rates better than conventional oxygen therapy (COT); however, few large-s...

    Authors: Hideto Yasuda, Hiromu Okano, Takuya Mayumi, Chihiro Narita, Yu Onodera, Masaki Nakane and Nobuaki Shime

    Citation: Critical Care 2021 25:135

    Content type: Research

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  19. Teleultrasound provides an effective solution to problems that arise from limited medical resources, a lack of local expertise, and scenarios where the risk of infection is high. This study aims to explore the...

    Authors: Shaobo Duan, Luwen Liu, Yongqing Chen, Long Yang, Ye Zhang, Shuaiyang Wang, Liuwei Hao and Lianzhong Zhang

    Citation: Critical Care 2021 25:134

    Content type: Research

    Published on:

  20. 2-Deoxy-2-[18F]fluoro-D-glucose (FDG) positron emission tomography (PET)/computed tomography (CT) is an advanced imaging technique that can be used to examine the whole body for an infection focus in a single ...

    Authors: Jordy P. Pijl, Mark Londema, Thomas C. Kwee, Maarten W. N. Nijsten, Riemer H. J. A. Slart, Rudi A. J. O. Dierckx, Peter H. J. van der Voort, Andor W. J. M. Glaudemans and Janesh Pillay

    Citation: Critical Care 2021 25:133

    Content type: Research

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  21. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Mailis Maes, Ellen Higginson, Joana Pereira-Dias, Martin D. Curran, Surendra Parmar, Fahad Khokhar, Delphine Cuchet-Lourenço, Janine Lux, Sapna Sharma-Hajela, Benjamin Ravenhill, Islam Hamed, Laura Heales, Razeen Mahroof, Amelia Soderholm, Sally Forrest, Sushmita Sridhar…

    Citation: Critical Care 2021 25:130

    Content type: Correction

    Published on:

    The original article was published in Critical Care 2021 25:25

  22. Limited data are available on the use of prone position in intubated, invasively ventilated patients with Coronavirus disease-19 (COVID-19). Aim of this study is to investigate the use and effect of prone posi...

    Authors: Thomas Langer, Matteo Brioni, Amedeo Guzzardella, Eleonora Carlesso, Luca Cabrini, Gianpaolo Castelli, Francesca Dalla Corte, Edoardo De Robertis, Martina Favarato, Andrea Forastieri, Clarissa Forlini, Massimo Girardis, Domenico Luca Grieco, Lucia Mirabella, Valentina Noseda, Paola Previtali…

    Citation: Critical Care 2021 25:128

    Content type: Research

    Published on:

  23. Hemorrhagic events remain a major concern in patients under extracorporeal membrane oxygenation (ECMO) support. We tested the association between anticoagulation levels and hemorrhagic events under ECMO using ...

    Authors: Richard Descamps, Mouhamed D. Moussa, Emmanuel Besnier, Marc-Olivier Fischer, Sébastien Preau, Fabienne Tamion, Cédric Daubin, Nicolas Cousin, André Vincentelli, Julien Goutay and Damien Du Cheyron

    Citation: Critical Care 2021 25:127

    Content type: Research

    Published on:

    The Letter to this article has been published in Critical Care 2021 25:210

  24. Pulmonary artery thermodilution is the clinical reference method for cardiac output monitoring. Because both continuous and intermittent pulmonary artery thermodilution are used in clinical practice it is impo...

    Authors: Karim Kouz, Frederic Michard, Alina Bergholz, Christina Vokuhl, Luisa Briesenick, Phillip Hoppe, Moritz Flick, Gerhard Schön and Bernd Saugel

    Citation: Critical Care 2021 25:125

    Content type: Research

    Published on:

    The Letter to this article has been published in Critical Care 2021 25:215

  25. The possible benefits associated with corticosteroid treatment in acute respiratory distress syndrome (ARDS) patients are not fully known. We conducted an updated meta-analysis to assess the effect of corticos...

    Authors: Ping Lin, Yuean Zhao, Xiaoqian Li, Faming Jiang and Zongan Liang

    Citation: Critical Care 2021 25:122

    Content type: Research

    Published on:

  26. Although several international guidelines recommend early over late intubation of patients with severe coronavirus disease 2019 (COVID-19), this issue is still controversial. We aimed to investigate the effect...

    Authors: Eleni Papoutsi, Vassilis G. Giannakoulis, Eleni Xourgia, Christina Routsi, Anastasia Kotanidou and Ilias I. Siempos

    Citation: Critical Care 2021 25:121

    Content type: Research

    Published on:

    The Letter to this article has been published in Critical Care 2021 25:173

  27. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Keyvan Razazi, Romain Arrestier, Anne Fleur Haudebourg, Brice Benelli, Guillaume Carteaux, Jean‑Winoc Decousser, Slim Fourati, Paul Louis Woerther, Frederic Schlemmer, Anais Charles-Nelson, Francoise Botterel, Nicolas de Prost and Armand Mekontso Dessap

    Citation: Critical Care 2021 25:118

    Content type: Correction

    Published on:

    The original article was published in Critical Care 2020 24:699

  28. Medical emergency teams (MET) are mostly led by physicians. Some hospitals are currently using nurse practitioners (NP) to lead MET calls. These are no studies comparing clinical outcomes between these two car...

    Authors: Sachin Gupta, Mayurathan Balachandran, Gaby Bolton, Naomi Pratt, Jo Molloy, Eldho Paul and Ravindranath Tiruvoipati

    Citation: Critical Care 2021 25:117

    Content type: Research

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  29. The mortality of critically ill patients with COVID-19 is high, particularly among those receiving mechanical ventilation (MV). Despite the high number of patients treated worldwide, data on respiratory mechan...

    Authors: Giacomo Grasselli, Emanuele Cattaneo, Gaetano Florio, Mariachiara Ippolito, Alberto Zanella, Andrea Cortegiani, Jianbo Huang, Antonio Pesenti and Sharon Einav

    Citation: Critical Care 2021 25:115

    Content type: Review

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  30. A recent randomised trial showed that recombinant thrombomodulin did not benefit patients who had sepsis with coagulopathy and organ dysfunction. Several recent studies suggested presence of clinical phenotype...

    Authors: Daisuke Kudo, Tadahiro Goto, Ryo Uchimido, Mineji Hayakawa, Kazuma Yamakawa, Toshikazu Abe, Atsushi Shiraishi and Shigeki Kushimoto

    Citation: Critical Care 2021 25:114

    Content type: Research

    Published on: