Automated continuous noninvasive ward monitoring may enable subtle changes in vital signs to be recognized. There is already some evidence that automated ward monitoring can improve patient outcome. Before aut...
Authors: Ashish K. Khanna, Phillip Hoppe and Bernd Saugel
Quantification of intrinsic PEEP (PEEPi) has important implications for patients subjected to invasive mechanical ventilation. A new non-invasive breath-by-breath method (etCO2D) for determination of PEEPi is eva...
Authors: Sarah Heili-Frades, Fernando Suarez-Sipmann, Arnoldo Santos, Maria Pilar Carballosa, Alba Naya-Prieto, Carlos Castilla-Reparaz, Maria Jesús Rodriguez-Nieto, Nicolás González-Mangado and German Peces -Barba
Optimal infusion rate of colloids in patients with suspected hypovolemia is unknown, and the primary objective of the present study was to test if plasma volume expansion by 5% albumin is greater if fluid is a...
Authors: Svajunas Statkevicius, Johan Bonnevier, Jane Fisher, Björn P. Bark, Erik Larsson, Carl M. Öberg, Päivi Kannisto, Bobby Tingstedt and Peter Bentzer
Procalcitonin (PCT) is a biomarker used to assess systemic inflammation, infection, and sepsis and to optimize antimicrobial therapies. Its role in the in the differential diagnosis between candidemia and bact...
Authors: Andrea Cortegiani, Giovanni Misseri, Mariachiara Ippolito, Matteo Bassetti, Antonino Giarratano, Ignacio Martin-Loeches and Sharon Einav
Intensive care survivors suffer chronic and potentially life-changing physical, psychosocial and cognitive sequelae, and supporting recovery is an international priority. As survivors’ transition from the inte...
Authors: J. King, B. O’Neill, P. Ramsay, M. A. Linden, A. Darweish Medniuk, J. Outtrim and B. Blackwood
Multiple organ dysfunction is a common cause of morbidity and mortality in intensive care units (ICUs). Original development of the Sequential Organ Failure Assessment (SOFA) score was not to predict outcome, ...
Authors: Andrea Soo, Danny J. Zuege, Gordon H. Fick, Daniel J. Niven, Luc R. Berthiaume, Henry T. Stelfox and Christopher J. Doig
Antibiotic exposure in intensive care patients with sepsis is frequently inadequate and is associated with poorer outcomes. Antibiotic dosing is challenging in the intensive care, as critically ill patients ha...
Authors: Lucas M. Fleuren, Luca F. Roggeveen, Tingjie Guo, Petr Waldauf, Peter H. J. van der Voort, Rob J. Bosman, Eleonora L. Swart, Armand R. J. Girbes and Paul W. G. Elbers
Authors: Xavier Bemtgen, Florentine Schroth, Tobias Wengenmayer, Paul M. Biever, Daniel Duerschmied, Christoph Benk, Christoph Bode and Dawid L. Staudacher
Sepsis remains one of the most important causes of morbidity and mortality worldwide. In approximately 30–50% of cases of suspected sepsis, no pathogen is isolated, disabling the clinician to treat the patient...
Authors: Rishi S. Nannan Panday, Eline M. J. Lammers, Nadia Alam and Prabath W. B. Nanayakkara
The effect of high-flow nasal cannula (HFNC) therapy in patients after planned extubation remains inconclusive. We aimed to perform a rigorous and comprehensive systematic meta-analysis to robustly quantify th...
Authors: Youfeng Zhu, Haiyan Yin, Rui Zhang, Xiaoling Ye and Jianrui Wei
Fluid challenge (FC) is one of the most common practices in Intensive Care Unit (ICU). The present study aimed to evaluate whether echocardiographic assessment of the response to FC at the end of the infusion ...
Authors: Claire Roger, Laurent Zieleskiewicz, Christophe Demattei, Karim Lakhal, Gael Piton, Benjamin Louart, Jean-Michel Constantin, Russell Chabanne, Jean-Sébastien Faure, Yazine Mahjoub, Isabelle Desmeulles, Hervé Quintard, Jean-Yves Lefrant and Laurent Muller
Timely initiation of physical, occupational, and speech therapy in critically ill patients is crucial to reduce morbidity and improve outcomes. Over a 5-year time interval, we sought to determine the utilizati...
Authors: Clare C. Prohaska, Peter D. Sottile, Amy Nordon-Craft, Matt D. Gallagher, Ellen L. Burnham, Brendan J. Clark, Michael Ho, Tyree H. Kiser, R. William Vandivier, Wenhui Liu, Margaret Schenkman and Marc Moss
We aimed to examine recent trends in patient characteristics and mortality in patients with acute kidney injury (AKI) receiving renal replacement therapy (RRT), including continuous RRT (CRRT) and intermittent...
Authors: Yoshihisa Miyamoto, Masao Iwagami, Shotaro Aso, Hideo Yasunaga, Hiroki Matsui, Kiyohide Fushimi, Yoshifumi Hamasaki, Masaomi Nangaku and Kent Doi
Cerebral hypoperfusion may aggravate neurological damage after cardiac arrest. Near-infrared spectroscopy (NIRS) provides information on cerebral oxygenation but its relevance during post-resuscitation care is...
Authors: Pekka Jakkula, Johanna Hästbacka, Matti Reinikainen, Ville Pettilä, Pekka Loisa, Marjaana Tiainen, Erika Wilkman, Stepani Bendel, Thomas Birkelund, Anni Pulkkinen, Minna Bäcklund, Sirkku Heino, Sari Karlsson, Hiski Kopponen and Markus B. Skrifvars
Extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-E) are disseminating worldwide leading to increased hospital length of stay and mortality in intensive care units (ICU). ESBL-E dissemination wa...
Septic shock is the most severe phase of sepsis and is associated with high rates of mortality. However, early stage prediction of septic shock outcomes remains difficult. Metabolomic techniques have emerged a...
Authors: Zhicheng Liu, Mohamed N. Triba, Roland Amathieu, Xiangping Lin, Nadia Bouchemal, Edith Hantz, Laurence Le Moyec and Philippe Savarin
Catecholamines, especially norepinephrine, are the most frequently used vasopressors for treating patients with septic shock. During the recent decades, terlipressin, vasopressin V1A agonist, and even Ca2+ sensit...
Authors: Lu Cheng, Jing Yan, Shutang Han, Qiuhua Chen, Mingqi Chen, Hua Jiang and Jun Lu
At least a third of the world’s population consumes alcohol regularly. Patients with alcohol use disorders (AUDs) are frequently hospitalized for both alcohol-related and unrelated medical conditions. It is we...
To elucidate the incidence of acute kidney injury (AKI) after out-of-hospital cardiac arrest (OHCA) and to examine the impact of target temperature management (TTM) and early coronary angiography on renal func...
Authors: Malin Rundgren, Susann Ullén, Matt P. G. Morgan, Guy Glover, Julius Cranshaw, Nawaf Al-Subaie, Andrew Walden, Michael Joannidis, Marlies Ostermann, Josef Dankiewicz, Niklas Nielsen and Matthew P. Wise
The aim of this study was to evaluate oxidative stress from glutathione depletion in critically ill patients with a septic shock through the abnormal presence of pyroglutamic acid (PyroGlu) in the urine (indir...
Authors: Yenifer Gamarra, Felipe C. Santiago, Jorge Molina-López, José Castaño, Lourdes Herrera-Quintana, Álvaro Domínguez and Elena Planells
The optimal securement method of endotracheal tubes is unknown but should prevent dislodgement while minimizing complications. The use of an endotracheal tube fastener might reduce complications among critical...
Authors: Janna S. Landsperger, Jesse M. Byram, Bradley D. Lloyd and Todd W. Rice
Recent evidence suggests that acetate-buffered infusions result in better hemodynamic stabilization than 0.9% saline in patients undergoing major surgery. The choice of buffer in balanced crystalloid solutions...
Authors: Carmen A. Pfortmueller, Livia Faeh, Martin Müller, Balthasar Eberle, Hansjörg Jenni, Björn Zante, Josef Prazak, Lars Englberger, Jukka Takala and Stephan M. Jakob
Authors: Koichiro Shinozaki, Lee S. Jacobson, Kota Saeki, Naoki Kobayashi, Steve Weisner, Julianne M. Falotico, Timmy Li, Junhwan Kim, Joshua W. Lampe and Lance B. Becker
Randomised controlled trials (RCTs) enrolling patients with sepsis or acute respiratory distress syndrome (ARDS) generate heterogeneous trial populations. Non-random variation in the treatment effect of an int...
Authors: Shalini Santhakumaran, Anthony Gordon, A. Toby Prevost, Cecilia O’Kane, Daniel F. McAuley and Manu Shankar-Hari
Elevated intracranial pressure (ICP) is frequent after traumatic brain injury (TBI) and may cause abnormal pupillary reactivity, which in turn is associated with a worse prognosis. Using automated infrared pup...
Authors: Fritz-Patrick Jahns, John Paul Miroz, Mahmoud Messerer, Roy T. Daniel, Fabio Silvio Taccone, Philippe Eckert and Mauro Oddo
It is unclear whether influenza infection and associated co-infection are associated with patient-important outcomes in critically ill immunocompromised patients with acute respiratory failure.
Authors: Ignacio Martin-Loeches, Virginie Lemiale, Pierce Geoghegan, Mary Aisling McMahon, Peter Pickkers, Marcio Soares, Anders Perner, Tine Sylvest Meyhoff, Ramin Brandt Bukan, Jordi Rello, Philippe R. Bauer, Andry van de Louw, Fabio Silvio Taccone, Jorge Salluh, Pleun Hemelaar, Peter Schellongowski…
After publication of this article [1], it was noticed that the affiliations of Honghong Zhou were incorrect. The sole affiliation should be, “Department of Nephrology, the Second Affiliated Hospital of Nanchan...
