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  1. The obesity paradox has been observed in short-term outcomes from critical illness. However, little is known regarding the impact of obesity on long-term outcomes for survivors of critically ill patients. We a...

    Authors: Dawei Zhou, Chao Wang, Qing Lin and Tong Li
    Citation: Critical Care 2022 26:198
  2. Sepsis is a heterogeneous syndrome, and the identification of clinical subphenotypes is essential. Although organ dysfunction is a defining element of sepsis, subphenotypes of differential trajectory are not w...

    Authors: Zhenxing Xu, Chengsheng Mao, Chang Su, Hao Zhang, Ilias Siempos, Lisa K. Torres, Di Pan, Yuan Luo, Edward J. Schenck and Fei Wang
    Citation: Critical Care 2022 26:197
  3. Heart rate, acidosis, consciousness, oxygenation, and respiratory rate (HACOR) have been used to predict noninvasive ventilation (NIV) failure. However, the HACOR score fails to consider baseline data. Here, w...

    Authors: Jun Duan, Lijuan Chen, Xiaoyi Liu, Suha Bozbay, Yuliang Liu, Ke Wang, Antonio M. Esquinas, Weiwei Shu, Fuxun Yang, Dehua He, Qimin Chen, Bilin Wei, Baixu Chen, Liucun Li, Manyun Tang, Guodan Yuan…
    Citation: Critical Care 2022 26:196
  4. PEEP selection in severe COVID-19 patients under extracorporeal membrane oxygenation (ECMO) is challenging as no study has assessed the alveolar recruitability in this setting. The aim of the study was to comp...

    Authors: Jean-Christophe Richard, Florian Sigaud, Maxime Gaillet, Maciej Orkisz, Sam Bayat, Emmanuel Roux, Touria Ahaouari, Eduardo Davila, Loic Boussel, Gilbert Ferretti, Hodane Yonis, Mehdi Mezidi, William Danjou, Alwin Bazzani, Francois Dhelft, Laure Folliet…
    Citation: Critical Care 2022 26:195
  5. Authors: Luis Ortiz‑Reyes, Jayshil J. Patel, Xuran Jiang, Angel Coz Yataco, Andrew G. Day, Faraaz Shah, James Zelten, Maximiliano Tamae‑Kakazu, Todd Rice and Daren K. Heyland
    Citation: Critical Care 2022 26:192

    The original article was published in Critical Care 2022 26:173

  6. Severe COVID-19 induced acute respiratory distress syndrome (ARDS) often requires extracorporeal membrane oxygenation (ECMO). Recent German health insurance data revealed low ICU survival rates. Patient charac...

    Authors: Johannes Herrmann, Christopher Lotz, Christian Karagiannidis, Steffen Weber-Carstens, Stefan Kluge, Christian Putensen, Andreas Wehrfritz, Karsten Schmidt, Richard K. Ellerkmann, Daniel Oswald, Gösta Lotz, Viviane Zotzmann, Onnen Moerer, Christian Kühn, Matthias Kochanek, Ralf Muellenbach…
    Citation: Critical Care 2022 26:190
  7. Awake prone positioning (APP) reduces the intubation rate in COVID-19 patients treated by high-flow nasal cannula (HFNC). However, the lung aeration response to APP has not been addressed. We aimed to explore ...

    Authors: Miguel Ibarra-Estrada, María J. Gamero-Rodríguez, Marina García-de-Acilu, Oriol Roca, Laura Sandoval-Plascencia, Guadalupe Aguirre-Avalos, Roxana García-Salcido, Sara A. Aguirre-Díaz, David L. Vines, Sara Mirza, Ramandeep Kaur, Tyler Weiss, Claude Guerin and Jie Li
    Citation: Critical Care 2022 26:189
  8. Liberating patients from mechanical ventilation (MV) requires a systematic approach. In the context of a clinical trial, we developed a simple algorithm to identify patients who tolerate assisted ventilation b...

    Authors: Clement Brault, Jordi Mancebo, Juan-Carlos Suarez Montero, Tracey Bentall, Karen E. A. Burns, Thomas Piraino, François Lellouche, Pierre-Alexandre Bouchard, Emmanuel Charbonney, Guillaume Carteaux, Tommaso Maraffi, Gaëtan Beduneau, Alain Mercat, Yoanna Skrobik, Fei Zuo, Myriam Lafreniere-Roula…
    Citation: Critical Care 2022 26:188
  9. Fluid challenges are widely adopted in critically ill patients to reverse haemodynamic instability. We reviewed the literature to appraise fluid challenge characteristics in intensive care unit (ICU) patients ...

    Authors: Antonio Messina, Lorenzo Calabrò, Luca Pugliese, Aulona Lulja, Alexandra Sopuch, Daniela Rosalba, Emanuela Morenghi, Glenn Hernandez, Xavier Monnet and Maurizio Cecconi
    Citation: Critical Care 2022 26:186
  10. Whether targeting the driving pressure (∆P) when adjusting the tidal volume in mechanically ventilated patients with the acute respiratory distress syndrome (ARDS) may decrease the risk of ventilator-induced l...

    Authors: Anne-Fleur Haudebourg, Samuel Tuffet, François Perier, Keyvan Razazi, Nicolas de Prost, Armand Mekontso Dessap and Guillaume Carteaux
    Citation: Critical Care 2022 26:185
  11. Early haemorrhage control and minimizing the time to definitive care have long been the cornerstones of therapy for patients exsanguinating from non-compressible haemorrhage (NCH) after penetrating injuries, a...

    Authors: E. ter Avest, L. Carenzo, R. A. Lendrum, M. D. Christian, R. M. Lyon, C. Coniglio, M. Rehn, D. J. Lockey and Z. B. Perkins
    Citation: Critical Care 2022 26:184
  12. Clarithromycin may act as immune-regulating treatment in sepsis and acute respiratory dysfunction syndrome. However, clinical evidence remains inconclusive. We aimed to evaluate whether clarithromycin improves...

    Authors: Eleni Karakike, Brendon P. Scicluna, Maria Roumpoutsou, Ioannis Mitrou, Niki Karampela, Athanasios Karageorgos, Konstantinos Psaroulis, Eleni Massa, Achillefs Pitsoulis, Panagiotis Chaloulis, Evanthia Pappa, Irene T. Schrijver, Frantzeska Frantzeskaki, Malvina Lada, Nicolas Dauby, David De Bels…
    Citation: Critical Care 2022 26:183

    The Correspondence to this article has been published in Critical Care 2022 26:238

  13. Bacterial burden as well as duration of bacteremia influence the outcome of patients with bloodstream infections. Promptly decreasing bacterial load in the blood by using extracorporeal devices in addition to ...

    Authors: Gabriele Eden, Julius J. Schmidt, Stefan Büttner, Philipp Kümpers, Carsten Hafer, Alexandros Rovas, Benjamin Florian Koch, Bernhard M. W. Schmidt and Jan T. Kielstein
    Citation: Critical Care 2022 26:181
  14. Andexanet alfa is approved (FDA “accelerated approval”; EMA “conditional approval”) as the first specific reversal agent for factor Xa (FXa) inhibitor-associated uncontrolled or life-threatening bleeding. Four...

    Authors: Olivia S. Costa, Stuart J. Connolly, Mukul Sharma, Jan Beyer-Westendorf, Mary J. Christoph, Belinda Lovelace and Craig I. Coleman
    Citation: Critical Care 2022 26:180
  15. Mechanically ventilated patients have experienced greater periods of prolonged deep sedation during the coronavirus disease (COVID-19) pandemic. Multiple studies from the pre-COVID era demonstrate that early d...

    Authors: Robert J. Stephens, Erin M. Evans, Michael J. Pajor, Ryan D. Pappal, Haley M. Egan, Max Wei, Hunter Hayes, Jason A. Morris, Nicholas Becker, Brian W. Roberts, Marin H. Kollef, Nicholas M. Mohr and Brian M. Fuller
    Citation: Critical Care 2022 26:179
  16. Therapeutic drug monitoring (TDM) may represent an invaluable tool for optimizing antimicrobial therapy in septic patients, but extensive use is burdened by barriers. The aim of this study was to assess the im...

    Authors: Milo Gatti, Pier Giorgio Cojutti, Michele Bartoletti, Tommaso Tonetti, Amedeo Bianchini, Stefania Ramirez, Giacinto Pizzilli, Simone Ambretti, Maddalena Giannella, Rita Mancini, Antonio Siniscalchi, Pierluigi Viale and Federico Pea
    Citation: Critical Care 2022 26:178
  17. To assess the impact of treatment with steroids on the incidence and outcome of ventilator-associated pneumonia (VAP) in mechanically ventilated COVID-19 patients.

    Authors: Vittorio Scaravilli, Amedeo Guzzardella, Fabiana Madotto, Virginia Beltrama, Antonio Muscatello, Giacomo Bellani, Gianpaola Monti, Massimiliano Greco, Antonio Pesenti, Alessandra Bandera and Giacomo Grasselli
    Citation: Critical Care 2022 26:176
  18. With ICU mortality rates decreasing, it is increasingly important to identify interventions to minimize functional impairments and improve outcomes for survivors. Simultaneously, we must identify robust patien...

    Authors: Heather K. O’Grady, Lara Edbrooke, Christopher Farley, Sue Berney, Linda Denehy, Zudin Puthucheary and Michelle E. Kho
    Citation: Critical Care 2022 26:175
  19. Data on long-term outcomes after sepsis-associated critical illness have mostly come from small cohort studies, with no information about the incidence of new disability. We investigated whether sepsis-associa...

    Authors: Carol L. Hodgson, Alisa M. Higgins, Michael Bailey, Jonathon Barrett, Rinaldo Bellomo, D. James Cooper, Belinda J. Gabbe, Theodore Iwashyna, Natalie Linke, Paul S. Myles, Michelle Paton, Steve Philpot, Mark Shulman, Meredith Young and Ary Serpa Neto
    Citation: Critical Care 2022 26:174
  20. Real-world evidence on the timing and efficacy of enteral nutrition (EN) practices in intensive care unit (ICU) patients with circulatory shock is limited. We hypothesized early EN (EEN), as compared to delaye...

    Authors: Luis Ortiz-Reyes, Jayshil J. Patel, Xuran Jiang, Angel Coz Yataco, Andrew G. Day, Faraaz Shah, James Zelten, Maximiliano Tamae-Kakazu, Todd Rice and Daren K. Heyland
    Citation: Critical Care 2022 26:173

    The Correction to this article has been published in Critical Care 2022 26:192

  21. SARS-CoV-2 infection leads to acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). Both clinical data and animal experiments suggest that the renin–angiotensin system (RAS) is involved in th...

    Authors: Lingbing Zhang, Yandan Zhang, Xia Qin, Xuejun Jiang, Jun Zhang, Lejiao Mao, Ziqi Jiang, Yu Jiang, Gang Liu, Jingfu Qiu, Chengzhi Chen, Feng Qiu and Zhen Zou
    Citation: Critical Care 2022 26:171
  22. Rapid molecular tests could accelerate the control of extended-spectrum beta-lactamase-producing Enterobacterales (ESBL-PE) and carbapenemase-producing organisms (CPO) in intensive care units (ICUs).

    Authors: Romain Martischang, Patrice François, Abdessalam Cherkaoui, Gesuele Renzi, Carolina Fankhauser, Jacques Schrenzel, Jérôme Pugin and Stephan Harbarth
    Citation: Critical Care 2022 26:166
  23. Interleukin (IL)-18 is a marker of inflammasome activation, and high baseline plasma IL-18 is associated with increased mortality in patients with sepsis-induced ARDS. The aim of this analysis was to determine...

    Authors: Andrew James Boyle, Peter Ferris, Ian Bradbury, John Conlon, Manu Shankar-Hari, Angela J. Rogers, Cecilia M. O’Kane and Daniel F. McAuley
    Citation: Critical Care 2022 26:164
  24. Despite the benefits of mechanical ventilation, its use in critically ill patients is associated with complications and had led to the growth of noninvasive techniques. We assessed the effect of early intubati...

    Authors: Ricard Mellado-Artigas, Carlos Ferrando, Frédéric Martino, Agathe Delbove, Bruno L. Ferreyro, Cedric Darreau, Sophie Jacquier, Laurent Brochard and Nicolas Lerolle
    Citation: Critical Care 2022 26:163
  25. Whether dyspnea is present before starting a spontaneous breathing trial (SBT) and whether it may affect the outcome of the SBT is unknown. Mechanical Ventilation—Respiratory Distress Observation Scale (MV-RDO...

    Authors: Maxens Decavèle, Emmanuel Rozenberg, Marie-Cécile Niérat, Julien Mayaux, Elise Morawiec, Capucine Morélot-Panzini, Thomas Similowski, Alexandre Demoule and Martin Dres
    Citation: Critical Care 2022 26:162
  26. The burden of sepsis remains high in China. The relationship between case volume and hospital mortality among patients with septic shock, the most severe complication of sepsis, is unknown in China.

    Authors: Yan Chen, Xu-dong Ma, Xiao-hui Kang, Si-fa Gao, Jin-min Peng, Shan Li, Da-wei Liu, Xiang Zhou, Li Weng and Bin Du
    Citation: Critical Care 2022 26:161
  27. We determine the predictive value of transthoracic echocardiographic (TTE) metrics for clinical deterioration within 5 days in adults with intermediate-risk pulmonary embolism (PE).

    Authors: Anthony J. Weekes, Denise N. Fraga, Vitaliy Belyshev, William Bost, Christopher A. Gardner and Nathaniel S. O’Connell
    Citation: Critical Care 2022 26:160
  28. Acute respiratory distress syndrome (ARDS) has different phenotypes and distinct short-term outcomes. Patients with non-focal ARDS have a higher short-term mortality than focal ones. The aim of this study was ...

    Authors: Florian Blanchard, Thomas Godet, Stephanie Pons, Natacha Kapandji, Matthieu Jabaudon, Vincent Degos, Lucile Borao, Adrien Bougle, Antoine Monsel, Emmanuel Futier, Jean-Michel Constantin and Arthur James
    Citation: Critical Care 2022 26:159
  29. The aim is to characterise early and late respiratory and bloodstream co-infection in patients admitted to intensive care units (ICUs) with SARS-CoV-2-related acute hypoxemic respiratory failure (AHRF) needing...

    Authors: Manish Pandey, Alexander May, Laura Tan, Harriet Hughes, Jack Parry Jones, Wendy Harrison, Scott Bradburn, Sam Tyrrel, Babu Muthuswamy, Nidhika Berry, Richard Pugh, Daryn Sutton, Andy Campbell and Matthew Morgan
    Citation: Critical Care 2022 26:158
  30. Increasing evidence indicates the potential benefits of restricted fluid management in critically ill patients. Evidence lacks on the optimal fluid management strategy for invasively ventilated COVID-19 patien...

    Authors: Sanchit Ahuja, Harm-Jan de Grooth, Frederique Paulus, Fleur L. van der Ven, Ary Serpa Neto, Marcus J. Schultz and Pieter R. Tuinman
    Citation: Critical Care 2022 26:157
  31. A dysregulated immune response is emerging as a key feature of critical illness in COVID-19. Neutrophils are key components of early innate immunity that, if not tightly regulated, contribute to uncontrolled s...

    Authors: Chloé Loyer, Arnaud Lapostolle, Tomas Urbina, Alexandre Elabbadi, Jean-Rémi Lavillegrand, Thomas Chaigneau, Coraly Simoes, Julien Dessajan, Cyrielle Desnos, Mélanie Morin-Brureau, Yannick Chantran, Pierre Aucouturier, Bertrand Guidet, Guillaume Voiriot, Hafid Ait-Oufella and Carole Elbim
    Citation: Critical Care 2022 26:155
  32. The physiological effects of prone ventilation in ARDS patients have been discussed for a long time but have not been fully elucidated. Electrical impedance tomography (EIT) has emerged as a tool for bedside m...

    Authors: Yu-xian Wang, Ming Zhong, Min-hui Dong, Jie-qiong Song, Yi-jun Zheng, Wei Wu, Jia-le Tao, Ling Zhu and Xin Zheng
    Citation: Critical Care 2022 26:154
  33. The patients with prolonged mechanical ventilation (PMV) have the risk of ineffective coughing and infection due to diaphragm weakness. This study aimed to explore the effect of abdominal weight training (AWT)...

    Authors: Tsai-Yi Hung, Wen-Lan Wu, Ho-Chang Kuo, Shih-Feng Liu, Chia-Ling Chang, Hui-Chuan Chang, Yuh-Chyn Tsai and Jui-Fang Liu
    Citation: Critical Care 2022 26:153
  34. Caregivers and family members of Intensive Care Unit (ICU) survivors can face emotional problems following patient discharge from hospital. We aimed to evaluate the impact of a multi-centre integrated health a...

    Authors: Joanne McPeake, Philip Henderson, Pamela MacTavish, Helen Devine, Malcolm Daniel, Phil Lucie, Lynn Bollan, Lucy Hogg, Mike MacMahon, Sharon Mulhern, Pauline Murray, Laura O’Neill, Laura Strachan, Theodore J. Iwashyna, Martin Shaw and Tara Quasim
    Citation: Critical Care 2022 26:152
  35. Immunomodulatory therapies that improve the outcome of sepsis are not available. We sought to determine whether treatment of critically ill patients with sepsis with low-dose erythromycin—a macrolide antibioti...

    Authors: Tom D. Y. Reijnders, Hessel Peters-Sengers, Lonneke A. van Vught, Fabrice Uhel, Marc J. M. Bonten, Olaf L. Cremer, Marcus J. Schultz, Martijn M. Stuiver and Tom van der Poll
    Citation: Critical Care 2022 26:151
  36. Venous return is the flow of blood from the systemic venous network towards the right heart. At steady state, venous return equals cardiac output, as the venous and arterial systems operate in series. However,...

    Authors: Romain Persichini, Christopher Lai, Jean-Louis Teboul, Imane Adda, Laurent Guérin and Xavier Monnet
    Citation: Critical Care 2022 26:150