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  1. Although several trials were conducted to optimize the oxygenation range in intensive care unit (ICU) patients, no studies have yet reached a universal recommendation on the optimal a partial pressure of oxyge...

    Authors: Dong-gon Hyun, Jee Hwan Ahn, Jin Won Huh, Sang-Bum Hong, Younsuck Koh, Dong Kyu Oh, Su Yeon Lee, Mi Hyeon Park and Chae-Man Lim
    Citation: Critical Care 2024 28:187
  2. Critical illness syndromes including sepsis, acute respiratory distress syndrome, and acute kidney injury (AKI) are associated with high in-hospital mortality and long-term adverse health outcomes among surviv...

    Authors: Joseph Stevens, Oğuzhan Tezel, Valentina Bonnefil, Matthew Hapstack and Mihir R. Atreya
    Citation: Critical Care 2024 28:186
  3. Streptococcus pneumoniae is the most common bacterial cause of community acquired pneumonia and the acute respiratory distress syndrome (ARDS). Some clinical trials have demonstrated a beneficial effect of cortic...

    Authors: Hiroki Taenaka, Katherine D. Wick, Aartik Sarma, Shotaro Matsumoto, Rajani Ghale, Xiaohui Fang, Mazharul Maishan, Jeffrey E. Gotts, Charles R. Langelier, Carolyn S. Calfee and Michael A. Matthay
    Citation: Critical Care 2024 28:185
  4. The use of composite outcome measures (COM) in clinical trials is increasing. Whilst their use is associated with benefits, several limitations have been highlighted and there is limited literature exploring t...

    Authors: Humphrey G. M. Walker, Alastair J. Brown, Ines P. Vaz, Rebecca Reed, Max A. Schofield, Jeffrey Shao, Vinodh B. Nanjayya, Andrew A. Udy and Toby Jeffcote
    Citation: Critical Care 2024 28:184
  5. Despite significant progress in our understanding of the pathophysiology of sepsis and extensive clinical research, there are few proven therapies addressing the underlying immune dysregulation of this life-th...

    Authors: Marleen A. Slim, Niels van Mourik, Lieke Bakkerus, Katherine Fuller, Lydia Acharya, Tatiana Giannidis, Joanna C. Dionne, Simon J. W. Oczkowski, Mihai G. Netea, Peter Pickkers, Evangelos J. Giamarellos-Bourboulis, Marcella C. A. Müller, Tom van der Poll, W. Joost Wiersinga, Alexander P. J. Vlaar and Lonneke A. van Vught
    Citation: Critical Care 2024 28:183
  6. Triggers have been developed internationally to identify intensive care patients with palliative care needs. Due to their work, nurses are close to the patient and their perspective should therefore be include...

    Authors: Manuela Schallenburger, Jacqueline Schwartz, Andrea Icks, Jürgen in der Schmitten, Yann-Nicolas Batzler, Stefan Meier, Miguel Mendez-Delgado, Theresa Tenge and Martin Neukirchen
    Citation: Critical Care 2024 28:181
  7. Sepsis, an acute and potentially fatal systemic response to infection, significantly impacts global health by affecting millions annually. Prompt identification of sepsis is vital, as treatment delays lead to ...

    Authors: Sherali Bomrah, Mohy Uddin, Umashankar Upadhyay, Matthieu Komorowski, Jyoti Priya, Eshita Dhar, Shih-Chang Hsu and Shabbir Syed-Abdul
    Citation: Critical Care 2024 28:180
  8. Bacteraemia is a critical condition that generally leads to substantial morbidity and mortality. It is unclear whether delayed antimicrobial therapy (and/or source control) has a prognostic or defervescence ef...

    Authors: Ching-Chi Lee, Po-Lin Chen, Ching-Yu Ho, Ming-Yuan Hong, Yuan-Pin Hung and Wen-Chien Ko
    Citation: Critical Care 2024 28:176
  9. Dyspnea is a key symptom of de novo acute hypoxemic respiratory failure. This study explores dyspnea and its association with intubation and mortality in this population.

    Authors: Alexandre Demoule, Amandine Baptiste, Arnaud W. Thille, Thomas Similowski, Stephanie Ragot, Gwénael Prat, Alain Mercat, Christophe Girault, Guillaume Carteaux, Thierry Boulain, Sébastien Perbet, Maxens Decavèle, Lisa Belin and Jean-Pierre Frat
    Citation: Critical Care 2024 28:174
  10. Prognostication of outcome in severe stroke patients necessitating invasive mechanical ventilation poses significant challenges. The objective of this study was to assess the prognostic significance and preval...

    Authors: Sarah Benghanem, Nathalie Kubis, Etienne Gayat, Ambre Loiodice, Estelle Pruvost-Robieux, Tarek Sharshar, Arnaud Foucrier, Samy Figueiredo, Viviane Bouilleret, Etienne De Montmollin, François Bagate, Jean-Pascal Lefaucheur, Bertrand Guidet, Emmanuelle Appartis, Alain Cariou, Olivier Varnet…
    Citation: Critical Care 2024 28:173
  11. Traumatic brain injury (TBI) is a major cause of neurodisability worldwide, with notably high disability rates among moderately severe TBI cases. Extensive previous research emphasizes the critical need for ea...

    Authors: Hsiao-Ching Yen, Hung-Jui Chuang, Wei-Ling Hsiao, Yun-Chen Tsai, Po-Min Hsu, Wen-Shiang Chen and Yin-Yi Han
    Citation: Critical Care 2024 28:172
  12. Tidal expiratory flow limitation (EFLT) complicates the delivery of mechanical ventilation but is only diagnosed by performing specific manoeuvres. Instantaneous analysis of expiratory resistance (Rex) can be an ...

    Authors: Detajin Junhasavasdikul, Akarawut Kasemchaiyanun, Tanakorn Tassaneyasin, Tananchai Petnak, Frank Silva Bezerra, Ricard Mellado‐Artigas, Lu Chen, Yuda Sutherasan, Pongdhep Theerawit and Laurent Brochard
    Citation: Critical Care 2024 28:171
  13. The aim of this panel was to develop consensus recommendations on targeted temperature control (TTC) in patients with severe traumatic brain injury (TBI) and in patients with moderate TBI who deteriorate and r...

    Authors: Andrea Lavinio, Jonathan P. Coles, Chiara Robba, Marcel Aries, Pierre Bouzat, Dara Chean, Shirin Frisvold, Laura Galarza, Raimund Helbok, Jeroen Hermanides, Mathieu van der Jagt, David K. Menon, Geert Meyfroidt, Jean-Francois Payen, Daniele Poole, Frank Rasulo…
    Citation: Critical Care 2024 28:170
  14. Acute kidney injury (AKI) is a significant risk factor associated with reduced survival following out-of-hospital cardiac arrest (OHCA). Whether the severity of AKI simply serves as a surrogate measure of wors...

    Authors: Karoline Korsholm Jeppesen, Sebastian Buhl Rasmussen, Jesper Kjaergaard, Henrik Schmidt, Simon Mølstrøm, Rasmus Paulin Beske, Johannes Grand, Hanne Berg Ravn, Matilde Winther-Jensen, Martin Abild Stengaard Meyer, Christian Hassager and Jacob Eifer Møller
    Citation: Critical Care 2024 28:169
  15. Critically injured patients need rapid and appropriate hemostatic treatment, which requires prompt identification of trauma-induced coagulopathy (TIC) upon hospital admission. We developed and validated the pe...

    Authors: Louis Brac, Albrice Levrat, Charles-Hervé Vacheron, Pierre Bouzat, Tristan Delory and Jean-Stéphane David
    Citation: Critical Care 2024 28:168

    The Matters Arising to this article has been published in Critical Care 2024 28:234

  16. Non-resuscitation fluids constitute the majority of fluid administered for septic shock patients in the intensive care unit (ICU). This multicentre, randomized, feasibility trial was conducted to test the hypo...

    Authors: Anja Lindén, M. Spångfors, M. H. Olsen, J. Fisher, G. Lilja, F. Sjövall, M. Jungner, M. Lengquist, T. Kander, L. Samuelsson, J. Johansson, E. Palmnäs, J. Undén, J. Oras, M. Cronhjort, M. Chew…
    Citation: Critical Care 2024 28:166
  17. Mechanical ventilation, a lifesaving intervention in critical care, can lead to damage in the extracellular matrix (ECM), triggering inflammation and ventilator-induced lung injury (VILI), particularly in cond...

    Authors: Lou’i Al-Husinat, Saif Azzam, Sarah Al Sharie, Ahmed H. Al Sharie, Denise Battaglini, Chiara Robba, John J. Marini, Lauren T. Thornton, Fernanda F. Cruz, Pedro L. Silva and Patricia R. M. Rocco
    Citation: Critical Care 2024 28:165
  18. Hypoinflammatory and hyperinflammatory phenotypes have been identified in both Acute Respiratory Distress Syndrome (ARDS) and sepsis. Attributable mortality of ARDS in each phenotype of sepsis is yet to be det...

    Authors: Bruno Evrard, Pratik Sinha, Kevin Delucchi, Carolyn M. Hendrickson, Kirsten N. Kangelaris, Kathleen D. Liu, Andrew Willmore, Nelson Wu, Lucile Neyton, Emma Schmiege, Antonio Gomez, V. Eric Kerchberger, Ann Zalucky, Michael A. Matthay, Lorraine B. Ware and Carolyn S. Calfee
    Citation: Critical Care 2024 28:164
  19. Signal complexity (i.e. entropy) describes the level of order within a system. Low physiological signal complexity predicts unfavorable outcome in a variety of diseases and is assumed to reflect increased rigi...

    Authors: Stefan Yu Bögli, Ihsane Olakorede, Michael Veldeman, Erta Beqiri, Miriam Weiss, Gerrit Alexander Schubert, Jan Folkard Willms, Emanuela Keller and Peter Smielewski
    Citation: Critical Care 2024 28:163
  20. The effect of the periurethral cleansing range on catheter-associated urinary tract infection (CAUTI) occurrence remains unknown. The purpose of this study was to evaluate the efficacy of expanded periurethral...

    Authors: Xingsong Qin, He Zhao, Wei Qin, Xinglei Qin, Songying Shen and Hongyu Wang
    Citation: Critical Care 2024 28:162
  21. Authors: Bharat Paliwal, Nikhil Kothari, Trishita Saha and Pradeep Bhatia
    Citation: Critical Care 2024 28:161

    The original article was published in Critical Care 2024 28:42

    The Matters Arising to this article has been published in Critical Care 2024 28:190

  22. Limited data are available on organ donation practices and recipient outcomes, particularly when comparing donors who experienced cardiac arrest and received extracorporeal cardiopulmonary resuscitation (ECPR)...

    Authors: Tetsuya Yumoto, Kohei Tsukahara, Takafumi Obara, Takashi Hongo, Tsuyoshi Nojima, Hiromichi Naito and Atsunori Nakao
    Citation: Critical Care 2024 28:160
  23. An increasing number of patients requires extracorporeal membrane oxygenation (ECMO) for life support. This supportive modality is associated with nosocomial infections (NIs). This systematic review and meta-a...

    Authors: Ali Ait Hssain, Amir Vahedian-Azimi, Abdulsalam Saif Ibrahim, Ibrahim Fawzy Hassan, Elie Azoulay and Michael Darmon
    Citation: Critical Care 2024 28:158
  24. Invasive ventilation is a fundamental treatment in intensive care but its precise timing is difficult to determine. This study aims at assessing the effect of initiating invasive ventilation versus waiting, in...

    Authors: Ricard Mellado-Artigas, Xavier Borrat, Bruno L. Ferreyro, Christopher Yarnell, Sicheng Hao, Kerollos N. Wanis, Enric Barbeta, Antoni Torres, Carlos Ferrando and Laurent Brochard
    Citation: Critical Care 2024 28:157
  25. Current classification for acute kidney injury (AKI) in critically ill patients with sepsis relies only on its severity-measured by maximum creatinine which overlooks inherent complexities and longitudinal eva...

    Authors: Kullaya Takkavatakarn, Wonsuk Oh, Lili Chan, Ira Hofer, Khaled Shawwa, Monica Kraft, Neomi Shah, Roopa Kohli-Seth, Girish N. Nadkarni and Ankit Sakhuja
    Citation: Critical Care 2024 28:156
  26. Healthcare systems are large contributors to global emissions, and intensive care units (ICUs) are a complex and resource-intensive component of these systems. Recent global movements in sustainability initiat...

    Authors: Faisal N. Masud, Farzan Sasangohar, Iqbal Ratnani, Sahar Fatima, Marco Antonio Hernandez, Teal Riley, Jason Fischer, Atiya Dhala, Megan E. Gooch, Konya Keeling-Johnson, Jukrin Moon and Jean-Louis Vincent
    Citation: Critical Care 2024 28:154
  27. Re-intubation secondary to post-extubation respiratory failure in post-operative patients is associated with increased patient morbidity and mortality. Non-invasive respiratory support (NRS) alternative to con...

    Authors: Tommaso Pettenuzzo, Annalisa Boscolo, Elisa Pistollato, Chiara Pretto, Tommaso Antonio Giacon, Sara Frasson, Francesco Maria Carbotti, Francesca Medici, Giovanni Pettenon, Giuliana Carofiglio, Marco Nardelli, Nicolas Cucci, Clara Letizia Tuccio, Veronica Gagliardi, Chiara Schiavolin, Caterina Simoni…
    Citation: Critical Care 2024 28:152
  28. Intensive care unit (ICU)-survivors have an increased risk of mortality after discharge compared to the general population. On ICU admission subphenotypes based on the plasma biomarker levels of interleukin-8,...

    Authors: Marleen A. Slim, Rombout B. E. van Amstel, Lieuwe D. J. Bos, Olaf L. Cremer, W. Joost Wiersinga, Tom van der Poll and Lonneke A. van Vught
    Citation: Critical Care 2024 28:151
  29. Prior assessments of critical care outcomes in patients with cirrhosis have shown conflicting results. We aimed to provide nationwide generalizable results of critical care outcomes in patients with decompensa...

    Authors: Spencer R. Goble, Abdellatif S. Ismail, Jose D. Debes and Thomas M. Leventhal
    Citation: Critical Care 2024 28:150
  30. Sepsis occurs in 12–27% of patients with haematological malignancy within a year of diagnosis. Sepsis mortality has improved in non-cancer patients in the last two decades, but longitudinal trends in patients ...

    Authors: Aleece MacPhail, Claire Dendle, Monica Slavin, Robert Weinkove, Michael Bailey, David Pilcher and Zoe McQuilten
    Citation: Critical Care 2024 28:148
  31. A systematic review and meta-analysis to evaluate the impact of extracorporeal carbon dioxide removal (ECCO2R) on gas exchange and respiratory settings in critically ill adults with respiratory failure.

    Authors: Alexandra-Maria Stommel, Harald Herkner, Calvin Lukas Kienbacher, Brigitte Wildner, Alexander Hermann and Thomas Staudinger
    Citation: Critical Care 2024 28:146
  32. Screening for hazardous alcohol use and performing brief interventions (BIs) are recommended to reduce alcohol-related negative health consequences. We aimed to compare the effectiveness (defined as an at leas...

    Authors: Eliisa Nissilä, Marja Hynninen, Ville Jalkanen, Anne Kuitunen, Minna Bäcklund, Outi Inkinen and Johanna Hästbacka
    Citation: Critical Care 2024 28:145
  33. Physical rehabilitation of critically ill patients is implemented to improve physical outcomes from an intensive care stay. However, before rehabilitation is implemented, a risk assessment is essential, based ...

    Authors: Huw R. Woodbridge, Christopher J. McCarthy, Mandy Jones, Matthew Willis, David B. Antcliffe, Caroline M. Alexander and Anthony C. Gordon
    Citation: Critical Care 2024 28:144
  34. To determine whether intermittent intravenous (IV) paracetamol as primary analgesic would significantly reduce morphine consumption in children aged 0–3 years after cardiac surgery with cardiopulmonary bypass.

    Authors: Gerdien Zeilmaker-Roest, Christine de Vries-Rink, Joost van Rosmalen, Monique van Dijk, Saskia N. de Wildt, Catherijne A. J. Knibbe, Erik Koomen, Nicolaas J. G. Jansen, Martin C. J. Kneyber, Sofie Maebe, Greet Van den Berghe, Renata Haghedooren, Dirk Vlasselaers, Ad J. J. C. Bogers, Dick Tibboel and Enno D. Wildschut
    Citation: Critical Care 2024 28:143

    The Matters Arising to this article has been published in Critical Care 2024 28:193

  35. End-expiratory lung volume (EELV) is reduced in mechanically ventilated patients, especially in pathologic conditions. The resulting heterogeneous distribution of ventilation increases the risk for ventilation...

    Authors: J. A. Sanchez Giralt, G. Tusman, M. Wallin, M. Hallback, A. Perez Lucendo, M. Sanchez Galindo, B. Abad Santamaria, E. Paz Calzada, P. Garcia Garcia, D. Rodriguez Huerta, A. Canabal Berlanga and Fernando Suarez-Sipmann
    Citation: Critical Care 2024 28:142

    The Correction to this article has been published in Critical Care 2024 28:200

  36. Clinicians currently monitor pressure and volume at the airway opening, assuming that these observations relate closely to stresses and strains at the micro level. Indeed, this assumption forms the basis of cu...

    Authors: John J. Marini, Patricia R. M. Rocco, Lauren T. Thornton and Philip S. Crooke
    Citation: Critical Care 2024 28:141