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  1. Individuals who survive sepsis are at high risk of chronic sequelae, resulting in significant health-economic costs. Several studies have focused on aspects of healthcare pathways of sepsis survivors but compr...

    Authors: Fanny Pandolfi, Christian Brun-Buisson, Didier Guillemot and Laurence Watier
    Citation: Critical Care 2023 27:438
  2. The phase II CIGMA trial performed in 160 patients with severe community-acquired pneumonia (sCAP) found treatment with trimodulin (human polyvalent immunoglobulin [Ig]: ~ 23% IgM, ~ 21% IgA, ~ 56% IgG) was as...

    Authors: Mervyn Singer, Antoni Torres, Corina C. Heinz, Sabrina Weißmüller, Alexander Staus, Steffen Kistner, Ksenia Jakubczyk, Thomas Häder, Patrick Langohr, Andrea Wartenberg-Demand, Jörg Schüttrumpf, Jean-Louis Vincent and Tobias Welte
    Citation: Critical Care 2023 27:436
  3. Drug-induced kidney disease (DIKD) accounts for about one-fourth of all cases of acute kidney injury (AKI) in hospitalized patients, especially in critically ill setting. There is no standard definition or cla...

    Authors: Iman Karimzadeh, Erin F. Barreto, John A. Kellum, Linda Awdishu, Patrick T. Murray, Marlies Ostermann, Azra Bihorac, Ravindra L. Mehta, Stuart L. Goldstein, Kianoush B. Kashani and Sandra L. Kane-Gill
    Citation: Critical Care 2023 27:435
  4. While venoarterial extracorporeal membrane oxygenation (V-A ECMO) provides lifesaving support for cardiopulmonary failure, complications may increase mortality, with few studies focusing on ischemic/hemorrhagi...

    Authors: Jaeho Hwang, Andrew Kalra, Benjamin L. Shou, Glenn Whitman, Christopher Wilcox, Daniel Brodie, Akram M. Zaaqoq, Roberto Lorusso, Ken Uchino and Sung-Min Cho
    Citation: Critical Care 2023 27:433
  5. Given the success of recent platform trials for COVID-19, Bayesian statistical methods have become an option for complex, heterogenous syndromes like sepsis. However, study design will require careful consider...

    Authors: George Tomlinson, Ali Al-Khafaji, Steven A. Conrad, Faith N. F. Factora, Debra M. Foster, Claude Galphin, Kyle J. Gunnerson, Sobia Khan, Roopa Kohli-Seth, Paul McCarthy, Nikhil K. Meena, Ronald G. Pearl, Jean-Sebastien Rachoin, Ronald Rains, Michael Seneff, Mark Tidswell…
    Citation: Critical Care 2023 27:432
  6. Pulse pressure and stroke volume variation (PPV and SVV) have been widely used in surgical patients as predictors of fluid challenge (FC) response. Several factors may affect the reliability of these indices i...

    Authors: Antonio Messina, Mariagiovanna Caporale, Lorenzo Calabrò, Giulia Lionetti, Daniele Bono, Guia Margherita Matronola, Andrea Brunati, Luciano Frassanito, Emanuela Morenghi, Massimo Antonelli, Michelle S. Chew and Maurizio Cecconi
    Citation: Critical Care 2023 27:431

    The Matters Arising to this article has been published in Critical Care 2023 27:482

  7. The assessment of post-intensive care syndrome (PICS) is challenging due to the numerous types of instruments. We herein attempted to identify and propose recommendations for instruments to assess PICS in inte...

    Authors: Nobuto Nakanishi, Keibun Liu, Akira Kawauchi, Masatsugu Okamura, Kohei Tanaka, Sho Katayama, Yuki Mitani, Kohei Ota, Shunsuke Taito, Kenichi Fudeyasu, Yuki Masuka, Shodai Yoshihiro, Shu Utsumi, Mitsuaki Nishikimi, Mamoru Masuda, Yuki Iida…
    Citation: Critical Care 2023 27:430
  8. Capillary refill time (CRT) has been suggested as a variable to follow during the course of septic shock. We systematically investigated the effects on CRT of volume expansion and norepinephrine.

    Authors: Nicolas Fage, Francesca Moretto, Daniela Rosalba, Rui Shi, Christopher Lai, Jean-Louis Teboul and Xavier Monnet
    Citation: Critical Care 2023 27:429
  9. Critically ill patients suffer from acute muscle wasting, which is associated with significant physical functional impairment. We describe data from nested muscle biopsy studies from two trials of functional e...

    Authors: T. S. O. Jameson, M. K. Caldow, F. Stephens, L. Denehy, G. S. Lynch, R. Koopman, A. Krajcova, T. Urban, S. Berney, F. Duska and Z. Puthucheary
    Citation: Critical Care 2023 27:428
  10. It is yet to be better understood how outcomes during and after the critical illness potentially differ between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants from other lower respirator...

    Authors: Pontus Hedberg, Nicholas Baltzer, Fredrik Granath, Michael Fored, Johan Mårtensson and Pontus Nauclér
    Citation: Critical Care 2023 27:427
  11. Intention-to-treat analyses of POINCARE-2 trial led to inconclusive results regarding the effect of a conservative fluid balance strategy on mortality in critically ill patients. The present as-treated analysi...

    Authors: Adil Mansouri, Marie Buzzi, Sébastien Gibot, Claire Charpentier, Francis Schneider, Guillaume Louis, Hervé Outin, Alexandra Monnier, Jean-Pierre Quenot, Julio Badie, Laurent Argaud, Cédric Bruel, Marc Soudant and Nelly Agrinier
    Citation: Critical Care 2023 27:426
  12. Natural language processing (NLP) may help evaluate the characteristics, prevalence, trajectory, treatment, and outcomes of behavioural disturbance phenotypes in critically ill patients.

    Authors: Marcus Young, Natasha E. Holmes, Kartik Kishore, Sobia Amjad, Michele Gaca, Ary Serpa Neto, Michael C. Reade and Rinaldo Bellomo
    Citation: Critical Care 2023 27:425
  13. Acute cor pulmonale (ACP) is prognostic in patients with acute respiratory distress syndrome (ARDS). Identification of paradoxical septal motion (PSM) using two-dimensional echocardiography is highly subjectiv...

    Authors: Bruno Evrard, Jean-Baptiste Woillard, Annick Legras, Misylias Bouaoud, Maeva Gourraud, Antoine Humeau, Marine Goudelin and Philippe Vignon
    Citation: Critical Care 2023 27:424
  14. Trauma-induced coagulopathy (TIC) is common in trauma patients with major hemorrhage. Prothrombin complex concentrate (PCC) is used as a potential treatment for the correction of TIC, but the efficacy, timing,...

    Authors: Ioannis Hannadjas, Arthur James, Ross Davenport, Charlotte Lindsay, Karim Brohi and Elaine Cole
    Citation: Critical Care 2023 27:422

    The Matters Arising to this article has been published in Critical Care 2023 27:454

  15. Authors: Tjitske S. R. van Engelen, Tom D. Y. Reijnders, Fleur P. Paling, Marc J. M. Bonten, Leen Timbermont, Surbhi Malhotra-Kumar, Jan A. J. W. Kluytmans, Hessel Peters-Sengers and Tom van der Poll
    Citation: Critical Care 2023 27:420

    The original article was published in Critical Care 2023 27:269

  16. Acute respiratory distress syndrome (ARDS) subphenotypes differ in outcomes and treatment responses. Subphenotypes in high-flow nasal oxygen (HFNO)-treated ARDS patients have not been investigated.

    Authors: Pierre-Louis Blot, Benjamin G. Chousterman, Manel Santafè, Jérôme Cartailler, Andrés Pacheco, Mònica Magret, Joan R. Masclans, Antoni Artigas, Oriol Roca and Marina García-de-Acilu
    Citation: Critical Care 2023 27:419
  17. Despite cefoxitin's in vitro resistance to hydrolysis by extended-spectrum beta-lactamases (ESBL), treatment of ESBL-producing Klebsiella pneumoniae (KP) infections with cefoxitin remains controversial. The aim o...

    Authors: Tanguy Dequidt, Sylvaine Bastian, Mathieu Nacher, Sébastien Breurec, Michel Carles, Guillaume Thiery, Laurent Camous, Benoit Tressieres, Marc Valette and Jean-David Pommier
    Citation: Critical Care 2023 27:418
  18. Sepsis is one of the leading causes of death. Treatment attempts targeting the immune response regularly fail in clinical trials. As HCMV latency can modulate the immune response and changes the immune cell co...

    Authors: M. Unterberg, S. F. Ehrentraut, T. Bracht, A. Wolf, H. Haberl, A. von Busch, K. Rump, D. Ziehe, M. Bazzi, P. Thon, B. Sitek, K. Marcus, M. Bayer, K. Schork, M. Eisenacher, B. Ellger…
    Citation: Critical Care 2023 27:417

    The Matters Arising to this article has been published in Critical Care 2023 27:464

    The Matters Arising to this article has been published in Critical Care 2023 27:445

  19. Although the defining elements of “acute respiratory distress syndrome” (ARDS) have been known for over a century, the syndrome was first described in 1967. Since then, despite several revisions of its concept...

    Authors: Jesús Villar, Tamas Szakmany, Giacomo Grasselli and Luigi Camporota
    Citation: Critical Care 2023 27:416
  20. The results of clinical and weaning readiness tests and the spontaneous breathing trial (SBT) are used to predict the success of the weaning process and extubation.

    Authors: Fabio Varón-Vega, Luis F. Giraldo-Cadavid, Ana María Uribe, Adriana Rincón, Jonathan Palacios, Stephanie Crevoisier, Eduardo Tuta-Quintero, Lina Ordoñez, Natalia Boada, Paola Rincón, Marcela Poveda and Pablo Monedero
    Citation: Critical Care 2023 27:414
  21. The role of haloperidol as treatment for ICU delirium and related symptoms remains controversial despite two recent large controlled trials evaluating its efficacy and safety. We sought to determine whether ha...

    Authors: Lisa Smit, Arjen J. C. Slooter, John W. Devlin, Zoran Trogrlic, Nicole G. M. Hunfeld, Robert Jan Osse, Huibert H. Ponssen, Arjen J. B. W. Brouwers, Jeannette F. Schoonderbeek, Koen S. Simons, Mark van den Boogaard, Judith A. Lens, Dirk P. Boer, Diederik A. M. P. J. Gommers, Wim J. R. Rietdijk and Mathieu van der Jagt
    Citation: Critical Care 2023 27:413
  22. It has been 50 years since the pulmonary artery catheter was introduced, but the actual use of pulmonary artery catheters in recent years is unknown. Some randomized controlled trials have reported no causalit...

    Authors: Kentaro Fukano, Yusuke Iizuka, Seiya Nishiyama, Koichi Yoshinaga, Shigehiko Uchino, Yusuke Sasabuchi and Masamitsu Sanui
    Citation: Critical Care 2023 27:412
  23. Authors: Jheng‑Yan Wu, Ya‑Wen Tsai, Wan‑Hsuan Hsu, Ting‑Hui Liu, Po‑Yu Huang, Min‑Hsiang Chuang, Mei‑Yuan Liu and Chih‑Cheng Lai
    Citation: Critical Care 2023 27:411

    The original article was published in Critical Care 2023 27:274

  24. To assess the association with outcomes of cardiac index (CI) and mixed venous oxygen saturation (SvO2) in comatose patients resuscitated from out-of-hospital cardiac arrest (OHCA).

    Authors: Johannes Grand, Christian Hassager, Henrik Schmidt, Simon Mølstrøm, Benjamin Nyholm, Henrik Frederiksen Høigaard, Jordi S. Dahl, Martin Meyer, Rasmus P. Beske, Laust Obling, Jesper Kjaergaard and Jacob E. Møller
    Citation: Critical Care 2023 27:410

    The Matters Arising to this article has been published in Critical Care 2023 27:451

  25. Dual circulation is a common but underrecognized physiological occurrence associated with peripheral venoarterial extracorporeal membrane oxygenation (ECMO). Competitive flow will develop between blood ejected...

    Authors: Richa Asija, Justin A. Fried, Eric C. Siddall, Dana A. Mullin, Cara L. Agerstrand, Daniel Brodie, Joshua R. Sonett, Philippe H. Lemaitre and Darryl Abrams
    Citation: Critical Care 2023 27:408
  26. This study aimed to quantitatively analyse ultra-early brain diffusion-weighted magnetic resonance imaging (DW-MRI) findings to determine the apparent diffusion coefficient (ADC) threshold associated with neur...

    Authors: Jung A. Yoon, Changshin Kang, Jung Soo Park, Yeonho You, Jin Hong Min, Yong Nam In, Wonjoon Jeong, Hong Joon Ahn, In Ho Lee, Hye Seon Jeong, Byung Kook Lee and Jae Kwang Lee
    Citation: Critical Care 2023 27:407
  27. Venous thromboembolism (VTE) is a severe complication in critically ill patients, often resulting in death and long-term disability and is one of the major contributors to the global burden of disease. This st...

    Authors: Chengfu Guan, Fuxin Ma, Sijie Chang and Jinhua Zhang
    Citation: Critical Care 2023 27:406
  28. Shared decision-making is a joint process where patients, or their surrogates, and clinicians make health choices based on evidence and preferences. We aimed to determine the extent and predictors of shared de...

    Authors: Victoria Fleming, Abhinav Prasad, Connie Ge, Sybil Crawford, Shazeb Meraj, Catherine L. Hough, Bernard Lo, Shannon S. Carson, Jay Steingrub, Douglas B. White and Susanne Muehlschlegel
    Citation: Critical Care 2023 27:403
  29. Supplemental oxygen is commonly administered to patients after out-of-hospital cardiac arrest. However, the findings from studies on oxygen targeting for out-of-hospital cardiac arrest are inconclusive. Thus, ...

    Authors: Xin Cheng, Yu Zhang, Haidong Deng, Yuning Feng, Weelic Chong, Yang Hai, Pengfei Hao, Jialing He, Tiangui Li, Liyuan Peng, Peng Wang, Yangchun Xiao and Fang Fang
    Citation: Critical Care 2023 27:401

    The Matters Arising to this article has been published in Critical Care 2023 27:471

  30. Septic shock can be caused by a variety of mechanisms including direct effects of bacterial toxins such as endotoxin. Annually, approximately 5–7 million patients worldwide develop sepsis with very high endoto...

    Authors: John A. Kellum and Claudio Ronco
    Citation: Critical Care 2023 27:400
  31. Based on low-quality evidence, current nutrition guidelines recommend the delivery of high-dose protein in critically ill patients. The EFFORT Protein trial showed that higher protein dose is not associated wi...

    Authors: Christian Stoppe, Jayshil J. Patel, Alex Zarbock, Zheng-Yii Lee, Todd W. Rice, Bruno Mafrici, Rebecca Wehner, Man Hung Manuel Chan, Peter Chi Keung Lai, Kristen MacEachern, Pavlos Myrianthefs, Evdoxia Tsigou, Luis Ortiz-Reyes, Xuran Jiang, Andrew G. Day, M. Shahnaz Hasan…
    Citation: Critical Care 2023 27:399
  32. Although patients with interstitial pneumonia pattern (ILD-UIP) and acute exacerbation (AE) leading to severe acute respiratory failure may require invasive mechanical ventilation (MV), physiological data on l...

    Authors: Roberto Tonelli, Salvatore Grasso, Andrea Cortegiani, Lorenzo Ball, Ivana Castaniere, Luca Tabbì, Riccardo Fantini, Dario Andrisani, Filippo Gozzi, Antonio Moretti, Giulia Bruzzi, Linda Manicardi, Stefania Cerri, Anna Valeria Samarelli, Giulia Raineri, Francesco Murgolo…
    Citation: Critical Care 2023 27:398
  33. Appropriate antibiotic (AB) therapy remains a challenge in the intensive care unit (ICU). Procalcitonin (PCT)-guided AB stewardship could help optimize AB treatment and decrease AB-related adverse effects, but...

    Authors: Márton Papp, Nikolett Kiss, Máté Baka, Domonkos Trásy, László Zubek, Péter Fehérvári, Andrea Harnos, Caner Turan, Péter Hegyi and Zsolt Molnár
    Citation: Critical Care 2023 27:394
  34. Mega-dose sodium ascorbate (NaAscorbate) appears beneficial in experimental sepsis. However, its physiological effects in patients with septic shock are unknown.

    Authors: Fumitaka Yanase, Sofia Spano, Akinori Maeda, Anis Chaba, Thummaporn Naorungroj, Connie Pei Chen Ow, Yugeesh R. Lankadeva, Clive N. May, Ashenafi H. Betrie, Darius J. R. Lane, Glenn M. Eastwood, Mark P. Plummer and Rinaldo Bellomo
    Citation: Critical Care 2023 27:371
  35. Various approaches have been suggested to identify acute kidney injury (AKI) early and to initiate kidney-protective measures in patients at risk or with AKI. The objective of this study was to evaluate whethe...

    Authors: Chun Yin See, Heng-Chih Pan, Jui-Yi Chen, Chun-Yi Wu, Hung-Wei Liao, Yen-Ta Huang, Jung-Hua Liu, Vin-Cent Wu and Marlies Ostermann
    Citation: Critical Care 2023 27:390
  36. Low levels of high-density lipoprotein (HDL) cholesterol have been associated with higher rates and severity of infection. Alterations in inflammatory mediators and infection are associated with alterations in...

    Authors: Fergus Hamilton, Kasper Mønsted Pedersen, Peter Ghazal, Børge Grønne Nordestgaard and George Davey Smith
    Citation: Critical Care 2023 27:389