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  1. Content type: Research

    Anemia is frequent among patients with traumatic brain injury (TBI) and is associated with an increased risk of poor outcome. The optimal hemoglobin concentration to trigger red blood cell (RBC) transfusion in...

    Authors: André L. N. Gobatto, Milena A. Link, Davi J. Solla, Estevão Bassi, Paulo F. Tierno, Wellingson Paiva, Fabio S. Taccone and Luiz M. Malbouisson

    Citation: Critical Care 2019 23:89

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  2. Content type: Research

    Continuous coordination among organ systems is necessary to maintain biological stability in humans. Organ system network analysis in addition to organ-oriented medicine is expected to improve patient outcomes...

    Authors: Toshifumi Asada, Kent Doi, Ryota Inokuchi, Naoki Hayase, Miyuki Yamamoto and Naoto Morimura

    Citation: Critical Care 2019 23:83

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  3. Content type: Review

    This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2019. Other selected articles can be found online at

    Authors: Irene Telias and Mary Elizabeth Wilcox

    Citation: Critical Care 2019 23:82

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  4. Content type: Research

    Right ventricle (RV) size and function assessment by echocardiography (echo) is a standard tool in the ICU. Frequently subjective assessment is performed, and guidelines suggest its utility in adequately train...

    Authors: Sam Orde, Michel Slama, Konstantin Yastrebov, Anthony Mclean and Stephen Huang

    Citation: Critical Care 2019 23:70

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  5. Content type: Research

    Fever improves pathogen control at a significant metabolic cost. No randomized clinical trials (RCT) have compared fever treatment thresholds in critically ill children. We performed a pilot RCT to determine w...

    Authors: Mark J. Peters, Kerry Woolfall, Imran Khan, Elisabeth Deja, Paul R. Mouncey, Jerome Wulff, Alexina Mason, Rachel S. Agbeko, Elizabeth S. Draper, Blaise Fenn, Doug W. Gould, Abby Koelewyn, Nigel Klein, Christine Mackerness, Sian Martin, Lauran O’Neill…

    Citation: Critical Care 2019 23:69

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  6. Content type: Research

    Data on high-flow nasal oxygen after thoracic surgery are limited and confined to the comparison with low-flow oxygen. Different from low-flow oxygen, Venturi masks provide higher gas flow at a predetermined f...

    Authors: Mariano Alberto Pennisi, Giuseppe Bello, Maria Teresa Congedo, Luca Montini, Dania Nachira, Gian Maria Ferretti, Elisa Meacci, Elisabetta Gualtieri, Gennaro De Pascale, Domenico Luca Grieco, Stefano Margaritora and Massimo Antonelli

    Citation: Critical Care 2019 23:68

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  7. Content type: Research

    Organ dysfunction is common after cardiac arrest and associated with worse short-term outcome, but its impact on long-term outcome and treatment costs is unknown.

    Authors: Pirkka T. Pekkarinen, Minna Bäcklund, Ilmar Efendijev, Rahul Raj, Daniel Folger, Erik Litonius, Ruut Laitio, Stepani Bendel, Sanna Hoppu, Tero Ala-Kokko, Matti Reinikainen and Markus B. Skrifvars

    Citation: Critical Care 2019 23:67

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  8. Content type: Research

    Development of emergency department (ED) triage systems that accurately differentiate and prioritize critically ill from stable patients remains challenging. We used machine learning models to predict clinical...

    Authors: Yoshihiko Raita, Tadahiro Goto, Mohammad Kamal Faridi, David F. M. Brown, Carlos A. Camargo Jr. and Kohei Hasegawa

    Citation: Critical Care 2019 23:64

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  9. Content type: Research

    Mechanical ventilation is strongly associated with cognitive decline after critical illness. This finding is particularly evident among older individuals who have pre-existing cognitive impairment, most common...

    Authors: Shouri Lahiri, Giovanna C. Regis, Yosef Koronyo, Dieu-Trang Fuchs, Julia Sheyn, Elizabeth H. Kim, Mitra Mastali, Jennifer E. Van Eyk, Padmesh S. Rajput, Patrick D. Lyden, Keith L. Black, E. Wesley Ely, Heather D. Jones and Maya Koronyo-Hamaoui

    Citation: Critical Care 2019 23:63

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  10. Content type: Review

    There is a high degree of uncertainty regarding optimum care of patients with potential or known intake of oral anticoagulants and traumatic brain injury (TBI). Anticoagulation therapy aggravates the risk of i...

    Authors: Marion Wiegele, Herbert Schöchl, Alexander Haushofer, Martin Ortler, Johannes Leitgeb, Oskar Kwasny, Ronny Beer, Cihan Ay and Eva Schaden

    Citation: Critical Care 2019 23:62

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  11. Content type: Research

    The aim of this study was to explore the performance and outcomes for intravascular (IC) versus surface cooling devices (SFC) for targeted temperature management (TTM) after out-of-hospital cardiac arrest.

    Authors: Chiara De Fazio, Markus B. Skrifvars, Eldar Søreide, Jacques Creteur, Anders M. Grejs, Jesper Kjærgaard, Timo Laitio, Jens Nee, Hans Kirkegaard and Fabio Silvio Taccone

    Citation: Critical Care 2019 23:61

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  12. Content type: Research

    Rapid response teams (RRTs) respond to hospitalized patients experiencing clinical deterioration and help determine subsequent management and disposition. We sought to evaluate and compare the prognostic accur...

    Authors: Shannon M. Fernando, Alison E. Fox-Robichaud, Bram Rochwerg, Pierre Cardinal, Andrew J. E. Seely, Jeffrey J. Perry, Daniel I. McIsaac, Alexandre Tran, Steven Skitch, Benjamin Tam, Michael Hickey, Peter M. Reardon, Peter Tanuseputro and Kwadwo Kyeremanteng

    Citation: Critical Care 2019 23:60

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  13. Content type: Research

    Most of the previous studies focused on central line-associated bloodstream infection (CLABSI), while non-central line-associated bloodstream infection (N-CLABSI) was poorly studied. This study was performed t...

    Authors: Shichao Zhu, Yan Kang, Wen Wang, Lin Cai, Xin Sun and Zhiyong Zong

    Citation: Critical Care 2019 23:52

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  14. Content type: Research

    Data on the methods used for microbiological diagnosis of hospital-acquired pneumonia (HAP) are mainly extrapolated from ventilator-associated pneumonia. HAP poses additional challenges for respiratory samplin...

    Authors: Otavio T. Ranzani, Tarek Senussi, Francesco Idone, Adrian Ceccato, Gianluigi Li Bassi, Miquel Ferrer and Antoni Torres

    Citation: Critical Care 2019 23:51

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  15. Content type: Research

    Recent studies have reported that preadmission metformin users had lower mortality than non-metformin users in patients with sepsis and diabetes mellitus; however, these results are still controversial. Theref...

    Authors: Huoyan Liang, Xianfei Ding, Lifeng Li, Tian Wang, Quancheng Kan, Lexin Wang and Tongwen Sun

    Citation: Critical Care 2019 23:50

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  16. Content type: Research

    Hyperventilation-induced hypocapnia (HV) reduces elevated intracranial pressure (ICP), a dangerous and potentially fatal complication of traumatic brain injury (TBI). HV decreases the arteriolar diameter of in...

    Authors: Giovanna Brandi, Nino Stocchetti, Alberto Pagnamenta, Federica Stretti, Peter Steiger and Stephanie Klinzing

    Citation: Critical Care 2019 23:45

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  17. Content type: Research

    The acute respiratory distress syndrome (ARDS) is characterized by disruption of the alveolar-capillary barrier resulting in accumulation of proteinaceous edema and increased inflammatory cells in the alveolar...

    Authors: Yue Zhou, Pengfei Li, Andrew J. Goodwin, James A. Cook, Perry V. Halushka, Eugene Chang, Basilia Zingarelli and Hongkuan Fan

    Citation: Critical Care 2019 23:44

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  18. Content type: Research

    With the development of new techniques to easily obtain lower respiratory tract specimens, bronchoalveolar lavage fluid and other lung fluids are gaining importance in pulmonary disease diagnosis. We aimed to ...

    Authors: Yishan Wang, Huijuan Wang, Chunfang Zhang, Chao Zhang, Huqin Yang, Ruiyue Gao and Zhaohui Tong

    Citation: Critical Care 2019 23:43

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  19. Content type: Research

    Several lipid metabolites in cerebrospinal fluid are correlated with poor outcomes in aneurysmal subarachnoid haemorrhage. Most of these metabolites bind to ubiquitous thromboxane–prostaglandin (TP) receptors,...

    Authors: David Lagier, David Tonon, Philippe Garrigue, Benjamin Guillet, Laura Giacomino, Jean-Charles Martin, Marie-Christine Alessi, Nicolas Bruder and Lionel J. Velly

    Citation: Critical Care 2019 23:42

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  20. Content type: Research

    Theoretically, atrial natriuretic peptide (ANP), especially low-dose ANP, is beneficial in acute kidney injury (AKI). In this study, we examined whether low-dose ANP is effective in preventing or treating AKI ...

    Authors: Hiroyuki Yamada, Kent Doi, Tatsuo Tsukamoto, Hideyasu Kiyomoto, Kazuto Yamashita, Motoko Yanagita, Yoshio Terada and Kiyoshi Mori

    Citation: Critical Care 2019 23:41

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  21. Content type: Research

    There is a lack of validated tools to assess potential disease progression and hospitalisation decisions in patients presenting to the emergency department (ED) with a suspected infection. This study aimed to ...

    Authors: Kordo Saeed, Darius Cameron Wilson, Frank Bloos, Philipp Schuetz, Yuri van der Does, Olle Melander, Pierre Hausfater, Jacopo M. Legramante, Yann-Erick Claessens, Deveendra Amin, Mari Rosenqvist, Graham White, Beat Mueller, Maarten Limper, Carlota Clemente Callejo, Antonella Brandi…

    Citation: Critical Care 2019 23:40

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    The Letter to this article has been published in Critical Care 2019 23:129

  22. Content type: Research

    The Extracorporeal Life Support Organization (ELSO) Maastricht Treaty for Nomenclature in Extracorporeal Life Support (ECLS) established consensus nomenclature and abbreviations for ECLS to ensure accurate, co...

    Authors: Lars Mikael Broman, Fabio Silvio Taccone, Roberto Lorusso, Maximilian Valentin Malfertheiner, Federico Pappalardo, Matteo Di Nardo, Mirko Belliato, Melania M. Bembea, Ryan P. Barbaro, Rodrigo Diaz, Lorenzo Grazioli, Vincent Pellegrino, Malaika H. Mendonca, Daniel Brodie, Eddy Fan, Robert H. Bartlett…

    Citation: Critical Care 2019 23:36

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