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  1. The effectiveness and indications of open-chest cardiopulmonary resuscitation (OCCPR) have been still debatable. Although current guidelines state that the presence of signs of life (SOL) is an indication for ...

    Authors: Akira Endo, Mitsuaki Kojima, Zhi-Jie Hong, Yasuhiro Otomo and Raul Coimbra

    Citation: Critical Care 2020 24:541

    Content type: Research

    Published on:

  2. During critical illness, there are a multitude of forces such as antibiotic use, mechanical ventilation, diet changes and inflammatory responses that could bring the microbiome out of balance. This so-called d...

    Authors: Ignacio Martin-Loeches, Robert Dickson, Antoni Torres, Håkan Hanberger, Jeffrey Lipman, Massimo Antonelli, Gennaro de Pascale, Fernando Bozza, Jean Louis Vincent, Srinivas Murthy, Michael Bauer, John Marshall, Catia Cilloniz and Lieuwe D. Bos

    Citation: Critical Care 2020 24:537

    Content type: Review

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  3. In critically ill children, omitting early use of parenteral nutrition (late-PN versus early-PN) reduced infections, accelerated weaning from mechanical ventilation, and shortened PICU stay. We hypothesized th...

    Authors: Astrid De Bruyn, Jan Gunst, Chloë Goossens, Sarah Vander Perre, Gonzalo G. Guerra, Sascha Verbruggen, Koen Joosten, Lies Langouche and Greet Van den Berghe

    Citation: Critical Care 2020 24:536

    Content type: Research

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  4. Sepsis represents a major worldwide healthcare burden. However, how body-mass index (BMI) is related to the long-term risk of sepsis-related mortality in low- and middle-income countries remains uncertain.

    Authors: Li Weng, Junning Fan, Canqing Yu, Yu Guo, Zheng Bian, Yuxia Wei, Ling Yang, Yiping Chen, Huaidong Du, Liang Chang, Weiwei Gong, Junshi Chen, Zhengming Chen, Bin Du, Jun Lv and Liming Li

    Citation: Critical Care 2020 24:534

    Content type: Research

    Published on:

  5. Whether respiratory physiology of COVID-19-induced respiratory failure is different from acute respiratory distress syndrome (ARDS) of other etiologies is unclear. We conducted a single-center study to describ...

    Authors: Domenico Luca Grieco, Filippo Bongiovanni, Lu Chen, Luca S. Menga, Salvatore Lucio Cutuli, Gabriele Pintaudi, Simone Carelli, Teresa Michi, Flava Torrini, Gianmarco Lombardi, Gian Marco Anzellotti, Gennaro De Pascale, Andrea Urbani, Maria Grazia Bocci, Eloisa S. Tanzarella, Giuseppe Bello…

    Citation: Critical Care 2020 24:529

    Content type: Research

    Published on:

  6. Coronavirus disease 2019 (COVID-19) is a newly emerging infectious disease and rapidly escalating epidemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The pathogenesis of COVID-...

    Authors: Zhilin Zeng, Haijing Yu, Huilong Chen, Weipeng Qi, Liang Chen, Guang Chen, Weiming Yan, Tao Chen, Qin Ning, Meifang Han and Di Wu

    Citation: Critical Care 2020 24:525

    Content type: Research

    Published on:

  7. As an increasing number of deaths occur in the intensive care unit (ICU), studies have sought to describe, understand, and improve end-of-life care in this setting. Most of these studies are centered on the pa...

    Authors: Florence Boissier, Valérie Seegers, Amélie Seguin, Stéphane Legriel, Alain Cariou, Samir Jaber, Jean-Yves Lefrant, Thomas Rimmelé, Anne Renault, Isabelle Vinatier, Armelle Mathonnet, Danielle Reuter, Olivier Guisset, Christophe Cracco, Jacques Durand-Gasselin, Béatrice Éon…

    Citation: Critical Care 2020 24:521

    Content type: Research

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  8. Sepsis remains a common condition with high mortality when multiple organ failure develops. The evidence for therapeutic plasma exchange (TPE) in this setting is promising but inconclusive. Our study aims to e...

    Authors: Philip D. Keith, Adam H. Wells, Jeremy Hodges, Stephen H. Fast, Amber Adams and L. Keith Scott

    Citation: Critical Care 2020 24:518

    Content type: Research

    Published on:

  9. To evaluate the incidence and mortality of acute respiratory distress syndrome (ARDS) in medical/respiratory intensive care units (MICUs/RICUs) to assess ventilation management and the use of adjunct therapy i...

    Authors: Xu Huang, Ruoyang Zhang, Guohui Fan, Dawei Wu, Haining Lu, Daoxin Wang, Wang Deng, Tongwen Sun, Lihua Xing, Shaohua Liu, Shilei Wang, Ying Cai, Ye Tian, Yi Zhang, Jingen Xia and Qingyuan Zhan

    Citation: Critical Care 2020 24:515

    Content type: Research

    Published on:

  10. The optimal MAP target for patients with cardiogenic shock (CS) remains unknown. We sought to determine the relationship between mean arterial pressure (MAP) and mortality in the cardiac intensive care unit (C...

    Authors: Barry Burstein, Meir Tabi, Gregory W. Barsness, Malcolm R. Bell, Kianoush Kashani and Jacob C. Jentzer

    Citation: Critical Care 2020 24:513

    Content type: Research

    Published on:

  11. The use of trans-nasal pulmonary aerosol delivery via high-flow nasal cannula (HFNC) has expanded in recent years. However, various factors influencing aerosol delivery in this setting have not been precisely ...

    Authors: Jie Li, James B. Fink, Ronan MacLoughlin and Rajiv Dhand

    Citation: Critical Care 2020 24:506

    Content type: Review

    Published on:

  12. In-hospital cardiac arrest (IHCA) is a major adverse event with a high mortality rate if not treated appropriately. Extracorporeal cardiopulmonary resuscitation (ECPR), as adjunct to conventional cardiopulmona...

    Authors: Benjamin Yaël Gravesteijn, Marc Schluep, Maksud Disli, Prakriti Garkhail, Dinis Dos Reis Miranda, Robert-Jan Stolker, Henrik Endeman and Sanne Elisabeth Hoeks

    Citation: Critical Care 2020 24:505

    Content type: Research

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  13. Calcium release-activated calcium (CRAC) channel inhibitors stabilize the pulmonary endothelium and block proinflammatory cytokine release, potentially mitigating respiratory complications observed in patients...

    Authors: Joseph Miller, Charles Bruen, Michael Schnaus, Jeffrey Zhang, Sadia Ali, April Lind, Zachary Stoecker, Kenneth Stauderman and Sudarshan Hebbar

    Citation: Critical Care 2020 24:502

    Content type: Research

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  14. The goal of nutrition support is to provide the substrates required to match the bioenergetic needs of the patient and promote the net synthesis of macromolecules required for the preservation of lean mass, or...

    Authors: Christian Stoppe, Sebastian Wendt, Nilesh M. Mehta, Charlene Compher, Jean-Charles Preiser, Daren K. Heyland and Arnold S. Kristof

    Citation: Critical Care 2020 24:499

    Content type: Review

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  15. Post-mortem studies can provide important information for understanding new diseases and small autopsy case series have already reported different findings in COVID-19 patients.

    Authors: Myriam Remmelink, Ricardo De Mendonça, Nicky D’Haene, Sarah De Clercq, Camille Verocq, Laetitia Lebrun, Philomène Lavis, Marie-Lucie Racu, Anne-Laure Trépant, Calliope Maris, Sandrine Rorive, Jean-Christophe Goffard, Olivier De Witte, Lorenzo Peluso, Jean-Louis Vincent, Christine Decaestecker…

    Citation: Critical Care 2020 24:495

    Content type: Research

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  16. Deterioration of lung function during the first week of COVID-19 has been observed when patients remain with insufficient respiratory support. Patient self-inflicted lung injury (P-SILI) is theorized as the re...

    Authors: Pablo Cruces, Jaime Retamal, Daniel E. Hurtado, Benjamín Erranz, Pablo Iturrieta, Carlos González and Franco Díaz

    Citation: Critical Care 2020 24:494

    Content type: Review

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  17. Administration of dexmedetomidine has been reported to improve inflammatory response in animals. We explored the effects of administering dexmedetomidine on the levels of C-reactive protein (CRP) and procalcit...

    Authors: Yoshinori Ohta, Kyohei Miyamoto, Yu Kawazoe, Hitoshi Yamamura and Takeshi Morimoto

    Citation: Critical Care 2020 24:493

    Content type: Research

    Published on: