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  1. The use of instrumental tools for improving both the diagnostic accuracy and the prognostic soundness in patients with disorders of consciousness (DOC) plays an important role. However, the most recent interna...

    Authors: F. G. Magnani, F. Barbadoro, M. Cacciatore and M. Leonardi
    Citation: Critical Care 2022 26:245
  2. A greater understanding of disease heterogeneity may facilitate precision medicine for coronavirus disease 2019 (COVID-19). Previous work identified four distinct clinical phenotypes associated with outcome an...

    Authors: Niklas Bruse, Emma J. Kooistra, Aron Jansen, Rombout B. E. van Amstel, Nicolette F. de Keizer, Jason N. Kennedy, Christopher Seymour, Lonneke A. van Vught, Peter Pickkers and Matthijs Kox
    Citation: Critical Care 2022 26:244
  3. Droplet digital PCR (ddPCR) has emerged as a promising tool of pathogen detection in bloodstream infections (BSIs) in critical care medicine. However, different ddPCR platforms have variable sensitivity and sp...

    Authors: Jing Wu, Bin Tang, Yuzhen Qiu, Ruoming Tan, Jialin Liu, Jiang Xia, Jing Zhang, Jingjing Huang, Jieming Qu, Jingyong Sun, Xiaoli Wang and Hongping Qu
    Citation: Critical Care 2022 26:243
  4. A hallmark of ARDS is progressive shrinking of the ‘baby lung,’ now referred to as the ventilator-induced lung injury (VILI) ‘vortex.’ Reducing the risk of the VILI vortex is the goal of current ventilation st...

    Authors: Gary Nieman, Michaela Kollisch-Singule, Harry Ramcharran, Joshua Satalin, Sarah Blair, Louis A. Gatto, Penny Andrews, Auyon Ghosh, David W. Kaczka, Donald Gaver, Jason Bates and Nader M. Habashi
    Citation: Critical Care 2022 26:242
  5. Trauma is a heterogeneous condition, and specific clinical phenotypes may identify target populations that could benefit from certain treatment strategies. In this retrospective study, we determined clinical p...

    Authors: Jotaro Tachino, Hisatake Matsumoto, Fuminori Sugihara, Shigeto Seno, Daisuke Okuzaki, Tetsuhisa Kitamura, Sho Komukai, Yoshiyuki Kido, Takashi Kojima, Yuki Togami, Yusuke Katayama, Yuko Nakagawa and Hiroshi Ogura
    Citation: Critical Care 2022 26:241
  6. Clinical research on nutritional and metabolic interventions in critically ill patients is heterogenous regarding time points, outcomes and measurement instruments used, impeding intervention development and d...

    Authors: T. W. Davies, R. J. J. van Gassel, M. van de Poll, J. Gunst, M. P. Casaer, K. B. Christopher, J. C. Preiser, A. Hill, K. Gundogan, A. Reintam-Blaser, A. F. Rousseau, C. Hodgson, D. M. Needham, M. Castro, S. Schaller, T. McClelland…
    Citation: Critical Care 2022 26:240
  7. There is no consensus exists regarding the association between oxygen exposure (arterial oxygen tension or fraction of inspired oxygen) and outcomes for patients with mechanical ventilation. Additionally, whet...

    Authors: Zhu Zhu, Mingqin Zhou, Yao Wei and Hui Chen
    Citation: Critical Care 2022 26:239
  8. The objective was to investigate the role of gene expression and plasma levels of the muscular protein myostatin in intensive care unit-acquired weakness (ICUAW). This was performed to evaluate a potential cli...

    Authors: Julius J. Grunow, Katja Reiher, Niklas M. Carbon, Lilian Jo Engelhardt, Knut Mai, Susanne Koch, Joerg C. Schefold, Werner Z’Graggen, Stefan J. Schaller, Jens Fielitz, Joachim Spranger, Steffen Weber-Carstens and Tobias Wollersheim
    Citation: Critical Care 2022 26:237
  9. The COVID-19 pandemic presented major challenges for critical care facilities worldwide. Infections which develop alongside or subsequent to viral pneumonitis are a challenge under sporadic and pandemic condit...

    Authors: Andrew Conway Morris, Katharina Kohler, Thomas De Corte, Ari Ercole, Harm-Jan De Grooth, Paul W. G. Elbers, Pedro Povoa, Rui Morais, Despoina Koulenti, Sameer Jog, Nathan Nielsen, Alasdair Jubb, Maurizio Cecconi and Jan De Waele
    Citation: Critical Care 2022 26:236

    The Correction to this article has been published in Critical Care 2022 26:249

  10. Early corticosteroid treatment is used to treat COVID-19-related acute respiratory distress syndrome (ARDS). Infection is a well-documented adverse effect of corticosteroid therapy.

    Authors: Pauline Lamouche-Wilquin, Jérôme Souchard, Morgane Pere, Matthieu Raymond, Pierre Asfar, Cédric Darreau, Florian Reizine, Baptiste Hourmant, Gwenhaël Colin, Guillaume Rieul, Pierre Kergoat, Aurélien Frérou, Julien Lorber, Johann Auchabie, Béatrice La Combe, Philippe Seguin…
    Citation: Critical Care 2022 26:233
  11. The optimal level of positive end-expiratory pressure (PEEP) during mechanical ventilation for COVID-19 pneumonia remains debated and should ideally be guided by responses in both lung volume and perfusion. Ca...

    Authors: Luis Schulz, Antony Stewart, William O’Regan, Peter McCanny, Danielle Austin, Magnus Hallback, Mats Wallin and Anders Aneman
    Citation: Critical Care 2022 26:232
  12. Targeted temperature management at 33 °C (TTM33) has been employed in effort to mitigate brain injury in unconscious survivors of out-of-hospital cardiac arrest (OHCA). Current guidelines recommend prevention ...

    Authors: Joachim Düring, Martin Annborn, Alain Cariou, Michelle S. Chew, Josef Dankiewicz, Hans Friberg, Matthias Haenggi, Zana Haxhija, Janus C. Jakobsen, Halvor Langeland, Fabio Silvio Taccone, Matthew Thomas, Susann Ullén, Matt P. Wise and Niklas Nielsen
    Citation: Critical Care 2022 26:231
  13. While the Glasgow coma scale (GCS) is one of the strongest outcome predictors, the current classification of traumatic brain injury (TBI) as ‘mild’, ‘moderate’ or ‘severe’ based on this fails to capture enormo...

    Authors: Cecilia A. I. Åkerlund, Anders Holst, Nino Stocchetti, Ewout W. Steyerberg, David K. Menon, Ari Ercole and David W. Nelson
    Citation: Critical Care 2022 26:228
  14. During refractory cardiogenic shock and cardiac arrest, veno-arterial extracorporeal membrane oxygenation (VA-ECMO) is used to restore a circulatory output. However, it also impacts significantly arterial oxyg...

    Authors: Hadrien Winiszewski, Pierre-Grégoire Guinot, Matthieu Schmidt, Guillaume Besch, Gael Piton, Andrea Perrotti, Roberto Lorusso, Antoine Kimmoun and Gilles Capellier
    Citation: Critical Care 2022 26:226
  15. Acute kidney injury (AKI) has been reported as a frequent complication of critical COVID-19. We aimed to evaluate the occurrence of AKI and use of kidney replacement therapy (KRT) in critical COVID-19, to asse...

    Authors: Hannah Schaubroeck, Wim Vandenberghe, Willem Boer, Eva Boonen, Bram Dewulf, Camille Bourgeois, Jasperina Dubois, Alexander Dumoulin, Tom Fivez, Jan Gunst, Greet Hermans, Piet Lormans, Philippe Meersseman, Dieter Mesotten, Björn Stessel, Marc Vanhoof…
    Citation: Critical Care 2022 26:225
  16. Noninvasive ventilation (NIV) is a promising alternative to invasive mechanical ventilation (IMV) with a particular importance amidst the shortage of intensive care unit (ICU) beds during the COVID-19 pandemic...

    Authors: Kamil Polok, Jakub Fronczek, Antonio Artigas, Hans Flaatten, Bertrand Guidet, Dylan W. De Lange, Jesper Fjølner, Susannah Leaver, Michael Beil, Sigal Sviri, Raphael Romano Bruno, Bernhard Wernly, Bernardo Bollen Pinto, Joerg C. Schefold, Dorota Studzińska, Michael Joannidis…
    Citation: Critical Care 2022 26:224
  17. Factor XIII (FXIII) is a protein involved in blood clot stabilisation which also plays an important role in processes including trauma, wound healing, tissue repair, pregnancy, and even bone metabolism. Follow...

    Authors: Christian Kleber, Armin Sablotzki, Sebastian Casu, Martin Olivieri, Kai-Martin Thoms, Johannes Horter, Felix C. F. Schmitt, Ingvild Birschmann, Dietmar Fries, Marc Maegele, Herbert Schöchl and Michaela Wilhelmi
    Citation: Critical Care 2022 26:69
  18. Cognitive impairment has emerged as a common post-acute sequela of coronavirus disease 2019 (COVID-19). We hypothesised that cognitive impairment exists in patients after COVID-19 and that it is most severe in...

    Authors: Henriikka Ollila, Riikka Pihlaja, Sanna Koskinen, Annamari Tuulio-Henriksson, Viljami Salmela, Marjaana Tiainen, Laura Hokkanen and Johanna Hästbacka
    Citation: Critical Care 2022 26:223
  19. Providing palliative care at the end of life (EOL) in intensive care units (ICUs) seems to be modified during the COVID-19 pandemic with potential burden of moral distress to health care providers (HCPs). We s...

    Authors: Tereza Prokopová, Jan Hudec, Kamil Vrbica, Jan Stašek, Andrea Pokorná, Petr Štourač, Kateřina Rusinová, Paulína Kerpnerová, Radka Štěpánová, Adam Svobodník and Jan Maláska
    Citation: Critical Care 2022 26:221
  20. There is no formal diagnostic criterion for sepsis-induced cardiomyopathy (SICM), but left ventricular ejection fraction (LVEF) < 50% was the most commonly used standard. Tissue motion annular displacement (TM...

    Authors: Jieqiong Song, Yao Yao, Shilong Lin, Yizhou He, Duming Zhu and Ming Zhong
    Citation: Critical Care 2022 26:220
  21. Prone position is frequently used in patients with acute respiratory distress syndrome (ARDS), especially during the Coronavirus disease 2019 pandemic. Our study investigated the ability of pulse pressure vari...

    Authors: Rui Shi, Soufia Ayed, Francesca Moretto, Danila Azzolina, Nello De Vita, Francesco Gavelli, Simone Carelli, Arthur Pavot, Christopher Lai, Xavier Monnet and Jean-Louis Teboul
    Citation: Critical Care 2022 26:219
  22. The intensive care unit (ICU) is a complex environment where patients, family members and healthcare professionals have their own personal experiences. Improving ICU experiences necessitates the involvement of...

    Authors: Jos M. Latour, Nancy Kentish-Barnes, Theresa Jacques, Marc Wysocki, Elie Azoulay and Victoria Metaxa
    Citation: Critical Care 2022 26:218
  23. Neurologic manifestations are increasingly reported in patients with coronavirus disease 2019 (COVID-19). Yet, data on prevalence, predictors and relevance for outcome of neurological manifestations in patient...

    Authors: Konstantinos Dimitriadis, Jan Meis, Hermann Neugebauer, Kristian Barlinn, Bernhard Neumann, Georg Gahn, Piergiorgio Lochner, Benjamin Knier, Sarah Lindemann, Kurt Wolfram Sühs, Kristina Szabo, Thomas Pfefferkorn, Ingo Schirotzek, Tobias Freilinger, Bassa Burc, Albrecht Günther…
    Citation: Critical Care 2022 26:217
  24. Early prediction model of hemodynamic instability has the potential to improve the critical care, whereas limited external validation on the generalizability. We aimed to independently validate the Hemodynamic...

    Authors: Chiang Dung-Hung, Tian Cong, Jiang Zeyu, Ou-Yang Yu-Shan and Lin Yung-Yan
    Citation: Critical Care 2022 26:215
  25. The aim of this prospective longitudinal study was to compare driving pressure and absolute PaO2/FiO2 ratio in determining the best positive end-expiratory pressure (PEEP) level.

    Authors: Saida Rezaiguia-Delclaux, Léo Ren, Aurélie Gruner, Calypso Roman, Thibaut Genty and François Stéphan
    Citation: Critical Care 2022 26:214
  26. Multiple organ dysfunction syndrome (MODS) is a critical driver of sepsis morbidity and mortality in children. Early identification of those at risk of death and persistent organ dysfunctions is necessary to e...

    Authors: Mihir R. Atreya, Natalie Z. Cvijanovich, Julie C. Fitzgerald, Scott L. Weiss, Michael T. Bigham, Parag N. Jain, Adam J. Schwarz, Riad Lutfi, Jeffrey Nowak, Geoffrey L. Allen, Neal J. Thomas, Jocelyn R. Grunwell, Torrey Baines, Michael Quasney, Bereketeab Haileselassie, Christopher J. Lindsell…
    Citation: Critical Care 2022 26:210
  27. In response to the COVID-19 pandemic, concerted efforts were made by provincial and federal governments to invest in critical care infrastructure and medical equipment to bridge the gap of resource-limitation ...

    Authors: Mustafa Ali Khan, Hamna Shahbaz, Ali Aahil Noorali, Anam Noor Ehsan, Mareeha Zaki, Fahham Asghar, Mohammed Moizul Hassan, Haroon Muhammad Arshad, Muhammad Sohaib, Muhammad Ali Asghar, Muhammad Faisal Khan, Amber Sabeen, Masooma Aqeel, Muhammad Haroon Khan, Tahir Munir, Syed Kashif Amin…
    Citation: Critical Care 2022 26:209
  28. During the COVID-19 pandemic, many more patients were turned prone than before, resulting in a considerable increase in workload. Whether extending duration of prone position may be beneficial has received lit...

    Authors: Thaïs Walter, Noémie Zucman, Jimmy Mullaert, Ingrid Thiry, Coralie Gernez, Damien Roux and Jean-Damien Ricard
    Citation: Critical Care 2022 26:208
  29. Substantial interstudy heterogeneity exists in defining acute kidney injury (AKI) and baseline serum creatinine (SCr). This study assessed AKI incidence and its association with pediatric intensive care unit (...

    Authors: Yuxian Kuai, Min Li, Jiao Chen, Zhen Jiang, Zhenjiang Bai, Hui Huang, Lin Wei, Ning Liu, Xiaozhong Li, Guoping Lu and Yanhong Li
    Citation: Critical Care 2022 26:207
  30. The release of neutrophil extracellular traps (NETs) is associated with inflammation, coagulopathy, and organ damage found in severe cases of COVID-19. However, the molecular mechanisms underlying the release ...

    Authors: Camila Meirelles S. Silva, Carlos Wagner S. Wanderley, Flavio Protasio Veras, Augusto Velozo Gonçalves, Mikhael Haruo Fernandes Lima, Juliana Escher Toller-Kawahisa, Giovanni Freitas Gomes, Daniele Carvalho Nascimento, Valter V. Silva Monteiro, Isadora Marques Paiva, Cícero José Luíz Ramos Almeida, Diego Brito Caetité, Juliana Costa Silva, Maria Isabel Fernandes Lopes, Letícia Pastorelli Bonjorno, Marcela Cavichioli Giannini…
    Citation: Critical Care 2022 26:206
  31. The majority of central venous catheters (CVC) removed in the ICU are not colonized, including when a catheter-related infection (CRI) is suspected. We developed and validated a predictive score to reduce unne...

    Authors: Jeanne Iachkine, Niccolò Buetti, Harm-Jan de Grooth, Anaïs R. Briant, Olivier Mimoz, Bruno Mégarbane, Jean-Paul Mira, Stéphane Ruckly, Bertrand Souweine, Damien du Cheyron, Leonard A. Mermel, Jean-François Timsit and Jean-Jacques Parienti
    Citation: Critical Care 2022 26:205
  32. A profound inflammation-mediated lung injury with long-term acute respiratory distress and high mortality is one of the major complications of critical COVID-19. Immunoglobulin M (IgM)-enriched immunoglobulins...

    Authors: Tim Rahmel, Felix Kraft, Helge Haberl, Ute Achtzehn, Timo Brandenburger, Holger Neb, Dominik Jarczak, Maximilian Dietrich, Harry Magunia, Frieda Zimmer, Jale Basten, Claudia Landgraf, Thea Koch, Kai Zacharowski, Markus A. Weigand, Peter Rosenberger…
    Citation: Critical Care 2022 26:204
  33. Ventilator-associated pneumonia (VAP) is associated with high morbidity and health care costs, yet diagnosis remains a challenge. Analysis of airway microbiota by amplicon sequencing provides a possible soluti...

    Authors: Dominic Fenn, Mahmoud I. Abdel-Aziz, Pouline M. P. van Oort, Paul Brinkman, Waqar M. Ahmed, Timothy Felton, Antonio Artigas, Pedro Póvoa, Ignacio Martin-Loeches, Marcus J. Schultz, Paul Dark, Stephen J. Fowler and Lieuwe D. J. Bos
    Citation: Critical Care 2022 26:203
  34. The prognostic value of extravascular lung water (EVLW) measured by transpulmonary thermodilution (TPTD) in critically ill patients is debated. We performed a systematic review and meta-analysis of studies ass...

    Authors: Francesco Gavelli, Rui Shi, Jean-Louis Teboul, Danila Azzolina, Pablo Mercado, Mathieu Jozwiak, Michelle S. Chew, Wolfgang Huber, Mikhail Y. Kirov, Vsevolod V. Kuzkov, Tobias Lahmer, Manu L. N. G. Malbrain, Jihad Mallat, Samir G. Sakka, Takashi Tagami, Tài Pham…
    Citation: Critical Care 2022 26:202
  35. Chest wall loading has been shown to paradoxically improve respiratory system compliance (CRS) in patients with moderate to severe acute respiratory distress syndrome (ARDS). The most likely, albeit unconfirmed, ...

    Authors: John Selickman, Pierre Tawfik, Philip S. Crooke, David J. Dries, Jonathan Shelver, Luciano Gattinoni and John J. Marini
    Citation: Critical Care 2022 26:201
  36. In the ideal intensive care unit (ICU) of the future, all patients are free from delirium, a syndrome of brain dysfunction frequently observed in critical illness and associated with worse ICU-related outcomes...

    Authors: Katarzyna Kotfis, Irene van Diem-Zaal, Shawniqua Williams Roberson, Marek Sietnicki, Mark van den Boogaard, Yahya Shehabi and E. Wesley Ely
    Citation: Critical Care 2022 26:200

    The Correction to this article has been published in Critical Care 2022 26:285

  37. It remains elusive how the characteristics, the course of disease, the clinical management and the outcomes of critically ill COVID-19 patients admitted to intensive care units (ICU) worldwide have changed ove...

    Authors: Pedro David Wendel-Garcia, André Moser, Marie-Madlen Jeitziner, Hernán Aguirre-Bermeo, Pedro Arias-Sanchez, Janina Apolo, Ferran Roche-Campo, Diego Franch-Llasat, Gian-Reto Kleger, Claudia Schrag, Urs Pietsch, Miodrag Filipovic, Sascha David, Klaus Stahl, Souad Bouaoud, Amel Ouyahia…
    Citation: Critical Care 2022 26:199
  38. The obesity paradox has been observed in short-term outcomes from critical illness. However, little is known regarding the impact of obesity on long-term outcomes for survivors of critically ill patients. We a...

    Authors: Dawei Zhou, Chao Wang, Qing Lin and Tong Li
    Citation: Critical Care 2022 26:198