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  1. Fluid bolus therapy is a common intervention to improve urine output. Data concerning the effect of a fluid bolus on oliguria originate mainly from observational studies and remain controversial regarding the ...

    Authors: Nina Inkinen, Ville Pettilä, Miia Valkonen, Maija Serlo, Minna Bäcklund, Johanna Hästbacka, Anni Pulkkinen, Tuomas Selander and Suvi T. Vaara
    Citation: Critical Care 2022 26:401
  2. Acute kidney injury (AKI) is a common complication in sepsis. However, the trajectories of sepsis-induced AKI and their transcriptional profiles are not well characterized.

    Authors: Zhongheng Zhang, Lin Chen, Huiheng Liu, Yujing Sun, Pengfei Shui, Jian Gao, Decong Wang, Huilin Jiang, Yanling Li, Kun Chen and Yucai Hong
    Citation: Critical Care 2022 26:398
  3. The relationship between indices of mechanical ventilation and pulmonary artery pressures remains ill-defined in ARDS. As our understanding of mechanical ventilation has progressed, there is now a greater appr...

    Authors: Joseph R. Riddell, Benjamin J. Jones, Bruno M. Fernandes, Daniel J. Law, Jackie A. Cooper and Matt P. Wise
    Citation: Critical Care 2022 26:396
  4. Severe vitamin D deficiency (SVDD) dramatically increases the risks of mortality, infections, and many other diseases. Studies have reported higher prevalence of vitamin D deficiency in patients with critical ...

    Authors: Yu-Ting Kuo, Li-Kuo Kuo, Chung-Wei Chen, Kuo-Ching Yuan, Chun-Hsien Fu, Ching-Tang Chiu, Yu-Chang Yeh, Jen-Hao Liu and Ming-Chieh Shih
    Citation: Critical Care 2022 26:394
  5. Epinephrine is routinely utilized in cardiac arrest; however, it is unclear if the route of administration affects outcomes in acute myocardial infarction patients with cardiac arrest.

    Authors: Ali Aldujeli, Ayman Haq, Kristen M. Tecson, Zemyna Kurnickaite, Karolis Lickunas, Som Bailey, Vacis Tatarunas, Rima Braukyliene, Giedre Baksyte, Montazar Aldujeili, Hussein Khalifeh, Kasparas Briedis, Rasa Ordiene, Ramunas Unikas, Anas Hamadeh and Emmanouil S. Brilakis
    Citation: Critical Care 2022 26:393
  6. A diagnosis of ARDS serves as a pretext for several perilous clinical practices. Clinical trials demonstrated that tidal volume 12 ml/kg increases patient mortality, but 6 ml/kg has not proven superior to 11 m...

    Authors: Martin J. Tobin
    Citation: Critical Care 2022 26:392
  7. Acute kidney injury (AKI) is common in the critically ill. Inadequate renal medullary tissue oxygenation has been linked to its pathogenesis. Moreover, renal medullary tissue hypoxia can be detected before bio...

    Authors: Raymond T. Hu, Yugeesh R. Lankadeva, Fumitake Yanase, Eduardo A. Osawa, Roger G. Evans and Rinaldo Bellomo
    Citation: Critical Care 2022 26:389
  8. Machine learning algorithms have recently been developed to enable the automatic and real-time echocardiographic assessment of left ventricular ejection fraction (LVEF) and have not been evaluated in criticall...

    Authors: Rita Varudo, Filipe A. Gonzalez, João Leote, Cristina Martins, Jacobo Bacariza, Antero Fernandes and Frederic Michard
    Citation: Critical Care 2022 26:386
  9. The association of ageing with increased sepsis mortality is well established. Nonetheless, current investigations on the influence of age on host response aberrations are largely limited to plasma cytokine le...

    Authors: Erik H. A. Michels, Joe M. Butler, Tom D. Y. Reijnders, Olaf L. Cremer, Brendon P. Scicluna, Fabrice Uhel, Hessel Peters-Sengers, Marcus J. Schultz, Julian C. Knight, Lonneke A. van Vught and Tom van der Poll
    Citation: Critical Care 2022 26:385
  10. In the context of COVID-19 pandemic, antifungal overuse may have occurred in our hospitals as it has been previously reported for antibacterials.

    Authors: Anne-Lise Bienvenu, Audrey Bestion, Pierre Pradat, Jean-Christophe Richard, Laurent Argaud, Céline Guichon, Sandrine Roux, Vincent Piriou, Carole Paillet and Gilles Leboucher
    Citation: Critical Care 2022 26:384
  11. Ultra-lung-protective ventilation may be useful during veno-venous extracorporeal membrane oxygenation (vv-ECMO) for severe acute respiratory distress syndrome (ARDS) to minimize ventilator-induced lung injury...

    Authors: Christophe Guervilly, Théotime Fournier, Juliette Chommeloux, Laurent Arnaud, Camille Pinglis, Karine Baumstarck, Mohamed Boucekine, Sabine Valera, Celine Sanz, Mélanie Adda, Mickaël Bobot, Florence Daviet, Ines Gragueb-Chatti, Jean-Marie Forel, Antoine Roch, Sami Hraiech…
    Citation: Critical Care 2022 26:383
  12. This work aims to assess the performance of two post-arrest (out-of-hospital cardiac arrest, OHCA, and cardiac arrest hospital prognosis, CAHP) and one pre-arrest (good outcome following attempted resuscitatio...

    Authors: Simon A. Amacher, René Blatter, Matthias Briel, Christian Appenzeller-Herzog, Chantal Bohren, Christoph Becker, Katharina Beck, Sebastian Gross, Kai Tisljar, Raoul Sutter, Stephan Marsch and Sabina Hunziker
    Citation: Critical Care 2022 26:382
  13. Targeted temperature management (TTM) is recommended in the management of out-of-hospital cardiac arrest (OHCA) when coma persists after the return of spontaneous circulation. In the setting of extracorporeal ...

    Authors: Makoto Watanabe, Tasuku Matsuyama, Yuki Miyamoto, Tetsuhisa Kitamura, Sho Komukai and Bon Ohta
    Citation: Critical Care 2022 26:380

    The Correspondence to this article has been published in Critical Care 2023 27:39

  14. Critically ill patients undergo early impairment of their gut microbiota (GM) due to routine antibiotic therapies and other environmental factors leading to intestinal dysbiosis. The GM establishes connections...

    Authors: Alberto Corriero, Raffaella Maria Gadaleta, Filomena Puntillo, Francesco Inchingolo, Antonio Moschetta and Nicola Brienza
    Citation: Critical Care 2022 26:379
  15. Previously conducted physician-centered trials on the usefulness of vasopressin have yielded negative results; thus, patient-oriented trials have been warranted. We hypothesize that Augmented-Medication Cardio...

    Authors: June-sung Kim, Seung Mok Ryoo, Youn-Jung Kim, Chang Hwan Sohn, Shin Ahn, Dong Woo Seo, Seok In Hong, Sang-Min Kim, Bora Chae and Won Young Kim
    Citation: Critical Care 2022 26:378
  16. Delirium is a frequent manifestation of acute brain dysfunction and is associated with cognitive impairment. The hypothesized mechanism of brain dysfunction during critical illness is centered on neuroinflamma...

    Authors: Christopher G. Hughes, Christina S. Boncyk, Benjamin Fedeles, Pratik P. Pandharipande, Wencong Chen, Mayur B. Patel, Nathan E. Brummel, James C. Jackson, Rameela Raman, E. Wesley Ely and Timothy D. Girard
    Citation: Critical Care 2022 26:377
  17. In-hospital cardiac arrest (IHCA) is associated with a high risk of death, but mortality rates are decreasing. The latest epidemiological and outcome data from several cardiac arrest registries are helping to ...

    Authors: James Penketh and Jerry P. Nolan
    Citation: Critical Care 2022 26:376

    The Correspondence to this article has been published in Critical Care 2023 27:22

    The Correspondence to this article has been published in Critical Care 2023 27:17

  18. Veno-arterial (VA) extracorporeal membrane oxygenation (ECMO) can be used to restore organ perfusion in patients with cardiogenic shock until native heart recovery occurs. It may be challenging, however, to de...

    Authors: Francis Charbonneau, Karina Chahinian, Emmanuel Bebawi, Olivier Lavigueur, Émilie Lévesque, Yoan Lamarche, Karim Serri, Martin Albert, Pierre-Emmanuel Noly, Alexis Cournoyer and Yiorgos Alexandros Cavayas
    Citation: Critical Care 2022 26:375
  19. Ceftolozane/tazobactam, a combination antibacterial agent comprising an anti-pseudomonal cephalosporin and β-lactamase inhibitor, is approved for the treatment of hospital-acquired/ventilator-associated bacter...

    Authors: Marin H. Kollef, Jean-François Timsit, Ignacio Martin-Loeches, Richard G. Wunderink, Jennifer A. Huntington, Erin H. Jensen, Brian Yu and Christopher J. Bruno
    Citation: Critical Care 2022 26:373
  20. Although guidelines provide excellent expert guidance for managing patients with septic shock, they leave room for personalization according to patients’ condition. Hemodynamic monitoring depends on the evolut...

    Authors: Daniel De Backer, Maurizio Cecconi, Michelle S. Chew, Ludhmila Hajjar, Xavier Monnet, Gustavo A. Ospina-Tascón, Marlies Ostermann, Michael R. Pinsky and Jean-Louis Vincent
    Citation: Critical Care 2022 26:372
  21. Sepsis is a complex health condition, leading to long-term morbidity and mortality. Understanding the risk factors for recurrent sepsis, as well as its impact on mid- and long-term mortality among other risk f...

    Authors: Fanny Pandolfi, Christian Brun-Buisson, Didier Guillemot and Laurence Watier
    Citation: Critical Care 2022 26:371
  22. Magnetic resonance imaging (MRI) carries prognostic importance after traumatic brain injury (TBI), especially when computed tomography (CT) fails to fully explain the level of unconsciousness. However, in crit...

    Authors: Sophie Richter, Stefan Winzeck, Endre Czeiter, Krisztina Amrein, Evgenios N. Kornaropoulos, Jan Verheyden, Gabriela Sugar, Zhihui Yang, Kevin Wang, Andrew I. R. Maas, Ewout Steyerberg, András Büki, Virginia F. J. Newcombe and David K. Menon
    Citation: Critical Care 2022 26:369
  23. Acute kidney injury (AKI) requiring renal replacement therapy (RRT) is a serious complication in the ICU that results in increased mortality and risk of chronic kidney disease (CKD). Some studies suggest RRT m...

    Authors: Edouard Soum, Jean-François Timsit, Stephane Ruckly, Didier Gruson, Emmanuel Canet, Kada Klouche, Laurent Argaud, Maïté Garrouste-Orgeas, Christophe Mariat, François Vincent, Sophie Cayot, Michael Darmon, Julien Bohé, Carole Schwebel, Lila Bouadma, Claire Dupuis…
    Citation: Critical Care 2022 26:367
  24. Since the advent of critical care in the twentieth century, the core elements that are the foundation for critical care systems, namely to care for critically ill and injured patients and to save lives, have e...

    Authors: Annette M. Esper, Yaseen M. Arabi, Maurizio Cecconi, Bin Du, Evangelos J. Giamarellos-Bourboulis, Nicole Juffermans, Flavia Machado, Sandra Peake, Jason Phua, Kathryn Rowan, Gee Young Suh and Greg S. Martin
    Citation: Critical Care 2022 26:366
  25. Defining the optimal moment to start renal replacement therapy (RRT) in acute kidney injury (AKI) remains challenging. Multiple randomized controlled trials (RCTs) addressed this question whilst using absolute...

    Authors: Paweł Morzywołek, Johan Steen, Stijn Vansteelandt, Johan Decruyenaere, Sigrid Sterckx and Wim Van Biesen
    Citation: Critical Care 2022 26:365
  26. Renal hypoperfusion is one of the most common causes of acute kidney injury (AKI), especially in shock and perioperative patients. An optimal blood pressure (BP) target to prevent AKI remains undetermined. We ...

    Authors: Phu Nguyen Trong Tran, Prit Kusirisin, Piyanut Kaewdoungtien, Jeerath Phannajit and Nattachai Srisawat
    Citation: Critical Care 2022 26:364
  27. Patients with COVID-19-related acute respiratory distress syndrome (ARDS) require respiratory support with invasive mechanical ventilation and show varying responses to recruitment manoeuvres. In patients with...

    Authors: Daan F. L. Filippini, Elisa Di Gennaro, Rombout B. E. van Amstel, Ludo F. M. Beenen, Salvatore Grasso, Luigi Pisani, Lieuwe D. J. Bos and Marry R. Smit
    Citation: Critical Care 2022 26:363
  28. Mobilisation and exercise intervention in general are safe and feasible in critically ill patients. For patients requiring catecholamines, however, doses of norepinephrine safe for mobilisation in the intensiv...

    Authors: Maximilian Lindholz, Clara M. Schellenberg, Julius J. Grunow, Simone Kagerbauer, Annette Milnik, Daniel Zickler, Stefan Angermair, Anett Reißhauer, Martin Witzenrath, Mario Menk, Sebastian Boie, Felix Balzer and Stefan J. Schaller
    Citation: Critical Care 2022 26:362
  29. Most of the patients who die after cardiac arrest do so because of hypoxic-ischemic brain injury (HIBI). Experimental evidence shows that temperature control targeted at hypothermia mitigates HIBI. In 2002, on...

    Authors: Claudio Sandroni, Daniele Natalini and Jerry P. Nolan
    Citation: Critical Care 2022 26:361
  30. Among critically ill patients with acute kidney injury (AKI), earlier initiation of renal replacement therapy (RRT) may mitigate fluid accumulation and confer better outcomes among individuals with greater flu...

    Authors: Ron Wald, Brian Kirkham, Bruno R. daCosta, Ehsan Ghamarian, Neill K. J. Adhikari, William Beaubien-Souligny, Rinaldo Bellomo, Martin P. Gallagher, Stuart Goldstein, Eric A. J. Hoste, Kathleen D. Liu, Javier A. Neyra, Marlies Ostermann, Paul M. Palevsky, Antoine Schneider, Suvi T. Vaara…
    Citation: Critical Care 2022 26:360
  31. Sedative agents may variably impact the stress response. Dexmedetomidine is a sympatholytic alpha2-adrenergic agonist mainly used as a second-line sedative agent in mechanically ventilated patients. We hypothesis...

    Authors: John P. R. Moore, Yahya Shehabi, Michael C. Reade, Michael Bailey, John F. Fraser, Lauren Murray, Christopher Anstey and Mervyn Singer
    Citation: Critical Care 2022 26:359
  32. A defining feature of prolonged critical illness is muscle wasting, leading to impaired recovery. Supplementation with a tailored blend of amino acids may bolster the innate gut defence, promote intestinal muc...

    Authors: Nicholas Heming, Robert Carlier, Helene Prigent, Ahmed Mekki, Camille Jousset, Frederic Lofaso, Xavier Ambrosi, Rania Bounab, Virginie Maxime, Arnaud Mansart, Pascal Crenn, Pierre Moine, Fabien Foltzer, Bernard Cuenoud, Tobias Konz, John Corthesy…
    Citation: Critical Care 2022 26:358
  33. Targeted temperature management (TTM) is recommended following cardiac arrest; however, time to target temperature varies in clinical practice. We hypothesised the effects of a target temperature of 33 °C when...

    Authors: Rupert F. G. Simpson, Josef Dankiewicz, Grigoris V. Karamasis, Paolo Pelosi, Matthias Haenggi, Paul J. Young, Janus Christian Jakobsen, Jonathan Bannard-Smith, Pedro D. Wendel-Garcia, Fabio Silvio Taccone, Per Nordberg, Matt P. Wise, Anders M. Grejs, Gisela Lilja, Roy Bjørkholt Olsen, Alain Cariou…
    Citation: Critical Care 2022 26:356
  34. Ventilator-associated pneumonia caused by Pseudomonas aeruginosa (PA) in hospitalised patients is associated with high mortality. The effectiveness of the bivalent, bispecific mAb MEDI3902 (gremubamab) in prevent...

    Authors: Jean Chastre, Bruno François, Marc Bourgeois, Apostolos Komnos, Ricard Ferrer, Galia Rahav, Nicolas De Schryver, Alain Lepape, Iftihar Koksal, Charles-Edouard Luyt, Miguel Sánchez-García, Antoni Torres, Philippe Eggimann, Despoina Koulenti, Thomas L. Holland, Omar Ali…
    Citation: Critical Care 2022 26:355
  35. The survival rate of patients with critical coronavirus disease-19 (COVID-19) over time is inconsistent in different settings. In Japan, a national database was organized to monitor and share the patient gener...

    Authors: Shinichiro Ohshimo, Keibun Liu, Takayuki Ogura, Yoshiaki Iwashita, Shigeki Kushimoto, Nobuaki Shime, Satoru Hashimoto, Yuji Fujino and Shinhiro Takeda
    Citation: Critical Care 2022 26:354