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  1. Few studies have reported left ventricular wall findings in contrast-enhanced computed tomography (CE-CT) after extracorporeal cardiopulmonary resuscitation (ECPR). This study examined left ventricular wall CE...

    Authors: Kazuhiro Sugiyama, Masamichi Takahashi, Kazuki Miyazaki, Takuto Ishida, Mioko Kobayashi and Yuichi Hamabe

    Citation: Critical Care 2019 23:357

    Content type: Research

    Published on:

  2. Sepsis is an increasingly significant challenge throughout the world as one of the major causes of patient morbidity and mortality. Central to the host immunologic response to sepsis is the increase in circula...

    Authors: McKenzie K. Hollen, Julie A. Stortz, Dijoia Darden, Marvin L. Dirain, Dina C. Nacionales, Russell B. Hawkins, Michael C. Cox, Maria-Cecilia Lopez, Jaimar C. Rincon, Ricardo Ungaro, Zhongkai Wang, Quran Wu, Babette Brumback, Marie-Pierre L. Gauthier, Michael Kladde, Christiaan Leeuwenburgh…

    Citation: Critical Care 2019 23:355

    Content type: Research

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  3. Hypercapnia improves gastric microcirculatory oxygenation (μHbO2) and increases vasopressin plasma levels, whereas V1A receptor blockade abolishes the increase of μHbO2. The aim of this study was to evaluate the ...

    Authors: Richard Truse, Steven Grewe, Anna Herminghaus, Jan Schulz, Andreas P. M. Weber, Tabea Mettler-Altmann, Inge Bauer, Olaf Picker and Christian Vollmer

    Citation: Critical Care 2019 23:353

    Content type: Research

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  4. Acute respiratory distress syndrome (ARDS) survivors experience a high prevalence of cognitive impairment with concomitantly impaired functional status and quality of life, often persisting months after hospit...

    Authors: Cina Sasannejad, E. Wesley Ely and Shouri Lahiri

    Citation: Critical Care 2019 23:352

    Content type: Review

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  5. For patients who survive a critical illness and have their oral endotracheal tube removed, dysphagia is highly prevalent, and without intervention, it may persist far beyond hospital discharge. This pre- and p...

    Authors: Chung-Pei Wu, Yu-Juan Xu, Tyng-Guey Wang, Shih-Chi Ku, Ding-Cheng Chan, Jang-Jaer Lee, Yu-Chung Wei, Tzu-Yu Hsiao and Cheryl Chia-Hui Chen

    Citation: Critical Care 2019 23:350

    Content type: Research

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  6. Extracorporeal carbon dioxide removal (ECCO2R) uses an extracorporeal circuit to directly remove carbon dioxide from the blood either in lieu of mechanical ventilation or in combination with it. While the potenti...

    Authors: Sascha Gross-Hardt, Felix Hesselmann, Jutta Arens, Ulrich Steinseifer, Leen Vercaemst, Wolfram Windisch, Daniel Brodie and Christian Karagiannidis

    Citation: Critical Care 2019 23:348

    Content type: Research

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  7. Although tranexamic acid is widely used in patients with haemoptysis, whether it improves mortality has not been well investigated. The aim of this study was to evaluate the effect of tranexamic acid on in-hos...

    Authors: Takahiro Kinoshita, Hiroyuki Ohbe, Hiroki Matsui, Kiyohide Fushimi, Hiroshi Ogura and Hideo Yasunaga

    Citation: Critical Care 2019 23:347

    Content type: Research

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  8. Excessive respiratory muscle effort during mechanical ventilation may cause patient self-inflicted lung injury and load-induced diaphragm myotrauma, but there are no non-invasive methods to reliably detect ele...

    Authors: Michele Bertoni, Irene Telias, Martin Urner, Michael Long, Lorenzo Del Sorbo, Eddy Fan, Christer Sinderby, Jennifer Beck, Ling Liu, Haibo Qiu, Jenna Wong, Arthur S. Slutsky, Niall D. Ferguson, Laurent J. Brochard and Ewan C. Goligher

    Citation: Critical Care 2019 23:346

    Content type: Research

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  9. Adaptive mechanical ventilation automatically adjusts respiratory rate (RR) and tidal volume (VT) to deliver the clinically desired minute ventilation, selecting RR and VT based on Otis’ equation on least work of...

    Authors: Tobias Becher, Anna Adelmeier, Inéz Frerichs, Norbert Weiler and Dirk Schädler

    Citation: Critical Care 2019 23:338

    Content type: Research

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  10. Few viruses have shaped the course of human history more than influenza viruses. A century since the 1918–1919 Spanish influenza pandemic—the largest and deadliest influenza pandemic in recorded history—we hav...

    Authors: Taylor Kain and Robert Fowler

    Citation: Critical Care 2019 23:337

    Content type: Review

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  11. The performance of blood biomarkers (mid-regional proadrenomedullin (MR-proADM), procalcitonin (PCT), C-reactive protein (CRP), and lactate) and clinical scores (Sequential Organ Failure Assessment (SOFA), Nat...

    Authors: Juan Gonzalez del Castillo, Darius Cameron Wilson, Carlota Clemente-Callejo, Francisco Román, Ignasi Bardés-Robles, Inmaculada Jiménez, Eva Orviz, Macarena Dastis-Arias, Begoña Espinosa, Fernando Tornero-Romero, Jordi Giol-Amich, Veronica González and Ferran Llopis-Roca

    Citation: Critical Care 2019 23:335

    Content type: Research

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  12. The concept of personalized cardiopulmonary resuscitation (CPR) requires a parameter that reflects its hemodynamic efficiency. While intra-arrest ultrasound is increasingly implemented into the advanced life s...

    Authors: Roman Skulec, Petr Vojtisek and Vladimir Cerny

    Citation: Critical Care 2019 23:334

    Content type: Research

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  13. The interactive effect of cumulative input and output on achieving optimal fluid balance has not been well elucidated in patients with acute kidney injury (AKI) requiring continuous renal replacement therapy (...

    Authors: Jong Hyun Jhee, Hye Ah Lee, Seonmi Kim, Youn Kyung Kee, Ji Eun Lee, Shina Lee, Seung-Jung Kim, Duk-Hee Kang, Kyu Bok Choi, Hyung Jung Oh and Dong-Ryeol Ryu

    Citation: Critical Care 2019 23:329

    Content type: Research

    Published on:

  14. In the publication of this article [1], there was an error in a contributors Family Name. This has now been updated in the original article.

    Authors: Luca Cabrini, Giovanni Landoni, Martina Baiardo Redaelli, Omar Saleh, Carmine D. Votta, Evgeny Fominskiy, Alessandro Putzu, Cézar Daniel Snak de Souza, Massimo Antonelli, Rinaldo Bellomo, Paolo Pelosi and Alberto Zangrillo

    Citation: Critical Care 2019 23:325

    Content type: Correction

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    The original article was published in Critical Care 2018 22:6

  15. Antibiotic-associated diarrhea (AAD) is a risk factor for exacerbating the outcome of critically ill patients. Dysbiosis induced by the exposure to antibiotics reveals the potential therapeutic role of fecal m...

    Authors: Min Dai, Yafei Liu, Wei Chen, Heena Buch, Yi Shan, Liuhui Chang, Yong Bai, Chen Shen, Xiaoyin Zhang, Yufeng Huo, Dian Huang, Zhou Yang, Zhihang Hu, Xuwei He, Junyu Pan, Lili Hu…

    Citation: Critical Care 2019 23:324

    Content type: Research

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  16. Most deaths of comatose survivors of out-of-hospital sudden cardiac arrest result from withdrawal of life-sustaining treatment (WLST) decisions based on poor neurological prognostication and the family’s inten...

    Authors: Hiroshi Endoh, Natuo Kamimura, Hiroyuki Honda and Masakazu Nitta

    Citation: Critical Care 2019 23:323

    Content type: Research

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  17. Weaning-induced cardiac pulmonary edema (WiPO) is one of the main mechanisms of weaning failure during mechanical ventilation. We hypothesized that weaning-induced cardiac ischemia (WiCI) may contribute to wea...

    Authors: Alexandre Bedet, Françoise Tomberli, Gwenael Prat, Pierre Bailly, Achille Kouatchet, Sater Mortaza, Emmanuel Vivier, Sylvene Rosselli, Larissa Lipskaia, Guillaume Carteaux, Keyvan Razazi and Armand Mekontso Dessap

    Citation: Critical Care 2019 23:321

    Content type: Research

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  18. Venoarterial extracorporeal membrane oxygenation (VA-ECMO) can be a rescue therapy for patients in cardiogenic shock or in refractory cardiac arrest. After cannulation, vasoplegia and cardiac depression are fr...

    Authors: Viviane Zotzmann, Jonathan Rilinger, Corinna N. Lang, Klaus Kaier, Christoph Benk, Daniel Duerschmied, Paul M. Biever, Christoph Bode, Tobias Wengenmayer and Dawid L. Staudacher

    Citation: Critical Care 2019 23:320

    Content type: Research

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  19. Patients with acute hypoxemic respiratory failure are at risk for life-threatening complications during endotracheal intubation. Preoxygenation might help reduce the risk of hypoxemia and intubation-related co...

    Authors: Ka Man Fong, Shek Yin Au and George Wing Yiu Ng

    Citation: Critical Care 2019 23:319

    Content type: Research

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  20. Metabolic alterations in the critically ill have been studied for more than a century, but the heterogeneity of the critically ill patient population, the varying duration and severity of the acute phase of il...

    Authors: Jan Wernerman, Kenneth B. Christopher, Djillali Annane, Michael P. Casaer, Craig M. Coopersmith, Adam M. Deane, Elisabeth De Waele, Gunnar Elke, Carole Ichai, Constantine J. Karvellas, Stephen A. McClave, Heleen M. Oudemans-van Straaten, Olav Rooyackers, Renee D. Stapleton, Jukka Takala, Arthur R. H. van Zanten…

    Citation: Critical Care 2019 23:318

    Content type: Review

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  21. Innovative treatment modalities have not yet shown a clinical benefit in patients with septic shock. To reduce severe cytokinaemia, CytoSorb as an add-on to continuous renal replacement therapy (CRRT) showed p...

    Authors: Willem Pieter Brouwer, Servet Duran, Martijn Kuijper and Can Ince

    Citation: Critical Care 2019 23:317

    Content type: Research

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  22. Though echocardiographic evaluation assesses the right ventricular systolic function, which of the existing parameters best reflects the right ventricular ejection fraction (RVEF) in the critically ill patient...

    Authors: Romain Barthélémy, Xavier Roy, Tujia Javanainen, Alexandre Mebazaa and Benjamin Glenn Chousterman

    Citation: Critical Care 2019 23:312

    Content type: Research

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  23. In patients with septic shock, the skin is often chosen for the evaluation of peripheral perfusion and oxygenation. Changes in skin microcirculatory vessel oxygen saturation and relative hemoglobin concentrati...

    Authors: Sigita Kazune, Anastasija Caica, Karina Volceka, Olegs Suba, Uldis Rubins and Andris Grabovskis

    Citation: Critical Care 2019 23:311

    Content type: Research

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    The Letter to this article has been published in Critical Care 2019 23:359

  24. Over the last decade, multiple large randomized controlled trials have studied alternative transfusion strategies in critically ill patients, demonstrating the safety of restrictive transfusion strategies. Due...

    Authors: Sanne de Bruin, Thomas W. L. Scheeren, Jan Bakker, Robin van Bruggen and Alexander P. J. Vlaar

    Citation: Critical Care 2019 23:309

    Content type: Research

    Published on:

  25. Neuromuscular electrical stimulation (NMES) has been investigated as a preventative measure for intensive care unit-acquired weakness. Trial results remain contradictory and therefore inconclusive. As it has b...

    Authors: Julius J. Grunow, Moritz Goll, Niklas M. Carbon, Max E. Liebl, Steffen Weber-Carstens and Tobias Wollersheim

    Citation: Critical Care 2019 23:308

    Content type: Research

    Published on: