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  1. Electrical impedance tomography (EIT) can be used to assess ventilation/perfusion (V/Q) mismatch within the lungs. Several methods have been proposed, some of them neglecting the absolute value of alveolar ventil...

    Authors: Samuel Tuffet, Tommaso Maraffi, Matthieu Lacheny, François Perier, Anne-Fleur Haudebourg, Mohamed Ahmed Boujelben, Glasiele Alcala, Armand Mekontso-Dessap and Guillaume Carteaux
    Citation: Critical Care 2023 27:176
  2. High dose vasopressors portend poor outcome in vasodilatory shock. We aimed to evaluate the impact of baseline vasopressor dose on outcomes in patients treated with angiotensin II (AT II).

    Authors: Patrick M. Wieruszewski, Rinaldo Bellomo, Laurence W. Busse, Kealy R. Ham, Alexander Zarbock, Ashish K. Khanna, Adam M. Deane, Marlies Ostermann, Richard G. Wunderink, David W. Boldt, Stew Kroll, Chuck R. Greenfeld, Tony Hodges and Jonathan H. Chow
    Citation: Critical Care 2023 27:175

    The Comment to this article has been published in Critical Care 2023 27:210

  3. Several measurements have been used to predict the success of weaning from mechanical ventilation; however, their efficacy varies in different studies. In recent years, diaphragmatic ultrasound has been used f...

    Authors: Henry M. Parada-Gereda, Adriana L. Tibaduiza, Alejandro Rico-Mendoza, Daniel Molano-Franco, Victor H. Nieto, Wanderley A. Arias-Ortiz, Purificación Perez-Terán and Joan R. Masclans
    Citation: Critical Care 2023 27:174
  4. This study aims to provide an updated assessment of the efficacy of optimized enteral nutrition (EN) delivery by implementing the volume-based feeding (VBF) protocol in critically ill patients.

    Authors: Lu Wang, Yu Wang, Hua-Xin Li, Rui-peng Zhang, Li Chang, Jun Zeng and Hua Jiang
    Citation: Critical Care 2023 27:173
  5. To evaluate the heterogeneity in the definition of delirium in randomized controlled trials (RCTs) included in meta-analyses of delirium in intensive care units (ICUs) and to explore whether intervention effec...

    Authors: Lucie Collet, Aymeric Lanore, Camille Alaterre, Jean-Michel Constantin, Guillaume L. Martin, Agnès Caille, Arthur James and Agnès Dechartres
    Citation: Critical Care 2023 27:170
  6. Authors: Peter J. McGuigan, Elisa Giallongo, Bronagh Blackwood, James Doidge, David A. Harrison, Alistair D. Nichol, Kathryn M. Rowan, Manu Shankar‑Hari, Markus B. Skrifvars, Karen Thomas and Danny F. McAuley
    Citation: Critical Care 2023 27:169

    The original article was published in Critical Care 2023 27:4

  7. Identifying patterns within ICU medication regimens may help artificial intelligence algorithms to better predict patient outcomes; however, machine learning methods incorporating medications require further d...

    Authors: Andrea Sikora, Alireza Rafiei, Milad Ghiasi Rad, Kelli Keats, Susan E. Smith, John W. Devlin, David J. Murphy, Brian Murray and Rishikesan Kamaleswaran
    Citation: Critical Care 2023 27:167
  8. Neisseria meningitidis is the leading responsible bacterium of Purpura Fulminans (PF) accounting for two thirds of PF. Skin biopsy is a simple and minimally invasive exam allowing to perform skin culture and poly...

    Authors: Damien Contou, Gaëtan Béduneau, Charlotte Rabault, Romain Sonneville, Antoine Marchalot, Rémi Coudroy, Damien Roux, Martin Cour, Julien Massol, Sébastien Préau and Nicolas de Prost
    Citation: Critical Care 2023 27:166
  9. Polymyxin B is the first-line therapy for Carbapenem-resistant organism (CRO) nosocomial pneumonia. However, clinical data for its pharmacokinetic/pharmacodynamic (PK/PD) relationship are limited. This study a...

    Authors: Tiantian Tang, Ying Li, Ping Xu, Yanjun Zhong, Min Yang, Wanjun Ma, Daxiong Xiang, Bikui Zhang and Yangang Zhou
    Citation: Critical Care 2023 27:164
  10. The benefit–risk ratio of prophylactic non-invasive ventilation (NIV) and high-flow nasal oxygen therapy (HFNC-O2) during the early stage of blunt chest trauma remains controversial because of limited data. The m...

    Authors: Cédric Carrié, Benjamin Rieu, Antoine Benard, Kilian Trin, Laurent Petit, Alexandre Massri, Igor Jurcison, Guillaume Rousseau, David Tran Van, Marie Reynaud Salard, Jeremy Bourenne, Albrice Levrat, Laurent Muller, Damien Marie, Claire Dahyot-Fizelier, Julien Pottecher…
    Citation: Critical Care 2023 27:163
  11. Older adults are at high-risk for a post-operative intensive care unit (ICU) admission, yet little is known about the impact of these admissions on quality of life. The objective of this study was to evaluate ...

    Authors: Bourke W. Tillmann, Julie Hallet, Rinku Sutradhar, Matthew P. Guttman, Natalie Coburn, Tyler R. Chesney, Jesse Zuckerman, Alyson Mahar, Wing C. Chan and Barbara Haas
    Citation: Critical Care 2023 27:162
  12. Prognosis after resuscitation from cardiac arrest (CA) remains poor, with high morbidity and mortality as a result of extensive cardiac and brain injury and lack of effective treatments. Hypertonic sodium lact...

    Authors: Filippo Annoni, Fuhong Su, Lorenzo Peluso, Ilaria Lisi, Enrico Caruso, Francesca Pischiutta, Elisa Gouvea Bogossian, Bruno Garcia, Hassane Njimi, Jean-Louis Vincent, Nicolas Gaspard, Lorenzo Ferlini, Jacques Creteur, Elisa R. Zanier and Fabio Silvio Taccone
    Citation: Critical Care 2023 27:161
  13. Authors: David Pérez-Torres, Pedro Alberto Merino-García, Isabel Canas-Pérez, Cristina Cuenca-Rubio, Guillermo Javier Posadas-Pita, Cristina Colmenero-Calleja, Thalia Gloria Ticona-Espinoza and Cristina Díaz-Rodríguez
    Citation: Critical Care 2023 27:160

    The original article was published in Critical Care 2023 27:15

    The Correspondence to this article has been published in Critical Care 2023 27:182

  14. The development of stratification tools based on the assessment of circulating mRNA of genes involved in the immune response is constrained by the heterogeneity of septic patients. The aim of this study is to ...

    Authors: Maxime Bodinier, Guillaume Monneret, Marie Casimir, Aurore Fleurie, Filippo Conti, Fabienne Venet, Marie-Angélique Cazalis, Elisabeth Cerrato, Estelle Peronnet, Thomas Rimmelé, Anne-Claire Lukaszewicz, Karen Brengel-Pesce and Jean-François Llitjos
    Citation: Critical Care 2023 27:158
  15. At the bedside, assessing the risk of ventilator-induced lung injury (VILI) requires parameters readily measured by the clinician. For this purpose, driving pressure (DP) and end-inspiratory static ‘plateau’ pres...

    Authors: John J. Marini, Lauren T. Thornton, Patricia R. M. Rocco, Luciano Gattinoni and Philip S. Crooke
    Citation: Critical Care 2023 27:157
  16. There is insufficient evidence to guide ventilatory targets in acute brain injury (ABI). Recent studies have shown associations between mechanical power (MP) and mortality in critical care populations. We aime...

    Authors: Sarah Wahlster, Monisha Sharma, Shaurya Taran, James A. Town, Robert D. Stevens, Raphaël Cinotti, Karim Asehoune, Paolo Pelosi and Chiara Robba
    Citation: Critical Care 2023 27:156
  17. The mechanisms used by SARS-CoV-2 to induce major adverse cardiac events (MACE) are unknown. Thus, we aimed to determine if SARS-CoV-2 can induce necrotic cell death to promote MACE in patients with severe COV...

    Authors: Rosana Wiscovitch-Russo, Elsa D. Ibáñez-Prada, Cristian C. Serrano-Mayorga, Benjamin L. Sievers, Maeve A. Engelbride, Surya Padmanabhan, Gene S. Tan, Sanjay Vashee, Ingrid G. Bustos, Carlos Pachecho, Lina Mendez, Peter H. Dube, Harinder Singh, Luis Felipe Reyes and Norberto Gonzalez-Juarbe
    Citation: Critical Care 2023 27:155
  18. An increase in cardiac index (CI) during an end-expiratory occlusion test (EEOt) predicts fluid responsiveness in ventilated patients. However, if CI monitoring is unavailable or the echocardiographic window i...

    Authors: Sonia D’Arrigo, Antonio Maria Dell’Anna, Claudio Sandroni, Antonio Messina, Sofia Cacciola, Chiara Pacini and Massimo Antonelli
    Citation: Critical Care 2023 27:153
  19. Heterogeneity is an inherent nature of ARDS. Recruitment-to-inflation ratio has been developed to identify the patients who has lung recruitablity. This technique might be useful to identify the patients that ...

    Authors: Hiroki Taenaka, Takeshi Yoshida, Haruka Hashimoto, Andi Muhammad Fadlillah Firstiogusran, Suguru Ishigaki, Hirofumi Iwata, Yusuke Enokidani, Hironori Ebishima, Naoko Kubo, Moe Koide, Yukiko Koyama, Ryota Sakaguchi, Natsuko Tokuhira, Yu Horiguchi, Akinori Uchiyama and Yuji Fujino
    Citation: Critical Care 2023 27:152
  20. ICU risk assessment tools, routinely used for predicting population outcomes, are not recommended for evaluating individual risk. The state of health of single patients is mostly subjectively assessed to infor...

    Authors: Lucas Boeck, Hans Pargger, Peter Schellongowski, Charles-Edouard Luyt, Marco Maggiorini, Kathleen Jahn, Grégoire Muller, Rene Lötscher, Evelyne Bucher, Nadine Cueni, Thomas Staudinger, Jean Chastre, Martin Siegemund, Michael Tamm and Daiana Stolz
    Citation: Critical Care 2023 27:150
  21. Optimal noninvasive respiratory support for patients with hypoxemic respiratory failure should minimize work of breathing without increasing the transpulmonary pressure. Recently, an asymmetrical high flow nas...

    Authors: Douglas Slobod, Elena Spinelli, Stefania Crotti, Alfredo Lissoni, Alessandro Galazzi, Giacomo Grasselli and Tommaso Mauri
    Citation: Critical Care 2023 27:145
  22. Use of extracorporeal membrane oxygenation (ECMO) in cardiopulmonary resuscitation, termed eCPR, offers the prospect of improving survival with good neurological function after cardiac arrest. After death, ECM...

    Authors: Tamar Schiff, Christian Koziatek, Erin Pomerantz, Nichole Bosson, Robert Montgomery, Brendan Parent and Stephen P. Wall
    Citation: Critical Care 2023 27:144
  23. Previous studies have demonstrated a beneficial effect of early use of corticosteroids in patients with COVID-19. This study aimed to compare hospitalized patients with COVID-19 who received short-course corti...

    Authors: Marina Verçoza Viana, José Augusto Santos Pellegrini, Amanda Vilaverde Perez, Patrícia Schwarz, Daiandy da Silva, Cassiano Teixeira, Marcelo Basso Gazzana and Tatiana Helena Rech
    Citation: Critical Care 2023 27:143
  24. To accelerate the diagnosis and treatment of trauma-induced coagulopathy (TIC), viscoelastic haemostatic assays (VHA) are increasingly used worldwide, although their value is still debated, with a recent rando...

    Authors: Jean-Stéphane David, Arthur James, Maxime Orion, Agathe Selves, Mélody Bonnet, Pauline Glasman, Charles-Hervé Vacheron and Mathieu Raux
    Citation: Critical Care 2023 27:141
  25. Prone positioning is an evidence-based treatment for patients with moderate-to-severe acute respiratory distress syndrome. Lung recruitment has been proposed as one of the mechanisms by which prone positioning...

    Authors: Lorenzo Del Sorbo, Manuel Tisminetzky, Lu Chen, Laurent Brochard, Daniel Arellano, Roberto Brito, Juan C. Diaz and Rodrigo Cornejo
    Citation: Critical Care 2023 27:140
  26. Propofol is one of the most widely used hypnotic agents in the world. Nonetheless, propofol might have detrimental effects on clinically relevant outcomes, possibly due to inhibition of other interventions' or...

    Authors: Yuki Kotani, Alessandro Pruna, Stefano Turi, Giovanni Borghi, Todd C. Lee, Alberto Zangrillo, Giovanni Landoni and Laura Pasin
    Citation: Critical Care 2023 27:139

    The Correspondence to this article has been published in Critical Care 2023 27:208

    The Comment to this article has been published in Critical Care 2023 27:198

    The Correspondence to this article has been published in Critical Care 2023 27:192

    The Correspondence to this article has been published in Critical Care 2023 27:171

  27. There is very limited evidence identifying factors that increase respiratory drive in hypoxemic intubated patients. Most physiological determinants of respiratory drive cannot be directly assessed at the bedsi...

    Authors: Elena Spinelli, Antonio Pesenti, Douglas Slobod, Carla Fornari, Roberto Fumagalli, Giacomo Grasselli, Carlo Alberto Volta, Giuseppe Foti, Paolo Navalesi, Rihard Knafelj, Paolo Pelosi, Jordi Mancebo, Laurent Brochard and Tommaso Mauri
    Citation: Critical Care 2023 27:138
  28. For decades, one of the main targets in the management of severe acute brain injury (ABI) has been intracranial hypertension (IH) control. However, the determination of IH has suffered variations in its thresh...

    Authors: Daniel Agustín Godoy, Sérgio Brasil, Corrado Iaccarino, Wellingson Paiva and Andres M. Rubiano
    Citation: Critical Care 2023 27:137
  29. In patients on mechanical ventilation, positive end-expiratory pressure (PEEP) can decrease cardiac output through a decrease in cardiac preload and/or an increase in right ventricular afterload. Increase in c...

    Authors: Christopher Lai, Rui Shi, Alexandra Beurton, Francesca Moretto, Soufia Ayed, Nicolas Fage, Francesco Gavelli, Arthur Pavot, Martin Dres, Jean-Louis Teboul and Xavier Monnet
    Citation: Critical Care 2023 27:136

    The Correspondence to this article has been published in Critical Care 2023 27:191

  30. Magnetic resonance imaging (MRI) is the preferred neuroimaging technique in pediatric patients. However, in neonates and instable pediatric patients accessibility to MRI is often not feasible due to instabilit...

    Authors: Hemmen Sabir, Florian Kipfmueller, Soyhan Bagci, Till Dresbach, Tamara Grass, Patrizia Nitsch-Felsecker, Christos Pantazis, Joachim Schmitt, Lukas Schroeder and Andreas Mueller
    Citation: Critical Care 2023 27:134
  31. Stroke patients requiring mechanical ventilation often have a poor prognosis. The optimal timing of tracheostomy and its impact on mortality in stroke patients remains uncertain. We performed a systematic revi...

    Authors: Lavienraj Premraj, Christopher Camarda, Nicole White, Daniel Agustin Godoy, Brian H. Cuthbertson, Patricia R. M. Rocco, Paolo Pelosi, Chiara Robba, Jose I. Suarez, Sung-Min Cho and Denise Battaglini
    Citation: Critical Care 2023 27:132

    The Comment to this article has been published in Critical Care 2023 27:216

    The Comment to this article has been published in Critical Care 2023 27:151

  32. Supraphysiologic oxygen administration causes unfavorable clinical outcomes in various diseases, including traumatic brain injury, post–cardiac arrest syndrome, and acute lung injury. Accidental hypothermia is...

    Authors: Ryo Yamamoto, Jo Yoshizawa, Shuhei Takauji, Mineji Hayakawa and Junichi Sasaki
    Citation: Critical Care 2023 27:131
  33. Altered levels of cerebrospinal fluid (CSF) glucose and lactate concentrations are associated with poor outcomes in acute brain injury patients. However, no data on changes in such metabolites consequently to ...

    Authors: Elisa Gouvêa Bogossian, Chahnez Taleb, Raffaele Aspide, Rafael Badenes, Denise Battaglini, Federico Bilotta, Aaron Blandino Ortiz, Anselmo Caricato, Carlo Alberto Castioni, Giuseppe Citerio, Gioconda Ferraro, Costanza Martino, Isabella Melchionda, Federica Montanaro, Berta Monleon Lopez, Consolato Gianluca Nato…
    Citation: Critical Care 2023 27:130
  34. Patient-ventilator asynchronies are usually detected by visual inspection of ventilator waveforms but with low sensitivity, even when performed by experts in the field. Recently, estimation of the inspiratory ...

    Authors: Daniel Oliveira Silva, Patrícia Nery de Souza, Mayson Laercio de Araujo Sousa, Caio Cesar Araujo Morais, Juliana Carvalho Ferreira, Marcelo Alcantara Holanda, Wellington Pereira Yamaguti, Laerte Pastore Junior and Eduardo Leite Vieira Costa
    Citation: Critical Care 2023 27:128