Articles

Performance and impact of a multiplex PCR in ICU patients with ventilator-associated pneumonia or ventilated hospital-acquired pneumonia

Early appropriate antibiotic therapy reduces morbidity and mortality of severe pneumonia. However, the emergence of bacterial resistance requires the earliest use of antibiotics with the narrowest possible spe...

Authors: Nathan Peiffer-Smadja, Lila Bouadma, Vincent Mathy, Kahina Allouche, Juliette Patrier, Martin Reboul, Philippe Montravers, Jean-François Timsit and Laurence Armand-Lefevre

“War to the knife” against thromboinflammation to protect endothelial function of COVID-19 patients

In this viewpoint, we summarize the relevance of thromboinflammation in COVID-19 and discuss potential mechanisms of endothelial injury as a key point for the development of lung and distant organ dysfunction,...

Authors: Gabriele Guglielmetti, Marco Quaglia, Pier Paolo Sainaghi, Luigi Mario Castello, Rosanna Vaschetto, Mario Pirisi, Francesco Della Corte, Gian Carlo Avanzi, Piero Stratta and Vincenzo Cantaluppi

First do no harm—beware the risk of therapeutic plasma exchange in severe COVID-19

Authors: Klaus Stahl, Christian Bode and Sascha David

High doses of ketamine to improve neuronal edema in subarachnoid hemorrhage: we should consider other undesirable organ targets

Authors: Patrick M. Honore, Aude Mugisha, Luc Kugener, Sebastien Redant, Rachid Attou, Andrea Gallerani and David De Bels

Bedside rapid placement of nasointestinal feeding tube via ultrasound-guided stylet positioning in critical COVID-19 patients

Authors: Chuan-xi Chen, Zheng-deng Wei, Yong-jun Liu, Shou-zhen Cheng and Xiang-dong Guan

The unique characteristics of COVID-19 coagulopathy

Thrombotic complications and coagulopathy frequently occur in COVID-19. However, the characteristics of COVID-19-associated coagulopathy (CAC) are distinct from those seen with bacterial sepsis-induced coagulo...

Authors: Toshiaki Iba, Jerrold H. Levy, Jean Marie Connors, Theodore E. Warkentin, Jecko Thachil and Marcel Levi

Can augmented renal clearance be detected using estimators of glomerular filtration rate?

Authors: Matthias Gijsen, Alexander Wilmer, Geert Meyfroidt, Joost Wauters and Isabel Spriet

Compassionate use of others’ immunity — understanding gut microbiome in Covid-19

Authors: Prashanth Thalanayar Muthukrishnan and Robert Faillace

Single ventilator for multiple patients during COVID19 surge: matching and balancing patients

Authors: Lonnie G. Petersen, James Friend and Sidney Merritt

Prevalence and impact of acute renal impairment on COVID-19: a systematic review and meta-analysis

The aim of this study is to assess the prevalence of abnormal urine analysis and kidney dysfunction in COVID-19 patients and to determine the association of acute kidney injury (AKI) with the severity and prog...

Authors: Xianghong Yang, Yiyang Jin, Ranran Li, Zhongheng Zhang, Renhua Sun and Dechang Chen

Immortal time bias: a possible explanation for “Impact of acyclovir use on survival of patients with ventilator-associated pneumonia and high load herpes simplex virus replication”

Authors: Magnus Glindvad Ahlström, Lars Haukali Omland, Andreas Ronit and Niels Obel

Hypertonic sodium lactate improves microcirculation, cardiac function, and inflammation in a rat model of sepsis

Hypertonic sodium lactate (HSL) may be of interest during inflammation. We aimed to evaluate its effects during experimental sepsis in rats (cecal ligation and puncture (CLP)).

Authors: Emmanuel Besnier, David Coquerel, Geoffrey Kouadri, Thomas Clavier, Raphael Favory, Thibault Duburcq, Olivier Lesur, Soumeya Bekri, Vincent Richard, Paul Mulder and Fabienne Tamion

The vascular endothelium: the cornerstone of organ dysfunction in severe SARS-CoV-2 infection

In severe SARS-CoV-2 infections, emerging data including recent histopathological studies have emphasized the crucial role of endothelial cells (ECs) in vascular dysfunction, immunothrombosis, and inflammation.

Authors: Stéphanie Pons, Sofiane Fodil, Elie Azoulay and Lara Zafrani

Liver injury without liver failure in COVID-19 patients: how to explain, in some cases, elevated ammonia without hepatic decompensation

Authors: Patrick M. Honore, Leonel Barreto Gutierrez, Luc Kugener, Sebastien Redant, Rachid Attou, Andrea Gallerani and David De Bels

The ARDSnet protocol may be detrimental in COVID-19

Authors: Vasiliki Tsolaki, George E. Zakynthinos and Dimosthenis Makris

Paediatric and adult critical care medicine: joining forces against Covid-19

Authors: Martin C. J. Kneyber, Bernadette Engels and Peter H. J. van der Voort

Micronutrient status of COVID-19 patients: a critical consideration

Authors: Anitra C. Carr

Invasive mechanical ventilation in COVID-19 patient management: the experience with 469 patients in Wuhan

Authors: Jing Hua, Chenchen Qian, Zhibing Luo, Qiang Li and Feilong Wang

Health-related quality of life of children and their parents 2 years after critical illness: pre-planned follow-up of the PEPaNIC international, randomized, controlled trial

Pediatric intensive care unit (PICU) survivors are at risk for prolonged morbidities interfering with daily life. The current study examined parent-reported health-related quality of life (HRQoL) in former cri...

Authors: José Hordijk, Sascha Verbruggen, Ilse Vanhorebeek, Fabian Güiza, Pieter Wouters, Greet Van den Berghe, Koen Joosten and Karolijn Dulfer

Incidence of acute kidney injury in COVID-19 infection: a systematic review and meta-analysis

Authors: Yih-Ting Chen, Shih-Chieh Shao, Cheng-Kai Hsu, I-Wen Wu, Ming-Jui Hung and Yung-Chang Chen

Response to “COVID-19: room for treating T cell exhaustion?”

Authors: Anne M. Drewry, Richard Hotchkiss and Erik Kulstad

Success and complications by team composition for prehospital pediatric intubation: children also need physicians!

Authors: Romain Jouffroy, Stéphanie Fogel, Peter Jones and Benoît Vivien

Optic nerve sheath diameter in critically ill patients: nuances and interpretation

Authors: Amos Lal, Kamal Kant Sahu, Ajay Kumar Mishra and Jamal Akhtar

Early rehabilitation with dedicated use of belt-type electrical muscle stimulation for severe COVID-19 patients

Authors: Kensuke Nakamura, Hidehiko Nakano, Hiromu Naraba, Masaki Mochizuki and Hideki Hashimoto

Beta-2-glycoprotein I as a biomarker for sepsis in critically ill patients in the intensive care unit: a prospective cohort study

Authors: Irene T. Schrijver, Hans Kemperman, Mark Roest, Jozef Kesecioglu and Dylan W. de Lange

Clinical features and outcomes of COVID-19 patients with gastrointestinal symptoms

Authors: Chao Cao, Meiping Chen, Li He, Jiao Xie and Xiaomin Chen

COVID-19 targets the right lung

Authors: Jingwen Li, Xiaxia Yu, Shaoping Hu, Zhicheng Lin, Nian Xiong and Yi Gao

Infection prevention and control in nursing severe coronavirus disease (COVID-19) patients during the pandemic

Authors: Lei Ye, Shulan Yang and Caixia Liu

A plea for avoiding systematic intubation in severely hypoxemic patients with COVID-19-associated respiratory failure

Authors: Eduardo Villarreal-Fernandez, Ravi Patel, Reshma Golamari, Muhammad Khalid, Ami DeWaters and Philippe Haouzi

The interaction between arterial oxygenation and carbon dioxide and hospital mortality following out of hospital cardiac arrest: a cohort study

Outcomes following out of hospital cardiac arrest (OHCA) are poor. The optimal arterial oxygen and carbon dioxide (PaCO₂) levels for managing patients following OHCA are unknown. We hypothesized that abnormalitie...

Authors: Peter J. McGuigan, Manu Shankar-Hari, David A. Harrison, John G. Laffey and Danny F. McAuley

Interferon beta-1a for COVID-19: critical importance of the administration route

Authors: Juho Jalkanen, Maija Hollmén and Sirpa Jalkanen

A valuable and affordable handheld ultrasound in combating COVID-19

The handheld ultrasound demonstrates clinical and economic value in combating COVID-19 based on interviews with frontline ultrasound physician and cardiologist as well as a national expert in medical ultrasound.

Authors: Feng Qian, Xueqin Zhou, Jianqiao Zhou, Zhenhua Liu and Qian Nie

Non-invasive ventilation in the treatment of early hypoxemic respiratory failure caused by COVID-19: considering nasal CPAP as the first choice

Authors: Lili Guan, Luqian Zhou, Jehane Michael Le Grange, Zeguang Zheng and Rongchang Chen

COVID-19: opening a new paradigm in thromboprophylaxis for critically ill patients?

Authors: Raquel Ferrandis, Juan V. Llau, Manuel Quintana, Pilar Sierra, Francisco Hidalgo, Concepción Cassinello and Aurelio Gómez-Luque

Exploring pharmacological approaches for managing cytokine storm associated with pneumonia and acute respiratory distress syndrome in COVID-19 patients

Sars-CoV-2 complications include pneumonia and acute respiratory distress syndrome (ARDS), which require intensive care unit admission. These conditions have rapidly overwhelmed healthcare systems, with detrim...

Authors: Irma Convertino, Marco Tuccori, Sara Ferraro, Giulia Valdiserra, Emiliano Cappello, Daniele Focosi and Corrado Blandizzi

The performance of acute versus antecedent patient characteristics for 1-year mortality prediction during intensive care unit admission: a national cohort study

Multiple factors contribute to mortality after ICU, but it is unclear how the predictive value of these factors changes during ICU admission. We aimed to compare the changing performance over time of the acute...

Authors: Monika C. Kerckhoffs, Sylvia Brinkman, Nicolet de Keizer, Ivo W. Soliman, Dylan W. de Lange, Johannes J. M. van Delden and Diederik van Dijk

Ventilator management in the age of COVID-19: response to “Logistic and organizational aspects of a dedicated intensive care unit for COVID-19 patients”

Authors: Alastair E. Moody, Bryce D. Beutler, Daniel Antwi-Amoabeng, Eric X. Lu, Charles E. Willyard, Irtqa Ilyas and Nageshwara Gullapalli

Intra-hospital preventive principles to protect frontline healthcare workers to overcome pandemic COVID-19 in Taiwan

Authors: Ting-Wan Tan, Chih-Ming Chang and Man-Na Chang

Severe Covid-19 disease: rather AVDS than ARDS?

Authors: Yazine Mahjoub, Daniel Oscar Rodenstein and Vincent Jounieaux

In regard to P. von Platen et al., “The dawn of physiological closed-loop ventilation—a review”

Authors: Fleur T. Tehrani

Low molecular weight heparins in COVID-19 patients: beware of augmented renal clearance!

Authors: Teresa Maria Tomasa-Irriguible, Sergi Martínez-Vega, Ester Mor-Marco, Alba Herraiz-Ruiz, Laura Raguer-Pardo and Carlos Cubells-Larrosa

Potential benefit of angiotensin II in COVID-19 patients: beyond reasonable doubt?

Authors: António Tralhão, Luís Ferreira Moita and Pedro Póvoa

COVID-19: desperate times call for desperate measures

Authors: Stephan von Düring, Steve Primmaz and Karim Bendjelid

Early latency evoked potentials can no longer be considered an infallible predictor of neurologic outcome

Authors: Patrick M. Honore, Leonel Barreto Gutierrez, Luc Kugener, Sebastien Redant, Rachid Attou, Andrea Gallerani and David De Bels

Should we deny ICU admission to the elderly? Ethical considerations in times of COVID-19

Authors: Lenneke E. M. Haas, Dylan W. de Lange, Diederik van Dijk and Johannes J. M. van Delden

Systemic hypoferremia and severity of hypoxemic respiratory failure in COVID-19

Authors: Akshay Shah, Joe N. Frost, Louise Aaron, Killian Donovan and Hal Drakesmith

Three-step checklist for tracheostomy in critically ill COVID-19 patients

Authors: Maria Vargas and Giuseppe Servillo

Prehospital pulse oximetry: a red flag for early detection of silent hypoxemia in COVID-19 patients

Authors: Romain Jouffroy, Daniel Jost and Bertrand Prunet

Peritoneal dialysis for COVID-19-associated acute kidney injury

Authors: Mika Nagatomo, Hiroyuki Yamada, Ken Shinozuka, Manabu Shimoto, Tomoyuki Yunoki and Shigeru Ohtsuru

Health-related quality of life after critical care—the emperor’s new clothes

Authors: Folke Sjöberg, Lotti Orwelius and Sören Berg