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  1. Whereas ICU-acquired weakness may delay extubation in mechanically ventilated patients, its influence on extubation failure is poorly known. This study aimed at assessing the role of ICU-acquired weakness on e...

    Authors: Arnaud W. Thille, Florence Boissier, Michel Muller, Albrice Levrat, Gaël Bourdin, Sylvène Rosselli, Jean-Pierre Frat, Rémi Coudroy and Emmanuel Vivier

    Citation: Critical Care 2020 24:86

    Content type: Research

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  2. Diaphragm atrophy and dysfunction are consequences of mechanical ventilation and are determinants of clinical outcomes. We hypothesize that partial preservation of diaphragm function, such as during assisted m...

    Authors: Alice Grassi, Daniela Ferlicca, Ermes Lupieri, Serena Calcinati, Silvia Francesconi, Vittoria Sala, Valentina Ormas, Elena Chiodaroli, Chiara Abbruzzese, Francesco Curto, Andrea Sanna, Massimo Zambon, Roberto Fumagalli, Giuseppe Foti and Giacomo Bellani

    Citation: Critical Care 2020 24:85

    Content type: Research

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  3. Postextubation high-flow nasal cannula (HFNC) is used as a support therapy in high-risk patients in ICU. This study aimed to determine the effects of HFNC therapy on lung recruitment and overdistension assesse...

    Authors: Rui Zhang, Huaiwu He, Long Yun, Xiang Zhou, Xu Wang, Yi Chi, Siyi Yuan and Zhanqi Zhao

    Citation: Critical Care 2020 24:82

    Content type: Research

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  4. Although studies on the effectiveness of the use of ICU diaries on psychiatric disorders and quality of life have been published, the results still seem to be controversial. The study aimed to determine the ef...

    Authors: Shuo Wang, Hui-Ning Xin, Chiang Chung Lim Vico, Jin-Hua Liao, Sai-Lan Li, Na-Mei Xie and Rong-Fang Hu

    Citation: Critical Care 2020 24:81

    Content type: Research

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  5. The association of central venous pressure (CVP) and mortality and acute kidney injury (AKI) in critically ill adult patients remains unclear. We performed a meta-analysis to determine whether elevated CVP is ...

    Authors: Chuan-Yu Chen, Yan Zhou, Peng Wang, En-Yao Qi and Wan-Jie Gu

    Citation: Critical Care 2020 24:80

    Content type: Research

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  6. In the publication of this article [1], there was an error in the Family Name of one of the authors. This has now been updated in the original article.

    Authors: Aurelien Flatres, Yassir Aarab, Stephanie Nougaret, Fanny Garnier, Romaric Larcher, Mathieu Amalric, Kada Klouche, Pascal Etienne, Gilles Subra, Samir Jaber, Nicolas Molinari, Stefan Matecki and Boris Jung

    Citation: Critical Care 2020 24:79

    Content type: Correction

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    The original article was published in Critical Care 2020 24:34

  7. The aim of this study is to validate a previously published consensus-based quality indicator set for the management of patients with traumatic brain injury (TBI) at intensive care units (ICUs) in Europe and t...

    Authors: Jilske A. Huijben, Eveline J. A. Wiegers, Ari Ercole, Nicolette F. de Keizer, Andrew I. R. Maas, Ewout W. Steyerberg, Giuseppe Citerio, Lindsay Wilson, Suzanne Polinder, Daan Nieboer, David Menon, Hester F. Lingsma and Mathieu van der Jagt

    Citation: Critical Care 2020 24:78

    Content type: Research

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  8. Mechanical ventilation to alter and improve respiratory gases is a fundamental feature of critical care and intraoperative anesthesia management. The range of inspired O2 and expired CO2 during patient management...

    Authors: W. Alan C. Mutch, Renée El-Gabalawy, Lawrence Ryner, Josep Puig, Marco Essig, Kayla Kilborn, Kelsi Fidler and M. Ruth Graham

    Citation: Critical Care 2020 24:76

    Content type: Research

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  9. Although current guidelines for AKI suggested against the use of furosemide in AKI management, the effect of furosemide on outcomes in real-world clinical settings remains uncertain. The aim of the present stu...

    Authors: Guang-ju Zhao, Chang Xu, Jian-chao Ying, Wen-biao Lü, Guang-liang Hong, Meng-fang Li, Bing Wu, Yong-ming Yao and Zhong-qiu Lu

    Citation: Critical Care 2020 24:75

    Content type: Research

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  10. Pseudomonas aeruginosa infections are a serious threat in intensive care units (ICUs). The aim of this confirmatory, randomized, multicenter, placebo-controlled, double-blind, phase 2/3 study was to assess the ef...

    Authors: Christopher Adlbrecht, Raphael Wurm, Pieter Depuydt, Herbert Spapen, Jose A. Lorente, Thomas Staudinger, Jacques Creteur, Christian Zauner, Andreas Meier-Hellmann, Philipp Eller, Margot Vander Laenen, Zsolt Molnár, István Várkonyi, Bernhard Schaaf, Mária Héjja, Vladimír Šrámek…

    Citation: Critical Care 2020 24:74

    Content type: Research

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  11. Patient safety and critical care quality remain a challenging issue in the ICU. However, the effects of the national quality improvement (QI) program remain unknown in China.

    Authors: Huaiwu He, Xudong Ma, Longxiang Su, Lu Wang, Yanhong Guo, Guangliang Shan, Hui Jing He, Xiang Zhou, Dawei Liu, Yun Long, Yupei Zhao and Shuyang Zhang

    Citation: Critical Care 2020 24:73

    Content type: Research

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  12. A dysbalanced coagulation system is part of the pathological host response to infection in sepsis. Activation of pro-coagulant pathways and attenuation of anti-coagulant activity ultimately lead to microvascul...

    Authors: Klaus Stahl, Julius J. Schmidt, Benjamin Seeliger, Bernhard M. W. Schmidt, Tobias Welte, Hermann Haller, Marius M. Hoeper, Ulrich Budde, Christian Bode and Sascha David

    Citation: Critical Care 2020 24:71

    Content type: Research

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  13. Administration of diuretics has been shown to assist fluid management and improve clinical outcomes in the critically ill post-shock resolution. Current guidelines have not yet included standardization or guid...

    Authors: Brittany D. Bissell, Melanie E. Laine, Melissa L. Thompson Bastin, Alexander H. Flannery, Andrew Kelly, Jeremy Riser, Javier A. Neyra, Jordan Potter and Peter E. Morris

    Citation: Critical Care 2020 24:70

    Content type: Research

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  14. Pneumococcal infections remain the main cause of overwhelming post-splenectomy infections, and purpura fulminans may develop in almost 20% of patients with overwhelming post-splenectomy infection. We aimed at ...

    Authors: Damien Contou, Rémi Coudroy, Gwenhaël Colin, Jean-Marc Tadié, Martin Cour, Romain Sonneville, Armand Mekontso Dessap and Nicolas de Prost

    Citation: Critical Care 2020 24:68

    Content type: Research

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  15. The effect of alternative spontaneous breathing trial (SBT) techniques on extubation success and other clinically important outcomes is uncertain. A systematic review and meta-analysis was performed to clarify...

    Authors: Yuting Li, Hongxiang Li and Dong Zhang

    Citation: Critical Care 2020 24:67

    Content type: Research

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  16. Intensive care unit (ICU) delirium is a frequent secondary neurological complication in critically ill patients undergoing prolonged mechanical ventilation. Quantitative pupillometry is an emerging modality fo...

    Authors: Eva Favre, Adriano Bernini, Paola Morelli, Jerôme Pasquier, John-Paul Miroz, Samia Abed-Maillard, Nawfel Ben-Hamouda and Mauro Oddo

    Citation: Critical Care 2020 24:66

    Content type: Research

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  17. Point-of-care ultrasound (POCUS) is nowadays an essential tool in critical care. Its role seems more important in neonates and children where other monitoring techniques may be unavailable. POCUS Working Group...

    Authors: Yogen Singh, Cecile Tissot, María V. Fraga, Nadya Yousef, Rafael Gonzalez Cortes, Jorge Lopez, Joan Sanchez-de-Toledo, Joe Brierley, Juan Mayordomo Colunga, Dusan Raffaj, Eduardo Da Cruz, Philippe Durand, Peter Kenderessy, Hans-Joerg Lang, Akira Nishisaki, Martin C. Kneyber…

    Citation: Critical Care 2020 24:65

    Content type: Research

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  18. In septic patients, multiple retrospective studies show an association between large volumes of fluids administered in the first 24 h and mortality, suggesting a benefit to fluid restrictive strategies. Howeve...

    Authors: Zach Shahn, Nathan I. Shapiro, Patrick D. Tyler, Daniel Talmor and Li-wei H. Lehman

    Citation: Critical Care 2020 24:62

    Content type: Research

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  19. To quantitatively summarize the available epidemiological evidence on the survival rate of out-of-hospital cardiac arrest (OHCA) patients who received cardiopulmonary resuscitation (CPR).

    Authors: Shijiao Yan, Yong Gan, Nan Jiang, Rixing Wang, Yunqiang Chen, Zhiqian Luo, Qiao Zong, Song Chen and Chuanzhu Lv

    Citation: Critical Care 2020 24:61

    Content type: Research

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  20. The knowledge of new prognostic factors in out-of-hospital cardiac arrest (OHCA) that can be evaluated since the beginning of cardiopulmonary resuscitation (CPR) manoeuvres could be helpful in the decision-mak...

    Authors: Ervigio Corral Torres, Alberto Hernández-Tejedor, Rosa Suárez Bustamante, Ramón de Elías Hernández, Isabel Casado Flórez and Antonio San Juan Linares

    Citation: Critical Care 2020 24:60

    Content type: Research

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  21. Optimal antimicrobial drug exposure in the lung is required for successful treatment outcomes for nosocomial pneumonia. Little is known about the intrapulmonary pharmacokinetics (PK) of meropenem when administ...

    Authors: Adela Benítez-Cano, Sonia Luque, Luisa Sorlí, Jesús Carazo, Isabel Ramos, Nuria Campillo, Víctor Curull, Albert Sánchez-Font, Carles Vilaplana, Juan P. Horcajada, Ramón Adalia, Silvia Bermejo, Enric Samsó, William Hope and Santiago Grau

    Citation: Critical Care 2020 24:55

    Content type: Research

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  22. We aimed to synthesize up-to-date trials to validate the effects of neuromuscular blocking agent (NMBA) use in patients with moderate-to-severe acute respiratory distress syndrome (ARDS).

    Authors: Wei Chang, Qin Sun, Fei Peng, Jianfeng Xie, Haibo Qiu and Yi Yang

    Citation: Critical Care 2020 24:54

    Content type: Research

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  23. Despite sound basis to suspect that aggressive and early administration of nutritional support may hold therapeutic benefits during sepsis, recommendations for nutritional support have been somewhat underwhelm...

    Authors: Gustav van Niekerk, Charné Meaker and Anna-Mart Engelbrecht

    Citation: Critical Care 2020 24:53

    Content type: Viewpoint

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  24. Optimal timing for the start of vasopressors (VP) in septic shock has not been widely studied since it is assumed that fluids must be administered in advance. We sought to evaluate whether a very early start o...

    Authors: Gustavo A. Ospina-Tascón, Glenn Hernandez, Ingrid Alvarez, Luis E. Calderón-Tapia, Ramiro Manzano-Nunez, Alvaro I. Sánchez-Ortiz, Egardo Quiñones, Juan E. Ruiz-Yucuma, José L. Aldana, Jean-Louis Teboul, Alexandre Biasi Cavalcanti, Daniel De Backer and Jan Bakker

    Citation: Critical Care 2020 24:52

    Content type: Research

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  25. Renal replacement therapy (RRT) is associated with high mortality and costs; however, no clinical guidelines currently provide specific recommendations for clinicians on when and how to stop RRT in recovering ...

    Authors: Riley Jeremy Katulka, Abdalrhman Al Saadon, Meghan Sebastianski, Robin Featherstone, Ben Vandermeer, Samuel A. Silver, R. T. Noel Gibney, Sean M. Bagshaw and Oleksa G. Rewa

    Citation: Critical Care 2020 24:50

    Content type: Research

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  26. Severe blunt chest injury sometimes induces acute respiratory failure (ARF), requiring ventilator use. We aimed to evaluate the effect of performing rib fixation with the addition of video-assisted thoracoscop...

    Authors: Tung-Ho Wu, Hsing-Lin Lin, Yi-Pin Chou, Fong-Dee Huang, Wen-Yen Huang and Yih-Wen Tarng

    Citation: Critical Care 2020 24:49

    Content type: Research

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  27. The intestinal epithelium compartmentalizes the sterile bloodstream and the commensal bacteria in the gut. Accumulating evidence suggests that this barrier is impaired in sepsis, aggravating systemic inflammat...

    Authors: Jeffery Ho, Hung Chan, Yonghao Liang, Xiaodong Liu, Lin Zhang, Qing Li, Yuchen Zhang, Judeng Zeng, Felix N. Ugwu, Idy H. T. Ho, Wei Hu, Johnny C. W. Yau, Sunny H. Wong, Wai Tat Wong, Lowell Ling, Chi H. Cho…

    Citation: Critical Care 2020 24:47

    Content type: Research

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  28. Plasma lactate concentrations and their trends over time are used for clinical prognosis, and to guide treatment, in critically ill patients. Although heavily relied upon for clinical decision-making, lactate ...

    Authors: Jonathan Grip, Tobias Falkenström, Panuwat Promsin, Jan Wernerman, Åke Norberg and Olav Rooyackers

    Citation: Critical Care 2020 24:46

    Content type: Research

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  29. Spontaneous intracerebral hemorrhage is a devastating disease, accounting for 10 to 15% of all types of stroke; however, it is associated with disproportionally higher rates of mortality and disability. Despit...

    Authors: Airton Leonardo de Oliveira Manoel

    Citation: Critical Care 2020 24:45

    Content type: Review

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  30. Naloxone is the usual drug used in opioid-induced respiratory depression but it has a short half-life, precipitates withdrawal in dependent patients, and thus for persistent reversal of long-acting opioids has...

    Authors: Nasim Zamani, Nicholas A. Buckley and Hossein Hassanian-Moghaddam

    Citation: Critical Care 2020 24:44

    Content type: Research

    Published on:

  31. In the publication of this article [1], there are 4 collaborating authors missing from the ‘MARS consortium’. This has now been included in this correction article.

    Authors: Peter M. C. Klein Klouwenberg, Cristian Spitoni, Tom van der Poll, Marc J. Bonten and Olaf L. Cremer

    Citation: Critical Care 2020 24:41

    Content type: Correction

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    The original article was published in Critical Care 2019 23:408