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  1. Research

    The association of early combined lactate and glucose levels with subsequent renal and liver dysfunction and hospital mortality in critically ill patients

    The development of renal and liver dysfunction may be accompanied by initially subtle derangements in the gluconeogenetic function. Discrepantly low glucose levels combined with high lactate levels might indic...

    Pedro Freire Jorge, Nienke Wieringa, Eva de Felice, Iwan C. C. van der Horst, Annemieke Oude Lansink and Maarten W. Nijsten

    Critical Care 2017 21:218

    Published on: 21 August 2017

  2. Research

    Circulating levels of soluble Fas (sCD95) are associated with risk for development of a nonresolving acute kidney injury subphenotype

    Critically ill patients with acute kidney injury (AKI) can be divided into two subphenotypes, resolving or nonresolving, on the basis of the trajectory of serum creatinine. It is unknown if the biology underly...

    Pavan K. Bhatraju, Cassianne Robinson-Cohen, Carmen Mikacenic, Susanna Harju-Baker, Victoria Dmyterko, Natalie S. J. Slivinski, W. Conrad Liles, Jonathan Himmelfarb, Susan R. Heckbert and Mark M. Wurfel

    Critical Care 2017 21:217

    Published on: 17 August 2017

  3. Research

    Early troponin I in critical illness and its association with hospital mortality: a cohort study

    Troponin I (TnI) is frequently elevated in critical illness, but its interpretation is unclear. Our primary objectives in this study were to evaluate whether TnI is associated with hospital mortality and if th...

    Annemarie B. Docherty, Malcolm Sim, Joao Oliveira, Michael Adlam, Marlies Ostermann, Timothy S. Walsh, John Kinsella and Nazir I. Lone

    Critical Care 2017 21:216

    Published on: 16 August 2017

  4. Research

    Selepressin, a novel selective vasopressin V1A agonist, is an effective substitute for norepinephrine in a phase IIa randomized, placebo-controlled trial in septic shock patients

    Vasopressin is widely used for vasopressor support in septic shock patients, but experimental evidence suggests that selective V1A agonists are superior. The initial pharmacodynamic effects, pharmacokinetics, and...

    James A. Russell, Jean-Louis Vincent, Anne Louise Kjølbye, Håkan Olsson, Allan Blemings, Herbert Spapen, Peder Carl, Pierre-Francois Laterre and Lars Grundemar

    Critical Care 2017 21:213

    Published on: 15 August 2017

  5. Research

    Dehydroepiandrosterone sulfate and dehydroepiandrosterone sulfate/cortisol ratio in cirrhotic patients with septic shock: another sign of hepatoadrenal syndrome?

    Cirrhotic patients are susceptible to sepsis and critical illness-related corticosteroid insufficiency (CIRCI). Dehydroepiandrosterone sulfate (DHEAS) is a corticotropin-dependent adrenal androgen, which has i...

    Ming-Hung Tsai, Hui-Chun Huang, Yun-Shing Peng, Yung-Chang Chen, Ya-Chung Tian, Chih-Wei Yang, Jau-Min Lien, Ji-Tseng Fang, Cheng-Shyong Wu, Sen-Yung Hsieh and Fa-Yauh Lee

    Critical Care 2017 21:214

    Published on: 15 August 2017

  6. Research

    Software-guided versus nurse-directed blood glucose control in critically ill patients: the LOGIC-2 multicenter randomized controlled clinical trial

    Blood glucose control in the intensive care unit (ICU) has the potential to save lives. However, maintaining blood glucose concentrations within a chosen target range is difficult in clinical practice and hold...

    Jasperina Dubois, Tom Van Herpe, Roosmarijn T. van Hooijdonk, Ruben Wouters, Domien Coart, Pieter Wouters, Aimé Van Assche, Guy Veraghtert, Bart De Moor, Joost Wauters, Alexander Wilmer, Marcus J. Schultz, Greet Van den Berghe and Dieter Mesotten

    Critical Care 2017 21:212

    Published on: 14 August 2017

    The Editorial to this article has been published in Critical Care 2017 21:237

  7. Research

    Voluntary running exercise protects against sepsis-induced early inflammatory and pro-coagulant responses in aged mice

    Despite many animal studies and clinical trials, mortality in sepsis remains high. This may be due to the fact that most experimental studies of sepsis employ young animals, whereas the majority of septic pati...

    Karel Tyml, Scott Swarbreck, Cynthia Pape, Dan Secor, James Koropatnick, Qingping Feng, Ruud A. W. Veldhuizen and Sean E. Gill

    Critical Care 2017 21:210

    Published on: 8 August 2017

  8. Research

    What is the impact of the fluid challenge technique on diagnosis of fluid responsiveness? A systematic review and meta-analysis

    The fluid challenge is considered the gold standard for diagnosis of fluid responsiveness. The objective of this study was to describe the fluid challenge techniques reported in fluid responsiveness studies an...

    Laura Toscani, Hollmann D. Aya, Dimitra Antonakaki, Davide Bastoni, Ximena Watson, Nish Arulkumaran, Andrew Rhodes and Maurizio Cecconi

    Critical Care 2017 21:207

    Published on: 4 August 2017

  9. Research

    Could remifentanil reduce duration of mechanical ventilation in comparison with other opioids for mechanically ventilated patients? A systematic review and meta-analysis

    Sedation and analgesia are commonly required to relieve anxiety and pain in mechanically ventilated patients. Fentanyl and morphine are the most frequently used opioids. Remifentanil is a selective μ-opioid re...

    Yibing Zhu, Yinhua Wang, Bin Du and Xiuming Xi

    Critical Care 2017 21:206

    Published on: 3 August 2017

  10. Research

    A systematic review and meta-analysis comparing mortality in pre-hospital tracheal intubation to emergency department intubation in trauma patients

    Pre-hospital endotracheal intubation is frequently used for trauma patients in many emergency medical systems. Despite a wide range of publications in the field, it is debated whether the intervention is assoc...

    Espen Fevang, Zane Perkins, David Lockey, Elisabeth Jeppesen and Hans Morten Lossius

    Critical Care 2017 21:192

    Published on: 31 July 2017

  11. Review

    Continuous glucose monitoring in the ICU: clinical considerations and consensus

    Glucose management in intensive care unit (ICU) patients has been a matter of debate for almost two decades. Compared to intermittent monitoring systems, continuous glucose monitoring (CGM) can offer benefit i...

    James S. Krinsley, J. Geoffrey Chase, Jan Gunst, Johan Martensson, Marcus J. Schultz, Fabio S. Taccone, Jan Wernerman, Julien Bohe, Christophe De Block, Thomas Desaive, Pierre Kalfon and Jean-Charles Preiser

    Critical Care 2017 21:197

    Published on: 31 July 2017

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