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  1. In the current SARS-CoV-2 pandemic, there has been worldwide debate on the use of corticosteroids in COVID-19. In the recent RECOVERY trial, evaluating the effect of dexamethasone, a reduced 28-day mortality i...

    Authors: Judith van Paassen, Jeroen S. Vos, Eva M. Hoekstra, Katinka M. I. Neumann, Pauline C. Boot and Sesmu M. Arbous

    Citation: Critical Care 2020 24:696

    Content type: Research

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  2. A subset of critically ill COVID-19 patients develop a hyperinflammatory state. Anakinra, a recombinant interleukin-1 receptor antagonist, is known to be effective in several hyperinflammatory diseases. We inv...

    Authors: Emma J. Kooistra, Nicole J. B. Waalders, Inge Grondman, Nico A. F. Janssen, Aline H. de Nooijer, Mihai G. Netea, Frank L. van de Veerdonk, Esther Ewalds, Johannes G. van der Hoeven, Matthijs Kox and Peter Pickkers

    Citation: Critical Care 2020 24:688

    Content type: Research

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  3. The short-term and long-term consequences of the most frequent painful procedures performed in the ICU are unclear. This study aimed to identify the risk factors associated with pain-related discomfort perceiv...

    Authors: Pierre Kalfon, Mohamed Boucekine, Philippe Estagnasie, Marie-Agnès Geantot, Audrey Berric, Georges Simon, Bernard Floccard, Thomas Signouret, Mélanie Fromentin, Martine Nyunga, Juliette Audibert, Adel Ben Salah, Bénédicte Mauchien, Achille Sossou, Marion Venot, René Robert…

    Citation: Critical Care 2020 24:685

    Content type: Research

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  4. The benefits of extracorporeal membrane oxygenation (ECMO) in children with sepsis remain controversial. Current guidelines on management of septic shock in children recommend consideration of ECMO as salvage ...

    Authors: Kollengode Ramanathan, Nicholas Yeo, Peta Alexander, Lakshmi Raman, Ryan Barbaro, Chuen Seng Tan, Luregn J. Schlapbach and Graeme MacLaren

    Citation: Critical Care 2020 24:684

    Content type: Research

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  5. The postoperative period is critical for a patient’s recovery, and postoperative hypotension, specifically, is associated with adverse clinical outcomes and significant harm to the patient. However, little is ...

    Authors: Nathan J. Smischney, Andrew D. Shaw, Wolf H. Stapelfeldt, Isabel J. Boero, Qinyu Chen, Mitali Stevens and Ashish K. Khanna

    Citation: Critical Care 2020 24:682

    Content type: Research

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  6. Acute respiratory distress syndrome (ARDS) is heterogeneous and may be amenable to sub-phenotyping to improve enrichment for trials. We aimed to identify subtypes of pediatric ARDS based on whole blood transcr...

    Authors: Nadir Yehya, Brian M. Varisco, Neal J. Thomas, Hector R. Wong, Jason D. Christie and Rui Feng

    Citation: Critical Care 2020 24:681

    Content type: Research

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  7. Early prognostication in patients with acute consciousness impairment is a challenging but essential task. Current prognostic guidelines vary with the underlying etiology. In particular, electroencephalography...

    Authors: Michael Müller, Andrea O. Rossetti, Rebekka Zimmermann, Vincent Alvarez, Stephan Rüegg, Matthias Haenggi, Werner J. Z’Graggen, Kaspar Schindler and Frédéric Zubler

    Citation: Critical Care 2020 24:680

    Content type: Research

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  8. Microaspiration of gastric and oropharyngeal secretions is the main causative mechanism of ventilator-associated pneumonia (VAP). Transesophageal echocardiography (TEE) is a routine investigation tool in inten...

    Authors: François Bagate, Anahita Rouzé, Farid Zerimech, Florence Boissier, Vincent Labbe, Keyvan Razazi, Guillaume Carteaux, Nicolas de Prost, Malika Balduyck, Patrice Maboudou, Saad Nseir and Armand Mekontso Dessap

    Citation: Critical Care 2020 24:679

    Content type: Research

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  9. Patients with coronavirus disease-19-related acute respiratory distress syndrome (C-ARDS) could have a specific physiological phenotype as compared with those affected by ARDS from other causes (NC-ARDS).

    Authors: François Perier, Samuel Tuffet, Tommaso Maraffi, Glasiele Alcala, Marcus Victor, Anne-Fleur Haudebourg, Keyvan Razazi, Nicolas De Prost, Marcelo Amato, Guillaume Carteaux and Armand Mekontso Dessap

    Citation: Critical Care 2020 24:678

    Content type: Research

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  10. There is emerging evidence for enhanced blood coagulation in coronavirus 2019 (COVID-19) patients, with thromboembolic complications contributing to morbidity and mortality. The mechanisms underlying this prot...

    Authors: Jan Matthias Kruse, Abakar Magomedov, Annika Kurreck, Frédéric H. Münch, Roland Koerner, Julian Kamhieh-Milz, Andreas Kahl, Inka Gotthardt, Sophie K. Piper, Kai-Uwe Eckardt, Thomas Dörner and Daniel Zickler

    Citation: Critical Care 2020 24:676

    Content type: Research

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  11. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Vincent Bonny, Vincent Janiak, Savino Spadaro, Andrea Pinna, Alexandre Demoule and Martin Dres

    Citation: Critical Care 2020 24:675

    Content type: Correction

    Published on:

    The original article was published in Critical Care 2020 24:596

  12. There is wide variability between intensivists in the decisions to forgo life-sustaining treatment (DFLST). Advance directives (ADs) allow patients to communicate their end-of-life wishes to physicians. We ass...

    Authors: Margot Smirdec, Mercé Jourdain, Virginie Guastella, Céline Lambert, Jean-Christophe Richard, Laurent Argaud, Samir Jaber, Kada Klouche, Anne Medard, Jean Reignier, Jean-Philippe Rigaud, Jean-Marc Doise, Russell Chabanne, Bertrand Souweine, Jeremy Bourenne, Julie Delmas…

    Citation: Critical Care 2020 24:672

    Content type: Research

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  13. To investigate the prevalence and prognostic impact of right heart failure and right ventricular-arterial uncoupling in Corona Virus Infectious Disease 2019 (COVID-19) complicated by an Acute Respiratory Distr...

    Authors: Michele D’Alto, Alberto M. Marra, Sergio Severino, Andrea Salzano, Emanuele Romeo, Rosanna De Rosa, Francesca Maria Stagnaro, Gianpiero Pagnano, Raffaele Verde, Patrizia Murino, Andrea Farro, Giovanni Ciccarelli, Maria Vargas, Giuseppe Fiorentino, Giuseppe Servillo, Ivan Gentile…

    Citation: Critical Care 2020 24:670

    Content type: Research

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  14. Diaphragm dysfunction is highly prevalent in mechanically ventilated patients. Recent work showed that changes in diaphragm shear modulus (ΔSMdi) assessed using ultrasound shear wave elastography (SWE) are str...

    Authors: Quentin Fossé, Thomas Poulard, Marie-Cécile Niérat, Sara Virolle, Elise Morawiec, Jean-Yves Hogrel, Thomas Similowski, Alexandre Demoule, Jean-Luc Gennisson, Damien Bachasson and Martin Dres

    Citation: Critical Care 2020 24:669

    Content type: Research

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  15. Traumatic brain injury (TBI) is a major cause of morbidity and mortality, but there are no clinically proven treatments that specifically target neuronal loss and secondary injury development following TBI. In...

    Authors: Rita Campos-Pires, Haldis Onggradito, Eszter Ujvari, Shughoofa Karimi, Flavia Valeo, Jitka Aldhoun, Christopher J. Edge, Nicholas P. Franks and Robert Dickinson

    Citation: Critical Care 2020 24:667

    Content type: Research

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  16. Multisystem inflammatory syndrome temporally associated with COVID-19 (MIS-C) has been described as a novel and often severe presentation of SARS-CoV-2 infection in children. We aimed to describe the character...

    Authors: Alberto García-Salido, Juan Carlos de Carlos Vicente, Sylvia Belda Hofheinz, Joan Balcells Ramírez, María Slöcker Barrio, Inés Leóz Gordillo, Alexandra Hernández Yuste, Carmina Guitart Pardellans, Maite Cuervas-Mons Tejedor, Beatriz Huidobro Labarga, José Luís Vázquez Martínez, Míriam Gutiérrez Jimeno, Ignacio Oulego-Erróz, Javier Trastoy Quintela, Carmen Medina Monzón, Laura Medina Ramos…

    Citation: Critical Care 2020 24:666

    Content type: Research

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  17. Effective antimicrobial treatment is key to reduce mortality associated with bacterial sepsis in patients on intensive care units (ICUs). Dose adjustments are often necessary to account for pathophysiological ...

    Authors: Dennis Kühn, Carlos Metz, Frederik Seiler, Holger Wehrfritz, Sophie Roth, Mohammad Alqudrah, André Becker, Hendrik Bracht, Stefan Wagenpfeil, Mathias Hoffmann, Robert Bals, Ulrich Hübner, Jürgen Geisel, Philipp M. Lepper and Sören L. Becker

    Citation: Critical Care 2020 24:664

    Content type: Research

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  18. Flow-controlled ventilation is a novel ventilation method which allows to individualize ventilation according to dynamic lung mechanic limits based on direct tracheal pressure measurement at a stable constant ...

    Authors: Patrick Spraider, Judith Martini, Julia Abram, Gabriel Putzer, Bernhard Glodny, Tobias Hell, Tom Barnes and Dietmar Enk

    Citation: Critical Care 2020 24:662

    Content type: Research

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  19. Even brief hypotension is associated with increased morbidity and mortality. We developed a machine learning model to predict the initial hypotension event among intensive care unit (ICU) patients and designed...

    Authors: Joo Heung Yoon, Vincent Jeanselme, Artur Dubrawski, Marilyn Hravnak, Michael R. Pinsky and Gilles Clermont

    Citation: Critical Care 2020 24:661

    Content type: Research

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  20. Acute kidney injury (AKI) affects a large proportion of the critically ill and is associated with worse patient outcomes. Early identification of AKI can lead to earlier initiation of supportive therapy and be...

    Authors: Christopher Bourdeaux, Erina Ghosh, Louis Atallah, Krishnamoorthy Palanisamy, Payaal Patel, Matthew Thomas, Timothy Gould, John Warburton, Jon Rivers and John Hadfield

    Citation: Critical Care 2020 24:656

    Content type: Research

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  21. Nasal high flow delivered at flow rates higher than 60 L/min in patients with acute hypoxemic respiratory failure might be associated with improved physiological effects. However, poor comfort might limit feas...

    Authors: Maria Cristina Basile, Tommaso Mauri, Elena Spinelli, Francesca Dalla Corte, Giacomo Montanari, Ines Marongiu, Savino Spadaro, Alessandro Galazzi, Giacomo Grasselli and Antonio Pesenti

    Citation: Critical Care 2020 24:654

    Content type: Research

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  22. A substantial proportion of critically ill COVID-19 patients develop thromboembolic complications, but it is unclear whether higher doses of thromboprophylaxis are associated with lower mortality rates. The pu...

    Authors: Sandra Jonmarker, Jacob Hollenberg, Martin Dahlberg, Otto Stackelberg, Jacob Litorell, Åsa H. Everhov, Hans Järnbert-Pettersson, Mårten Söderberg, Jonathan Grip, Anna Schandl, Mattias Günther and Maria Cronhjort

    Citation: Critical Care 2020 24:653

    Content type: Research

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  23. Pressure support ventilation (PSV) should allow spontaneous breathing with a “normal” neuro-ventilatory drive. Low neuro-ventilatory drive puts the patient at risk of diaphragmatic atrophy while high neuro-ven...

    Authors: Rosa Di mussi, Savino Spadaro, Carlo Alberto Volta, Nicola Bartolomeo, Paolo Trerotoli, Francesco Staffieri, Luigi Pisani, Rachele Iannuzziello, Lidia Dalfino, Francesco Murgolo and Salvatore Grasso

    Citation: Critical Care 2020 24:652

    Content type: Research

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  24. Coronavirus disease 2019 (COVID-19), a highly infectious disease, has been rapidly spreading all over the world and remains a great threat to global public health. Patients diagnosed with severe or critical ca...

    Authors: Xiaoming Li, Chao Liu, Zhi Mao, Minglu Xiao, Li Wang, Shuang Qi and Feihu Zhou

    Citation: Critical Care 2020 24:647

    Content type: Research

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  25. Sepsis is often treated with penicillin-binding protein 3 (PBP-3) acting β-lactam antibiotics, such as piperacillin-tazobactam, cefotaxime, and meropenem. They cause considerable bacterial structural changes a...

    Authors: Paul Skorup, Lisa Maudsdotter, Miklós Lipcsey, Anders Larsson and Jan Sjölin

    Citation: Critical Care 2020 24:646

    Content type: Research

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  26. Myoglobin clearance in acute kidney injury requiring renal replacement therapy is important because myoglobin has direct renal toxic effects. Clinical data comparing different modalities of renal replacement t...

    Authors: Lorenz Weidhase, Jonathan de Fallois, Elena Haußig, Thorsten Kaiser, Meinhard Mende and Sirak Petros

    Citation: Critical Care 2020 24:644

    Content type: Research

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  27. The CRASH-3 trial hypothesised that timely tranexamic acid (TXA) treatment might reduce deaths from intracranial bleeding after traumatic brain injury (TBI). To explore the mechanism of action of TXA in TBI, w...

    Authors: Amy Brenner, Antonio Belli, Rizwana Chaudhri, Timothy Coats, Lauren Frimley, Sabariah Faizah Jamaluddin, Rashid Jooma, Raoul Mansukhani, Peter Sandercock, Haleema Shakur-Still, Temitayo Shokunbi and Ian Roberts

    Citation: Critical Care 2020 24:560

    Content type: Research

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  28. Invasive pulmonary aspergillosis (IPA) is an increasingly recognized complication in intensive care unit (ICU) patients, especially those with influenza, cirrhosis, chronic obstructive pulmonary disease, and o...

    Authors: Toine Mercier, Albert Dunbar, Vincent Veldhuizen, Michelle Holtappels, Alexander Schauwvlieghe, Johan Maertens, Bart Rijnders and Joost Wauters

    Citation: Critical Care 2020 24:642

    Content type: Research

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