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  1. Early appropriate antibiotic therapy reduces morbidity and mortality of severe pneumonia. However, the emergence of bacterial resistance requires the earliest use of antibiotics with the narrowest possible spe...

    Authors: Nathan Peiffer-Smadja, Lila Bouadma, Vincent Mathy, Kahina Allouche, Juliette Patrier, Martin Reboul, Philippe Montravers, Jean-François Timsit and Laurence Armand-Lefevre

    Citation: Critical Care 2020 24:366

    Content type: Research

    Published on:

  2. In this viewpoint, we summarize the relevance of thromboinflammation in COVID-19 and discuss potential mechanisms of endothelial injury as a key point for the development of lung and distant organ dysfunction,...

    Authors: Gabriele Guglielmetti, Marco Quaglia, Pier Paolo Sainaghi, Luigi Mario Castello, Rosanna Vaschetto, Mario Pirisi, Francesco Della Corte, Gian Carlo Avanzi, Piero Stratta and Vincenzo Cantaluppi

    Citation: Critical Care 2020 24:365

    Content type: Viewpoint

    Published on:

  3. Thrombotic complications and coagulopathy frequently occur in COVID-19. However, the characteristics of COVID-19-associated coagulopathy (CAC) are distinct from those seen with bacterial sepsis-induced coagulo...

    Authors: Toshiaki Iba, Jerrold H. Levy, Jean Marie Connors, Theodore E. Warkentin, Jecko Thachil and Marcel Levi

    Citation: Critical Care 2020 24:360

    Content type: Review

    Published on:

  4. The aim of this study is to assess the prevalence of abnormal urine analysis and kidney dysfunction in COVID-19 patients and to determine the association of acute kidney injury (AKI) with the severity and prog...

    Authors: Xianghong Yang, Yiyang Jin, Ranran Li, Zhongheng Zhang, Renhua Sun and Dechang Chen

    Citation: Critical Care 2020 24:356

    Content type: Research

    Published on:

  5. Hypertonic sodium lactate (HSL) may be of interest during inflammation. We aimed to evaluate its effects during experimental sepsis in rats (cecal ligation and puncture (CLP)).

    Authors: Emmanuel Besnier, David Coquerel, Geoffrey Kouadri, Thomas Clavier, Raphael Favory, Thibault Duburcq, Olivier Lesur, Soumeya Bekri, Vincent Richard, Paul Mulder and Fabienne Tamion

    Citation: Critical Care 2020 24:354

    Content type: Research

    Published on:

  6. Pediatric intensive care unit (PICU) survivors are at risk for prolonged morbidities interfering with daily life. The current study examined parent-reported health-related quality of life (HRQoL) in former cri...

    Authors: José Hordijk, Sascha Verbruggen, Ilse Vanhorebeek, Fabian Güiza, Pieter Wouters, Greet Van den Berghe, Koen Joosten and Karolijn Dulfer

    Citation: Critical Care 2020 24:347

    Content type: Research

    Published on:

  7. Outcomes following out of hospital cardiac arrest (OHCA) are poor. The optimal arterial oxygen and carbon dioxide (PaCO2) levels for managing patients following OHCA are unknown. We hypothesized that abnormalitie...

    Authors: Peter J. McGuigan, Manu Shankar-Hari, David A. Harrison, John G. Laffey and Danny F. McAuley

    Citation: Critical Care 2020 24:336

    Content type: Research

    Published on:

  8. The handheld ultrasound demonstrates clinical and economic value in combating COVID-19 based on interviews with frontline ultrasound physician and cardiologist as well as a national expert in medical ultrasound.

    Authors: Feng Qian, Xueqin Zhou, Jianqiao Zhou, Zhenhua Liu and Qian Nie

    Citation: Critical Care 2020 24:334

    Content type: Research Letter

    Published on:

  9. Sars-CoV-2 complications include pneumonia and acute respiratory distress syndrome (ARDS), which require intensive care unit admission. These conditions have rapidly overwhelmed healthcare systems, with detrim...

    Authors: Irma Convertino, Marco Tuccori, Sara Ferraro, Giulia Valdiserra, Emiliano Cappello, Daniele Focosi and Corrado Blandizzi

    Citation: Critical Care 2020 24:331

    Content type: Viewpoint

    Published on:

  10. Multiple factors contribute to mortality after ICU, but it is unclear how the predictive value of these factors changes during ICU admission. We aimed to compare the changing performance over time of the acute...

    Authors: Monika C. Kerckhoffs, Sylvia Brinkman, Nicolet de Keizer, Ivo W. Soliman, Dylan W. de Lange, Johannes J. M. van Delden and Diederik van Dijk

    Citation: Critical Care 2020 24:330

    Content type: Research

    Published on: