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Fig. 6 | Critical Care

Fig. 6

From: Fibroblast growth factor 21 attenuates ventilator-induced lung injury by inhibiting the NLRP3/caspase-1/GSDMD pyroptotic pathway

Fig. 6

FGF21 protects against VILI via inhibiting NLRP3/Caspase-1/GSDMD pyroptotic pathway. A. Relative caspase-1 activity in mice lung tissue; B-E. Relative mRNA expression levels of key nodes in NLRP3/caspase-1/GSDMD pathway (N = 6, *P < 0.05, **P < 0.01); F–H. Relative protein expression levels of key nodes in NLRP3/caspase-1/GSDMD pathway (N = 3; ns, no significance, *P < 0.05, **P < 0.01 vs. Control; #P < 0.05, ##P < 0.01 vs. PBS). Lung tissue samples in Fig. 6 are from the same batch of mice in Fig. 3

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Critical Care

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