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Fig. 4 | Critical Care

Fig. 4

From: Fibroblast growth factor 21 attenuates ventilator-induced lung injury by inhibiting the NLRP3/caspase-1/GSDMD pyroptotic pathway

Fig. 4

FGF21 treatment inhibits endothelial injury and downregulates pulmonary interstitial pro-fibrosis factors. A. Immunofluorescence of vascular endothelial marker, VE-cadherin, in lung tissue; B. Immunofluorescence of pulmonary interstitial marker, α-SMA, in lung tissue; C. Immunofluorescence of pulmonary interstitial marker, vimentin, in lung tissue; N = 6 in A-C; ns, no significance, *P < 0.05, **P < 0.01 vs. Control; #P < 0.05, ##P < 0.01 vs. PBS; Bar scale = 100 μm; MV, mechanical ventilation; DAPI, 4',6-diamidino-2-phenylindole

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Critical Care

ISSN: 1364-8535