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Fig. 1 | Critical Care

Fig. 1

From: Fibroblast growth factor 21 attenuates ventilator-induced lung injury by inhibiting the NLRP3/caspase-1/GSDMD pyroptotic pathway

Fig. 1

FGF21 is induced after MV in patients and mice. A. The average serum FGF21 increased in patients after mechanical ventilation (N = 69); B. The average serum FGF21 increased in patients after short duration (< 4 h) of mechanical ventilation (N = 33); C. The average serum FGF21 increased in patients after long duration (> 4 h) of mechanical ventilation (N = 36); D. The elevated FGF21 level was positively correlated with duration of mechanical ventilation; E. Serum FGF21 increased in VILI mice (N = 6, 0 h referred to the time point immediately after VILI modeling); F. FGF21 protein expression in mice lung/liver tissues after mechanical ventilation; G. Serum IL-1β increased in VILI mice (N = 6); H. Serum IL-18 increased in VILI mice (N = 6); ns, no significance, *P < 0.05, **P < 0.01; MV, mechanical ventilation; VILI, ventilator-induced lung injury

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Critical Care

ISSN: 1364-8535