The lower limit of reactivity as a potential individualised cerebral perfusion pressure target in traumatic brain injury: a CENTER-TBI high-resolution sub-study analysis

Table 2 Univariate analysis for mortality prediction

Variable	Median (N = 171)	IQR	Mann-U test p value	Univariate logistic regression p value
Variable	Median (N = 171)	IQR	Mann-U test p value		AUC (95% CI)
Relationship between CPP and LLR
Dose of CPP below LLR (mmHg*h)	52.2	( 16.4–118.6)	< 0.001	0.002	0.69 (0.58–0.80)
Time with CPP below LLR (%)	12.8	( 6.4–25.2)	< 0.001	< 0.001	0.73 (0.63–0.83)
Relationship between CPP below LLR and high ICP
Dose of CPP below LLR when ICP > 20 mmHg (mmHg*h)	5.0	( 0.8–18.9)	< 0.001	< 0.001	0.69 (0.58–0.80)
Dose of CPP below LLR when ICP > 22 mmHg (mmHg*h)	2.6	( 0.4–11.6)	< 0.001	< 0.001	0.69 (0.58–0.80)
Dose of CPP below LLR when ICP > 25 mmHg (mmHg*h)	1.1	( 0.0–8.2)	0.002	< 0.001	0.67 (0.56–0.78)
Dose of ICP above 20 mmHg (mmHg*h)	15.8	( 3.0–56.9)	< 0.001	0.003	0.69 (0.57–0.80)
Dose of ICP above 22 mmHg (mmHg*h)	9.5	( 1.5–31.9)	< 0.001	0.005	0.68 (0.56–0.79)
Dose of ICP above 25 mmHg (mmHg*h)	4.6	( 0.6–16.5)	0.002	0.009	0.67 (0.55–0.78)
Dose of ICP above 20 mmHg when CPP < LLR (mmHg*h)	3.2	( 0.3–13.8)	0.001	< 0.001	0.67 (0.56–0.79)
Dose of ICP above 22 mmHg when CPP < LLR (mmHg*h)	1.6	( 0.1–9.7)	0.002	< 0.001	0.67 (0.56–0.78)
Dose of ICP above 25 mmHg when CPP < LLR (mmHg*h)	0.6	( 0.0–5.4)	0.004	0.002	0.65 (0.54–0.77)

The table shows univariate analysis for mortality prediction for variables that describe the relationship between CPP and LLR and between CPP, LLR and ICP. Variables are considered for the whole 7-day period from the day of injury. DeLong test did not show superiority of any of the models considered. p values are not corrected for multiple comparisons
CPP cerebral perfusion pressure, ICP intracranial pressure, LLR lower limit of reactivity

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