Fig. 3

Median (IQR) total daily urine output (upper panel) and daily urine output to furosemide dose ratio (lower panel) during the first seven days since empagliflozin initiation (red lines). In the treatment group (red lines), day zero is the day of empagliflozin initiation. In the control group (green lines), day zero is the day of ICU arrival. Urine output to furosemide dose ratio was calculated by dividing the total daily urine output (ml) by the total amount (in mg) of furosemide administered on the same day. When no furosemide was administered on a single day, a zero dose was replaced by 1.0 mg in the denominator. P values represent the interaction between group and time on generalized linear mixed modeling