Fig. 1

Median (IQR) blood gas parameters during 24 h before until 144 h after initiation of empagliflozin therapy (red curves). Minus 24 h data are the averages of the measurements obtained 36–24 h before therapy; minus 12 h data are the averages of the measurements obtained 24–12 h before therapy; zero hour data are the averages of the measurements obtained 12 h before therapy; twelve hour data are the averages obtained during the first 12 h after therapy initiation. In the control group (green lines), time zero was set at 34 h after ICU admission (corresponding to the median time between ICU admission and empagliflozin initiation in the treatment group). aSID, abbreviated strong ion difference