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Table 1 Baseline characteristics of patients

From: Association between prolonged corticosteroids use in COVID-19 and increased mortality in hospitalized patients: a retrospective study with inverse probability of treatment weighting analysis

Characteristic

Overall (n = 1,539)

Short corticosteroids (n = 412)

Prolonged corticosteroids (n = 1,127)

p

All hospitalized patients (n = 1539)

    

Demographics

    

 Age (years)

59 ± 15

61 ± 15

59 ± 14

0.008

 Men (n, %)

837 (54.4)

221 (53.6)

616 (54.7)

0.766

 Need for ICU at any time (n, %)

1,364 (88.6)

338 (82)

1,026 (91)

< 0.001

Use of corticosteroids

    

 Maximum MED (mg)

46 (32–80)

32 (32–36)

56 (36–96)

< 0.001

 Total length of corticosteroids use (days)

15 (10–24)

9 (7–10)

19 (14–28)

< 0.001

Biochemical measurements

    

 CRP (mg/dL)

121 (62–199)

114 (56–188)

125 (67–206)

0.014

 LDH (U/L)

481 (337–642)

455 (311–599)

491 (339–663)

0.024

 D-dimer (mg/L)

1.9 (0.9–5.5)

1.9 (0.9–5.3)

1.9 (0.9–5.6)

0.869

 

Overall (n = 622)

Short corticosteroids (n = 163)

Prolonged corticosteroids (n = 459)

p

Critically ill patients (n = 622)

    

Demographic

    

 Age (years old)

57 ± 14

57 ± 15

57 ± 14

0.748

 Men (n, %)

347 (55.8)

90 (55.2)

257 (56)

0.936

Use of corticosteroids

    

 Maximum MED (mg)

53 (2.5–90)

32 (32–40)

64 (40–100)

< 0.001

 Total duration of corticosteroid use (days)

15 (10–26)

9 (7–10)

20 (14–30)

< 0.001

Time from hospital admission to initiation of corticosteroids (days)

0 (0–0)

0 (0–1)

0 (0–0)

< 0.001

Biochemical measurements

    

 CRP (mg/dL)

139 (83–219)

127 (75–197)

145 (84–229)

0.066

 LDH (U/L)

553 (415–729)

527 (450–647)

562 (412–757)

0.315

 D-dimer (mg/L)

2.3 (1.1–8.7)

2.3 (1.2–10.4)

2.3 (1.1–7.6)

0.376

  1. Values are mean ± SD or median and interquartile range
  2. ICU intensive care unit, MV mechanical ventilation, MED methylprednisolone equivalent dose, CRP C-reactive protein, LDH lactate dehydrogenase