Fig. 5
From: Major adverse cardiovascular events are associated with necroptosis during severe COVID-19
Hamster hearts show increased necroptosis in the model of severe SARS-CoV-2. A–C Male 5-to-6-week-old golden Syrian hamsters were IT infected with WA1 or mock challenged with vehicle (PBS) and hearts excised at 4 days post-infection for transcriptomics. A Normalised Transcript levels of MLKL and gasdermin-D (GSDMD) in uninfected vs SARS-CoV-2 infected hamsters. B Immunoblot for pMLKL in homogenates of hamsters' hearts. C Immunoblot for pMLKL in serum of hospitalised patients experiencing MACE or no-MACE. Mean ± SEM analysed by B student T test or C Kruskal–Wallis test with Dunn's multiple-comparison post-test. Asterisks denote the level of significance observed: * = p ≤ 0.05; ** = p ≤ 0.01; *** = p ≤ 0.001; *** = p ≤ 0.0001