Fig. 4
From: Major adverse cardiovascular events are associated with necroptosis during severe COVID-19
Cardiac transcriptional changes in a hamster model of severe SARS-CoV-2. A Male 5-to-6-week-old golden Syrian hamsters were IT infected with WA1, or mock challenged with vehicle (PBS), and hearts excised at 4 days post-infection for transcriptomics. B Log PFU per gram tissue of SARS-CoV-2 in hearts of hamsters (student t-test, p-value < 0.001 ****). C–F Log fold change (log FC) of transcriptional changes in infected hearts vs uninfected hamsters. Representative gene ontology terms selected were C programmed cell death, D regulation of ROS, E defence response to the virus, and F carbohydrate metabolic processes