Table 5 Sensitivity, specificity, PPV, and NPV of a novel biomarker for predicting good neurological outcomes using the cut-off values of predefined normal range
Sensitivity | Specificity | PPV | NPV | |
|---|---|---|---|---|
NSE, 0 h | 96.3 (87.3–99.6) | 4.4 (0.5–15.2) | 54.7 (52.7–56.8) | 50.0 (2.8–87.2) |
NSE, 24 h | 98.0 (89.4–99.9) | 13.0 (4.9–26.3) | 55.1 (52.1–58.0) | 85.7 (42.9–98.0) |
NSE, 48 h | 90.2 (76.9–97.3) | 35.6 (21.9–51.2) | 56.1 (50.1–61.8) | 80.0 (59.3–91.7) |
NSE, 72 h | 91.7 (77.5–98.3) | 36.6 (22.1–53.1) | 55.9 (49.7–62.0) | 83.3 (61.2–94.1) |
S100B, 0 h | 100 (91.4–100) | 3.3 (0.1–17.2) | 58.6 (57.0–60.2) | 100 |
S100B, 24 h | 84.9 (68.1–94.9) | 63.3 (43.9–80.1) | 71.8 (60.9–80.6) | 79.2 (61.8–89.9) |
S100B, 48 h | 78.8 (61.1–91.0) | 66.7 (47.2–82.7) | 72.2 (60.3–81.6) | 74.1 (58.6–85.3) |
S100B, 72 h | 81.5 (61.9–93.7) | 61.3 (42.2–78.2) | 64.7 (53.2–74.7) | 79.2 (62.2–89.8) |
Tau, 0 h | 87.8 (75.2–95.4) | 45.0 (29.3–61.5) | 66.2 (59.2–72.5) | 75.0 (56.8–87.2) |
Tau, 24 h | 79.0 (62.7–90.5) | 63.6 (47.8–77.6) | 65.2 (55.1–74.1) | 77.8 (64.5–87.1) |
Tau, 48 h | 83.8 (68.0–93.8) | 61.9 (45.6–76.4) | 66.0 (56.2–74.5) | 81.3 (66.7–90.4) |
Tau, 72 h | 86.1 (70.5–95.3) | 65.1 (49.1–79.0) | 67.4 (57.4–76.0) | 84.9 (70.7–92.9) |
NFL, 0 h | 46.9 (32.5–61.7) | 72.5 (56.1–85.4) | 67.7 (53.8–79.0) | 52.7 (44.6–60.7) |
NFL, 24 h | 92.1 (78.6–98.3) | 61.4 (45.5–75.6) | 67.3 (58.4–75.1) | 90.0 (74.8–96.5) |
NFL, 48 h | 94.4 (81.3–99.3) | 52.4 (36.4–68.0) | 63.0 (55.1–70.2) | 91.7 (73.5–97.8) |
NFL, 72 h | 97.1 (85.1–99.9) | 51.2 (35.5–67.0) | 61.8 (54.3–68.9) | 95.7 (75.7–99.4) |
GFAP, 0 h | 100 (92.5–100) | 0 (0–8.8) | 54.0 (54.0–54.0) | |
GFAP, 24 h | 100 (89.7–100) | 15.9 (6.6–30.1) | 47.9 (44.7–51.1) | 100 |
GFAP, 48 h | 96.9 (83.8–99.9) | 14.3 (5.4–28.5) | 46.3 (42.9–49.7) | 85.7 (43.2–97.9) |
GFAP, 72 h | 97.0 (84.2–99.9) | 11.6 (3.9–25.1) | 45.7 (42.7–48.8) | 83.3 (38.0–97.6) |
UCH-L1, 0 h | 42.9 (28.8–57.8) | 87.5 (73.2–95.8) | 80.8 (63.5–91.0) | 55.6 (48.9–62.1) |
UCH-L1, 24 h | 56.4 (39.6–72.2) | 97.7 (88.0–99.9) | 95.7 (75.7–99.4) | 71.7 (63.8–78.4) |
UCH-L1, 48 h | 59.5 (42.1–75.3) | 95.2 (83.8–99.4) | 91.7 (73.5–97.8) | 72.7 (64.2–79.9) |
UCH-L1, 72 h | 52.8 (35.5–69.6) | 97.7 (87.7–99.9) | 95.0 (72.8–99.3) | 71.2 (66.4–85.9) |