Table 3 Cutoff values of novel biomarkers with sensitivities, PPVs and NPVs at 0, 24, 48, 72 h after ROSC according to 100% of specificity
AUC | Cutoff (pg/mL) | Sensitivity | Specificity | PPV | NPV | |
|---|---|---|---|---|---|---|
Tau, 0 h, 100% | 0.724 | > 748 | 11.1 (4.2–22.6) | 100 (92.3–100.0) | 100 (54.1–100.0) | 48.9 (38.5–59.5) |
Tau, 24 h, 100% | 0.767 | > 131 | 21. (9.6–37.3) | 100 (92.0–100.0) | 100 (63.1–100.0) | 59.5 (47.4–70.7) |
Tau, 48 h, 100% | 0.837 | > 406* | 18.9 (8.0–35.2) | 100 (91.6–100.0) | 100 (59.0–100.0) | 58.3 (46.0–69.9) |
Tau, 72 h, 100% | 0.906 | > 698 | 8.3 (1.8–22.5) | 100 (91.8–100.0) | 100 (15.8–100.0) | 56.6 (44.7–67.9) |
NFL, 0 h, 100% | 0.664 | > 1890 | 0 (0.0–7.3) | 100 (91.2–100.0) | 44.9 (34.4–55.9) | |
NFL, 24 h, 100% | 0.900 | > 521 | 57.9 (40.8–73.7) | 100 (92.0–100.0) | 100 (84.6–100.0) | 73.3 (60.3–83.9) |
NFL, 48 h, 100% | 0.921 | > 4660* | 36.1 (20.8–53.8) | 100 (91.6–100.0) | 100 (75.3–100.0) | 64.6 (51.8–76.1) |
NFL, 72 h, 100% | 0.946 | > 690 | 77.1 (59.9–89.6) | 100 (91.8–100.0) | 100 (87.2–100.0) | 84.3 (71.3–93.0) |
GFAP, 0 h, 100% | 0.850 | > 392 | 53.2 (38.1–67.9) | 100 (91.2–100.0) | 100 (86.3–100.0) | 64.5 (51.3–76.3) |
GFAP, 24 h, 100% | 0.827 | > 1970 | 44.1 (27.2–62.1) | 100 (92.0–100.0) | 100 (78.2–100.0) | 69.8 (57.0–80.8) |
GFAP, 48 h, 100% | 0.839 | > 9520* | 43.8 (26.4–62.3) | 100 (91.6–100.0) | 100 (76.8–100.0) | 70 (56.8–81.2) |
GFAP, 72 h, 100% | 0.875 | > 1180 | 54.6 (36.4–71.9) | 100 (91.8–100.0) | 100 (81.5–100.0) | 74.1 (61.0–84.7) |
UCH-L1, 0 h, 100% | 0.766 | > 827.8 | 28.6 (16.6–43.3) | 100 (91.2––100.0) | 100 (76.8–100.0) | 53.3 (41.4–64.9) |
UCH-L1, 24 h, 100% | 0.886 | > 492.4 | 41.0 (25.6–57.9) | 100 (92.0–100.0) | 100 (79.4–100.0) | 65.7 (53.0–76.9) |
UCH-L1, 48 h, 100% | 0.911 | > 2935* | 27.0 (13.8–44.1) | 100 (91.6–100.0) | 100 (69.2–100.0) | 60.9 (48.3–72.5) |
UCH-L1, 72 h, 100% | 0.935 | > 356.4 | 50.0 (32.9–67.1) | 100 (91.8–100.0) | 100 (81.5–100.0) | 70.5 (57.4–81.5) |