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Table 2 Novel biomarker concentrations at 0, 24, 48 and 72 h after ROSC according to neurological outcomes at 6 months after cardiac arrest

From: Novel serum biomarkers for predicting neurological outcomes in postcardiac arrest patients treated with targeted temperature management

 

Good outcome

Poor outcome

P

Tau, pg/mL

 0 h

1.78 (0.58–9.79)

6.65 (2.26–32.58)

0.001

 24 h

0.99 (0.24–3.29)

3.48 (1.43–42.00)

< 0.001

 48 h

0.74 (0.24–2.88)

11.20 (3.12–126.00)

< 0.001

 72 h

0.67 (0.28–2.14)

14.00 (4.92–234.25)

< 0.001

NFL, pg/mL

 0 h

19.45 (9.33–78.68)

29.25 (14.30–131.00)

0.008

 24 h

31.15 (11.49–169.25)

504.00 (156.50–1540.00)

< 0.001

 48 h

51.30 (15.15–165.00)

1515.00 (342.75–4380.00)

< 0.001

 72 h

56.65 (15.85–153.25)

2565.00 (429.00–5812.50)

< 0.001

GFAP, pg/mL

 0 h

109.50 (62.20–185.00)

253.50 (134.00–1061.50)

< 0.001

 24 h

118.50 (60.23–209.50)

603.00 (234.75–17,050.00)

< 0.001

 48 h

143.50 (86.58–327.25)

1138.50 (422.00–48,087.50)

< 0.001

 72 h

119.50 (78.70–272.50)

1095.00 (303.00–11,445.00)

< 0.001

UCHL1, pg/mL

 0 h

75.52 (35.19–179.50)

146.85 (73.30–578.78)

< 0.001

 24 h

26.53 (10.37–50.58)

309.60 (65.13–1004.55)

< 0.001

 48 h

18.85 (12.27–51.63)

324.40 (125.90–1321.98)

< 0.001

 72 h

18.40 (9.91–38.26)

222.65 (94.63–858.55)

< 0.001

  1. NFL neurofilament light chain, GFAP glial fibrillary acidic protein, UCHL1 ubiquitin C-terminal hydrolase-L1