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Table 2 Outcomes according to allocated group

From: Early adjunctive methylene blue in patients with septic shock: a randomized controlled trial

Outcomes

MB (n = 45)

Control (n = 46)

Median difference (CI95)

p

Time to vasopressor discontinuation—hours, median (IQR)

69 (59–83)

94 (74–141)

29.4 (15.4–50.7)

 < 0.001

Vasopressor-free days at 28 days, median (IQR)

23.9 (0.0–24.8)

19.5 (0.0–23.7)

1.0 (0–4.1)

0.008

Cumulative fluid balance at 4 days, mean (SD)

834 ± 1106

1575 ± 1040

741 (293–1188)

0.001

Days on mechanical ventilation, median (IQR)

4.2 (3.3–5.1)

5.1 (3.9–5.9)

0.6 (− 0.06–1.2)

0.075

Serum lactate—mmol/L, median (IQR)

 24 h

2.9 (2.2–3.7)

3.1 (2.6–6.0)

0.5 (0.0–1.4)

0.054

 48 h

1.7 (1.4–3.4)

2.5 (1.1–3.3)

0.3 (− 0.5–0.9)

0.36

 72 h

1.4 (1.0–2.1)

1.7 (0.5–3.1)

0.0 (− 0.06–0.7)

0.98

ICU length of stay—days, median (IQR)

6.6 (4.8–7.6)

7.9 (5.0–10.0)

1.5 (0.08–2.5)

0.039

Hospital length of stay—days, median (IQR)

9.0 (6.3–9.3)

10.5 (6.1–14.0)

2.7 (0.3–4.6)

0.027

   

Relative Risk (CI95)

 

Mortality at 28 days—no. (%)

15/45 (33)

21/46 (46)

0.76 (0.55–1.05)

0.23

  1. Median with interquartile ranges are in parentheses
  2. MB Methylene blue, CI confidence interval, ICU intensive care unit