Outcomes | No. of studies | Sample size | Absolute effect estimates (95% CI) | Certainty (GRADE) | |
---|---|---|---|---|---|
Vitamin C | Control | ||||
Delta SOFA score | 17 | 1624 | 1622 | − 0.62 (− 1.00 to − 0.25) | Moderate |
Dose—< 25 mg/kg/d | 0 | 0 | 0 | – | – |
Dose—25–100 mg/kg/d | 14 | 908 | 901 | − 0.85 (− 1.23 to − 0.46) | Moderate |
Dose—> 100 mg/kg/d | 3 | 716 | 721 | 0.18 (− 0.29 to 0.65) | Moderate |
Therapy regimens—combined therapy | 11 | 952 | 949 | − 0.53 (− 0.81 to − 0.25) | Low |
Therapy regimens—monotherapy | 6 | 672 | 673 | − 0.66 (− 1.83 to 0.50) | Low |
Duration—< 96 h | 1 | 53 | 58 | 0 (− 1.46 to 1.46) | Moderate |
Duration—96 h | 5 | 629 | 635 | − 0.50 (− 0.91 to − 0.08) | High |
Duration—unclear | 11 | 942 | 929 | − 0.76 (− 1.32 to − 0.20) | Very low |
Patient—sepsis | 1 | 61 | 56 | − 1.47 (− 2.68 to − 0.26) | Low |
Patient—septic shock | 9 | 620 | 622 | − 0.41 (− 0.73 to − 0.09) | Low |
Patient—unclear | 7 | 943 | 944 | − 0.86 (− 1.63 to − 0.08) | Very low |