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Fig. 1 | Critical Care

Fig. 1

From: Targeting circulating high mobility group box-1 and histones by extracorporeal blood purification as an immunomodulation strategy against critical illnesses

Fig. 1

© 2018 Gruda et al.); d Hemoadsorption of different concentrations of histones presented as percentage of reduction (%) after 6-h incubation with Cytosorb® adsorber (© 2020 Weber et al.); e Plasma histone levels of 22 multiple injured humans (µg/mL) in the Emergency room (pre) and after 6-h hemoadsorption (post) (© 2020 Weber et al.)

Structure, adsorption spectrum and HMGB1/histone adsorption performance of the Cytosorb® adsorber. a Microstructure of the Cytosorb® adsorber (©2022 Cytosorbents Europe GMBH); b Cytosorb adsorption spectrum (©2022 Cytosorbents Europe GMBH); c Adsorption of HMGB1 from whole blood with Cytosorb® adsorber or a control device (

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Critical Care

ISSN: 1364-8535