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Table 2 Case examples using metagenomics for the diagnosis of infectious disease and identification of disease-causing organisms

From: Metagenomic Sequencing in the ICU for Precision Diagnosis of Critical Infectious Illnesses

Disease of interest

Samples

Studies [Ref]

CNS infection

CSF

Wilson et al. [22]

Gu et al. [23]

Sepsis

Plasma

Blauwkamp et al. [18]

Ren et al. [24]

Kalantar et al. [16]

Respiratory infection

BAL

Pleural fluid

Tracheal aspirate

Gu et al. [23] Langelier et al. [25]

Langelier et al. [26] Tsitsiklis et al. [27]

Abscess

Abscess fluid

Gu et al. [23]

Peritonitis

Peritoneal fluid

Gu et al. [23]

Urinary tract infection

Urine

Gu et al. [23]

Septic arthritis

Joint fluid

Gu et al. [23]

  1. CNS central nervous system, CSF cerebrospinal fluid, BAL bronchoalveolar lavage