Table 1 Host mRNA signatures for the diagnosis and prognosis of sepsis
From: The Role of Transcriptomics in Redefining Critical Illness
Setting [Ref] | Transcriptomic score | Performance (validated AUC) | Commercial platform |
|---|---|---|---|
Sepsis vs. non-infectious SIRS on ICU admission in adults [27] | 4-mRNA classifier (SeptiCyte™ LAB SeptiScore™) | 0.82–0.89 | SeptiCyte™ LAB (Immunexpress, Seattle, WA) |
Sepsis vs. noninfectious SIRS in patients with malignancy or treated with antineoplastic/immunosuppressant [28] | Simpler version of SeptiCyte™ LAB (SeptiCyte® RAPID SeptiScore®) | Adult: > 0.88 | SeptiCyte® RAPID (Immunexpress, Seattle, WA) |
Pediatric: > 0.96 | |||
Sepsis vs. non-infectious SIRS [29] | 11-mRNA classifier (Sepsis MetaScore) | 0.83 (0.73–0.89) | Component of the InSep™ test (Inflammatix, Bulingame, CA) |
Bacterial vs. viral infection [26] | 7-mRNA classifier (Bacterial-Viral MetaScore) | 0.91 (0.82–0.96) | Component of the InSep™ test (Inflammatix, Bulingame, CA) |
30-day mortality prediction in sepsis patients [30] | 12-mRNA classifier (Stanford Score) | 0.87 (0.64–1.0) | Component of the InSep™ test (Inflammatix, Bulingame, CA) |
28-day mortality prediction in pediatric septic shock [31] | 4-mRNA + 12-protein classifier (PERSEVERE-XP) | 0.96 (0.91–1.0) | |
Abdominal sepsis vs. post-op gastrointestinal surgery control on ICU admission [32] | 3-mRNA classifier (sNIP score) | 0.91 (0.84–0.97) |