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Table 1 Demographics of patients

From: Personalized ventilatory strategy based on lung recruitablity in COVID-19-associated acute respiratory distress syndrome: a prospective clinical study

 

All (n = 43)

High recruiter (n = 22)

Low recruiter (n = 21)

p value*

Age, years

73 (62–78)

72 (61–79)

73 (72–76)

0.70

Sex, M, n (%)

29 (67)

11 (50)

18 (86)

0.01

Height, cm

168 (160–170)

164 (156–170)

170 (165–172)

0.05

BMI, kg/m2

23 (22–26)

23 (22–27)

23 (22–25)

0.68

APACHE2 score

16 (14–20)

16 (14–19)

17 (14–20)

0.93

MV days before ICU admission, days

0 (0–0)

0 (0–0)

0 (0–0)

0.94

Severity of ARDS, n (%)

   

0.12

Mild

10 (23)

3 (14)

7 (33)

 

Moderate

27 (63)

14 (64)

13 (62)

 

Severe

6 (14)

5 (23)

1 (5)

 

Tidal volume, ml/kg

6.0 (5.9–6.0)

6.0 (5.9–6.0)

6.0 (5.9–6.1)

0.87

Total PEEP, cmH2O

5.6 (5.4–6.2)

5.6 (5.4–6.1)

5.7 (5.4–6.2)

0.81

Airway opening pressure, n (%)

27 (63)

13 (59)

14 (64)

0.33

Airway opening pressure, cmH2O†

5.9 (5.0–6.3)

6.0 (5.0–6.3)

5.9 (5.1–6.4)

0.85

Respiratory rate, breaths/min

18 (15–20)

20 (18–20)

15 (15–20)

< 0.01

Plateau pressure, cmH2O

14 (13–16)

16 (14–17)

14 (13–15)

0.03

Driving pressure, cmH2O

9 (8–10)

10 (8–11)

8 (7–9)

0.01

Respiratory system compliance, ml/cmH2O

43 (33–49)

36 (29–44)

47 (43–56)

< 0.01

Recruitment to Inflation ratio in supine

0.68 (0.52–0.84)

0.84 (0.78–0.99)

0.51 (0.39–0.58)

< 0.01

Recruitment to Inflation ratio in prone

0.69 (0.54–0.86)

0.83 (0.72–0.94)

0.53 (0.37–0.65)

< 0.01

PaO2/FiO2 at Baseline, mmHg

174 (135–191)

170 (111–189)

179 (153–226)

0.19

pH

7.33 (7.27–7.37)

7.32 (7.25–7.35)

7.34 (7.29–7.40)

0.16

PaCO2, mmHg

50 (42–54)

52 (45–55)

47 (41–53)

0.26

Dead space ventilation, %

17 (9–24)

18 (14–27)

16 (9–21)

0.30

CT analysis, %

    

Hyper inflated

2 (1–8)

2 (1–3)

7 (1–12)

0.06

Normally aerated

63 (58–72)

60 (54–65)

69 (60–73)

0.05

Poorly aerated

15 (13–21)

21 (16–24)

14 (10–15)

< 0.01

Non aerated

12 (9–17)

14 (10–19)

11 (7–14)

0.03

ICU Mortality, n (%)

4 (9)

2 (9)

2 (10)

1.00

Length of ICU stay, days

14 (8–39)

21 (14–39)

9 (7–21)

0.04

  1. Data are presented as median (interquartile range) unless otherwise indicated
  2. BMI, body mass index; APACHE2, Acute Physiology, Age and Chronic Health Evaluation; MV, mechanical ventilation; ARDS, acute respiratory distress syndrome; PEEP, positive end-expiratory pressure; PaO2, partial pressure of arterial oxygen; FiO2, fraction of inspired oxygen; PaCO2, partial pressure of carbon dioxide
  3. *p values refer to the comparison between the high and low recruiters
  4. †Airway opening pressure was measured in supine position
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