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Table 1 Baseline characteristics of patients included in cluster-randomized analyses of the POINCARE-2 trial

From: Fluid balance control in critically ill patients: results from POINCARE-2 stepped wedge cluster-randomized trial

 

Control group, No. (%) (n = 472)

Strategy group, No. (%) (n = 433)

Stdiff

Age, mean (SD), y

65.7 (14.3)

63.7 (14.1)

0.15

Male sex

308 (65.3)

278 (64.2)

0.02

Weight at ICU admission, mean (SD), kg

79.4 (23.5)

78.5 (20.0)

0.04

Height, mean (SD), cm

169.8 (9.5)

170.1 (9.4)

0.03

Mc Cabe scorea

  

0.20

 Unknown

32

31

 

 A

263/440 (59.8)

279/402 (69.4)

 

 B

143/440 (32.5)

98/402 (24.4)

 

 C

34/440 (7.7)

25/402 (6.2)

 

Coexisting conditions

   

 Congestive heart failure

38/452 (8.4)

37/419 (8.8)

0.02

 Chronic respiratory failure

92/463 (19.0)

80/423 (18.9)

0.02

 Chronic kidney disease

12/466 (2.6)

8/425 (1.9)

0.05

 Diabetes mellitus

131/464 (28.2)

102/425 (24.0)

0.10

 Cirrhosis

32/457 (7.0)

26/419 (6.2)

0.03

 Immunodeficiency

64/463 (13.8)

63/426 (14.8)

0.03

 Cancer

78/462 (16.9)

78/422 (18.5)

0.04

SAPS II at day 1, median (IQR)b

60.0 (47.0–72.0)

56.0 (45.0–69.0)

0.15

SOFA score at admissionc, median (IQR)

9.0 (6.0–12.0)

9.0 (6.0–11.0)

0.08

Serum sodium level, mean (SD), mmol/L

137.8 (6.7)

138.1 (6.6)

0.03

Serum potassium level, mean (SD), mmol/L

4.2 (1.0)

4.0 (0.9)

0.22

Serum bicarbonate level, mean (SD), mmol/L

20.8 (7.4)

22.0 (6.4)

0.17

Serum creatinine level, median (IQR), mg/dL

1.1 (0.7–1.9)

1.0 (0.7–1.7)

0.10

PaO2:FiO2, mean (SD), mmHg

216.9 (140.8)

214.5 (133.3)

0.02

Main cause of admission

  

0.23

 Septic shockd

88 (18.6)

70 (16.2)

 

 ARDS or acute respiratory failure

172 (36.4)

151 (34.9)

 

 Heart failure

36 (7.6)

22 (5.1)

 

 Acute renal failure

10 (2.1)

8 (1.8)

 

 Post-surgery

14 (3.0)

20 (4.6)

 

 CNS injury

118 (25.0)

139 (32.1)

 

 Other

34 (7.2)

23 (5.3)

 

Vasopressors at day 0

268 (56.8)

236 (54.5)

0.05

Renal replacement therapy at day 0

33 (7.0)

25 (5.8)

0.05

ICU length of stay, median (IQR), days

12 (8–20)

11 (7–21)

 
  1. Stdiff denotes standardized difference (absolute value)
  2. ARDS Acute respiratory distress syndrome, CNS Central nervous system, ICU Intensive care unit, IQR Interquartile range
  3. aMcCabe score of A indicates no underlying disease that compromises life expectancy, B an estimated life expectancy with the chronic disease of less than 5 years, and C an estimated life expectancy with the chronic disease of less than 1 year. bSimplified Acute Physiology Score (SAPS) II ranges from 0 to 164, with higher scores indicating greater severity of symptoms. cSepsis-related Organ Failure Assessment (SOFA) score ranges from 0 to 24, with higher scores indicating more severe organ failure. dSeptic shock was defined as sepsis-related hypotension despite emergency fluid loading, requiring a vasopressor
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Critical Care

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