Plasma neurofilament light is a predictor of neurological outcome 12 h after cardiac arrest

Table 2 Accuracy of NfL at 95 and 100% specificity for prediction of poor outcome

	Time point	N	95% specificity				100% specificity
	Time point	N	Sensitivity %	Cut-off, pg/mL	NPV %	PPV %	Sensitivity %	Cut-off, pg/mL	NPV %	PPV %	pAUROC 95–100%
OHCA	0 h	289	15 (5–53)	59	33	87	6 (3–14)	118	32	100	0.53
	12 h	300	70 (56–78)	61	60	97	53 (47–71)	90	50	100	0.81
	48 h	210	89 (81–94)	220	80	97	82 (76–90)	336	72	100	0.92
IHCA	0 h	83	22 (0–51)	114	49	83	4 (0–42)	393	47	100	0.54
	12 h	87	45 (20–73)	133	57	92	29 (18–63)	207	52	100	0.67
	48 h	54	57 (34–77)	323	50	95	49 (34–77)	640	51	100	0.74

Sensitivities with 95% CI, cut-offs, negative predictive values (NPV), and positive predictive values (PPV) at pre-defined high specificities (95% and 100%) for neurofilament light (NfL) on admission (0 h), 12 and 48 h after OHCA and IHCA. The pAUROC presents the performance of NfL in the 95–100% specificity range. A 95% specificity indicates that 5% of the patients with good outcome had NfL levels above the cut-off. OHCA out-of-hospital cardiac arrest, IHCA in-hospital cardiac arrest, pAUROC partial area under the receiver operating curve

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