From: Plasma neurofilament light is a predictor of neurological outcome 12 h after cardiac arrest
OHCA (n = 328) | IHCA (n = 100) | |
---|---|---|
Age, years–median (IQR) | 67 (59–75) | 71 (59–77) |
Sex, male–n (%) | 247 (75) | 63 (63) |
Medical history | ||
Myocardial infarction–n (%) | 50 (15) | 19 (19) |
Congestive heart failure–n (%) | 52 (16) | 26 (26) |
Hypertension–n (%) | 124 (38) | 48 (48) |
Liver disease–n (%) | 6 (2) | 4 (4) |
Renal disease–n (%) | 24 (7) | 18 (18) |
Diabetes–n (%) | 66 (20) | 37 (37) |
Cerebrovascular disease–n (%) | 25 (8) | 15 (15) |
Dementia/cognitive impairment–n (%) | 13 (4) | 6 (6) |
Solid tumour–n (%) | 31 (9.5) | 17 (17) |
Cardiac arrest characteristics | ||
Time to ROSC, min–median (IQR) | 25 (15–40) | 10 (6–20) |
Witnessed cardiac arrest–n (%) | 256 (78) | 83 (83) |
Bystander-performed CPR–n (%) | 206 (63) | NA |
Arrest with medical personnel present–n (%) | 39 (12) | 100 (100) |
Shockable rhythm–n (%) | 177 (54)a | 21 (21)a |
Adrenaline–n (%) | 262 (80) | 83 (83) |
Cardiac cause–n (%) | 246 (75) | 38 (38) |
Characteristics on ICU admission | ||
GCS-M–median (IQR) | 1 (1–2)e | 3 (1–5)c |
Circulatory shock–n (%) | 103 (31) | 32 (32) |
Lactate–median (IQR) | 8.7 (5.3–11.6) | 6.7 (4.7–9.9) |
pH–median (IQR) | 7.2 (7.0–7.3) | 7.2 (7.0–7.3)a |
Outcome | ||
ICU length of stay, days–median (IQR) | 3.1 (1.9–5.0) | 3.2 (1.4–4.9) |
Hospital length of stay, days–median (IQR) | 6.0 (3.0–12.0)c | 9.5 (4.0–20.8)b |
WLST–n (%) | 181 (55) | 34 (34)a |
WLST due to poor neurological prognosis–n (%) | 159 (48)d | 26 (26)b |
Mortality at 30 days–n (%) | 214 (65)a | 46 (46)c |
Mortality at 180 days–n (%) | 221 (67)a | 53 (53)c |
Time to follow-up, months–median (IQR) | 4 (3–6) | 6 (4–6) |
CPC at follow-up–n (%) | ||
CPC 1 | 69 (21) | 24 (24) |
CPC 2 | 36 (11) | 21 (21) |
CPC 3 | 2 (1) | 3 (3) |
CPC 4 | 0 (0) | 0 (0) |
CPC 5 | 221 (67) | 52 (52) |