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Table 2 Parameter estimates, bootstrap medians, and confidence intervals

From: Target attainment and population pharmacokinetics of flucloxacillin in critically ill patients: a multicenter study

Parameter

Base model

Final model

Bootstrap of final model

Estimate, mean

RSE,%

Estimate, mean

RSE, %

Estimate, median

95% CI

CL, L/h/70kg0.75

52.8

23

–

–

–

–

Æ’r, CL/CLcr

–

–

19

13

19

12–27

V, L/70 kg

324

14

330

15

321

204–476

Æ’u, %

24

6

25

4.7

25

21–30

ex

-

-

0.67

16

0.63

0.29–1.14

Proportional error, total flucloxacillin, %

44

5

42

5.2

42

26–52

Proportional error, unbound flucloxacillin, %

35

5

35

5.2

35

25–42

IIV CL, %

127

–

–

–

-

–

IIV Æ’r, %

–

–

71

–

70

–

IIV V, %

79

–

84

–

80

–

IIV Æ’u, %

31

–

26

–

23

–

IIV ex, %

–

–

88

–

78

–

  1. CI confidence interval, CL clearance, Æ’r the unbound renal clearance of flucloxacillin divided by the creatinine clearance, Æ’u fraction unbound, IIV inter-individual variability, RSE relative standard error, ex exponent for serum albumin, V volume of distribution