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Table 2 Association between time-varying ventilatory variables and mortality in ARDS patients with different lung morphology

From: Lung morphology impacts the association between ventilatory variables and mortality in patients with acute respiratory distress syndrome

Model

Lung morphology

P for interaction

Focal (n = 142)

Non-focal (n = 254)

HR (95% CI)

P value

HR (95% CI)

P value

Model A

 Driving pressure

1.045 (0.962–1.135)

0.30

1.151 (1.111–1.193)

< 0.001

0.0039

Model B

 Mechanical Power

1.083 (1.04–1.128)

 < 0.001

1.066 (1.042–1.091)

< 0.001

0.31

Model C

 Ventilatory ratio

1.549 (1.045–2.294)

0.029

1.191 (0.988–1.436)

0.066

0.25

Model D*

 Driving pressure

1.060 (0.985–1.142)

0.12

1.156 (1.116–1.199)

< 0.001

–

 Respiratory rate

1.096 (1.030–1.167)

0.0041

1.027 (1.002–1.053)

0.033

–

Model E

 [(4 × DP) + RR]

1.019 (0.999–1.039)

0.057

1.036 (1.027–1.045)

< 0.001

0.093

Model F ([(4 × DP) + RR] vs. Power)#

 Mechanical Power

1.079 (1.029–1.131)

0.0017

1.034 (1.012–1.057)

0.0026

–

 [(4 × DP) + RR]

1.004 (0.983–1.025)

0.74

1.030 (1.020–1.040)

< 0.001

–

  1. ARDS acute respiratory distress syndrome, DP driving pressure, RR respiratory rate, HR hazard ratio, CI confidence interval
  2. *Model D was employed to compare the effect size of DP and RR on 28-day mortality in two groups, and interaction P value was not calculated
  3. #The interaction effect between lung morphology and power or [(4 × DP) + RR] on 28-day mortality was assessed in Model B and Model E, respectively. Model F was aimed to assess which variable had a stronger association with mortality in two groups, and interaction P value was not calculated
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Critical Care

ISSN: 1364-8535