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Table 4 Factors independently associated with clinical improvement at 72 h and 30-day mortality in univariate analysis of patients with Streptococcus pneumoniae meningitis

From: Severe community-acquired Streptococcus pneumoniae bacterial meningitis: clinical and prognostic picture from the intensive care unit

Factors

Failure of treatment at 72 h

30-day mortality

OR (95% CI)

p value

OR (95% CI)

p value

Age

1.02 (1.00–1.04)

0.020

1.01 (0.98–1.03)

0.525

Male

1.20 (0.70–2.05)

0.509

1.23 (0.58–2.60)

0.588

Predisposing conditions

    

Otitis

0.77 (0.45–1.33)

0.352

0.40 (0.17–0.95)

0.038

Sinusitis

1.12 (0.522–2.40)

0.771

0.85 (0.28–2.58)

0.774

HIV

0.54 (0.11–2.66)

0.450

3.35 (0.80–14.04)

0.099

Prior neurological symptomatology

0.76 (0.38–1.50)

0.423

0.23 (0.05–0.99)

0.049

Glasgow score

0.77 (0.70–0.85)

< 0.001

0.76 (0.67–0.86)

< 0.001

Glasgow < 8

3.25 (1.90–5.57)

< 0.001

2.96 (1.41–6.20)

0.004

APACHE-II score

1.14 (1.09–1.19)

< 0.001

1.14 (1.08–1.20)

< 0.001

SOFA score

1.44 (1.28–1.63)

< 0.001

1.42 (1.25–1.63)

< 0.001

SAPS3 score

1.09 (1.05–1.12)

< 0.001

1.05 (1.01–1.08)

0.006

Septic shock

4.44 (2.16–9.09)

< 0.001

3.14 (1.39–7.11)

0.006

Mechanical ventilation

19.78 (6.94–56.42)

< 0.001

4.61 (1.57–13.51)

0.005

CSF data

    

Glucose

1.00 (0.99–1.00)

0.140

0.98 (0.97–1.00)

0.046

White cell counts

1.00 (1.00–1.00)

0.921

1.00 (1.00–1.00)

0.635

Polymorphonuclears

1.00 (1.00–1.00)

0.950

1.00 (1.00–1.00)

0.831

Protein

1.00 (1.00–1.00)

 < 0.001

1.00 (1.00–1.00)

0.001

Serum data

    

White cell counts

1.00 (1.00–1.00)

0.781

1.00 (1.00–1.00)

0.366

Polymorphonuclears

1.00 (1.00–1.00)

0.465

1.00 (1.00–1.00)

0.587

Lymphocytes

1.00 (1.00–1.00)

0.624

1.00 (1.00–1.00)

0.217

C-reactive protein

1.00 (1.00–1.00)

0.625

1.00 (1.00–1.00)

0.785

Procalcitonin

1.01 (1.00–1.03)

0.080

1.01 (1.00–1.02)

0.097

Third-generation cephalosporin alone

0.69 (0.41–1.16)

0.163

1.57 (0.76–3.23)

0.219

Plus vancomycin regimen

1.38 (0.78–2.43)

0.267

0.88 (0.39–1.99)

0.762

Plus linezolid regimen

1.50 (0.71–3.17)

0.283

1.14 (0.41–3.19)

0.799

Other regimens

0.81 (0.35–1.85)

0.613

0.19 (0.26–1.47)

0.112

Delay start antibiotic therapy

0.81 (0.22–2.96)

0.746

5.43 (1.41–20.91)

0.014

Corticosteroids

1.41 (0.60–3.33)

0.432

0.56 (0.21–1.50)

0.252

Delay in starting steroids treatment

1.87 (0.83–4.21)

0.130

3.57 (1.39–9.15)

0.008

Early failure treatment

-

-

10.92 (4.53–26.32)

< 0.001