Factors | Failure of treatment at 72 h | 30-day mortality | ||
---|---|---|---|---|
OR (95% CI) | p value | OR (95% CI) | p value | |
Age | 1.02 (1.00–1.04) | 0.020 | 1.01 (0.98–1.03) | 0.525 |
Male | 1.20 (0.70–2.05) | 0.509 | 1.23 (0.58–2.60) | 0.588 |
Predisposing conditions | ||||
Otitis | 0.77 (0.45–1.33) | 0.352 | 0.40 (0.17–0.95) | 0.038 |
Sinusitis | 1.12 (0.522–2.40) | 0.771 | 0.85 (0.28–2.58) | 0.774 |
HIV | 0.54 (0.11–2.66) | 0.450 | 3.35 (0.80–14.04) | 0.099 |
Prior neurological symptomatology | 0.76 (0.38–1.50) | 0.423 | 0.23 (0.05–0.99) | 0.049 |
Glasgow score | 0.77 (0.70–0.85) | < 0.001 | 0.76 (0.67–0.86) | < 0.001 |
Glasgow < 8 | 3.25 (1.90–5.57) | < 0.001 | 2.96 (1.41–6.20) | 0.004 |
APACHE-II score | 1.14 (1.09–1.19) | < 0.001 | 1.14 (1.08–1.20) | < 0.001 |
SOFA score | 1.44 (1.28–1.63) | < 0.001 | 1.42 (1.25–1.63) | < 0.001 |
SAPS3 score | 1.09 (1.05–1.12) | < 0.001 | 1.05 (1.01–1.08) | 0.006 |
Septic shock | 4.44 (2.16–9.09) | < 0.001 | 3.14 (1.39–7.11) | 0.006 |
Mechanical ventilation | 19.78 (6.94–56.42) | < 0.001 | 4.61 (1.57–13.51) | 0.005 |
CSF data | ||||
Glucose | 1.00 (0.99–1.00) | 0.140 | 0.98 (0.97–1.00) | 0.046 |
White cell counts | 1.00 (1.00–1.00) | 0.921 | 1.00 (1.00–1.00) | 0.635 |
Polymorphonuclears | 1.00 (1.00–1.00) | 0.950 | 1.00 (1.00–1.00) | 0.831 |
Protein | 1.00 (1.00–1.00) | < 0.001 | 1.00 (1.00–1.00) | 0.001 |
Serum data | ||||
White cell counts | 1.00 (1.00–1.00) | 0.781 | 1.00 (1.00–1.00) | 0.366 |
Polymorphonuclears | 1.00 (1.00–1.00) | 0.465 | 1.00 (1.00–1.00) | 0.587 |
Lymphocytes | 1.00 (1.00–1.00) | 0.624 | 1.00 (1.00–1.00) | 0.217 |
C-reactive protein | 1.00 (1.00–1.00) | 0.625 | 1.00 (1.00–1.00) | 0.785 |
Procalcitonin | 1.01 (1.00–1.03) | 0.080 | 1.01 (1.00–1.02) | 0.097 |
Third-generation cephalosporin alone | 0.69 (0.41–1.16) | 0.163 | 1.57 (0.76–3.23) | 0.219 |
Plus vancomycin regimen | 1.38 (0.78–2.43) | 0.267 | 0.88 (0.39–1.99) | 0.762 |
Plus linezolid regimen | 1.50 (0.71–3.17) | 0.283 | 1.14 (0.41–3.19) | 0.799 |
Other regimens | 0.81 (0.35–1.85) | 0.613 | 0.19 (0.26–1.47) | 0.112 |
Delay start antibiotic therapy | 0.81 (0.22–2.96) | 0.746 | 5.43 (1.41–20.91) | 0.014 |
Corticosteroids | 1.41 (0.60–3.33) | 0.432 | 0.56 (0.21–1.50) | 0.252 |
Delay in starting steroids treatment | 1.87 (0.83–4.21) | 0.130 | 3.57 (1.39–9.15) | 0.008 |
Early failure treatment | - | - | 10.92 (4.53–26.32) | < 0.001 |