Skip to main content

Table 3 Treatment and neurological complications

From: Severe community-acquired Streptococcus pneumoniae bacterial meningitis: clinical and prognostic picture from the intensive care unit

Variables

Survivors (n = 220)

Non-survivors (n = 35)

p value

Treatment

   

Corticosteroids (n, %)

197 (89.50)

29 (82.86)

0.254

Third-generation cephalosporin alone (n, %)

101 (45.91)

20 (57.14)

0.274

Plus vancomycin regimen (n, %)

62 (28.18)

9 (25.71)

0.841

Plus linezolid regimen (n, %)

28 (12.73)

5 (14.29)

0.788

Other regimens (n, %)

29 (13.18)

1 (2.86)

0.092

Delay 2 h in starting antibiotic therapy (n, %)

64 (29.09)

13 (37.14)

0.105

Delay 6 h in starting antibiotic therapy (n, %)

6 (2.73)

4 (11.43)

0.023

Delay in starting steroid treatment (n, %)

19 (8.64)

8 (22.86)

0.011

Neurological complications

92 (41.82)

32 (91.42)

 <0.001

Brain abscess (n, %)

7 (3.18)

2 (5.71)

0.435

Cerebritis (n, %)

12 (5.45)

3 (8.57)

0.442

Epilepsy (n, %)

36 (16.36)

9 (25.71)

0.151

Ischemic stroke (n, %)

24 (10.91)

6 (17.14)

0.228

Brain edema (n, %)

23 (10.45)

14 (40.00)

< 0.001