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Table 2 Predictive performance of PPV change after TVC in low tidal mechanically ventilated patients

From: Does tidal volume challenge improve the feasibility of pulse pressure variation in patients mechanically ventilated at low tidal volumes? A systematic review and meta-analysis

Study/year

predictor

Subjective numbers could be calculated

Threshold (%)

Sensitivity

Specificity

AUROC of PPV change

AUROC of PPV

TP

FP

FN

TN

Myatra2017 [14]*

PPV

16

0

1

14

3.5

0.94

1.00

0.99 (0.98, 1.00)

0.69

PPV%

16

0

1

14

48

0.94

1.00

0.97 (0.92, 1.00)

 

Yonis 2017 [15]

PPV%

9

15

0

10

29

1.00 (0.66, 1.00)

0.40 (0.1, 0.7)

0.59 (0.31, 0.88)

0.49 (0.21, 0.77)

Jun2019 [16]*

PPV

24

2

2

14

1

0.92 (0.73, 0.99)

0.86 (0.57, 0.98)

0.95 (0.83, 0.99)

0.69 (0.52, 0.83)

PPV%

24

4

5

14

25

0.83 ((0.63, 0.95)

0.79 (0.49, 0.95)

0.87 (0.72, 0.96)

 

Messina2019 [17]

PPV%

21

5

1

19

13.3

0.95 (0.74, 1.00)

0.76 (0.53, 0.92)

0.94 (0.82, 0.99)

0.68 (0.50, 0.85)

Messina2020 [18]

PPV%

19

1

1

21

12.2

0.95

0.95

0.96 (0.87, 1.00)

0.69

Elsayed2021 [19]

PPV

16

2

1

30

3.5

0.94

0.94

0.96

0.85

Taccheri2021 [20]*

PPV

15

0

1

15

1

0.93 (0.68, 1.00)

1.00 (0.78, 1.00)

0.98 ± 0.02

0.66

PPV%

15

2

1

15

20

0.93 (0.68, 1)

0.87 (0.59, 0.98)

0.94 ± 0.04

 

Hamzaoui2021 [21]

PPV

22

10

10

32

2

0.69

0.76

0.73 (0.60, 0.84)

0.61 (0.48, 0.75)

Shi2022 [22]

PPV

42

7

1

42

3.5

0.98 (0.89, 0.99)

0.86 (0.75, 0.79)

0.94 (0.88, 0.99)

0.85 (0.77, 0.92)

Xu2022 [23]

PPV

31

9

14

45

2

0.84

0.84

0.90 (0.81, 0.96)

0.69 (0.57, 0.79)

  1. PPV pulse pressure variation, PPV absolute change of pulse pressure variation, PPV% percentage change of pulse pressure variation, Sen sensitivity, Spec specificity, AUROC area under the receiver operator characteristics curve, TP true positive, FP false positive, FN false negative, TN truth negative
  2. *The studies including both PPV and PPV%. Data were presented with 95% confidence interval or mean ± standard deviation if possible