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Table 1 General characteristics of selected studies

From: Does tidal volume challenge improve the feasibility of pulse pressure variation in patients mechanically ventilated at low tidal volumes? A systematic review and meta-analysis

Study/year

Patients

Setting

Sample size

Position during study

Primary /study predictor of PPV change

Secondary predictor of PPV change

PPV acquirement

Reference preload change

Reference standard

Reference standard acquirement

Tidal volume (ml/kg)

Mean lung compliance (ml/cm H2O)

Mean PEEP (cmH2O)

SB activity

Myatra2017 [14]

Acute circulatory failure patients

ICU

30

Supine

PPV

PPV%

PiCCO

VE 6 ml/kg PBW

CI ≥ 15%

TPTD

6

28.0 ± 7.0

8.4 ± 2.9

Avoid

Yonis 2017 [15]

ARDS patients

ICU

19

Prone

PPV%

N

PiCCO

VE 500 ml crystalloids

CI ≥ 15%

TPTD

6

30 (23, 39)

8 (5, 10)

Avoid

Jun2019 [16]

Patients undergoing robot-assisted laparoscopic surgery

OR

38

Trendelenburg

PPV

PPV%

CARESCAPE monitor

VE6ml/kg colloid

SVI ≥ 15%

ODM

6

16.8

5

Avoid

Messina2019 [17]

Patients undergoing neurosurgery

OR

40

Supine

PPV%

N

MostCare

VE 250 ml crystalloids

SVI ≥ 10%

MostCare

6

65 (58, 73)

5 (5, 5.5)

Avoid

Messina2020 [18]

Prone Neurosurgical Patients

OR

40

Prone

PPV%

N

MostCare

VE 250 ml crystalloids

SVI ≥ 10%

MostCare

6

65

5

Avoid

Elsayed2021 [19]

Hemodynamic instability patients

ICU

46

Semi-recumbent

PPV

N

Mindray monitor

VE 4 ml/kg

CI ≥ 15%

ODM

6

28.0 ± 6.0

unclear

Avoid

Taccheri2021 [20]

Mechanical ventilated patients

ICU

30

Semi-recumbent

PPV

PPV%

PiCCO

PLR

CI ≥ 10%

TPTD

6

31.5 ± 12.3

10.5 ± 3.3

Avoid

Hamzaoui2021 [21]

critically ill adult patients

ICU

54

semi-recumbent

PPV

N

Hemodynamic monitors

PLR

VTI ≥ 12%

TTE

6.0 (5.9, 6.3)

41 (36, 46)

10 (9, 11)

Yes

Shi2022 [22]

ARDS patients

ICU

84

Prone

PPV

N

PiCCO

Both Trendelenburg EEO8

CI ≥ 8% CI ≥ 5%

TPTD

6

32 (22, 41)

14 (11, 16)

Avoid

Xu2022 [23]

Septic shock patients

ICU

76

Supine

PPV

N

PiCCO

VE 250 ml crystalloids

CI ≥ 15%

TPTD

6

25.7 ± 3.8

9.5 ± 2.8

Avoid

  1. PiCCO pulse contour cardiac output, TPTD transpulmonary thermodilution, ODM esophageal Doppler monitor, iMEC10 Mindray monitor, OR operation room, ICU intensive care unit, RDS acute respiratory distress syndrome, PPV absolute change of pulse pressure variation, PPV% percentage change of pulse pressure variation, EEO8 end-expiratory occlusion performed at 8 ml/kg tidal volume, VE volume expansion, CI cardiac index, SVI stroke volume index, TTE Trans-thoracic echocardiography, VTI velocity–time integral, AUROC area under the receiver operator characteristics curve, N none, PEEP positive end-expiratory pressure, SB spontaneous breathing. Data were presented with 95% confidence interval or mean ± standard deviation if possible