Table 3 Outcomes of patients with early mobility levels 4–7, 1–3, and 0
Outcome | Early mobility 4–7 N = 85 | Early mobility 1–3 N = 356 | Early mobility 0 N = 1267 | Mobility 4–7 versus 0 | Mobility 1–3 versus 0 | ||
|---|---|---|---|---|---|---|---|
Hazard ratio (95% CI) | p value | Hazard ratio (95% CI) | p value | ||||
Primary outcomes | |||||||
Incident proximal lower-limb deep-vein thrombosis—no. (%) | 1/85 (1.2) | 7/348 (2.0) | 50/1230 (4.1) | 1.19 (0.16, 8.90) | 0.87 | 0.91 (0.39, 2.12) | 0.83 |
90-day mortality—no. (%) | 8/85 (9.4) | 37/356 (10.4) | 380/1266 (30.0) | 0.35 (0.17, 0.70) | 0.003 | 0.39 (0.27, 0.55) | < 0.0001 |
Secondary outcomes | |||||||
Prevalent proximal lower-limb deep-vein thrombosis—no. (%) | 0/85 (0) | 8/356 (2.2) | 37/1267 (2.9) | – | – | 1.17 (0.53, 2.61) | 0.69 |
Pulmonary embolism—no. (%) | 1/85 (1.2) | 0/356 (0) | 14/1267 (1.1) | 1.67 (0.21, 13.57) | 0.63 | – | 0.99 |
ICU mortality—no. (%) | 2/85 (2.4) | 18/ 356(5.1) | 236/1266 (18.6) | 0.53 (0.13, 2.19) | 0.38 | 0.59 (0.36, 0.97) | 0.037 |
28-day mortality—no. (%) | 5/85 (5.9) | 26/ 356(7.3) | 231/1266 (18.2) | 0.37 (0.15, 0.90) | 0.028 | 0.48 (0.31, 0.73) | 0.0006 |
Hospital mortality—no. (%) | 8/85 (9.4) | 32/356 (9.0) | 390/1266 (30.8) | 0.70 (0.34, 1.42) | 0.32 | 0.49 (0.34, 0.70) | 0.0001 |
| Â | Â | Â | Â | Beta estimate* (95% CI) | Â | Beta estimate* (95% CI) | Â |
Duration of mechanical ventilation—median (IQR)—days | 0 (0, 3) | 0 (0, 5) | 5 (1, 11) | − 0.90 (− 1.24, − 0.57) | < 0.0001 | − 0.42 (− 0.59, − 0.25) | < 0.0001 |
Mechanical ventilation-free days—median (IQR) | 28 (25, 28) | 28 (22, 28) | 21 (2, 26) | 0.27 (0.01, 0.52) | 0.04 | 0.19 (0.05, 0.33) | 0.009 |
Duration of vasopressor use—median (IQR)—days | 0 (0, 0) | 0 (0, 0) | 1 (0, 3) | − 1.08 (− 1.51, − 0.64) | < 0.0001 | − 0.60 (− 0.81, − 0.39) | < 0.0001 |
Vasopressor-free days—median IQR) | 28 (27, 28) | 28 (27, 28) | 27 (21, 28) | 0.15 (− 0.06, 0.37) | 0.17 | 0.10 (− 0.02, 0.22) | 0.09 |
ICU length of stay—median (IQR)—days | 4 (3, 7) | 6 (4, 9) | 9 (5, 18) | − 0.78 (− 1.00, − 0.55) | < 0.0001 | − 0.37 (− 0.49, − 0.25) | < 0.0001 |
ICU-free days, median (IQR) | 24 (21, 25) | 22 (18, 24) | 16 (0, 22) | 0.40 (0.10, 0.71) | 0.01 | 0.27 (0.10, 0.44) | 0.002 |
Hospital length of stay—median (IQR)—days | 10 (7, 18) | 13 (8, 23) | 22 (12, 46) | − 0.66 (− 0.90, − 0.42) | < 0.0001 | − 0.33 (− 0.46, − 0.20) | < 0.0001 |