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Fig. 5 | Critical Care

Fig. 5

From: Point-of-care diagnosis and monitoring of fibrinolysis resistance in the critically ill: results from a feasibility study

Fig. 5

Monitoring changes in fibrinolysis during 24 h alteplase infusion. A patient with fibrinolysis resistance secondary to bacterial pneumonia complicated by ARF was identified using the ClotPro TPA-test. Baseline TPA-test LT was 450 s. A low-dose alteplase infusion was commenced starting with a 25 mg bolus over 2 h, followed by a 1 mg/h infusion over 22 h. ClotPro analysis was repeated at the times indicated with EX-test, FIB-test and TPA-tests being performed. Analyses were performed within 10 min of blood collection. The plot depicts the results of the TPA-test lysis time presented as a percentage of the baseline value. The upper level of normal (ULN) at 50% on the Y-axis approximates the highest level measured in our healthy control population (LT range: 132–227 s, n = 20)

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Critical Care

ISSN: 1364-8535