Fig. 1
Similar levels of disordered coagulation and fibrinolysis occur in critically ill patients with or without COVID-19 disease. Standard ClotPro analysis was carried out from patients admitted to intensive care (n = 105) and the results compared based on the presence of COVID-19, with the results obtained from healthy ICU staff provided as a reference (n = 20). A FIB-test A10 indicates the fibrin clot amplitude 10 min after the commencement of clot formation stimulated with tissue factor. B EX-test A10 represents the fibrin (ogen) and platelet-dependent clot amplitude 10 min after the commencement of clot formation stimulated with tissue factor. C Platelet A10 is calculated by subtracting the FIB-test A10 value from the EX-test A10 value and indicates the platelet contribution to the clot. D TPA-test LT indicates the time at which 50% of the maximum fibrin clot formed is degraded by recombinant t-PA (650 ng/mL blood). A value of 2400 s indicates no lysis occurred within the timeframe of the assay. Individual data points presented, bars represent median and interquartile ranges. Nonparametric Mann–Whitney test performed between patient groups; ns = nonsignificant p value