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Table 1 Baseline characteristics of participants

From: Cytokine hemoadsorption with CytoSorb® in post-cardiac arrest syndrome, a pilot randomized controlled trial

 

Control (n = 11)

Hemoadsorption (n = 10)

p value

Patients’ characteristics

  Age, years

68 (48, 72)

72 (63, 77)

0.16

  Charlson score

5 (1, 5)

5 (3, 6)

0.33

  Chronic kidney disease (GFR < 30 ml/min)

1 (9%)

1 (10%)

1.00

  Chronic heart failure

1 (9%)

4 (40%)

0.15

  Diabetes

3 (27%)

3 (30%)

1.00

  Hypertension

9 (82%)

4 (40%)

0.08

  COPD

2 (18%)

1 (10%)

1.00

  Active smoker

9 (82%)

5 (50%)

0.18

  Aspirin

8 (73%)

2 (20%)

0.03

  Blockers of the renin–angiotensin system

5 (45%)

3 (30%)

 

Cardiac arrest characteristics

  No-flow duration, minutes

4 (0, 9)

4 (1, 10)

0.81

  Low-flow duration, minutes

20 (15, 40)

30 (22, 45)

0.31

  Time-to-ROSC

22 (18, 40)

36 (24, 50)

0.24

  Presenting rhythm

  

0.08

   Non-shockable

7 (64%)

2 (20%)

 

   Shockable

4 (36%)

8 (80%)

 

  Cause of cardiac arrest

  

1.00

   Ischemic

5 (45%)

6 (60%)

 

   Hypoxic

2 (18%)

1 (10%)

 

   Other

4 (37%)

3 (30%)

 

  Location of cardiac arrest

  

0.31

   In-hospital

4 (36%)

1 (10%)

 

   Out-of-hospital

7 (64%)

9 (90%)

 

Laboratory at ICU admission

   

  Serum creatinine, µmol/L

117 (92, 204)

133 (123, 210)

0.22

  Lactate, mmol/L

7 (5, 12)

4 (3, 5)

0.02

  Hemoglobin, g/L

122 (109, 137)

130 (120, 149)

0.44

  C-reactive protein, mg/L

5 (2, 18)

3 (2, 70)

0.96

  Thrombocytes, G/l

192 (111, 225)

203 (172, 261)

0.42

  aPTT, sec

34 (30, 39)

41 (34, 150)

0.16

  Plasma interleukin-6, pg/mL (at randomization)

79 (55, 11,296)

319 (80, 19,653)

0.40

Scores and vasopressors at randomization

   

  SOFA score

12 (9, 13)

11 (8, 13)

0.52

  Noradrenalin, µg/min

10 (4, 20)

16 (6, 32)

0.60

Targeted temperature management

   

  Delay ICU admission to TTM, hours

3 (0.5, 4)

4 (2, 5)

0.45

  Delay TTM to randomization, hours

10 (− 0.5, 12)

8 (0.25, 17)

0.48

  Average temperature during TTM, °C

35 (35, 36)

35 (35, 36)

0.46

  Duration of TTM, hours

23 (17, 24)

24 (22, 24)

0.43

  1. Data are presented as median (interquartile range—IQR) for continuous measures, and n (%) for categorical measures. Continuous measures are compared with a Wilcoxon rank-sum test and categorical measures are compared with a Fisher's exact test
  2. aPTT activated partial thromboplastin clotting time, COPD chronic obstructive pulmonary disease, GFR glomerular filtration rate, ICU intensive care unit, ROSC return of spontaneous circulation, TTM targeted temperature management