Fig. 3

Odds ratios for mortality of each threshold in comparison with usual care. For both primary analysis (MIMIC-IV) and secondary analysis (AmsterdamUMCdb), this figure shows the posterior odds ratios (mean and 95% credible interval) for 28-day mortality alongside the probabilities that the posterior odds ratio (OR) is less than 1 (P(OR < 1.0)), less than 0.9 (P(OR < 0.9)), and less than 0.8 (P(OR < 0.8)). The reference threshold is usual care (OR = 1). SF = saturation-to-inspired oxygen fraction ratio, RR = respiratory rate. Respiratory trial criteria were 2 of RR > 40, saturation < 90 on inspired oxygen 0.90 or higher, abnormal work of breathing, or pH < 7.35; hemodynamic criterion was use of vasopressors; neurologic criterion was Glasgow Coma Scale < 9. Predicted SF was calculated using linear extrapolation between the current and previous SF measurements (measurements occurred every 2 h)