Association of ultra-early diffusion-weighted magnetic resonance imaging with neurological outcomes after out-of-hospital cardiac arrest

Table 4 Prediction of poor neurological outcome at 6 months using DW-MRI and various predictor combinations

Combination	AUC (95% CI)	TP	TN	FN	Sensitivity (95% CI)	Specificity (95% CI)	PPV (95% CI)	NPV (95% CI)
DW-MRI + Serum NSE	0.91 (0.84–0.96)	45	48	17	72.6 (60.3–82.2)	100.0 (91.2–100.0)	100.0 (90.6–100.0)	73.8 (62.0–83.1)
DW-MRI + CSF NSE, 89^a	0.97 (0.90–0.99)	47	36	6	88.7 (77.1–95.1)	100.0 (88.5–100.0)	100.0 (91.0–100.0)	85.7 (71.8–93.7)
DW-MRI + PV 650	0.89 (0.82–0.95)	48	48	14	77.4 (65.5–86.2)	100.0 (91.2–100.0)	100.0 (91.2–100.0)	77.4 (65.5–86.2)
DW-MRI + GWR, 95^a	0.90 (0.83–0.96)	44	38	13	77.2 (64.7–86.3)	100.0 (89.1–100.0)	100.0 (90.4–100.0)	74.5 (61.0–84.6)
DW-MRI + Low flow time	0.91 (0.84–0.96)	46	48	16	74.2 (62.0–83.5)	100.0 (91.2–100.0)	100.0 (90.8–100.0)	75.0 (63.1–84.1)
DW-MRI + Q_A, 89^a	0.86 (0.77–0.92)	39	36	14	73.6 (60.3–83.7)	100.0 (88.5–100.0)	100.0 (89.3–100.0)	72.0 (58.2–82.6)

AUC area under curve; TP true positive; TN true negative; FP false negative; FN false positive; CI confidence interval; NPV negative predictive value; PPV positive predictive value; DW-MRI diffusion-weighted magnetic resonance imaging; NSE neuron-specific enolase; CSF cerebrospinal fluid; PV 650 the percentage of voxels below 650 × 10⁻⁶ mm²/s; GWR gray-white matter ratio; Q_A albumin quotient
^aNumber of patients included in the analysis

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