Skip to main content

Table 2 Primary, secondary, and exploratory outcomes

From: Effect of high-flow oxygen versus T-piece ventilation strategies during spontaneous breathing trials on weaning failure among patients receiving mechanical ventilation: a randomized controlled trial

Outcomes

T-piece SBT

(n = 54)

High-flow oxygen SBT

(n = 54)

Risk difference

(95% CI)

p value

Primary outcome

Weaning failure on Day 2, no. (%)a

5 (9.3)

3 (5.6)

3.7 (− 6.1–13.6)

0.713

Secondary and exploratory outcomes

Weaning failure on day 7, no (%)b

13 (24.1)

7 (13.0)

11.1 (− 3.4–25.6)

0.215

Successful SBT within 72 h, no. (%)

53 (98.1)

54 (100)

− 1.9 (− 5.5–1.7)

> 0.999

Extubation after first SBT, no. (%)

51 (94.4)

53 (98.1)

− 3.7 (− 10.8–3.4)

0.610

Reintubation within 48 h, n/total (%)c

4/53 (7.5)

2/53 (3.8)

3.7 (− 5.0–12.5)

0.674

Reintubation within 7 d, n/total (%)c

12/53 (22.6)

6/53 (11.3)

11.3 (− 2.8–25.4)

0.196

Apply NIV within 48 h after extubation, no. (%)c

11/53 (20.7)

13/53 (24.5)

− 3.8 (− 19.7–12.1)

0.816

Apply HFNC within 48 h after extubation, no. (%)c

40/53 (75.5)

42/53 (79.2)

− 3.7 (− 19.7–12.1)

0.816

ICU length of stay, d

3 (1–7)

2 (1–5)

 

0.107

Hospital length of stay, d

22 (12–44)

25 (16–46)

 

0.435

ICU mortality, no. (%)

3 (5.6)

3 (5.6)

0.0 (− 8.6–8.6)

> 0.999

Hospital mortality, no. (%)

21 (38.9)

19 (35.2)

3.7 (− 14.5–21.9)

0.842

  1. HFNC High-flow nasal cannula, ICU Intensive care unit, NIV Noninvasive ventilation, SBT Spontaneous breathing trial
  2. aDefined as either the failure of SBT within 72 h after starting the first SBT or the need for reintubation or death within 48 h following extubation
  3. bDefined as either the failure of SBT within 72 h after starting the first SBT or the need for reintubation or death within 7 days following extubation
  4. cAmong patients extubated after successful SBT within 72 h
Back to article page

Critical Care

ISSN: 1364-8535